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| 1 | Review of risk factors for human echinococcosis prevalence on the Qinghai-Tibet Plateau, China: a prospective for control options显示文摘Objective: Echinococcosis is a major parasitic zoonosis of public health importance in western China. In 2004, the Chinese Ministry of Health estimated that 380,000 people had the disease in the region. The Qinghai-Tibet Plateau is highly co-endemic with both alveolar echinococcosis (AE) and cystic echinococcosis (CE). In the past years, the Chinese government has been increasing the financial support to control the diseases in this region. Therefore, it is very important to identify the significant risk factors of the diseases by reviewing studies done in the region in the past decade to help policymakers design appropriate control strategies. Review: Selection criteria for which literature to review were firstly defined. Medline, CNKI (China National Knowledge Infrastructure), and Google Scholar were systematically searched for literature published between January 2000 and July 2011. Significant risk factors found by single factor and/or multiple factors analysis were listed, counted, and summarized. Literature was examined to check the comparability of the data;age and sex specific prevalence with same data structures were merged and used for further analysis. A variety of assumed social, economical, behavioral, and ecological risk factors were studied on the Plateau. Those most at risk were Tibetan herdsmen, the old and female in particular. By analyzing merged comparable data, it was found that females had a significant higher prevalence, and a positive linearity relationship existed between echinococcosis prevalence and increasing age. In terms of behavioral risk factors, playing with dogs was mostly correlated with CE and/or AE prevalence. In terms of hygiene, employing ground water as the drinking water source was significantly correlated with CE and AE prevalence. For definitive hosts, dog related factors were most frequently identified with prevalence of CE or/and AE;fox was a potential risk factor for AE prevalence only. Overgrazing and deforestation were significant for AE prevalence only. Conclusion: Tibetan herdsmen communities were at the highest risk of echinococcosis prevalence and should be the focus of echinococcosis control. Deworming both owned and stray dogs should be a major measure for controlling echinococcosis;treatment of wild definitive hosts should also be considered for AE endemic areas. Health education activities should be in concert with the local people's education backgrounds and languages in order to be able to improve behaviors. Further researches are needed to clarify the importance of wild hosts for AE/CE prevalence, the extent and range of the impacts of ecologic changes (overgrazing and deforestation) on the AE prevalence, and risk factors in Tibet. | Qian Wang Yan Huang Liang Huang Wenjie Yu Wei He Bo Zhong Wei Li Xiangman Zeng Dominique A Vuitton Patrick Giraudoux Philip S Craig Weiping Wu | 2014 | Infectious Diseases of Poverty2014，3，1： | 35 |
| 2 | Identification and functional analysis of the MOC1 interacting protein 1显示文摘Rice tillering is one of the most important agronomic traits that determine grain yields.Our previous study has demonstrated that the MONOCULM1 (MOC1) gene is a key component that controls the formation of rice tiller buds.To further elucidate the molecular mechanism of MOC1 involved in the regulation of rice tillering,we performed a yeast-two-hybrid screening to identify MOC1 interacting proteins (MIPs).Here we reported that MIP1 interacted with MOC1 both in vitro and in vivo.The overexpression of MIP1 resulted in enhanced tillering and reduced plant height.In-depth characterization of the context of MIP1 and MOC1 would further our understanding of molecular regulatory mechanisms of rice tillering. | Fengli Sun Weiping Zhang Guosheng Xiong Meixian Yan Qian Qian Jiayang Li Yonghong Wang | 2010 | Journal of Genetics and Genomics2010，37，1： | 9 |
