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| 1 | Distribution pattern of Caragana species under the influence of climate gradient in the Inner Mongolia region, China显示文摘There is a strong climate gradient in the Inner Mongolia region, China, with solar radiation and air temperature increasing but precipitation decreasing gradually from the northeast to the southwest. Sixteen Cara- gana species exist in the Inner Mongolia region. These Caragana species exhibit a distribution pattern across moisture zones and form a geographical replacement series. In order to examine the mechanisms responsible for Caragana species distribution pattern, we selected 12 Caragana species that exhibit a distinct distribution pattern across multiple moisture zones in the Inner Mongolia region, and determined the relationships between the leaf ecological and physiological traits of these Caragana species and the aridity index and solar radiation. Along with the climatic drought gradient and the solar radiation intensification from the northeast to the southwest, leaf eco- logical characteristics of Caragana species changed drastically, i.e. the leaf shape gradually turned from flat into tegular or tubbish; the leaf hair became denser, longer and lighter in color; the leaf area, leaf biomass and specific leaf area(SLA) decreased significantly; the leaf thickness and the ratio of leaf thickness to leaf area increased sig- nificantly; and the leaf chlorophyll content decreased significantly. As the climatic drought stress increased, osmotic potentials of the main osmotic adjustment substances and the cytoplasmic ion concentration of Caragana species increased significantly. Meanwhile, the total and free water contents and water potential of leaves decreased sig- nificantly; the ratio of bound to free water increased significantly; the stomatal conductance and transpiration rate reduced significantly; and the water use efficiency(WUE) increased significantly. In addition, with the intensification of climatic drought stress, peroxidase(POD) and superoxide dismutase(SOD) activities in leaves increased sig- nificantly. As a result, the malondialdehyde(MDA) content increased while the oxygen free radical content decreased. Our results showed that most of the leaf ecological and physiological traits of the 12 Caragana species varied in ac- cordance with the climatic drought gradient in the Inner Mongolia region, which reflected the adaptation of the Cara- gana species to the local climate conditions. With relatively more active metabolism and faster growth, the Caragana species in the northeast had strong competitive abilities; on the other hand, with stronger resistance to climatic drought stress, the Caragana species in the southwest could survive in harsh environments. Based on our results, we con- cluded that both the environmental gradients and the adaptive responses of Caragana species to their environments played important roles in the formation of the Caragana species distribution pattern across the Inner Mongolia region. | LiNa XIE ChengCang MA HongYu GUO QingFang LI YuBao GAO | 2014 | Journal of Arid Land2014，6，3： | 5 |
| 2 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 3 | Regulatory effect of salicylic acid and methyl jasmonate supplementation on ergosterol production in Hericium erinaceus mycelia显示文摘We evaluated the biomass and ergosterol content of Hericium erinaceus mycelium, and extracellular enzyme activities in H. erinaceus liquid culture following salicylic acid(SA) and methyl jasmonic acid(Me JA)supplementation. The optimal SA concentration was100 lmoláL-1, where the highest ergosterol content of 2.33 mgág-1was obtained following 6-day cultivation with100 lmoláL-1SA supplementation, and which was significantly higher than the unsupplemented control(p \ 0.01). Following 4-day supplementation with50 lmoláL-1Me JA, the highest ergosterol content obtained was 1.988 mgág-1, which was 25.8 % higher than the unsupplemented control. Our data indicate that SA and Me JA supplementation improves ergosterol content in H.erinaceus mycelium. | Xiaodong Dai Yaguang Zhan Jiechi Zhang Piqi Zhang Zenghua Han Qingfang Ma Xianghui Kong Jianing Liu Yinpeng Ma | 2015 | Journal of Forestry Research2015，26，1： | 5 |
| 4 | Crystalline behaviors and phase transition during the manufacture of fine denier PA6 fibers显示文摘Recently we have successfully produced fine denier PA6 fibers by using additives containing lanthanide compounds.Meanwhile,crystallization and phase transition of PA6 fibers during spinning and drawing processes were investigated.During the spinning process,β phase crystal could be obtained in as-spun PA6 fibers which were produced with relatively high melt draw ratio,while γ phase crystal predominated when the melt draw ratio was relatively low.β phase crystal,whose behaviors are similar with those of γ phase by FT-IR and XRD characterization,could be transformed to α form easily when PA6 fibers are immersed in boiling water.However,γ phase crystal of PA6 remains unchanged in boiling water.Thus,β and γ phase crystals of PA6 can be differentiated by the crystalline behaviors of PA6 fibers after treatment in boiling water.Further experiments demonstrate that the β phase can also be produced during a drawing process where a phase transformation from γ to α occurs.In other words,β phase may act as an intermediate state during the phase transformation. | ZHANG ChengFeng LIU YuHai LIU ShaoXuan LI HuiZhen HUANG Kun PAN QingHua HUA XiaoHui HAO ChaoWei MA QingFang LV ChangYou LI WeiHong YANG ZhanLan ZHAO Ying WANG DuJin LAI GuoQiao JIANG JianXiong XU YiZhuang WU JinGuang | 2009 | Science China Chemistry2009，52，11： | 4 |
