|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The Inhibitory Effect of Oridonin on the Growth of Fifteen Human Cancer Cell Lines显示文摘OBJECTIVE To study the inhibitory effect of oridonin on the growth of cancer cells. METHODS Fifteen human cancer cell lines were subjected to various concentrations of oridonin in culture medium. The inhibitory rate of cell growth was measured by the MTT assay, and compared with a negative con- trol and 5-Fu-positive control. RESULTS The 50% inhibiting concentration (IC50) and maximal inhibition (Imax) of oridonin shown by studying the growth of the cancer cell lines were as follows: leukemias (HL60 cells: 3.9 μg/ml and 73.8%, K562 cells: 4.3 μg/ml and 76.2%); esophageal cancers(SHEEC cells: 15.4 μg/ml and 99.2%, Eca109 cells: 15.1 μg/ml and 84.6%, TE1 cells: 4.0 μg/ml and 70.2%); gastric cancers (BGC823 cells: 7.6 μg/ml and 98.7%, SGC7901 cells: 12.3 μg/ml and 85.7%); colon cancers (HT29 cells: 13.6 μg/ml and 97.2%, HCT cells: 14.5 μg/ml and 96.5%); liver cancers (Bel7402 cells: 15.2 μg/ml and 89.2%, HepG2 cells: 7.1 μg/ml and 88.3%); pancreatic cancer (PC3 cells: 11.3 μg/ml and 68.4%); lung cancer (A549 cells: 18.6 μg/ml and 98.0% ); breast cancer (MCF7 cells: 18.4 μg/ml and 84.7%); uterine cervix cancer (Hela cells: 13.7 μg/ml and 98.5%). CONCLUSION Oridonin had a relatively wide anti-tumor spectrum, and a relatively strong inhibitory effect on the growth of the 15 human cancer cells. Inhibitory effects were concentration dependent. | Junhui Chen Shaobin Wang Dongyang Chen Guisheng Chang Qingfeng Xin Shoujun Yuan Zhongying Shen | 2007 | Chinese Journal of Clinical Oncology2007，4，1： | 32 |
| 2 | The next generation models for crops and agro-ecosystems显示文摘Growth in population, decrease in arable land area, and change in climate are endangering our food security. Precision agriculture has the potential to increase crop productivity thorough tailored agricultural practices for different growing areas. Many models of crops and agro-ecosystems capable of predicting interaction between plants and environments have been developed for precision agriculture. Currently, there are several representative categories of crop and agro-ecosystem models, including the de Wit school models, the DSSAT series models and the APSIM series models, which have contributed substantially to improvement of agricultural practices. However, these models are weak in predicting performances of crops under environmental and genetic perturbations are generally weak, which severely limits the application of these models in guiding precision agriculture. We need to develop the next generation crop and agro-ecosystems models with a high level of mechanistic basis, which can be integrated with high throughput data and can predict the heterogeneity of environmental factors inside canopy and dynamic canopy photosynthesis. In developing such a model close collaboration is inevitably required among scientists from different disciplines. The successful development and application of such models will undoubtedly advance precision agriculture through providing better agronomical practices tailored for different growing environments. These models will also form a basis to identify breeding targets for increased productivity at given location with given soil and climatic conditions. | ZHU XinGuang ZHANG GuiLian THOLEN Danny WANG Yu XIN ChangPeng SONG QingFeng | 2011 | Science China(Information Sciences)2011，54，3： | 6 |
| 3 | ePlant for quantitative and predictive plant science research in the big data era --Lay the foundation for the future model guided crop breeding, engineering and agronomy显示文摘背景在着急地在最近的十年统一陆地区域基础上的庄稼产量的全球人口,气候变化和停滞的增加打电话让一条新途径支持当代的庄稼改进。ePlant 与机械学的细节的高水平是植物生长和开发的一个数学模型遇见这挑战。结果 ePlant 集成为过程发生在开发的模块急速地不同时间( 108106 秒)并且空间( 101010 米)可伸缩,合并多样的物理、生物物理、生物化学的过程包括基因规定,新陈代谢的反应,底层运输和散开,精力吸收,转移和变换,机关形态发生,植物环境相互作用,等等。单个模块用一条 divide-and-conquer 途径被开发;在不同时间、空间的规模的模块进一步通过转移 variables.We 是综合的基于信息几何学建议一个监督学习过程为两知识发现和模型扩展或进展联合模型和数据。我们最后讨论一个全球协会的最近的形成,它在植物生物学包括专家,计算机科学,统计,农学, phenomics ,等等试图由支持模型作为一个社区努力被开发而不是在哪儿的一个新模型开发范例帮助 ePlant 或它的等价物的开发和应用程序主要由单个实验室努力开车。结论 ePlant 支持量、预兆的植物科学研究的一个主要研究工具,将在未来模型起一个关键作用指导庄稼工程,繁殖并且农学。 | Yi Xiao Tiangen Chang Qingfeng Song Shuyue Wang Danny Tholen Yu Wang Changpeng xin Guangyong Zheng Honglong Zhao Xin-Guang Zhu | 2017 | Frontiers of Electrical and Electronic Engineering in China2017，5，3： | 3 |
