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| 1 | A Resource for Inactivation of MicroRNAs Using Short Tandem Target Mimic Technology in Model and Crop Plants显示文摘microRNAs (miRNAs)are endogenous small non-coding RNAs that bind to mRNAs and target them for cleavage and/or translational repression,leading to gene silencing.We previously developed short tandem target mimic (STTM)technology to deactivate endogenous miRNAs in Arabidopsis.Here,we created hundreds of STTMs that target both conserved and species-specific miRNAs in Arabidopsis,tomato,rice,and maize,providing a resource for the functional interrogation of miRNAs.We not only revealed the functions of several miRNAs in plant development,but also demonstrated that tissue-specific inactivation of a few miRNAs in rice leads to an increase in grain size without adversely affecting overall plant growth and development.RNA-seq and small RNAseq analyses of STTM156/157 and STTM165/166 transgenic plants revealed the roles of these miRNAs in plant hormone biosynthesis and activation,secondary metabolism,and ion-channel activity-associated electrophysiology,demonstrating that STTM technology is an effective approach for studying miRNA functions.To facilitate the study and application of STTM transgenic plants and to provide a useful platform for storing and sharing of information about miRNA-regulated gene networks,we have established an online Genome Browser (http://gffzzc750bc0108fa4044skuwcccvuobwv69n0.ffgz.tsg.suse.edu.cn/designindex2.php) to display the transcriptomic and miRNAomic changes in STTMinduced miRNA knockdown plants. | Ting Peng Mengmeng Qiao Haiping Liu Sachin Teotia Zhanhui Zhang Yafan Zhao Bobo Wang Dongjie Zhao Lina Shi Cui Zhang Brandon Le Kestrel Rogers Chathura Gunasekara Haitang Duan Yiyou Gu Lei Tian Jinfu Nie Jian Qi Fanrong Meng Lan Huang Qinghui Chen Zhenlin Wang Jinshan Tang Xiaoqing Tang Ting Lan Xuemei Chen Hairong Wei Quanzhi Zhao Guiliang Tang | 2018 | Molecular Plant2018，11，11： | 7 |
| 2 | Hardware-in-the-loop simulation for the contact dynamic process of flying objects in space显示文摘在地面上的一个严肃环境,自从人首先由飞目标探索了空间,在空间的零严肃的环境的二个飞的目标的接触过程的模拟是一个挑战性的问题。Hardware-in-the-loop (HIL ) 模拟是一个重要、有效的方法在空间测试真实停靠机制的可用性,可靠性,和安全。为 HIL 模拟系统有四个主要问题:能够高频率反应,高运动精确,高速度,和快速的加速的模拟器的设计;为模拟失真的赔偿;为 HIL 模拟进程的一个控制模型的设计;并且试验性的确认。这里,我们与 6-DOF 3-3 建议一个新奇 HIL 模拟器系统垂直平行机制和 3-DOF 3-PRS 平行机制;发现模拟失真的原则;为模拟器的力量测量系统,动态反应,和结构的动力学介绍失真赔偿模型;并且为 HIL 模拟过程提供一个控制模型。二种实验在被动未受潮的有弹性的杆和停靠机制上被执行测试他们的表演并且验证 HIL 模拟器的有效性和可用性。在这份报纸建议的 HIL 模拟系统为开发停靠的空格是有用的, berthing, refueling,修理,升级,搬运,并且 rescuing 技术。 | GAO Feng QI ChenKun REN AnYe ZHAOXianChao CAO Rui SUN Qiao WANG Qian HU Yan HE Jun JIN ZhenLin LIU RenQiang ZHANG Yong GUO WeiZhong HU ZhenYu TANG Ping NI Bo JING QianFeng WANG WeiJun GAO Peng | 2016 | Science China(Technological Sciences)2016，59，8： | 4 |
| 3 | Study on the downhole permanent low frequency pulsating water injection technique显示文摘Waterflood technique with pressure fluctuation, especially with low, ultra low frequency, changes the continuous water flow into the flow with pressure fluctuation, and can prevent contamination precipitation, formation plugging and Jamin effect. It also can prevent the plugging of water injection well, decrease the pressure of waterflood and increase the rate of water injection. On the basis of the existing eccentric injection mandrel, used the energy storage character of air energy accumulator and the pressure switch character of pressure control valve, fixed the plunger valve for pressure control on the position of blanking plug, then developed one new injection mandrel with low frequency character, which can inject water continuously with low, ultra low frequency. Water fluctuation produced during the water injection affect the formation directly and is useful to break down, prevent plugging and augment injection. | WANG Zhiming QI Zhenlin XUE Liang | 2009 | 石油钻采工艺2009，31，1： | 2 |
