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| 1 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 2 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 3 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 4 | Risk Assessment of Heavy Metal Pollution in Sediments of the Fenghe River by the Fuzzy Synthetic Evaluation Model and Multivariate Statistical Methods显示文摘Concentrations of heavy metals in 74 sediment samples from the Fenghe River, which originates from the north of the Qinling Mountains and flows through Xi'an, Shaanxi Province, China, were characterized by employing geographic information system(GIS)mapping, fuzzy synthetic assessment, and multivariate statistical analysis to determine the enrichment characteristics of heavy metals as well as their potential risks of pollution to sediments. Al, Cd, and Co were the major pollutants, with a high enrichment factor(EF) value. Heavy metal concentrations from samples near the paper plant were maintained at a high level. Significant enrichment of Al, Ba, Cr, Ni, Pb, and Co was found in the midstream and downstream, while high concentration of Cu occurred in the headwater stream. Based on the cluster and principal component analyses, sediment metals mainly came from the paper plants, agronomic practices, natural sources, and tourism, with a contribution of 51.59%, 23.01%, 14.21%, and 9.88%, respectively. Sediment pollution assessment explored using fuzzy theory based on the entropy method and toxicity coefficient showed that 26, 32, and 11 sites fell into Class III(slightly polluted), Class IV(moderately polluted), and Class V(heavily polluted), respectively, and their scores of membership degree in the polluted level were on the rise, suggesting a relatively high degree of sediment metal pollution in the study area. Closely related to the excessive industrial and agricultural applications, metal pollution in sediment is necessary to be addressed in the Fenghe River. | YANG Yang ZHOU Zhengchao BAI Yanying CAI Yimin CHEN Weiping | 2016 | Pedosphere2016，26，3： | 12 |
| 5 | Transmission scheme and performance analysis for decode-and-forward MIMO two-way relay systems显示文摘In decode-and-forward (DF) MIMO two-way relay systems, the transmission schemes are designed and the closed-form expressions for the outage probability and average symbol error rate (ASER) of the twoway relay system are derived based on two different scenarios of channel state information (CSI). For perfect CSI, the maximum-ratio-transmission and combining (MRT-MRC) technique is applied to design the beamforming and combining vectors. Without perfect CSI, the transmission scheme with limited feedback is designed, and the analytical results are verified through two kinds of codebooks, i.e., random vector quantization and Grassmann. The simulation results show that, the proposed transmission schemes for the two-way relay system can outperform other transmission schemes in the performance of outage probability and ASER, and the accuracy of the derived closed-form expressions is also verified by the numerical simulations. | ZHAO Rui YANG LuXi ZHU WeiPing | 2009 | Science in China(Series F)2009，52，12： | 11 |
| 6 | The IRE1α-XBP1 pathway regulates metabolic stressinduced compensatory proliferation of pancreatic β-cells显示文摘 | Tongfu Xu Liu Yang Cheng Yan Xiaoxia Wang Ping Huang Feng Zhao Liyun Zhao Mingliang Zhang Weiping Jia Xiangdong Wang Yong Liu | 2014 | Cell Research2014，24，9： | 8 |
| 7 | BRIF and CARIF progress显示文摘China Institute of Atomic Energy (CIAE) is currently constructing Beijing rare ion beam facility (BRIF) and is proposing China advanced rare ion beam facility (CARIF). This paper is aiming at introducing the progress of BRIF project and the con ceptual design CARIF. The ISOL type facility BRIF under construction is composed of a 100 MeV 300 ?A proton cyclotron, an ISOL with mass resolution of 20000, and a super-conducting LINAC of 2 MeV/q, and will be commissioned in 2013. CARIF facility proposed is planned to use both ISOL and PF techniques. It is based on a China advanced research reactor CARR that was critical, with ISOL separation of fission fragment, post acceleration to 150 MeV/u, and fragmentation of neu tron-rich fission fragment beam like 132Sn. Such unique combination will allow CARIF to deliver beam intensity better than the best world facilities by more than one order of magnitude. | LIU WeiPing, LI ZhiHong, BAI XiXiang, WANG YouBao, GUO Bing, PENG ChaoHua, YANG Yi, SU Jun, CUI BaoQun, ZHOU ShuHua, ZHU ShengYun, XIA HaiHong, GUAN XiaLing, ZENG Sheng, ZHANG HuanQiao, CHEN YongShou, TANG HongQing, HUANG Li & FENG BeiYuan China Institute of Atomic Energy, P. O. Box 275(1), Beijing 102413, China | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S1： | 8 |
