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| 1 | An overview of the latest developments in facial imaging显示文摘Facial imaging is a term used to describe methods that use facial images to assist or facili-tate human identification. This pertains to two craniofacial identification procedures that use skulls and faces—facial approximation and photographic superimposition—as well as face-only methods for age progression/regression, the construction of facial graphics from eye-witness memory (including composites and artistic sketches), facial depiction, face mapping and newly emerging methods of molecular photofitting. Given the breadth of these facial imaging techniques, it is not surprising that a broad array of subject-matter experts partici-pate in and/or contribute to the formulation and implementation of these methods (includ-ing forensic odontologists, forensic artists, police officers, electrical engineers, anatomists, geneticists, medical image specialists, psychologists, computer graphic programmers and software developers). As they are concerned with the physical characteristics of humans, each of these facial imaging areas also falls in the domain of physical anthropology, although not all of them have been traditionally regarded as such. This too offers useful opportunities to adapt established methods in one domain to others more traditionally held to be disciplines within physical anthropology (e.g. facial approximation, craniofacial super-imposition and face photo-comparison). It is important to note that most facial imaging methods are not currently used for identification but serve to assist authorities in narrowing or directing investigations such that other, more potent, methods of identification can be used (e.g. DNA). Few, if any, facial imaging approaches can be considered honed end-stage scientific methods, with major opportunities for physical anthropologists to make meaningful contributions. Some facial imaging methods have considerably stronger scientific underpin-nings than others (e.g. facial approximation versus face mapping), some currently lie entirely within the artistic sphere (facial depiction), and yet others are so aspirational that realistic capacity to obtain their aims has strongly been questioned despite highly advanced tech-nical approaches (molecular photofitting). All this makes for a broad-ranging, dynamic and energetic field that is in a constant state of flux. This manuscript provides a theoretical snap-shot of the purposes of these methods, the state of science as it pertains to them, and their latest research developments. | Carl N.Stephan Jodi M.Caple Pierre Guyomarc'h Peter Claes | 2019 | Forensic Sciences Research2019，4，1： | 3 |
| 2 | NOTUM inhibition increases endocortical bone formation and bone strength显示文摘The disability,mortality and costs caused by non-vertebral osteoporotic fractures are enormous.Existing osteoporosis therapies are highly effective at reducing vertebral but not non-vertebral fractures.Cortical bone is a major determinant of non-vertebral bone strength.To identify novel osteoporosis drug targets,we phenotyped cortical bone of 3 366 viable mouse strains with global knockouts of druggable genes.Cortical bone thickness was substantially elevated in Notum?/?mice.NOTUM is a secreted WNT lipase and we observed high NOTUM expression in cortical bone and osteoblasts but not osteoclasts.Three orally active small molecules and a neutralizing antibody inhibiting NOTUM lipase activity were developed.They increased cortical bone thickness and strength at multiple skeletal sites in both gonadal intact and ovariectomized rodents by stimulating endocortical bone formation.Thus,inhibition of NOTUM activity is a potential novel anabolic therapy for strengthening cortical bone and preventing non-vertebral fractures. | Robert Brommage Jeff Liu Peter Voge Faika Mseeh Andrea Y.Thompson David G.Potter Melanie K.Shadoan Gwenn M.Hansen Sabrina Jeter-Jones Jie Cui Dawn Bright Jennifer P.Bardenhagen Deon D.Doree Sofia Moverare-Skrtic Karin H.Nilsson Petra Henning Ulf H.Lerner Claes Ohlsson Arthur T.Sands James E.Tarver David R.Powell Brian Zambrowicz Qingyun Liu | 2019 | Bone Research2019，7，1： | 2 |
