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| 1 | Spatial-temporal spectrum hole discovery:a hybrid spectrum sensing and geolocation database framework显示文摘A hybrid spectrum sensing and geolocation database framework is proposed to tackle the discovery of spatial-temporal spectrum hole in cognitive radio networks.We first analyze the advantages and disadvantages of spectrum sensing-based and geolocation database-based approaches respectively,which motivate us to further propose a hybrid protocol framework by effectively integrating the benefits of both spectrum sensing and geolocation database.Specifically,in the proposed hybrid approach,the goal is to maximize the utilization of spatialtemporal spectrum hole while satisfying the protection constraints for the primary users.Analytical and numerical results demonstrate the superior performance of the proposed hybrid approach over the existing spectrum sensing only and geolocation database only approaches,in terms of interference-free throughput.This article serves as a fundamental framework for advancing the design of hybrid approaches for spatial-temporal spectrum hole discovery. | Jinlong Wang Guoru Ding Qihui Wu Liang Shen Fei Song | 2014 | Chinese Science Bulletin2014，59，16： | 6 |
| 2 | Evolution and functional analysis of the Pif97 gene of the Pacific oyster Crassostrea gigas显示文摘 | Xiaotong WANG Xiaorui SONG Tong WANG Qihui ZHU Guoying MIAO Yuanxin CHEN Xiaodong FANG Huayong QUE Li LI Guofan ZHANG | 2013 | Current Zoology2013，59，1： | 3 |
| 3 | Market socialism meets the lost generation:motivational orientations of adult learners in Shanghai 显示文摘 | Boshier R Yan Huang Qihui Song | 2006 | Journal of Research and Theory2006，56，3： | 1 |
| 4 | The antigenicity of SARS-CoV-2 Delta variants aggregated 10 high-frequency mutations in RBD has not changed sufficiently to replace the current vaccine strain显示文摘Emerging SARS-CoV-2 variants are the most serious problem for COVID-19 prophylaxis and treatment.To determine whether the SARS-CoV-2 vaccine strain should be updated following variant emergence like seasonal flu vaccine,the changed degree on antigenicity of SARS-CoV-2 variants and H3N2 flu vaccine strains was compared.The neutralization activities of Alpha,Beta and Gamma variants’spike protein-immunized sera were analysed against the eight current epidemic variants and 20 possible variants combining the top 10 prevalent RBD mutations based on the Delta variant,which were constructed using pseudotyped viruses.Meanwhile,the neutralization activities of convalescent sera and current inactivated and recombinant protein vaccine-elicited sera were also examined against all possible Delta variants.Eight HA protein-expressing DNAs elicited-animal sera were also tested against eight pseudotyped viruses of H3N2 flu vaccine strains from 2011–2019.Our results indicate that the antigenicity changes of possible Delta variants were mostly within four folds,whereas the antigenicity changes among different H3N2 vaccine strains were approximately 10–100-fold.Structural analysis of the antigenic characterization of the SARS-CoV-2 and H3N2 mutations supports the neutralization results.This study indicates that the antigenicity changes of the current SARS-CoV-2 may not be sufficient to require replacement of the current vaccine strain. | Jiajing Wu Jianhui Nie Li Zhang Hao Song Yimeng An Ziteng Liang Jing Yang Ruxia Ding Shuo Liu Qianqian Li Tao Li Zhimin Cui Mengyi Zhang Peng He Youchun Wang Xiaowang Qu Zhongyu Hu Qihui Wang Weijin Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 1 |
| 5 | Spectrum Sensing in Op- portunity-Heterogeneous Cognitive Sensor Networks : How to Coop- erate 显示文摘 | Ding Guoru Wu Qihui Song Fei | 2013 | IEEE Sensor Journal2013，13，11： | 1 |