| 3 | Plasmonic biosensors and nanoprobes based on gold nanoshells显示文摘Gold nanoshells (GNSs), consisting of a dielectric core coated with gold, have gained extensive attention as they show readily tunable optical properties and good biocompatibility. As highly sensitive and label-free optical biosensors with wide applications, GNSs have been investigated in many fields including drug delivery, immunoassay, cancer treatment, biological sensing and imaging. Taking advantage of the adjustability of the local surface plasmon resonance (LSPR) and the sensitivity of the surfaceenhanced Raman scattering (SERS) signal of GNSs, we have developed diverse applications including plasmonic biosensors and nanoprobes based on GNSs. In this review we introduce plasmonic and electromagnetic properties and fabrication methods of GNSs. We describe research progress in recent years, and highlight several applications of GNSs developed by our group. Finally we provide a brief assessment of future development of GNSs as plasmonic materials that can be integrated with complementary analytical techniques. | XU BeiBei MA XiaoYuan RAO YanYing DONG Jian QIAN WeiPing | 2011 | Chinese Science Bulletin2011，56，31： | 6 |
| 4 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 5 | Measurement of γ detector backgrounds in the energy range of 3-8 MeV at Jinping underground laboratory for nuclear astrophysics显示文摘The astrophysical reaction rate of the charged-particleinduced reaction is dominated by the cross section within the Gamow window.The total cross section σ(E)of a chargedparticle-induced reaction is known to drops steeply with decreasing energy owing to the Coulomb barrier in the entrance channel: | YangPing Shen Jun Su WeiPing Liu Gang Lian Lin Gan LvHua Qiao ShengQuan Yan Yong Zhou Qian Yue Zhi Zeng QingDong Hu YuHao Mi Wei Zhao | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，10： | 5 |
| 6 | Investigation of Geiger-mode detector in multi-hit model for laser ranging显示文摘The performance of detector limits the overall performance of laser ranging system. And the design of multi-hit detector is one of the feasible ways to promote the performance of detector. Currently, the segmentation method or the recursive method is commonly used to analyze the multi-hit detector model. To the best of our knowledge, this paper is the first to propose a combinatorial method to solve the multi-hit detector model from the perspective of discrete time. Then, universal formulas of total signal detection probability and the average count are deduced based on the Poisson distribution signal. Furthermore, analysis is made to figure out how the average count changes with different parameters, such as the dead time, gating time, rate intensity. As a result, for GM-APD, the multi-hit detector model is verified advantageously compared to the single-hit detector model in improving the average count theoretically. Meanwhile, a discrete step feature is presented when average count changes with dead time or the gating time, which is of great significance in gating time optimization. | ZHAO Peng ZHANG Yan QIAN WeiPing XUAN Ying | 2015 | Science China(Technological Sciences)2015，58，5： | 4 |
| 7 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 8 | Boron-doped microporous nano carbon as cathode material for high-performance Li-S batteries显示文摘在这研究,做硼的多微孔的碳(BMC )/sulfur nanocomposite 为先进 Li-S 电池作为新奇阴极材料被综合并且适用。有这阴极的房间展出一个超离频的骑车稳定性和率能力。在激活以后, 749.5 mAh/g 的一个能力在 54 在 3.2 A/g 的分泌物电流的 th 周期。在 500 个周期以后, 561.8 mAh/g 的能力留下了(74.96% 保留) ,与 0.056% 的仅仅很小的平均能力腐烂。新奇的硫阴极的优秀可逆性和稳定性能被归因于的做硼的多微孔的碳宿主的能力身体上限制 polysulfides 并且化学上绑这些宿主表面上的种类。理论计算证实那做硼的碳比 undoped 碳能够和 polysulfide 种类的显著地更强壮的相互作用,由于硼的更低的 electronegativity 最可能。我们相信这做的策略能被扩大到另外的金属空气电池和燃料房间,和那它为许多不同应用有有希望的潜力。 | Feng Wu Ji Qian Weiping Wu Yusheng Ye Zhiguo Sun Bin Xu Xiaoguang Yang Yuhong Xu Jiatao Zhang Renjie Chen | 2017 | Nano Research2017，10，2： | 3 |
| 9 | Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma显示文摘 | Jin Hou Li Lin Weiping Zhou Zhengxin Wang Guoshan Ding Qiongzhu Dong Lunxiu Qin Xiaobing Wu Yuanyuan Zheng Yun Yang Wei Tian Qian Zhang Chunmei Wang Qinghua Zhang Shi-Mei Zhuang Limin Zheng Anmin Liang Wenzhao Tao Xuetao Cao | 2011 | Cancer Cell2011，，2： | 3 |
| 10 | A Platform to Improve Echinococcosis Control in Tibetan Populations-Sichuan Province,China,2015‒2020显示文摘Echinococcosis is a neglected parasitic zoonotic disease that is distributed worldwide.Previous data has shown that China holds the highest disease burden of echinococcosis in the world,resulting in 22.97×10^(5) disability adjusted life year(DALYs)lost annually(1).Echinococcosis is one of the epidemiological factors responsible for poverty in China.Since 2000,China’s central government(CG)has taken several actions to control echinococcosis in Western China.Since 2005. | Tian Tian Shuai Han Chuizhao Xue Xu Wang Shijie Yang Bo Zhong Qian Wang Wenjie Yu Sha Liao Dan Ba Ze Li Wei Li Fei Xie Qiang Wang Zelin Zhu Yuwan Hao Weiping Wu Ning Xiao Xiao-nong Zhou | 2021 | China CDC weekly2021，3，5： | 2 |
