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| 1 | A high-resolution climatic change since Holocene inferred from multi-proxy of lake sediment in westerly area of China显示文摘Multi-proxy data are presented and a discuss is made of paleoclimatic and paleoenvironmental changes during Holocene from a 225-cm-long sediment core from Wulungu Lake, located in westerly area of China. The chronology is constructed from six AMS radiocarbon dates on the bulk organic matter. Analyses of pollen, TOC, TN, δ 13Corg, ostracod assemblages and the shell stable isotopes, suggest Holocene climate pattern as follows: temperate and dry (10.0―7.6 cal. ka BP)-warm and wet (7.6―5.3 cal. ka BP) -warm and moist (5.3―3.6 cal. ka BP) -temperate and dry (3.6―2.1 cal. ka BP)-temperate and moist (2.1―1.3 cal. ka BP) -cool and dry (1.3 cal. ka BP―present). With the climatic change, Wulungu Lake experienced two large-scale retreat (5.3―3.6 cal. ka BP and 1.3 cal. ka BP―present) and an obvious transgression (7.6―5.3 cal. ka BP). The records of climatic and environmental evolution of Wulungu Lake were in good accordance with those of adjacent areas. It responded to regional environmental change, global abrupt climate events and followed the westerly climate change mode. | JIANG QingFeng SHEN Ji LIU XingQi ZHANG EnLou XIAO XiaYun | 2007 | Chinese Science Bulletin2007，52，14： | 28 |
| 2 | A Highly Pathogenic Strain of Porcine Deltacoronavirus Caused Watery Diarrhea in Newborn Piglets显示文摘Porcine deltacoronavirus(PDCoV) is a newly identified virus that causes watery diarrhea in newborn piglets and results in significant economic losses to the pig industry. Since first reported in Hong Kong in 2012, PDCoV has been subsequently detected in USA, South Korea, Thailand, and China's Mainland. Here we isolated a strain of PDCoV, named CHN-GD-2016,from the intestinal content of a diseased newborn piglet with severe diarrhea in a pig farm in Guangdong, China. PDCoV CHN-GD-2016 could be identified by immunofluorescence with PDCoV specific rabbit antisera, and typical crown-shaped particles with spiky surface projections of this PDCoV were observed with electron microscopy. Genomic analysis showed that the PDCoV CHN-GD-2016 was closely related to other Chinese PDCoV strains, with the highest sequence similarity with the strain CHN/Tianjin/2016. Importantly, inoculation of newborn piglets with 1×10~5 TCID_(50) of CHN-GD-2016 by oral feeding successfully reproduced clear clinical symptoms, including vomiting, dehydration, and severe diarrhea in piglets. In addition, the virus RNA in rectal swabs from 1 to 7 days post inoculation was detected, macroscopic and microscopic lesions in small intestine were observed, and viral antigen was also detected in the small intestines with immunohistochemical staining. Collectively, the data show in this study confirms that PDCoV is present in Guangdong,China and is highly pathogenic in newborn piglets. | Zhichao Xu Huiling Zhong Qingfeng Zhou Yunping Du Li Chen Yun Zhang Chunyi Xue Yongchang Cao | 2018 | Virologica Sinica2018，33，2： | 16 |
| 3 | Environmental changes during early-middle Holocene from the sediment record of the Chaohu Lake,Anhui Province显示文摘A typical lake sediment core is obtained from the Chaohu Lake in the lower reaches of the Yangtze River,Anhui Province,China.The timing scale is constrained by AMS 14 C dating method.Climate proxies such as pollen and grain size in the core are analyzed to reconstruct the environment changes at this site approximately between 9870 and 2170 cal.a BP.The results indicate that at the research area, the climate in the early-middle Holocene had evolved through 3 stages.From 9870 to 6040 cal.a BP, proxy records show a warm and dry climate with low water levels after the late-glacial period.During this stage,cool and dry events occurred at about 8910 and 6060-6030 cal.a BP.Then,between 6040 and 4860 cal.a BP,the climate was humid and vegetation was more flourishing in the Chaohu Lake Valley.The Holocene Optimum occurred at 5840-5500 cal.a BP in the Chaohu Lake,showing the best condition of water and heat.Elm Decline occurred at the period of 5380-4930 cal.a BP.Since 4860 cal.a BP,the climate was warm and dry through 2170 cal.a BP as shown in both pollen spectrum and grain-size histories.Two obvious dry events occurred in 3760 and 2170 cal.a BP,respectively.At 2170 cal.a BP,the water level of the Chaohu Lake reached the lowest as the lakebed possibly exposed. Such lake sediment observations are consistent with the historical records in this area. | XinYuan Wang GuangSheng Zhang Li Wu XiHui Zhang EnLou Zhang XiaYun Xiao QingFeng Jiang | 2008 | Chinese Science Bulletin2008，53，S1： | 15 |
| 4 | Climatic and lake environmental changes in the Serling Co region of Tibet over a variety of timescales显示文摘The Serling Co region is located at the transitional zone of the interaction between the Indian monsoon and the westerlies over the Tibetan Plateau. The Serling Co lake covers a water area of2,389 km2(June 2017) in a 45,530 km2drainage basin. Under the dramatic hydro-meteorological changes on the Tibetan Plateau in recent decades, and complex hydrological compositions of rivers and lakes in the basin, the lake area expanded by 43%, from1,667 km2in 1976, to 2,389 km2in 2017 (1)In 2014 it surpassed Nam Co as the largest lake on the Tibetan Plateau [2], and exerts significant effect on regional environmental conditions. | Liping Zhu Junbo Wang Jianting Ju Ning Ma Yinsheng Zhang Chong Liu Boping Han Linshan Liu Mingda Wang Qingfeng Ma | 2019 | Science Bulletin2019，64，7： | 13 |