| 4 | A modified scar model with controlled tension on secondary wound healing in mice显示文摘Pathological scars might cause a distorted appearance and restricted mobility,and the study of scar pathophysiology has been hindered by the absence of a reliable model.In this study,we introduce a model with a modified device to induce controlled tension on a wound healing by secondary intention to overcome the shortcomings of the model generated by Aarabi et al.We investigated and recommend an induction of 0.1 N/mm^(2) tension on day 7 for 14 days to mimic the characteristics of human scars.A 3.5-fold increase in scar tissue and a 2-fold increase in collagen production were induced by the modified model.Histologically,the modified method increased scar thickness.However,no significant difference was found in cell density between the two groups.This modified procedure significantly increased scar tissue,which could be used for further cellular and biomolecular research.The mechanical force applied to the wound became measurable and controllable.This method is more convenient for researchers to observe in realtime and for providing timely adjustments of the tension used in this modified model. | Zi Wang Xin Huang Tao Zan Qingfeng Li Haizhou Li | 2020 | Burns & Trauma2020，8，1： | 2 |
| 5 | Characterization and flocculation mechanism of a bioflocculant from hydrolyzate of rice stover显示文摘 | Junyuan Guo Jing Yu Xin Xin Changwu Zou Qingfeng Cheng Huaijin Yang Lichao Nengzi | 2014 | Bioresource Technology2014，，： | 1 |
| 6 | Ultra strong and ductile eutectic high entropy alloy fabricated by selective laser melting显示文摘With important application prospects, eutectic high entropy alloys have received extensive attention for their excellent strength and ductility in a large temperature range. The excellent casting characteristics of eutectic high entropy alloys make it possible to achieve well manufacturability of selective laser melting.For the first time, we have achieved crack-free eutectic high entropy alloy fabricated by selective laser melting, which has excellent mechanical properties in a wide temperature range from -196 ℃ to 760 ℃ due to ultra-fine eutectic lamellar spacing of 150–200 nm and lamellar colony of 2–6 μm. Specifically,the room temperature tensile strength exceeds 1400 MPa and the elongation is more than 20%, which significantly improved compared with those manufactured by other techniques with lower cooling rate. | Fan Yang Lilin Wang Zhijun Wang Qingfeng Wu Kexuan Zhou Xin Lin Weidong Huang | 2022 | Journal of Materials Science & Technology2022，，11： | 1 |
| 7 | Genome-wide profiling of histone H3 lysine 27 trimethylation and its modification in response to chilling stress in grapevine leaves显示文摘Histone H3 lysine 27 trimethylation(H3K27me3) is a histone modification associated with transcriptional repression. However, insights into the genome-wide pattern of H3K27me3 in grapevines are limited. Here, anti-H3K27 chromatin immunoprecipitation(ChIP), high-throughput sequencing, and transcriptome analysis were performed using leaves of Vitis amurensis. The leaves were treated at 4°C for 2 h and 24 h and used to investigate changes in H3K27me3 under chilling treatment. The results show that H3K27me3 is well-distributed both in gene regions(-50%) and in the intergenic region(-50%) in the grapevine genome(Vitis vinifera ‘Pinot Noir PN40024'). H3K27me3 was found to be localized in8 368 annotated gene regions in all detected samples(leaves at normal temperature and under chilling treatments) and