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| 1 | 1999~2006年急性冠脉综合征患者死亡及心力衰竭发生率降低显示文摘背景:有关药物和介入治疗对ST段抬高型和非ST段抬高型急性冠脉综合征(non—ST-segment elevation acute coronary syndrome,NSTE ACS)患者的作用,随机试验已经提供了足够的证据,但是是否已经转化为相应的临床变化还不清楚。
目的:确定ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)和NSTE ACS患者的院内治疗改变是否伴随临床结果的改善。
设计、地点及患者:全球急性冠脉事件注册研究(Global Registry of Acute Coronary Events,GRACE)是一项多国家队列研究。自1999年7月1日至2006年12月31日,该研究共入选并随访了来自14个国家、113家医院的44372例ACS患者。
主要观测指标:当前循证药物和介入治疗应用的趋势及患者预后(死亡、充血性心力衰竭、肺水肿、心源性休克、卒中和心肌梗死)。
结果:随着研究时间的进展,相关药物的应用增加(β-受体阻滞剂、他汀类药物、血管紧张素转换酶抑制剂、行或未行经皮冠状动脉介入治疗[percutaneous coronary intervention,PCI]患者应用噻氯毗啶、糖蛋白Ⅱb/Ⅲa抑制剂和低分子肝素;P〈0.001)。STEMI患者药物再灌注治疗下降了22个百分点(95%可信区间[confidence interval,CI],-27~-17),而直接PCI增加了37个百分点(95%CI,33—41)。在NSTEMI患者中,PCI的比例显著升高了18个百分点(95%CI,15~20)。充血性心力衰竭和肺水肿在STEMI患者中降低了9个百分点(95%CI,-12~-6),在NSTEACS患者中降低了6.9个百分点(95%CI,-8.4~-4.7)。STEMI患者的院内死亡率降低了18个百分点(95%CI,-5.3~-1.9),心源性休克降低了24个百分点(95%CI,-4.3~-0.5)。校正了危险评分后,NSTEACS患者的院内死亡率降低了0.7个百分点(95%CI,-1.7~0.3);STEMI患者6个月随访时卒中发生率降低了0.8个百分点(95%CI,-1.7~0.1),心肌梗死发生率降低了2.8个百分点(95%CI,-6.4~0.9)。NSTEACS患者6个月死亡率降低了1.6个百分点(95%CI,-3.0~-0.1),卒中发生率降低了0.7个百分点(95%CI,-1.4~0.1)。
结论:在本项多国家观察性研究中,ACS患者治疗的改善与6个月新发心力衰竭、死亡率、卒中和心肌梗死发生率显著降低相关。 | Keith A. A. Fox Philippe Gabriel Steg Kim A. Eagle Shaun G. Goodman Frederick A. Anderson Christopher B. Granger Marcus D. Flather Andrzej Budaj Ann Quill Joel M. Gore 康俊萍(译) 马长生(校) | 2007 | 美国医学会杂志(中文版)2007，26，6： | 6 |
| 2 | 多器官床旁即时超声在新型冠状病毒肺炎中的应用:国际专家共识显示文摘新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征(ARDS)。前期,由于缺乏相关研究,面对日益紧迫的临床困境,医务人员不得不借鉴采取一些经验性措施以应对疫情。 | 王臻(译) Arif Hussain Gabriele Via Lawrence Melniker Alberto Goffi Guido Tavazzi Luca Neri Tomas Villen Richard Hoppmann Francesco Mojoli Vicki Noble Laurent Zieleskiewicz Pablo Blanco Irene W.Y.Ma Mahathar Abd.Wahab Abdulmohsen Alsaawi Majid AI Salamah Martin Balik Diego Barca Karim Bendjelid Belaid Bouhemad Pablo Bravo-Figueroa Raoul Breitkreutz Juan Calderon Jim Connolly Roberto Copetti Francesco Corradi Anthony J.Dean AndréDenault Deepak Govil Carmela Graci Young-Rock Ha Laura Hurtado Toru Kameda Michael Lanspa Christian B Laursen Francis Lee Rachel Liu Massimiliano Meineri Miguel Montorfano Peiman Nazerian Bret P.Nelson Aleksandar N.Neskovic Ramon Nogue Adi Osman JoséPazeli Elmo Pereira-Junior Tomislav Petrovic Emanuele Pivetta Jan Poelaert Susanna Price Gregor Prosen Shalim Rodriguez Philippe Rola Colin Royse Yale Tung Chen Mike Wells Adrian Wong Wang Xiaoting Wang Zhen Yaseen Arabi | 2021 | 中国呼吸与危重监护杂志2021，20，2： | 5 |
| 3 | Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice显示文摘 | Tiphaine Le Roy Marta Llopis Patricia Lepage Aurélia Bruneau Sylvie Rabot Claudia Bevilacqua Patrice Martin Catherine Philippe Francine Walker André Bado Gabriel Perlemuter Anne-Marie Cassard-Doulcier Philippe Gérard | 2013 | Gut2013，，12： | 3 |