| 3 | Vorapaxar in patients with peripheral artery disease and acute coronary syndrome: Insights from Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER)显示文摘 | William Schuyler Jones Pierluigi Tricoci Zhen Huang David J. Moliterno Robert A. Harrington Peter R. Sinnaeve John Strony Frans Van de Werf Harvey D. White Claes Held Paul W. Armstrong Philip E. Aylward Edmond Chen Manesh R. Patel Kenneth W. Mahaffey | 2014 | American Heart Journal2014，，4： | 1 |
| 4 | Does glyceryl nitrate prevent post-ERCP pancreatitis? A prospective, randomized, double-blind, placebo-controlled multicenter trial显示文摘 | Camilla N?jgaard Mads Hornum Margarita Elkjaer Claes Hjalmarsson Laurent Heyries Truls Hauge K?re Bakkevold Per Kragh Andersen Peter Matzen | 2009 | Gastrointestinal Endoscopy2009，，6： | 1 |
| 5 | On measurement of intangible assets:A study of robustness of partial least squares显示文摘 | Cassel Claes M Hackl Peter | 2000 | Total Quality Management2000，11，7： | 1 |
| 6 | Microsatellite instability in sporadic colon carcinomas has no independent prognostic value in a Belgian study population显示文摘 | Vanessa Deschoolmeester Nancy Van Damme Marc Baay Kathleen Claes Eric Van Marck Filip J. Baert Wim Wuyts Marc Cabooter Joost Weyler Peter Vermeulen Filip Lardon Jan B. Vermorken Marc Peeters | 2008 | European Journal of Cancer2008，，15： | 1 |
| 7 | Intrathecal and epidural somatostatin in rats:Can antinociception, motor effects and neurotoxicity be separated 显示文摘 | Peter M Claes P Ivar P | 1990 | Pain1990，43，： | 1 |
| 8 | VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: an analysis of data from the AViTA and AVOREN randomised trials显示文摘 | Diether Lambrechts Bart Claes Paul Delmar Joke Reumers Massimiliano Mazzone Betül T Yesilyurt Roland Devlieger Chris Verslype Sabine Tejpar Hans Wildiers Sanne de Haas Peter Carmeliet Stefan J Scherer Eric Van Cutsem | 2012 | Lancet Oncology2012，，7： | 1 |
| 9 | The effect of mecha nical o n local vascularization and tissue differentiation in callus healing显示文摘 | Lutz claes Kerstin Eckert-Heubner Peter Augat | 2002 | J of O rthop Res2002，20，5： | 1 |
| 10 | Complications after tonsillectomy显示文摘 | Peter Claes J Saldien V | 2001 | Acta Otorhinolaryngol2001，55，： | 1 |
| 11 | The effect of mechanical stability on local vascularization and tissue differentiation in callus healing显示文摘 | Lutz Claes Kerstin Eckert-Hübner Peter Augat | 2002 | Journal of Orthopaedic Research2002，，： | 1 |
| 12 | Framing Politics at the Launch of the Euro: A Cross-National Comparative Study of Frames in the News显示文摘 | Claes H. De Vreese Jochen Peter Holli A. Semetko | 2001 | Political Communication2001，，2： | 1 |
| 13 | In Silico Analysis of Kinase Expression Identifies WEE1 as a Gatekeeper against Mitotic Catastrophe in Glioblastoma显示文摘 | Shahryar E. Mir Philip C. De Witt Hamer Przemek M. Krawczyk Leonora Balaj An Claes Johanna M. Niers Angela A.G. Van Tilborg Aeilko H. Zwinderman Dirk Geerts Gertjan J.L. Kaspers W. Peter Vandertop Jacqueline Cloos Bakhos A. Tannous Pieter Wesseling Jacob | 2010 | Cancer Cell2010，，3： | 1 |
| 14 | 醛糖还原酶抑制剂对小鼠胰岛山梨醇代谢的影响显示文摘观察了一种醛糖还原酶抑制剂(ICI 128436)对小鼠胰岛体外培养时山梨醇代谢的影响情况。小鼠胰岛培养72小时后,酶抑制剂处理过的胰岛山梨醇水平较对照组显著降低。结果表明小鼠胰岛可以合成山梨醇,其生成水平与醛糖还原酶的活性密切有关。 | 李佐强 Naeser Peter Claes Hellerstr | 1993 | 中华内分泌代谢杂志1993，9，3： | 1 |
| 15 | Self-Critical Perfectionism, Stress Generation, and Stress Sensitivity in Patients with Chronic Fatigue Syndrome: Relationship with Severity of Depression显示文摘 | Luyten Patrick Kempke Stefan Van Wambeke Peter Claes Stephan Blatt Sidney J. Van Houdenhove Boudewijn | 2011 | EN2011，，： | 1 |
| 16 | De Novo Mutations in the Sodium-Channel Gene SCN1A Cause Severe Myoclonic Epilepsy of Infancy显示文摘 | Lieve Claes Jurgen Del-Favero Berten Ceulemans Lieven Lagae Christine Van Broeckhoven Peter De Jonghe | 2001 | The American Journal of Human Genetics2001，，6： | 1 |
| 17 | Influence of size and stability of the osteotomy gap on the success of fracture healing 显示文摘 | CLAES L PETER A SUGER G | 1997 | Journal of Orthopaedic Research1997，15，4： | 1 |
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