| 8 | Combined effects of p53 and MDM2 polymorphisms on susceptibility and surgical prognosis in hepatitis B virus-related hepatocellular carcinoma显示文摘The p53 signaling pathway works as a potent barrier to tumor progression.Two single nucleotide polymor-phisms(SNPs)in the gene loci of p53 pathway,p53 codon 72 Arg72Pro and MDM2 SNP309(T>G),have been shown to cause perturbation of p53 function,but the effect of the two SNPs on the risk of hepatocellular carcinoma(HCC)remains inconsistent.This study in-vestigated the influence of combined p53 Arg72Pro and MDM2 SNP309 on the risk of developing HCC in pa-tients with chronic hepatitis B virus infection,and evaluated the significance of the two combined SNPs on patient prognosis.In total,350 HCC patients,230 non-HCC patients,and 96 healthy controls were geno-typed for the p53 Arg72Pro and MDM2 SNP309.The combined p53 Pro/Pro and MDM2 G/G genotype was significantly associated with HCC risk(P=0.047).Mul-tivariate analysis indicated that combined p53 Pro/Pro and MDM2 G/G genotype was an independent factor affecting recurrence and survival(P<0.05).Patients with combined p53 Pro/Pro and MDM2 G/G genotypes had a poorer prognosis than other genotypes,P<0.01 for both disease-free survival(DFS)and overall survival(OS).DFS and OS rates also differed significantly be-tween Barcelona Clinic Liver Cancer(BCLC)stage A patients with combined p53 Pro/Pro and MDM2 G/G and other genotypes(P<0.05).Thus,the combined p53 Pro/Pro and MDM2 G/G genotype is associated with increased risk of developing HCC and is an independ-ent adverse prognostic indicator in early stage HCC. | Yun Yang Tian Xia Ning Li Jin Zhang Yuan Yang Wenming Cong Qiang Deng Ke Lan Weiping Zhou | 2013 | Protein & Cell2013，4，1： | 8 |
| 9 | Constructing a high-density linkage map for Gossypium hirsutum × Gossypium barbadense and identifying QTLs for lint percentage显示文摘To introgress the good fiber quality and yield from Gossypium barbadense into a commercial Upland cotton variety, a high-density simple sequence repeat(SSR) genetic linkage map was developed from a BC1F1 population of Gossypium hirsutum×Gossypium barbadense. The map comprised 2,292 loci and covered 5115.16 centi Morgan(c M) of the cotton AD genome, with an average marker interval of 2.23 c M. Of the marker order for 1,577 common loci on this new map, 90.36% agrees well with the marker order on the D genome sequence genetic map. Compared with five published high-density SSR genetic maps, 53.14% of marker loci were newly discovered in this map. Twenty-six quantitative trait loci(QTLs) for lint percentage(LP) were identified on nine chromosomes. Nine stable or common QTLs could be used for marker-assisted selection. Fifty percent of the QTLs were from G. barbadense and increased LP by 1.07%–2.41%. These results indicated that the map could be used for screening chromosome substitution segments from G. barbadense in the Upland cotton background, identifying QTLs or genes from G. barbadense, and further developing the gene pyramiding effect for improving fiber yield and quality. | Yuzhen Shi Wentan Li Aiguo Li Ruihua Ge Baocai Zhang Junzhi Li Guangping Liu Junwen Li Aiying Liu Haihong Shang Juwu Gong Wankui Gong Zemao Yang Feiyü Tang Zhi Liu Weiping Zhu Jianxiong Jiang Xiaonan Yu Tao Wang Wei Wang Tingting Chen Kunbo Wang Zhengsheng Zhang Youlu Yuan | 2015 | Journal of Integrative Plant Biology2015，57，5： | 7 |