| 4 | Stable femtosecond X-rays with tunable polarization from a laser-driven accelerator显示文摘Technology based on high-peak-power lasers has the potential to provide compact and intense radiation sources for a wide range of innovative applications.In particular,electrons that are accelerated in the wakefield of an intense laser pulse oscillate around the propagation axis and emit X-rays.This betatron source,which essentially reproduces the principle of a synchrotron at the millimeter scale,provides bright radiation with femtosecond duration and high spatial coherence.However,despite its unique features,the usability of the betatron source has been constrained by its poor control and stability.In this article,we demonstrate the reliable production of X-ray beams with tunable polarization.Using ionization-induced injection in a gas mixture,the orbits of the relativistic electrons emitting the radiation are reproducible and controlled.We observe that both the signal and beam profile fluctuations are significantly reduced and that the beam pointing varies by less than a tenth of the beam divergence.The polarization ratio reaches 80%,and the polarization axis can easily be rotated.We anticipate a broad impact of the source,as its unprecedented performance opens the way for new applications. | Andreas Döpp Benoit Mahieu Agustin Lifschitz Cedric Thaury Antoine Doche Emilien Guillaume Gabriele Grittani Olle Lundh Martin Hansson Julien Gautier Michaela Kozlova Jean Philippe Goddet Pascal Rousseau Amar Tafzi Victor Malka Antoine Rousse Sebastien Corde Kim Ta Phuoc | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 5 | Hepatic and Extrahepatic Colorectal Metastases: When Resectable, Their Localization Does Not Matter, But Their Total Number Has a Prognostic Effect显示文摘 | Dominique Elias MD PhD Gabriel Liberale MD Déwi Vernerey MSc Marc Pocard MD PhD Michel Ducreux MD PhD Valérie Boige MD David Malka MD PhD Jean-Pierre Pignon MD PhD Philippe Lasser MD | 2005 | Annals of Surgical Oncology2005，，11： | 2 |
| 6 | Prospective observational multicenter study to define a diagnostic algorithm for biliary candidiasis显示文摘AIM:To develop an algorithm to improve the diagnosis and treatment of patients with biliary candidiasis.METHODS:We performed a prospective study of 127patients who underwent endoscopic retrograde cholangiopancreatography,for various biliary disorders,at 3 tertiary referral centers in Germany from July 2011through July 2012(ClinicalTrials.gov:NCT01109550).Bile,buccal,and stool samples were collected.When indicated,endoscopic transpapillary bile duct biopsies were performed to clarify the etiology of bile duct strictures and to prove invasive fungal infections.RESULTS:Candida species were detected in 38 of the 127 bile samples(29.9%).By multivariate analysis patients’age and previous endoscopic sphincterotomy were independent risk factors for biliary candidiasis(P<0.05).Patients with immunosuppression(P=0.058)and recent long-term antibiotic therapy(>7 d)(P=0.089)tend to be at risk for biliary candidiasis.One patient was negative in mycological culture of bile fluid but invasive biliary candidiasis was diagnosed histologically.Of Candida subspecies detected,36.7%were azole-resistant,such as C glabrata.Eight patients received anti-mycotic therapy,based on our algorithm.Of these,3 had cancer with biliary tract involvement,2had secondary sclerosing cholangitis,1 had retroperitoneal fibrosis,and 5 had septicemia.In all patients contamination was ruled out by smears of the endoscope channel.CONCLUSION:Gastroenterologists should be aware of frequent candida colonization in patients with cholangitis and biliary disorders.Our suggested algorithm facilitates the further clinical management. | Philipp Lenz Franziska