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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | Low-dose tacrolimus ameliorates liver inflammation and fibrosis in steroid refractory autoimmune hepatitis显示文摘AIM: To determine the eff icacy of tacrolimus on clinical status, histopathological status and biochemical markers in patients with steroid refractory autoimmune hepatitis (AIH). METHODS: Retrospectively, clinical parameters, biochemistry and histology were obtained from patient records. RESULTS: Nine patients [8 females/1 male, median age 32 (range 16-64) years] were identified to have received tacrolimus for a median duration of 18 (12-37) mo. Before initiation of tacrolimus treatment the patients were maintained on a prednisolone dose of 20 mg daily (range 20-80 mg/d), which was tapered to 7.5 (5-12.5) mg/d (P = 0.004). Alanine aminotransferase and immunoglobulin-G concentrations decreased from 154 (100-475) to 47(22-61) U/L (P = 0.007), and from 16 (10-30.2) to 14.5 (8.4-20) g/L (P = 0.032), respectively. All patients showed improvement of the liver inflammatory activity, as determined by the Ishak score (P = 0.016), while the degree of f ibrosis tended to decrease (P = 0.049). CONCLUSION: The use of low dose tacrolimus can lead to biochemical and histologic improvement of inflammation with no progression of the stage of f ibrosis in patients with steroid refractory AIH. Low dose tacrolimus therapy also allows substantial reduction of prednisone dose. | Fin Stolze Larsen Ben Vainer Martin Eefsen Peter Nissen Bjerring Bent Adel Hansen | 2007 | World Journal of Gastroenterology2007，13，23： | 15 |
| 3 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 4 | 高中生生殖道感染/性知识、态度和行为调查显示文摘目的了解深圳市高中生生殖道感染(RTIs)/性相关知识、态度、行为(KAP)及求医、求助情况,探讨解决方法。方法采取社会学访谈、流行病学问卷调查方法,选择深圳市普通、职业高中的学生作为访谈及问卷调查对象。结果艾滋病(AIDS)知识总知晓率为50%,RTIs症状的知晓率为0,安全套知识正确回答率64.55%,使用率低;对早恋、婚前性行为多持理解及支持态度;多数去私人诊所求医,大多向朋友、同学求助。结论当今中学生性观念和性行为均日趋开放,而性知识、性病、AIDS预防知识缺乏,求医、求助方式不安全;因此,在中学阶段开展AIDS教育应与性健康教育结合,正确引导其求医、求助方式,以此作为中学生预防AIDS一项重要措施。 | 梁秀 余莉 曾光 吴淑艳 Peter Hansen | 2006 | 中国公共卫生2006，22，9： | 4 |
| 5 | Efficacy of SpyGlass^(TM)-directed biopsy compared to brush cytology in obtaining adequate tissue for diagnosis in patients with biliary strictures显示文摘AIM: To evaluate the diagnostic yield(inflammatory activity) and efficiency(size of the biopsy specimen) of SpyGlassTM-guided biopsy vs standard brush cytology in patients with and without primary sclerosing cholangitis(PSC).METHODS: At the University Medical Center Mainz, Germany, 35 consecutive patients with unclear biliarylesions(16 patients) or long-standing PSC(19 patients) were screened for the study. All patients underwent a physical examination, lab analyses, and abdominal ultrasound. Thirty-one patients with non-PSC strictures or with PSC were scheduled to undergo endoscopic retrograde cholangiography(ERC) and subsequent per-oral cholangioscopy(POC). Standard ERC was initially performed, and any lesions or strictures were localized. POC was performed later during the same session. The Boston Scientific SpyGlass SystemTM(Natick, MA, United States) was used for choledochoscopy. The biliary tree was visualized, and suspected lesions or strictures were biopsied, followed by brush cytology of the same area. The study endpoints(for both techniques) were the degree of inflammation, tissue specimen size, and the patient populations(PSC vs non-PSC). Inflammatory changes were divided into three categories: none, low activity, and high activity. The specimen quantity was rated as low, moderate, or sufficient.RESULTS: SpyGlassTM imaging and brush cytology with material retrieval were performed in 29 of 31(93.5%) patients(23 of the 29 patients were male). The median patient age was 45 years(min, 20 years; max, 76 years). Nineteen patients had known PSC, and 10 showed non-PSC strictures. No procedure-related complications were encountered. However, for both methods, tissues could only be retrieved from 29 pa-tients. In cases of inflammation of the biliary tract, the diagnostic yield of the