| 6 | Engineering white blood cell membrane-camouflaged nanocarriers for inflammation-related therapeutics显示文摘White blood cells(WBCs)play essential roles against inflammatory disorders,bacterial infections,and cancers.Inspired by nature,WBC membrane-camouflaged nanocarriers(WBC-NCs)have been developed to mimic the“dynamic”functions of WBCs,such as transendothelial migration,adhesion to injured blood vessels,etc,which make them promising for diverse medical applications.WBC-NCs inherit the cell membrane antigens of WBCs,while still exhibiting the robust inflammation-related therapeutic potential of synthetic nanocarriers with excellent(bio)physicochemical performance.This review summarizes the proposed concept of cell membrane engineering,which utilizes physical engineering,chemical modification,and biological functionalization technologies to endow the natural cell membrane with abundant functionalities.In addition,it highlights the recent progress and applications of WBC-NCs for inflammation targeting,biological neutralization,and immune modulation.Finally,the challenges and opportunities in realizing the full potential of WBC-NCs for the manipulation of inflammation-related therapeutics are discussed. | Wanli Song Pengfei Jia Yaping Ren Junmiao Xue Bingqian Zhou Xinkai Xu Yansheng Shan Jing Deng Qihui Zhou | 2023 | Bioactive Materials2023，，5： | 1 |
| 7 | On the origin of SARS-CoV-2——The blind watchmaker argument显示文摘In the comparison with SARS-CoVof 2003,SARS-CoV-2 is extremely well adapted to the human populations and its adaptive shift from the animal host to humans must have been even more extensive.By the blind watchmaker argument,such an adaptive shift can only happen prior to the onset of the current pandemic and with the aid of step-by-step selection. | Chung-I Wu Haijun Wen Jian Lu Xiao-dong Su Alice CHughes Weiwei Zhai Chen Chen Hua Chen Mingkun Li Shuhui Song Zhaohui Qian Qihui Wang Bingjie Chen Zixiao Guo Yongsen Ruan Xuemei Lu Fuwen Wei Li Jin Le Kang Yongbiao Xue Guoping Zhao Ya-Ping Zhang | 2021 | Science China(Life Sciences)2021，64，9： | 1 |
| 8 | Market socialismmeets the lost-generation : motivational orientations of adultlearners in Shanghai 显示文摘 | Boshier R Yan Huang Qihui Song | 2006 | Adult Education Quarterly2006，56，3： | 1 |
| 9 | Abnormal Aggregation of Invasive Cancer Cells Induced by Collective Polarization and ECM-Mediated Mechanical Coupling in Coculture Systems显示文摘Studiesonpattern formation in coculturecell systemscan provide insights intomany physiological and pathologicalprocesses Here,we investigate how theextracellular matrix(ECM)may influence the patterning in coculture systems.Themodel coculture system we use is composed of highly motile invasivebreast cancer cells,initially mixed with inert nonmetastatic cells on a 2D substrate and covered with a Matrigel layer introduced to mimic ECM.We observe that the invasive cells exhibit persistent centripetal motion and yield abnormal aggregation,rather than random spreading,due to a“cllective pulling”effect resultingfrom ECM-mediated transmssion of active contractile forces generated bythe polarized migration of the invasive cells along the vertical direction.Themechanism we report may open a new window for the understanding of biological processes that involve multiple types of cells. | Xiaochen Wang Shaohua Chen Hanqing Nan Ruchuan Liu Yu Ding Kena Song Jianwei Shuai Qihui Fan Yu Zheng Fangu Ye Yang Jiao Liyu Liu | 2022 | Research2022，，2： | 0 |
| 10 | Abnormal Aggregation of Invasive Cancer Cells Induced by Collective Polarization and ECM-Mediated Mechanical Coupling in Coculture Systems显示文摘Studies on pattern formation in coculture cell systems can provide insights into many physiological and pathological processes.Here,we investigate how the extracellular matrix(ECM)may influence the patterning in coculture systems.The model coculture system we use is composed of highly motile invasive breast cancer cells,initially mixed with inert nonmetastatic cells on a 2D substrate and covered with a Matrigel layer introduced to mimic ECM.We observe that the invasive cells exhibit persistent centripetal motion and yield abnormal aggregation,rather than random spreading,due to a“collective pulling”effect resulting from ECM-mediated transmission of active contractile forces generated by the polarized migration of the invasive cells along the vertical direction.The mechanism we report may open a new window for the understanding of biological processes that involve multiple types of cells. | Xiaochen Wang Shaohua Chen Hanqing Nan Ruchuan Liu Yu Ding Kena Song Jianwei Shuai Qihui Fan Yu Zheng Fangfu Ye Yang Jiao Liyu Liu | 2021 | Research2021，，1： | 0 |