| 11 | Oxidative stress response and gene expression with atrazine exposure in adult female zebrafish ( Danio rerio )显示文摘 | Yuanxiang Jin Xiangxiang Zhang Linjun Shu Lifang Chen Liwei Sun Haifeng Qian Weiping Liu Zhengwei Fu | 2009 | Chemosphere2009，，7： | 2 |
| 12 | Impact of pathological response after preoperative transcatheter arterial chemoembolization(TACE)on incidences of microvascular invasion and early tumor recurrence in hepatocellular carcinoma:a multicenter propensity score matching analysis显示文摘Background:To study the influence of pathological responses(PR)after transcatheter arterial chemoembolization(TACE)on incidences of microvascular invasion(MVI)and early recurrence in hepatocellular carcinoma(HCC)patients.Methods:Between 2013 to 2015,consecutive HCC patients who underwent liver resection with“curative”intent at three hospitals were enrolled in this study.Patients with different areas of PR after preoperative TACE were compared with those without preoperative TACE on the incidences of MVI,early recurrence rates and patterns of recurrence before and after propensity score matching(PSM).Results:Of 1,970 patients,737 patients who received preoperative TACE were divided into three groups according to the areas of PR:≥90%(n=226),60-90%(n=447),and<60%(n=64).PR≥90%was an independent protective factor of incidences of MVI[odds ratio(OR),0.144;95%confidence interval(CI),0.082-0.245,P<0.001)and early recurrence(HR,0.742;95%CI,0.561-0.963,P=0.032);while PR<60%was an independent risk factor of incidences of MVI(OR,6.076;95%CI,3.004-11.728,P<0.001)and early recurrence(HR,1.428;95%CI,1.095-1.929;P=0.009).Furthermore,patients with PR<60%were significantly more likely to develop multiple intrahepatic recurrences involving multiple hepatic segments when compared with patients without preoperative TACE.Conclusions:This study indicated the area of PR after TACE was closely associated with the incidences of MVI and early tumor recurrence.Patients with PR<60%were at significantly higher risks of having more MVI,early and multiple tumor recurrences. | Yun Yang Zheng Dang Peng Lu Youwen Qian Kongying Lin Zeya Pan Wan Yee Lau Weiping Zhou | 2022 | Hepatobiliary Surgery and Nutrition2022，11，3： | 2 |
| 13 | Environmental fate and effects of organophosphate flame retardants in the soil-plant system显示文摘Organophosphate flame retardants(OPFRs),as a replacement for polybrominated diphenyl ethers(PBDEs),are of increasing concern due to their high production over the years.Soil is the major environmental reservoir and interchange for OPFRs.OPFRs in soil could be transferred to the food chain,and pose potential ecological and human health risks.This review focused on the environmental fate and effects of typical OPFRs in the soil-plant system.We concluded that the sorption and transformation behaviors of OPFRs due to their crucial impact on bioavailability.The root uptake and translocation of OPFRs by plants were summarized with analyses of their potential affecting factors.The in planta transformation and potential ecological effects of OPFRs were also briefly discussed.Finally,we highlighted several research gaps and provided suggestions for future research,including the development of simulative/computative methods to evaluate the bioavailability of OPFRs,the effects of root exudates and rhizosphere microorganisms on the bioavailability and plant uptake of OPFRs,and the development of green and sustainable technologies for in situ remediation of OPFRs-contaminated soil. | Qing Zhang Weiping Mei Longfei Jiang Qian Zheng Chunling Luo Gan Zhang | 2021 | Soil Ecology Letters2021，3，3： | 2 |