| 10 | Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy显示文摘Objective:Hepatocellular carcinoma(HCC),the main type of liver cancer,has a high morbidity and mortality,and a poor prognosis.RNA helicase DDX5,which acts as a transcriptional co-regulator,is overexpressed in most malignant tumors and promotes cancer cell growth.Heat shock protein 90(HSP90)is an important molecular chaperone in the conformational maturation and stabilization of numerous proteins involved in cell growth or survival.Methods:DDX5 m RNA and protein expression in surgically resected HCC tissues from 24 Asian patients were detected by quantitative real-time PCR and Western blot,respectively.The interaction of DDX5-HSP90 was determined by molecular docking,immunoprecipitation,and laser scanning confocal microscopy.The autophagy signal was detected by Western blot.The cell functions and signaling pathways of DDX5 were determined in 2 HCC cell lines.Two different murine HCC xenograft models were used to determine the function of DDX5 and the therapeutic effect of an HSP90 inhibitor.Results:HSP90 interacted directly with DDX5 and inhibited DDX5 protein degradation in the AMPK/ULK1-regulated autophagy pathway.The subsequent accumulation of DDX5 protein induced the malignant phenotype of HCC by activating theβ-catenin signaling pathway.The silencing of DDX5 or treatment with HSP90 inhibitor both blocked in vivo tumor growth in a murine HCC xenograft model.High levels of HSP90 and DDX5 protein were associated with poor prognoses.Conclusions:HSP90 interacted with DDX5 protein and subsequently protected DDX5 protein from AMPK/ULK1-regulated autophagic degradation.DDX5 and HSP90 are therefore potential therapeutic targets for HCC. | Ting Zhang Xinrui Yang Wanping Xu Jing Wang Dawei Wu Zhixian Hong Shengxian Yuan Zhen Zeng Xiaodong Jia Shanshan Lu Rifaat Safadi Sen Han Zhihong Yang Leonard M.Neckers Suthat Liangpunsakul Weiping Zhou Yinying Lu | 2021 | Cancer Biology & Medicine2021，18，3： | 7 |
| 11 | Highly efficient base editing in human tripronuclear zygotes显示文摘 | Changyang Zhou Meiling Zhang Yu Wei Yidi Sun Yun Sun Hong Pan Ning Yao Wanxia Zhong Yixue Li Weiping Li3 Hui Yang Zi-jiang Chen | 2017 | Protein & Cell2017，8，10： | 6 |
| 12 | Upregulated KPNA2 promotes hepatocellular carcinoma progression and indicates prognostic significance across human cancer types显示文摘Hepatocellular carcinoma(HCC)is one of the most aggressive cancers worldwide.Identification of the molecular mechanisms underlying the development and progression of HCC is particularly important.Here,we demonstrated the expression pattern,clinical significance,and function of Karyopherin α2(KPNA2)in HCC.The expression of KPNA2 was upregulated in tumor tissue and negatively associated with the survival time,and a significant correlation between KPNA2 expression and aggressive clinical characteristics was established.Both in vitro and in vivo experiments demonstrated that knockdown of KPNA2 reduced migration and proliferation capacities of HCC cells,while over-expression of KPNA2 increased these malignant characteristics.The analysis of the Cancer Genome Atlas cohorts also reveals that high-KPNA2 expression is associated with poor outcome in multiple cancer types.In addition,gene sets enrichment analysis exhibited cell cycle and DNA replication as the top altered pathways in the high-KPNA2 expression group in HCC and other two cancer types.Overall,this study identified KPNA2 as a potential diagnostic and prognostic biomarker in HCC and other neoplasms,probably by regulating cell cycle and DNA replication. | Xinggang Guo Zhiheng Wang Jianing Zhang Qingguo Xu Guojun Hou Yuan Yang Chuanpeng Dong Gang Liu Chenhua Liang Lei Liu Weiping Zhou Hui Liu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 6 |
| 13 | Effect of Mg/Al atom ratio of support on catalytic performance of Co-Mo/MgO-Al_2O_3 catalyst for water gas shift reaction显示文摘Co-Mo-based catalysts supported on mixed oxide supports MgO-Al2O3 with different Mg/Al atom ratios for water gas shift reaction were studied by means of TPR, Raman, XPS and ESR. It was found that the octahedral Mo species in oxidized Co-Mo/MgO(x)-Al2O3 catalyst and the contents of Mo5+, Mo4+, S2- and S22- species in the functioning catalysts increased with increasing the Mg/Al atom ratio of the support under the studied experimental conditions. This is favorable for the formation of the active Co-Mo-S phase of the catalysts. Catalytic performance testing results showed that the catalysts Co-Mo/MgO-Al2O3 with the Mg/Al atom ratio of the support in the range of 0.475-0.525 exhibited optimal catalytic activity for the reaction. | Yixin Lian Huifang Wang Quanxing Zheng Weiping Fang Yiquan Yang | 2009 | Journal of Natural Gas Chemistry2009，18，2： | 6 |