mainly enriched in gene bodies with the adjacent promoter and downstream areas. The short-term chilling treatments(4°C for 2 h) induced 2 793 gains and 305losses in H3K27me3 modification. Subsequently, 97.3% of the alterations were restored to original levels after 24 h treatment. The ChIP-qPCR for five differential peaks showed similar results to the data for ChIP-seq, indicating that the chilling-induced H3K27me3 modification is reliable.Integrative analysis of transcriptome and ChIP-seq results showed that the expression of H3K27me3 target genes was significantly lower than those of non-target genes, indicating transcriptional repression of H3K27me3 in grapevine leaves. Furthermore, histone methylation alterations were detected in 82 genes and were related to either repression or activation of their expression during chilling stress. The findings provide the genome-wide H3K27me3 patterns in grapevines and shed light on uncovering its regulation in chilling stress responses. | Zhenfei Zhu Qingyun Li Duncan Kiragu Gichuki Yujun Hou Yuanshuang Liu Huimin Zhou Chen Xu Linchuan Fang Linzhong Gong Beibei Zheng Wei Duan Peige Fan Qingfeng Wang Haiping Xin | 2023 | Horticultural Plant Journal2023，9，3： | 1 |
| 8 | The study on psychological resilience of tinnitus and associated influencing factors显示文摘The association between tinnitus and psychological resilience is an underdeveloped area of research.This cross-sectional study investigated such associations and factors potentially affecting resilience in 61 patients.Demographic and psychometric data were collected by questionnaires.The ConnoreDavidson Resilience Scale(CD-RISC),Medical Coping Modes Questionnaire(MCMQ),Satisfaction with Life Scale(SWLS),General Self-Efficacy Scale(GSES),Big Five Inventory(BFI)and Perceived Social Support Scale(PSSS)were completed by participants.Data were analyzed using independent t-test and Pearson's correlation analysis and multiple linear regression modeling.The CD-RISC score was relatively low(66.97±15.71),negatively correlated with tinnitus(r=0.276,p<0.001)and associated with age(r=0.270,P<0.001).As protective factors,SWLS(r=0.486,p<0.001),GSES(r=0.555,p<0.001),PSSS(r=0.538,p<0.001)and extraversion were positively correlated with CD-RISC and BFI scores(r=0.287,p<0.001).We also detected a negative correlation with neuroticism(r=0.395,p<0.001),which is a known risk factor for worse CD-RISC scores.Identifying protective and risk factors for psychological resilience can be used to predict treatment outcomes in tinnitus patients,which will help devise personalized solutions and improve patients'quality of life. | Feng Xin Qingfeng Li Fangling Guan Minli Suo Jie Yang Dan Li Changqing Zhao | 2022 | Journal of Otology2022，17，1： | 1 |
| 9 | Atom transfer radical polymerization of styrene initiated by 2- (4-chloromethyl (-phenyl) -benzoxazole) with high activity and fluorescent property显示文摘 | Xin Yuan Jianmei Lu Qingfeng Xu | 2005 | Polymer2005，46，： | 1 |
| 10 | The clinicopathological significance and relationship of G li1, MDM 2 and p53 expression in resectable pancreatic cancer显示文摘 | Weiwei Sheng Ming Dong Jianping Zhou Xin Li QingFeng Liu Qi Dong Feng Li | 2014 | Histopathology2014，，4： | 1 |
| 11 | Geochemistry of rare earth elements and yttrium in Late Permian coals from the Zhongliangshan coalfield, southwestern China显示文摘Rare earth elements and yttrium(REY)in coal deposits are considered promising alternative sources for these resources owing to their increasing global demand.This paper reports the geochemical characteristics of REY in the Late Permian coals from an underground K1a seam section of the Zhongliangshan coalfield in Chongqing,southwestern China.The mineralogy,degree of enrichment,distribution patterns,modes of occurrence,and sediment origin of REY were investigated.Compared with the average of world coals,the concentration of REY in the K1a coals were normal,dominated by light REY(LREY),with less medium