SpyGlassTM-directed biopsies was greater than that using brush cytology. More tissue material was obtained for the biopsy method than for the brush cytology method(P = 0.021). The biopsies showed significantly more inflammatory characteristics and greater inflammatory activity compared to the cy-tological investigation(P = 0.014). The greater quantity of tissue samples proved useful for both PSC and non-PSC patients.CONCLUSION: SpyGlassTM imaging can be recom-mended for proper inflammatory diagnosis in PSC pa-tients. However, its value in diagnosing dysplasia wasnot addressed in this study and requires further investi-gation. | Johannes Wilhelm Rey Torsten Hansen Sebastian Dümcke Achim Tresch Katja Kramer Peter Robert Galle Martin Goetz Marcus Schuchmann Ralf Kiesslich Arthur Hoffman | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 2 |
| 6 | Phonocardiography as a Monitor of Cardiac Performance During Anesthesia显示文摘 | Peter B. Hansen Aldo A. Luisada David J. Miletich Ronald F. Albrecht | 1989 | Anesthesia & Analgesia1989，，3： | 1 |
| 7 | Ethanol-diesel fuel blends--A Review 显示文摘 | HANSEN Alan C ZHANG Qin LYNE Peter W L | 2005 | Bioresource Technology2005，96，3： | 1 |
| 8 | Ethanol-diesel fuel blends:A review显示文摘 | Hansen Alan C Zhang Qing Lyne Peter W L | 2005 | Bioresource Technology2005，96，： | 1 |
| 9 | Ethanol-Diesel Fuel Blends-A Review显示文摘 | Hansen Alan C Zhang Qin Lyne Peter W L | 2005 | Bioresource Technology2005，96，3： | 1 |
| 10 | Subclinical Coronary and Aortic Atherosclerosis Detected by Magnetic Resonance Imaging in Type 1 Diabetes With and Without Diabetic Nephropathy显示文摘 | Won Yong Kim Anne Sofie Astrup Matthias Stuber Lise Tarnow Erling Falk René M. Botnar Cheryl Simonsen Lotte Pietraszek Peter R. Hansen Warren J. Manning Niels T. Andersen Hans-Henrik Parving | 2007 | Circulation2007，，2： | 1 |
| 11 | Preoperative lateral subluxation of the patella is a predictor of poor early outcome of Oxford phase-III medial unicompartmental knee arthroplasty显示文摘 | Stig Munk Anders Odgaard Frank Madsen Jesper Dalsgaard Lars Peter Jorn Otto Langhoff Claus Fink Jepsen Torben B?k Hansen | 2011 | Acta Orthopaedica2011，，5： | 1 |
| 12 | Bile duct injury in laparoscopic cholecystectomy显示文摘 | SAVEN ADAMSEN OLE HART HANSEN PETER FUNCHJENSEN | 1997 | J An Coll Surg1997，184，6： | 1 |
| 13 | Catheter ablation of stable ventricular tachycardia before defibrillator implantation in patients with coronary heart disease (VTACH): a multicentre randomised controlled trial显示文摘 | Karl-Heinz Kuck Anselm Schaumann Lars Eckardt Stephan Willems Rodolfo Ventura Etienne Delacrétaz Heinz-Friedrich Pitschner Josef Kautzner Burghard Schumacher Peter S Hansen | 2010 | The Lancet2010，，9708： | 1 |
| 14 | A Test for Superior Predictive Ability显示文摘 | Peter Reinhard Hansen | 2005 | Journal of Business & Economic Statistics2005，，4： | 1 |
| 15 | Exaggeration of nonculprit stenosis severity during acute myocardial infarction: implications for immediate multivessel revascularization显示文摘 | Colm G Hanratty Yutaka Koyama Helge H Rasmussen Greg I.C Nelson Peter S Hansen Michael R Ward | 2002 | Journal of the American College of Cardiology2002，，5： | 1 |
| 16 | Multilevel optimization in aircraft structural design evaluation显示文摘 | Lars U. Hansen Peter Horst | 2007 | Computers and Structures2007，，1： | 1 |
| 17 | Evaluation of the embryotoxic potency of compounds in a newly revised high throughput embryonic stem cell test显示文摘 | Peters AK Steemans M Hansen E | 2008 | Toxicol Sci2008，105，2： | 1 |
| 18 | Endurance training reduces the contraction-induced interleukin-6 mRNA expression in human skeletal muscle显示文摘 | CHRISTIAN P FISCHER PETER PLOMGAARD ANNE K HANSEN | 2004 | Am J Physiol Endocrinol Metab2004，287，6： | 1 |
| 19 | Ethanol-diesel fuel blends-a review显示文摘 | HANSEN A C QIN ZHANG PETER W L LYNE | 2005 | Bioresource Technology2005，96，： | 1 |
| 20 | Large Sample Properties of Gener- alized Method of Moments Estimators显示文摘 | Lars Peter Hansen | 1982 | Economet- rica1982，50，： | 1 |
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