| 14 | Catalytic conversion of lignocellulosic biomass into chemicals and fuels显示文摘In the search of alternative resources to make commodity chemicals and transportation fuels for a low carbon future,lignocellulosic biomass with over 180-billion-ton annual production rate has been identified as a promising feedstock.This review focuses on the state-of-the-art catalytic transformation of lignocellulosic biomass into value-added chemicals and fuels.Following a brief introduction on the structure,major resources and pretreatment methods of lignocellulosic biomass,the catalytic conversion of three main components,i.e.,cellulose,hemicellulose and lignin,into various compounds are comprehensively discussed.Either in separate steps or in one-pot,cellulose and hemicellulose are hydrolyzed into sugars and upgraded into oxygen-containing chemicals such as 5-HMF,furfural,polyols,and organic acids,or even nitrogen-containing chemicals such as amino acids.On the other hand,lignin is first depolymerized into phenols,catechols,guaiacols,aldehydes and ketones,and then further transformed into hydrocarbon fuels,bioplastic precursors and bioactive compounds.The review then introduces the transformations of whole biomass via catalytic gasification,catalytic pyrolysis,as well as emerging strategies.Finally,opportunities,challenges and prospective of woody biomass valorization are highlighted. | Weiping Deng Yunchao Feng Jie Fu Haiwei Guo Yong Guo Buxing Han Zhicheng Jiang Lingzhao Kong Changzhi Li Haichao Liu Phuc T.T.Nguyen Puning Ren Feng Wang Shuai Wang Yanqin Wang Ye Wang Sie Shing Wong Kai Yan Ning Yan Xiaofei Yang Yuanbao Zhang Zhanrong Zhang Xianhai Zeng Hui Zhou | 2023 | Green Energy & Environment2023，8，1： | 6 |
| 15 | Epidemiological Characteristics of Echinococcosis in Non-Endemic PLADs—China,2017–2020显示文摘Summary What is already known about this topic?Echinococcosis,also known as hydatid disease,is a zoonotic parasitic disease caused by the larvae of Echinococcus granulosus.Western China has one of the most severe epidemics worldwide.Echinococcosis is endemic in 370 counties of 9 provincial-level administrative divisions(PLADs)including Inner Mongolia,Sichuan,Yunnan,Tibet,Shaanxi,Gansu,Qinghai,Ningxia,Xinjiang and Xinjiang Production and Construction Corps(XPCC). | Yan Kui Baixue Liu Xu Wang Cuizhao Xue Jingbo Xue Yalan Zhang Benguang Zhang Yang Dai Shuai Han Weiping Wu | 2021 | China CDC weekly2021，3，51： | 5 |
| 16 | INTERCROPPING:FEED MORE PEOPLE AND BUILD MORE SUSTAINABLE AGROECOSYSTEMS显示文摘Intercropping is a traditional farming system that increases crop diversity to strengthen agroecosystem functions while decreasing chemical inputs and minimizing negative environmental effects of crop production.Intercropping is currently considerable interest because of its importance in sustainable agriculture.Here,we synthesize the factors that make intercropping a sustainable means of food production by integrating biodiversity of natural ecosystems and crop diversity.In addition to well-known yield increases,intercropping can also increase yield stability over the long term and increase systemic resistance to plant diseases,pests and other unfavorable factors(e.g.,nutrient deficiencies).The efficient use of resources can save mineral fertilizer inputs,reduce environmental pollution risks and greenhouse gas emissions caused by agriculture,thus mitigating global climate change.Intercropping potentially increases above-and belowground biodiversity of various taxa at field scale,consequently it enhances ecosystem services.Complementarity and selection effects allow a better understanding the mechanisms behind enhanced ecosystem functioning.The development of mechanization is essential for largescale application of intercropping.Agroecosystem multifunctionality and soil health should be priority topics in future research on intercropping. | Hao YANG Weiping ZHANG Long LI | 2021 | Frontiers of Agricultural Science and Engineering2021，8，3： | 5 |