and heavy REY(MREY,HREY).The fractionation degree of the MREY and HREY are higher than that of LREY in most K1a coal samples,deduced from the mixed enrichment type of REY,mainly including M-H-type,and a few L-M type and H-type.In addition,the combination of anomalies of Ce,Eu,Gd,and Al_(2)O_(3)/TiO_(2) parameters,the terrigenous materials in the K1a coal were derived from the felsic-intermediate rocks at the top of the Emeishan basalt sequence,and the samples were affected by seawater intrusion during early peat accumulation.Although the minerals primarily consist of kaolinite,illite,pyrite,and small amounts of quartz,calcite and anatase,REY are correlated with ash yield,SiO2,and Al_(2)O_(3),revealing that the REY mainly occur in aluminosilicate minerals,especially kaolinite and illite.Meanwhile,REY positively relate to P_(2)O_(5) and Zr,which may exist in phosphate-containing minerals or zircon.Furthermore,most samples in the K1a coal or ash do not reach the cut-off grade for the beneficial recovery of REY.With the exception of central Guizhou,southwestern Chongqing,and the junction of western Guizhou and northeastern Yunnan,the REY content in coals from southwestern China are high,and its by-products are suitable as potential REY sources. | Qingfeng LU Shenjun QIN Hongyang BAI Wenfeng WANG De’e QI Xin HE Bofei ZHANG | 2023 | Frontiers of Earth Science2023，17，1： | 0 |
| 12 | PVDF/PLA electrospun fiber membrane impregnated with metal nanoparticles for emulsion separation,surface antimicrobial,and antifouling activities显示文摘Although many superwetting materials have been designed for the treatment of oil-containing wastewater,separation strategies for oil-in-water systems containing bacteria have rarely been reported.Herein,poly(vinylidene difluoride)-and poly(lactic acid)-blended fibrous membranes loaded with silver and copper oxide nanoparticles were successfully prepared by a two-step method of electrostatic spinning and liquid-phase synthesis.The product membrane showed excellent super-oleophilic properties in air and hydrophobicity under oil.It could separate water-in-oil emulsion systems containing surfactants with an efficiency above90%.More importantly,the nanoparticle-loaded fibers were characterized by material degradability and slowly released ions.The fibers exhibited excellent antibacterial activities against both gram-positive and-negative bacteria.This work provides a feasible strategy for water-in-oil emulsion separation and bacterial treatment of wastewater. | XIANG Xin CHEN DongYun LI NaJun XU QingFeng LI Hua HE JingHui LU JianMei | 2023 | Science China(Technological Sciences)2023，66，5： | 0 |
| 13 | Photoinduced Ultrafast Process of Relaxation in Polymer显示文摘On the basis of multi-phonon transition theory,the origin of the fust component(100fs)and the slow component(ns)in photoexcitiition dynfmiics is explained and their evolution time is calcuhited.From these results,it is seen that the fast component is due to the formation from freii electron-hole pair to neutral bipolaron, and the slow one is due to the non-radiative decay of bipoltiron. | YU Zhigang HUANG Qingfeng SUN Xin | 1993 | Chinese Physics Letters1993，10，9： | 0 |
| 14 | Geochemical Characteristics of the Fluid Inclusions Trapped in Primary Gypsum of the Lop Nor Basin显示文摘Objective The Lop Nor Basin is a very important Quaternary potash-formation basin in China.It is a typical sulphatepotash brine mine with an average grade of 1.4%(KG)in underground concentrated brines.It is extraordinary that the reservoir of potassium-rich brines is glauberite stratum rather than halite rock.The anomalous potassium enrichment,advanced in relative early stage of | MA Lichun TANG Qingfeng WANG Xin SUN Xiaohong | 2016 | Acta Geologica Sinica(English Edition)2016，90，1： | 0 |