| 5 | Targeted therapy for head and neck cancer:signaling pathways and clinical studies显示文摘Head and neck cancer(HNC)is malignant,genetically complex and difficult to treat and is the sixth most frequent cancer,with tobacco,alcohol and human papillomavirus being major risk factors.Based on epigenetic data,HNC is remarkably heterogeneous,and treatment remains challenging.There is a lack of significant improvement in survival and quality of life in patients with HNC.Over half of HNC patients experience locoregional recurrence or distal metastasis despite the current multiple traditional therapeutic strategies and immunotherapy.In addition,resistance to chemotherapy,radiotherapy and some targeted therapies is common.Therefore,it is urgent to explore more effective and tolerable targeted therapies to improve the clinical outcomes of HNC patients.Recent targeted therapy studies have focused on identifying promising biomarkers and developing more effective targeted therapies.A well understanding of the pathogenesis of HNC contributes to learning more about its inner association,which provides novel insight into the development of small molecule inhibitors.In this review,we summarized the vital signaling pathways and discussed the current potential therapeutic targets against critical molecules in HNC,as well as presenting preclinical animal models and ongoing or completed clinical studies about targeted therapy,which may contribute to a more favorable prognosis of HNC.Targeted therapy in combination with other therapies and its limitations were also discussed. | Qingfang Li Yan Tie Aqu Alu Xuelei Ma Huashan Shi | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 2 |
| 6 | Maximizing the number of oxygen-containing functional groups on activated carbon by using ammonium persulfate and improving the temperature-programmed desorption characterization of carbon surface chemistry显示文摘 | Na Li Xiaoliang Ma Qingfang Zha Kyungsoo Kim Yongsheng Chen Chunshan Song | 2011 | Carbon2011，，15： | 1 |
| 7 | Gender and magnetic resonance imaging classification-related differences in clinical and biochemical characteristics of Cushing's disease: a single-centre study显示文摘 | Chen Yufan Mei Xiaobo Jian Fangfang Ma Qinyun Chen Xiao Bian Liuguan Sun Qingfang | 2014 | Chinese Medical Journal2014，，22： | 1 |
| 8 | Impact of climate variability and human activity on streamflow decrease in the Miyun Reservoir catchment显示文摘 | Huan Ma Dawen Yang Soon Keat Tan Bing Gao Qingfang Hu | 2010 | Journal of Hydrology2010，389，： | 1 |
| 9 | Effect of aluminum on microstructure and magnetic properties of sintered Nd-Fe-B magnets processed by grain boundary diffusion of Tb-Al显示文摘The grain boundary diffusion process(GBDP)of Tb can improve the coercivity of sintered Nd-Fe-B magnets.In this study,the effect of AI on the diffusion of Tb in the GBDP was investigated.The content of diffused Tb-Al was precisely controlled by adjusting the magnetron sputtering process.The Tb equivalent of Al was also studied.Results show that AI promotes the diffusion of Tb deeper into the magnet,reducing the thickness of the shell in the core-shell structure.This study is helpful for further developing the process,reducing the consumption of heavy rare earth elements(Tb),and improving the coercivity of sintered Nd-Fe-B magnets. | Tinghui Wang Zhaokun Ma Qihang Zhu Lijing Yang Baosheng Liu Yu Zhao Cheng Xu Bizhang Zheng Fangqin Hu Jianzhong Li Qingfang Huang Zhenlun Song | 2023 | Journal of Rare Earths2023，41，5： | 0 |
| 10 | Extracting Named Entity Using Entity Labeling in Geological Text Using Deep Learning Approach显示文摘Artificial intelligence(AI) is the key to mining and enhancing the value of big data, and knowledge graph is one of the important cornerstones of artificial intelligence, which is the core foundation for the integration of statistical and physical representations. Named entity recognition is a fundamental research task for building knowledge graphs, which needs to be supported by a high-quality corpus, and currently there is a lack of high-quality named entity recognition corpus in the field of geology, especially in Chinese. In this paper, based on the conceptual structure of geological ontology and the analysis of the characteristics of geological texts, a classification system of geological named entity types is designed with the guidance and participation of geological experts, a corresponding annotation specification is formulated, an annotation tool is developed, and the first named entity recognition corpus for the geological domain is annotated based on real geological reports. The total number of words annotated was 698 512 and the number of entities was 23 345. The paper also explores the feasibility of a model pre-annotation strategy and presents a statistical analysis of the distribution of technical and term categories across genres and the consistency of corpus annotation. Based on this corpus, a Lite Bidirectional Encoder Representations from Transformers(ALBERT)-Bi-directional Long Short-Term Memory(BiLSTM)-Conditional Random Fields(CRF) and ALBERT-BiLSTM models are selected for experiments, and the results show that the F1-scores of the recognition performance of the two models reach 0.75 and 0.65 respectively, providing a corpus basis and technical support for information extraction in the field of geology. | Qinjun Qiu Miao Tian Zhong Xie Yongjian Tan Kai Ma Qingfang Wang Shengyong Pan Liufeng Tao | 2023 | Journal of Earth Science2023，34，5： | 0 |
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