Eckelskemper Thomas Erichsen Tim Lankisch Alexander Dechêne Gabriele Lubritz Frank Lenze Torsten Beyna Hansjorg Ullerich Andre Schmedt Dirk Domagk | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 7 | Ticagrelor Effects on Myocardial Infarction and the Impact of Event Adjudication in the Platelet Inhibition and Patient Outcomes (PLATO) Trial显示文摘 | Kenneth W. Mahaffey Claes Held Daniel M. Wojdyla Stefan K. James Hugo A. Katus Steen Husted Philippe Gabriel Steg Christopher P. Cannon Richard C. Becker Robert F. Storey Nardev S. Khurmi José C. Nicolau Cheuk-Man Yu Diego Ardissino Andrzej Budaj Joao Mor | 2014 | Journal of the American College of Cardiology2014，，： | 2 |
| 8 | Design and rationale of the TOTAL trial: A randomized trial of routine aspiration ThrOmbecTomy with percutaneous coronary intervention (PCI) versus PCI ALone in patients with ST elevation myocardial infarction undergoing primary PCI显示文摘 | Sanjit S. Jolly John Cairns Salim Yusuf Brandi Meeks Olga Shestakovska Lehana Thabane Kari Niemel? Philippe Gabriel Steg Olivier F. Bertrand Sunil V. Rao Alvaro Avezum Warrren J. Cantor Samir B. Pancholy Raul Moreno Anthony Gershlick Ravinay Bhindi Robert | 2013 | American Heart Journal2013，，： | 1 |
| 9 | Carotid Atherosclerosis and Risk of Subsequent Coronary Event in Outpatients With Atherothrombosis显示文摘 | Gaia Sirimarco Pierre Amarenco Julien Labreuche Pierre-Jean Touboul Mark Alberts Shinya Goto Joachim Rother Jean-Louis Mas Deepak L. Bhatt Philippe Gabriel Steg | 2013 | Stroke2013，，2： | 1 |
| 10 | Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial显示文摘 | Shamir R Mehta Jean-Francois Tanguay John W Eikelboom Sanjit S Jolly Campbell D Joyner Christopher B Granger David P Faxon Hans-Jurgen Rupprecht Andrzej Budaj Alvaro Avezum Petr Widimsky Philippe Gabriel Steg Jean-Pierre Bassand Gilles Montalescot Carlos | 2010 | The Lancet2010，，9748： | 1 |
| 11 | Renal impairment and heart failure with preserved ejection fraction early post-myocardial infarction显示文摘AIM:To study if impaired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).METHODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after myocardial infarction (MI) were grouped into chronic kidney disease (CKD) stages based on estimated glomerular filtration rate (eGFR).Rates of early post-MI HF were compared among eGFR groups.Logistic regression was used to explore independent predictors of HF.RESULTS:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal impairment (eGFR < 60 mL/min every 1.73 m2) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P < 0.0001),despite a small absolute difference in mean EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function among patients with preserved EF:10.1%,13.6% and 23.6% (P < 0.0001),but this relationship was not significant among patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).Moreover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-MI patients with occluded IRAs have impaired renal function.Impaired renal function was associated with an increased rate of early post-MI HF,the association being strongest in patients with preserved EF.These findings have implications for management of peri-infarct HF. | Vinod Jorapur Gervasio A Lamas Zygmunt P Sadowski Harmony R Reynolds Antonio C Carvalho Christopher E Buller James M Rankin Jean Renkin Philippe Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells Michael Ragosta C Edwin Martin Vankeepuram S Srinivas William W Wharton III Staci Abramsky Ana C Mon Shari S Kronsberg Judith S Hochman | 2010 | World Journal of Cardiology2010，2，1： | 1 |