| 15 | Channel modeling and influenced factor analysis of the broadband dual-orthogonal polarized MIMO land mobile satellite channel显示文摘An accurate, complete and realistic channel model is required to accurately analyze the system performance of a multiple input multiple output(MIMO) broadband satellite mobile communication system with dual-orthogonal polarized antennas(DPAs).In most current studies, the channel characteristic matrix(CCM) is always formed by an independent identical distribution(i.i.d) model of Rayleigh or Rice distribution and nevertheless incomplete and inaccurate to describe a broadband dual-orthogonal polarized MIMO land mobile satellite(BDM-LMS) channel. This paper focuses on establishing the BDM-LMS channel statistical model,which combines the 4-state broadband LMS channel model, the time selective fading features, the channel covariance information(CCI) channel model and polarization correlations between antennas. The modeling steps of the channel model are introduced.The main emphasis is placed on the effects of the factors, such as antenna numbers, temporal correlations, terminal environments,elevation angles and polarization correlations between the DPAs,on the channel capacity in the BDM-LMS system. Many simulation results are provided to illustrate the effects of these factors through comparisons of the transmit rate, ergodic capacity and outage capacity with different factor values. Besides, the MIMO outage capacity advantages, which indicate the benefits of MIMO compared with a single input single output(SISO) system under the same channel condition, are also studied under i.i.d or BDM-LMS channel. | Qingfeng Jing Jiajia Wu Yuping Lu Xin Liu Xiaoju Yan | 2015 | Journal of Systems Engineering and Electronics2015，26，4： | 0 |
| 16 | Bone-inspired(GNEC/HAPAAm)hydrogel with fatigue-resistance for use in underwater robots and highly piezoresistive sensors显示文摘A novel bone-inspired fatigue-resistant hydrogel with excellent mechanical and piezoresistive properties was developed,and it exhibited great potential as a load and strain sensor for underwater robotics and daily monitoring.The hydrogel was created by using the high edge density and aspect ratio of graphene nanosheet-embedded carbon(GNEC)nanomaterials to form a three-dimensional conductive network and prevent the expansion of microcracks in the hydrogel system.Multiscale progressive enhancement of the organic hydrogels(micrometer scale)was realized with inorganic graphene nanosheets(nanometer scale).The graphene nanocrystals inside the GNEC film exhibited good electron transport properties,and the increased distances between the graphene nanocrystals inside the GNEC film caused by external forces increased the resistance,so the hydrogel was highly sensitive and suitable for connection to a loop for sensing applications.The hydrogels obtained in this work exhibited excellent mechanical properties,such as tensile properties(strain up to 1685%)and strengths(stresses up to 171 kPa),that make them suitable for use as elastic retraction devices in robotics and provide high sensitivities(150 ms)for daily human monitoring. | Chaoyang Lyu Bo Wen Yangzhen Bai Daning Luo Xin Wang Qingfeng Zhang Chenyang Xing Tiantian Kong Dongfeng Diao Xi Zhang | 2023 | Microsystems & Nanoengineering2023，9，4： | 0 |
| 17 | Urolithin A prevents focal cerebral ischemic injury via attenuating apoptosis and neuroinflammation in mice显示文摘Neuroin fil ammation contributes to neuronal death in cerebral ischemia.Urolithin A(UA),a gut microbial metabolite of ellagic acid,has emerged as a potential antiinflammatory agent.However,its roles and precise mechanisms in stroke remain unknown.Riphenyltetrazolium chloride(TTC)staining was employed to assess cerebral infarct volume.The Morris water maze was used to detect cognitive function.A terminal deoxynucleotidyl transferase dUTP nick-end labeling(TUNEL)assay was performed to detect neuronal apoptosis. | Lin Xiaohong Ye Xiujuan Li Qingfeng Gong Zhuo Cao Xin Li Qingqing Sun Xiangdong He Xiaosong Xuan Aiguo | 2021 | 解剖学杂志2021，44，S01： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员