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| 1 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 2 | The arachnoid sleeve enveloping the pituitary stalk: anatomical and histologic study 显示文摘 | Qi ST Zhang XA Long H | 2010 | Neurosurgery2010，66，3： | 1 |
| 3 | Researh progress of Noroviruses 显示文摘 | Hu XF Diao YH Qi ST | 2007 | Port Health Control2007，12，6： | 1 |
| 4 | Septin I is required for spindle assembly and chromosome congression in mouse oocytes显示文摘 | ZhuJ Qi ST Wang YP | 2011 | Dev Dyn2011，240，10： | 1 |
| 5 | Arrested human embryos are more likely to have abnormal chromosomes than devel- oping embryos from women of advanced maternal age 显示文摘 | Qi ST Liang LF Xian YX | 2014 | J Ovarian Res2014，7，2： | 1 |
| 6 | Synaptotagminl is required for spindle stability and metaphase -to -anaphase transition in mouse oocytes显示文摘 | Zhu XL Qi ST Liu 1 | 2012 | Cell Cycle2012，11，4： | 1 |
| 7 | IDH mutations occur frequently in Chinese glioma patients and predict longer survival but not response to concomitant chemoradiotherapy in anaplastic glio mas显示文摘 | Qi ST Yu L Lu YT | 2011 | OncolRep2011，26，6： | 1 |
| 8 | IDH mutations occur frequently in Chinese glioma patients and predict longer survival but not response to concomitant chemoradiotherapy in anaplastic gliomas显示文摘 | Qi ST Yu L Lu YT et aI | 2011 | Oneol Rep2011，26，6： | 1 |
| 9 | Anatomical and histological study of Liliequist's membrane: with emphasis on its nature and lateral attachments显示文摘 | Zhang XA Qi ST Huang GL | 2012 | Childs Nerv Syst2012，28，1： | 1 |
| 10 | Overexpression of setJ3 , a protein localizing to centromeres, causes precocious separation of chromatids during the first meiosis of mouse oocytes显示文摘 | Qi ST Wang ZB Ouyang YC | 2013 | J Cell Sci2013，126，7： | 1 |
| 11 | Reinvestigation of the ambient cistern and its related arachnoid membranes: an anatomical study显示文摘 | Qi ST Fan J Zhang XA | 2011 | J Neurosurg2011，115，1： | 1 |
| 12 | Anatomical study of the arachnoid envelope over the pineal region显示文摘 | Qi ST Zhang XA Fan J | 2011 | Neurosurgery2011，68，1： | 1 |
| 13 | A radiopathological classification of dural tail sign of meningiomas显示文摘 | Qi ST Liu Y Pan J | 2012 | J Neurosurg2012，117，4： | 1 |
| 14 | IDH mutations predict longer sur-vival and response to temozolomide in secondary glioblast-oma 显示文摘 | Qi ST Yu L Gui S | 2012 | Cancer Sci2012，103，2： | 1 |
| 15 | Induction of heat shock response protects the heart against atrial fibrillation显示文摘 | Brundel BJ Akiko ST Qi XY | 2006 | Circ Res2006，99，： | 1 |
| 16 | Clinical features and surgical treatment of posttraunmfic epilepsy显示文摘 | Qiu BH Ouyang H | 2005 | Journal d The First Medical College of PLA2005，24，4： | 1 |
| 17 | Epithelial-mesenchymal transition and clinicopathological correlation in craniopharyngioma显示文摘 | Qi ST Zhou J Pan J | 2012 | His- topathology2012，61，4： | 1 |
| 18 | Reinvestigation of the ambient cistern and its related arachnoid membranes:an anatomical study显示文摘 | Qi ST Fan J Zhang XA | 2011 | J Neurosurg2011，115，1： | 1 |
| 19 | Anatomical study of the arachnoid en- velope over the pineal region 显示文摘 | Qi ST Zhang XA Fan J | 2011 | Neurosurgery2011，68，1： | 1 |
| 20 | Interference of Notch 2 inhibits the progression of gliomas and induces cell apop- tosis by induction of the cell cycle at the GO/G1 phase 显示文摘 | Yu HP Qi ST Feng WF | 2015 | Mol Med Rep2015，11，1： | 1 |
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