| 4 | Changes of Glutenin Subunits due to Water-Nitrogen Interaction Influence Size and Distribution of Glutenin Macropolymer Particles and Flour Quality显示文摘 | Li Yong Yin Yanping Zhao Qi Wang Zhenlin | 2011 | Crop Science2011，，6： | 1 |
| 5 | Survivin, a key component of the Wnt/β?catenin signaling pathway, contributesto traumatic brain injury-induced adult neurogenesis in the mouse dentate gyrus显示文摘 | Lin Zhang Rong Yan Qi Zhang Haining Wang Xiaokui Kang Jia Li Shuyuan Yang Jianning Zhang Zhenlin Liu Xinyu Yang | 2013 | International Journal of Molecular Medicine2013，，4： | 1 |
| 6 | A case-control study for the association between Change in weight,Family history and hypertension at different ages显示文摘 | Wu Guanglin Yang Huimin Qi Xiuying Jia Zhenlin | 2001 | Asia-Pacific Houranl of Public health2001，13，2： | 1 |
| 7 | Association of SOST gene polymorphisms with peak bone mineral density in Chinese nuclear families with male-offspring显示文摘Peak bone mineral density(BMD)achieved during early adulthood is a highly heritable trait and a strong determinant of subsequent osteoporotic fracture risk.Evidence has already suggested that 50–80% of the variance in peak BMD is genetically determined [1].Human SOST gene comprises three exons and two introns,mapping to chromosomal region 17q12–q21.It inhibits osteoblastic bone formation by inhibiting the Wnt signaling pathway,which is critically important for the development and function of osteoblasts [2].Our previous study in large samples of postmenopausal Chinese women showed that the polymorphisms in the SOST gene are associated with BMD of the lumbar spine [3],but little is known in men.Thus,the objective of this study was to investigate whether polymorphisms in the SOST gene are associated with variations of peak BMD in Chinese nuclear families with male-offspring. | Luyue Qi Shoukui Xiang Li Li Jinwei He Wenzhen Fu Yujuan Liu Yunqiu Hu Zhenlin Zhang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 0 |
| 8 | Glucagon-like peptide-1 receptor gene polymorphism is associated with fat mass in Chinese nuclear families with male offspring显示文摘Obesity is a serious and growing worldwide health threat associated with increased risk of Type 2 diabetes,hypertension,dyslipidemia,cardiovascular disease,and several forms of cancers[1].It is a complex disease under strong genetic control,and a number of genetic variants for obesity have been identified[2].However,the identified loci explain only a small proportion of the heritability for obesity,suggesting that more associated variants remain to be discovered.Glucagon-like peptide-1(GLP-1)is a potent glucose-dependent insulinotropic gut hormone that is secreted from enteroendocrine L cells of the terminal ileum.In addition to its insulinotropic effects,GLP-1 prevents fat accumulation through various mechanisms[3].GLP-1 exerts its action through the GLP-1 receptor(GLP-1R)which has a wide tissue distribution including adipose tissue.Previous studies have shown that single-nucleotide polymorphisms(SNPs)in the GLP-1R gene may alter binding affinity for GLP-1 and intracellular signaling after hormone-receptor binding[4,5]. | Shoukui Xiang Luyue Qi Fei Zhao Wenjie Wang Xiaoya Zhang Yunqiu Hu Fei Hua Zhenlin Zhang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，5： | 0 |
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