| 11 | Evidence that Natural Selection is the Primary Cause of the Guanine-cytosine Content Variation in Rice Genes显示文摘Cereal genes are classified into two distinct classes according to the guanine-cytosine(GC)content at the third codonsites(GC_3).Natural selection and mutation bias have been proposed to affect the GC content.However,there has beencontroversy about the cause of GC variation.Here,we characterized the GC content of 1092 paralogs and other single-copygenes in the duplicated chromosomal regions of the rice genome(ssp.indica)and classified the paralogs into GC_3-richand GC_3-poor groups.By referring to out-group sequences from Arabidopsis and maize,we confirmed that the averagesynonymous substitution rate of the GC_3-rich genes is significantly lower than that of the GC_3-poor genes.Furthermore,we explored the other possible factors corresponding to the GC variation including the length of coding sequences,thenumber of exons in each gene,the number of genes in each family,the location of genes on chromosomes and the proteinfunctions.Consequently,we propose that natural selection rather than mutation bias was the primary cause of the GCvariation. | Xiaoli Shi Xiyin Wang Zhe Li Qihui Zhu Ji Yang Song Ge Jingchu Luo | 2007 | Journal of Integrative Plant Biology2007，49，9： | 0 |
| 12 | Crystal structures of the two membrane-proximal Ig-like domains(D3D4)of LILRB1/B2:alternative models for their involvement in peptide-HLA binding显示文摘Leukocyte immunoglobulin-like receptors(LILRs),also called CD85s,ILTs,or LIRs,are important mediators of immune activation and tolerance that contain tandem immunoglobulin(Ig)-like folds.There are 11(in addition to two pseudogenes)LILRs in total,two with two Ig-like domains(D1D2)and the remaining nine with four Ig-like domains(D1D2D3D4).Thus far,the structural features of the D1D2 domains of LILR proteins are well defi ned,but no structures for the D3D4 domains have been reported.This is a very important fi eld to be studied as it relates to the unknown functions of the D3D4 domains,as well as their relative orientation to the D1D2 domains on the cell surface.Here,we report the crystal structures of the D3D4 domains of both LILRB1 and LILRB2.The two Ig-like domains of both LILRB1-D3D4 and LILRB2-D3D4 are arranged at an acute angle(~60°)to form a bent struc-ture,resembling the structures of natural killer inhibitory receptors.Based on these two D3D4 domain structures and previously reported D1D2/HLA I complex structures,two alternative models of full-length(four Ig-like domains)LILR molecules bound to HLA I are proposed. | Gol Nam Yi Shi Myongchol Ryu Qihui Wang Hao Song Jun Liu Jinghua Yan Jianxun Qi George F Gao | 2013 | Protein & Cell2013，4，10： | 0 |
| 13 | A protective human antibody against respiratory syncytial virus by targeting a prefusion epitope across sites IV and V of the viral fusion glycoprotein显示文摘Respiratory syncytial virus(RSV)is one of the leading pathogens that cause lower respiratory tract infections in infants and the elderly.Passive immunoprophylaxis with monoclonal antibody(mAb)has been approved to prevent morbidity and mortality from RSV infection in infants.Here we report the isolation of two neutralizing mAbs against RSV from convalescent children by prefusion form of fusion(F)glycoprotein as bait.One mAb RV11 exhibited good potency in neutralization of RSV strains from both A and B subtypes in cell-based assay,and protected mice from RSV infection in vivo.An RV11 escape mutant was identified,which contains an S443P mutation in F protein.Crystal structure showed the RV11 bound to a conserved prefusion epitope across the antigenic sites IV and V of the F glycoprotein.RV11 showed a strong synergistic effect when combined with two RSV antivirals,an F-targeting small molecular inhibitor ziresovir and a siteØneutralizing mAb D25(the parental mAb for nirsevimab).The study extended our knowledge to the neutralizing and protective epitopes of RSV,and the mAb RV11 deserves further development for clinical translation. | Lianpan Dai Jian Song Lili Xu Zhao Gao Senyu Xu Yan Chai Liang Wang Mi Yang Tong Ma Qihui Wang Sushan Cao Junming Yie Gang Zou Zhengde Xie Jim Zhen Wu George Fu Gao | 2023 | hLife2023，1，1： | 0 |