| 12 | Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial显示文摘 | Shamir R Mehta Jean-Francois Tanguay John W Eikelboom Sanjit S Jolly Campbell D Joyner Christopher B Granger David P Faxon Hans-Jurgen Rupprecht Andrzej Budaj Alvaro Avezum Petr Widimsky Philippe Gabriel Steg Jean-Pierre Bassand Gilles Montalescot Carlos | 2010 | The Lancet2010，，9748： | 1 |
| 13 | Impact of the History of Congestive Heart Failure on the Utility of B-Type Natriuretic Peptide in the Emergency Diagnosis of Heart Failure: Results from the Breathing Not Properly Multinational Study显示文摘 | Adam Strunk Vikas Bhalla Paul Clopton Richard M. Nowak James McCord Judd E. Hollander Philippe Duc Alan B. Storrow William T. Abraham Alan H.B. Wu Gabriel Steg Alberto Perez Radmila Kazanegra Howard C. Herrmann Marie Claude Aumont Peter A. McCullough Alan | 2006 | The American Journal of Medicine2006，，1： | 1 |
| 14 | B- type natriuretic peptide and echocardiographic determination of ejection fraction in the diagnosis of congestive heart failure in patients with acute d~pnea 显示文摘 | Philippe Gabriel Steg Laurence Joubin James McCord | 2005 | CHEST2005，128，12： | 1 |
| 15 | cDNA nucleotide sequence and expression of a maize cytoplasmic ribosomal protein S13 gene显示文摘 | Philippe Joanin Claude Gigot Gabriel Philipps | 1993 | Plant Molecular Biology1993，，4： | 1 |
| 16 | Impaired expression of the peroxisome proliferator–activated receptor alpha during hepatitis C virus infection显示文摘 | Sébastien Dharancy Mathilde Malapel Gabriel Perlemuter Tania Roskams Yang Cheng Laurent Dubuquoy Philippe Podevin Filoména Conti Valérie Canva David Philippe Luc Gambiez Philippe Mathurin Jean-Claude Paris Kristina Schoonjans Yvon Calmus Stanislas Pol Joh | 2005 | Gastroenterology2005，，2： | 1 |
| 17 | Three-dimensional geometric modeling of a faulted domain: The Soultz Horst example (Alsace, France) 显示文摘 | Philippe Renard Gabriel Courrioux | 1994 | Computers & Geoscienees1994，20，9： | 1 |
| 18 | Procedural Volume and Outcomes with Radial or Femoral access for coronary angiography and intervention显示文摘 | Sanjit S. Jolly John Cairns Salim Yusuf Kari Niemela Philippe Gabriel Steg Matthew Worthley Emile Ferrari Warren J. Cantor Anthony Fung Nicholas Valettas Michael Rokoss Goran Olivecrona Petr Widimsky Asim N. Cheema Peggy Gao Shamir R. Mehta | 2013 | Journal of the American College of Cardiology2013，，： | 1 |
| 19 | Secretion of TGF-βl, TGF-β2, EGF and PDGF into nasal fluid after sinus surgery显示文摘 | Jean-Baptiste Watelet Philippe Gevaert Claus Bachert Gabriele Holtappels Paul Van Cauwenberge | 2002 | European Archives of Oto - Rhino - Laryngology2002，，5： | 1 |
| 20 | Treatment‐related morbidity and toxicity of CRS and oxaliplatin‐based HIPEC compared to a mitomycin and doxorubicin‐based HIPEC protocol in patients with peritoneal carcinomatosis: A matched‐pair analysis显示文摘 | Gabriel Glockzin Philipp von Breitenbuch Hans J. Schlitt Pompiliu Piso | 2012 | J. Surg. Oncol2012，，： | 1 |
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