| 14 | National Alveolar Echinococcosis Distribution--China, 2012−2016显示文摘What is already known about this topic?Both alveolar echinococcosis(AE)and cystic echinococcosis are endemic in China,among which alveolar echinococcosis has a very high mortality rate.What is added by this report?The survey results showed the prevalence and scope of AE in China and identified high-risk groups including children,monks,herdsmen and illiterate people.At the same time,all the cases found in the survey(more than 90%of the patients did not go to the hospital for diagnosis and treatment before survey)were promptly diagnosed and treated.What are the implications for public health practice?This study provides information for the development of a plan for AE prevention and control and for the implementation of interventions targeted to high-risk populations. | Canjun Zheng Chuizhao Xue Shuai Han Zhongjie Li Hu Wang Liying Wang Ying Wang Qian Wang Yu Feng Yanyan Hou Xiao Ma Junying Ma Xiumin Han Gongsang Quzhen Xiaofeng Jiang Weidong Guo Xianglin Wu Yaming Yang Lei Cao Fanka Li Weiqi Chen Xinliu Yan Shicheng Yu Meihua Fu Qing Yu Ning Xiao Jiangping Cao Jun Yan Weiping Wu Xiao-nong Zhou | 2020 | China CDC weekly2020，2，1： | 2 |
| 15 | Virtual design and analysis with multi-dimension coupling for engineering machinery cooling system显示文摘A good cooling circle should ensure that the system can work at an appropriate temperature in the requirements of power increase,engine compartment constraint and working demands for modern engineering machinery,which asks for a thorough understanding of system thermal loads before practical production.However,traditional experiment method spends a long time,costs a huge resource but lacks efficiency,whereas virtual design can avoid the shortcomings of traditional method and can analyze operating states adequately with variable loads on engine,generator,drives,battery pack and HVAC systems.Therefore,this paper focuses on a new virtual design method based on multi-dimension coupled simulation adopting Flowmaster software for initial prediction and CFX tool for further optimization.The simulation results in different operating conditions are compared and validated with experiments.Orthogonal experiment and range analysis are used to explore key parameters of cooling system.The research will be helpful in guiding future design and optimization of engineering machinery. | CAI HuiKun QIAN YaoYi HOU Liang WANG WenWu ZHANG EnLai YANG WeiPing | 2015 | Science China(Technological Sciences)2015，58，1： | 2 |
| 16 | Effect of water on the mechanical and frictional behaviors of human fingernails 显示文摘 | WeiP Qian L M Zheng J | 2010 | Tribology Letters2010，38，： | 1 |
| 17 | Electrospinning of Nanofibers and Their Applications for Energy Devices显示文摘 | Xiaomin Shi Weiping Zhou Delong Ma Qian Ma Denzel Bridges Ying Ma Anming Hu Bala Vaidhyanathan | 2015 | Journal of Nanomaterials2015，，： | 1 |
| 18 | Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma显示文摘 | Jin Hou Li Lin Weiping Zhou Zhengxin Wang Guoshan Ding Qiongzhu Dong Lunxiu Qin Xiaobing Wu Yuanyuan Zheng Yun Yang Wei Tian Qian Zhang Chunmei Wang Qinghua Zhang Shi-Mei Zhuang Limin Zheng Anmin Liang Wenzhao Tao Xuetao Cao | 2011 | Cancer Cell2011，，2： | 1 |
| 19 | Squeezing bandwidth controllable twin beam light and phase sensitive nonlinear interferometer based on atomic ensembles显示文摘We review our recent experimental progress in quantum technology employing amplification effect of four-wave mixing in a rubidium vapor. We have produced an intensity difference squeezed light source at frequencies as low as 1.5 kHz which is so far the lowest frequency at which squeezing has been observed in an atomic system. Moreover, we find that the bandwidth of our squeezed light source can be controlled with light intensity pumping. Using our non-classical light source, we have further developed a nonlinear Mach-Zehnder (MZ) interferometer, for which the maximum fringe intensity depends quadratically on the intensity of the phase-sensing field at the high-gain regime, leading to much better sensitivity than a linear MZ interferometer in which the beam splitters have the same phase-sensing intensity. The quantum technologies developed by our group could have great potential in areas such as precision measurement and quantum information. | JING JieTai LIU CunJin ZHOU ZhiFan HUDELIST Florian YUAN ChunHua CHEN LiQing LI XiaoYun QIAN Jing ZHANG KeYe ZHOU Lu MA HongMei DONG GuangJiong OU ZeYu ZHANG WeiPing | 2012 | Chinese Science Bulletin2012，57，16： | 1 |
| 20 | Coupled-mode theory for LP modes显示文摘 | Jingren Qian Weiping Huang | 1986 | Journal of Lightwave Technology1986，4，6： | 1 |
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