| 14 | A MULTI-CRC SELECTIVE HARQ SCHEME FOR MIMO SYSTEMS显示文摘A multi-Cyclic Redundancy Check (CRC) selective Hybrid Automatic-Repeat-reQuest (HARQ) scheme for improving the throughput efficiency of Multiple Input Multiple Output (MIMO) systems is proposed in this paper. According to different feedback information from the receiver, the proposed HARQ scheme employs two strategies, referred to as retransmission frame selection and space diversity. These two strategies decrease the successive frame errors upon retransmission. Theoretic analysis and computer simulation results show that this HARQ scheme achieves higher throughput than the existing HARQ schemes even in poor conditions of low Signal-to-Noise Ratio (SNR). | Song Fei Tong Xiaobing Wu Qihui Wang Jinlong | 2008 | Journal of Electronics(China)2008，25，1： | 0 |
| 15 | Back to Science in Searching for SARS-CoV-2 Origins显示文摘In recent decades,emerging and re-emerging human-infecting pathogens have been represented as huge threats to public health and have become a global concern(1).After outbreaks of two coronaviruses(CoVs),severe acute respiratory syndrome coronavirus(SARS-CoV)and Middle East respiratory syndrome coronavirus(MERS-CoV),severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)became the first-known pandemic hastening CoV with tremendous wrecking to the world(2).The origin tracing of these emerging pathogens is of great significance in infectious disease prevention and control(3–4).The origin of SARS-CoV-2 remains elusive after the more than 3-year pandemic,though scientists around the world are making great efforts.From the experience of studying many other infectious pathogens,origin tracing is systematic and time-consuming work.The supposed origins of many infectious pathogens are still in debate,including SARS-CoV and human immunodeficiency virus,etc(5). | William J Liu Wenwen Lei Xiaozhou He Peipei Liu Qihui Wang Zhiqiang Wu Yun Tan Shuhui Song Gary Wong Jian Lu Jingkun Jiang Qiang Wei Mingkun Li Juncai Ma Xiaozhong Peng Yixue Li Baoxu Huang Yigang Tong Jun Han Guizhen Wu | 2023 | China CDC weekly2023，5，14： | 0 |
| 16 | A neutralizing-protective supersite of human monoclonal antibodies for yellow fever virus显示文摘The yellow fever virus(YFV)is a life-threatening human pathogen.Owing to the lack of available therapeutics,non-vaccinated individuals are at risk.Here,we isolated eight human monoclonal antibodies that neutralize YFV infection.Five recognized overlapping epitopes and exhibited potent neutralizing activity.Two(YD6 and YD73)were ultra-potent and conferred complete protection against the lethal challenge of YFV as both prophylactics and therapeutics in a mouse model.Crystal structures revealed that YD6 engaged the YFV envelope protein in both pre-and post-fusion states,suggesting viral inhibition by a“double-lock”mechanism.The recognition determinants for YD6 and YD73 are clustered at the premembrane(prM)-binding site.Notably,antibodies targeting this site were present in minute traces in YFV-infected individuals but contributed significantly to neutralization,suggesting a vulnerable supersite of YFV.We provide two promising candidates for immunotherapy against YFV,and the supersite represents an ideal target for epitope-based vaccine design. | Yan Li Zhihai Chen Lili Wu Lianpan Dai Jianxun Qi Yan Chai Shihua Li Qihui Wang Zhou Tong Sufang Ma Xiaomin Duan Shuning Ren Rui Song Mifang Liang Wenjun Liu Jinghua Yan George F.Gao | 2022 | The Innovation2022，3，6： | 0 |
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