| 17 | Adsorption of Acetanilide Herbicides on Soil and Its Components: Ⅳ. Sorption of Acetanilide Herbicides on Soils and its Correlation with Soil Properties显示文摘Sorption of acetanilide herbicides, metolachlor, acetochlor, pretilachlor and butachlor on eight soils with various physical and chemical properties was studied. The adsorption isotherms could fit Freundich equation well (r 2 ≥0.91) and the adsorption extents increased in the order: metolachlor < acetochlor < pratilachlor < butachlor. The product of Freundlich adsorption constants, Kf (1/n), showed to have a good correlation with organic matter content (OM) of soils for each of these herbicides, suggesting that OM is the primary factor dominating in the adsorption process of these asetanilide herbicides. Multivariant correlation regression between Kf (1/n) and two factors, water solubility (S.) of herbicides and OM, was also performed. Kf(1/n) correlated with 1/S. and OM/S. well, showing that high S. corresponds to a weak tendency to adsorb on soils. Infrared (IR) spectra and electron spin resonance (ESR) parameters confirmed that multifunctional H-bonds and charge-transfer bonds were the main adsorption mechanisms of these acetanilide herbicides. The abilities of herbicides to form these adsorption bonds with HA increased in the same order as the extent of adsorption. | LIU WEIPING WANG QIQUAN YANG WEICHUN and WANG XIAORONG State Key Laboratory of Pollution Control and Resource Reuse Research, Nanjing University, Nanjing 210093 (China) Institute of Environmental Science, Zhejiang University at Yuquan, Hangzhou 510027 | 2001 | Pedosphere2001，11，3： | 5 |
| 18 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 19 | SCStore: Managing Scientific Computing Packages for Hybrid System with Containers显示文摘Managing software packages in a scientific computing environment is a challenging task, especially in the case of heterogeneous systems. It is error prone when installing and updating software packages in a sophisticated computing environment. Testing and performance evaluation in an on-the-fly manner is also a troublesome task for a production system. In this paper, we discuss a package management scheme based on containers. The newly developed method can ease the maintenance complexity and reduce human mistakes. We can benefit from the self-containing and isolation features of container technologies for maintaining the software packages among intricately connected clusters. By deploying the Super Computing application Strore(SCStore) over the WAN connected world-largest clusters, it proved that it can greatly reduce the effort for maintaining the consistency of software environment and bring benefit to achieve automation. | Wusheng Zhang Jiao Lin Weiping Xu Haohuan Fu Guangwen Yang | 2017 | Tsinghua Science and Technology2017，22，6： | 5 |
| 20 | Efficacy of biofeedback therapy via a mini wireless device on sleep bruxism contrasted with occlusal splint:a pilot study显示文摘The putative causes of bruxism are multifactorial and there are no definite measures for bruxism management.The aim of this study was to evaluate the efficacy of biofeedback therapy on sleep bruxism,compared with occlusal splint.Twenty-four volunteers with sleep bruxism were divided into two groups:the GTB group that were treated with biofeedback therapy(n 512) and the GTO group that were treated with occlusal splint(n 512).A mini pressure sensor integrated with a monitoring circuit by use of a maxillary biofeedback splint was fabricated.To foster the relaxation of the masticatory muscles and the nervous system,the wireless device received signals from bruxism events and vibrations alerted the bruxer when the threshold was exceeded.Total episodes and average duration of bruxism events during8 hours of sleep were analyzed with the monitoring program(TRMY1.0).After 6 and 12 weeks,the episodes(P 50.001) and duration(P,0.05) in the GTB group declined dramatically.In contrast,there were no significant differences in the GTO group after the treatment(P.0.05).Furthermore,the episodes had significant differences between the GTB group and the GTO group after the same period of treatment(P 5 0.000).The results suggest that biofeedback therapy may be an effective and convenient measure for mild bruxers,when compared with occlusal splint therapy.The mini wireless biofeedback method may be of value for the diagnosis and management of bruxism in the future. | WeiPing Gu Jie Yang FeiMin Zhang XinMin Yin XiaoLong Wei Chen Wang | 2015 | The Journal of Biomedical Research2015，29，2： | 4 |
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