| 5 | A group of SUVH methyl-DNA binding proteins regulate expression of the DNA demethylase ROS_1 in Arabidopsis显示文摘DNA methylation is typically regarded as a repressive epigenetic marker for gene expression.Genome-wide DNA methylation patterns in plants are dynamically regulated by the opposing activities of DNA methylation and demethylation reactions. In Arabidopsis, a DNA methylation monitoring sequence(MEMS) in the promoter of the DNA demethylase gene ROS_1 functions as a methylstat that senses these opposing activities and regulates genome DNA methylation levels by adjusting ROS_1 expression. How DNA methylation in the MEMS region promotes ROS_1 expression is not known. Here, we show that several Su(var)3-9 homologs(SUVHs) can sense DNA methylation levels at the MEMS region and function redundantly to promote ROS_1 expression. The SUVHs bind to the MEMS region, and the extent of binding is correlated with the methylation level of the MEMS.Mutations in the SUVHs lead to decreased ROS_1 expression, causing DNA hypermethylation at more than 1,000 genomic regions. Thus, the SUVHs function to mediate the activation of gene transcription by DNA methylation. | Xinlong Xiao Jieqiong Zhang Tao Li Xing Fu Viswanathan Satheesh Qingfeng Niu Zhaobo Lang Jian-Kang Zhu Mingguang Lei | 2019 | Journal of Integrative Plant Biology2019，61，2： | 11 |
| 6 | Dry/wet climate zoning and delimitation of arid areas of Northwest China based on a data-driven fashion显示文摘The division of arid areas is important in water and land resources management, planning and for a long-term agricultural, economic and social planning. Northwest China(NW) dominates the main arid areas in China. There is thus a need to adopt adequate concepts relative to the scope of arid areas of NW China and identify its climate types and characteristics. In this study, we analyzed climatic data over the last 30 years(1981–2010) from 191 stations in three provinces and three autonomous regions of NW China. The factor-cluster analysis tech- nique(FC), an objective and automated method was employed to classify the dry/wet climate zones. The traditional methods with predefined thresholds were adopted for providing a comparison with FC. The results showed that the wet/dry climate zones by FC were mainly distributed along mountains, rivers and desert borders. Climate-division boundaries relied heavily on the major terrain features surrounding the grouped stations. It also showed that the climate was dry in the plain sandy areas but relatively wet in the high mountain areas. FC method can reflect the climate characteristics more fully in NW China with varied and complicated topography, and outperform the tradi- tional climate classifications. Arid areas of NW China were defined as four climate types, including five resultant classes in FC classifications. The Qinling and Da Hinggan Mountains were two important boundaries, besides main administrative boundaries. The results also indicated that there are some differences between two traditional clas- sifications. The precipitation moved and fluctuated to an extent, which confirmed that climate change played an important role in the dry/wet climate zoning, and the boundaries of dry/wet climate zones might change and migrate with time. This paper is expected to provide a more in-depth understanding on the climate characteristics in arid areas of NW China, and then contribute to formulate reasonable water and land management planning and agri- cultural production programs. | QingLing GENG PuTe WU QingFeng ZHANG XiNing ZHAO YuBao WANG | 2014 | Journal of Arid Land2014，6，3： | 9 |
| 7 | First-principles study of structure,mechanical and optical properties of La-and Sc-doped Y2O3显示文摘The electronic,mechanical and optical properties of La-and Sc-doped Y2O3 were investigated using firstprinciples calculations.Two doping sites of Sc and La in Y2O3 were modeled.The calculated values of the energy of formation show that the most energetically favorable site for a La atom in Y2O3 is a d-site Y atom,while for Sc a b-site Y atom is the more stable position.The calculated band gap shows a slight decrease with increasing La or Sc concentration.The calculated results for the mechanical and optical properties of Y(2-x)RxO3(R=Sc or La,0 | Xian Zhang Sen Gao Wenhua Gui Qingfeng Zeng | 2019 | Journal of Rare Earths2019，37，8： | 8 |
| 8 | An experimental and numerical study on the charring rate of timber beams exposed to three-side fire显示文摘To investigate the charring rate of timber beams exposed to three-side fire, a total of fifteen new and used Douglas-Fir timber beams in four groups exposed to three-side fire were experimentally studied, together with the finite element analyses of the temperature distribution in the beam section. The durations of fire exposure were 0 (on a test piece), 10, 15, 20 and 30 min, according to the ISO 834 standard fire curve. The charring depth of each timber beam was calculated by averaging the values at one-third and two-thirds along each cross section to give the charring rate of timber beams. It was found that the timber beam's charring rate reduces as the duration of fire exposure increases and the vertical charring rate is slightly higher than the horizontal one. The areas of beam sections reduce due to charring and the strength and stiffness of the pyrolysis layer near the charring edge decrease owing to the high-temperature. The average horizontal and vertical charring rates are 0.98 and 1.08 mm/min, respectively. To take into account the difference between the test furnace temperature curve and the ISO 834 stand- ard fire curve, some corrections were made for these data to yield the solution for charring rate. With the help of the finite element software ANSYS, the temperature distribution of the wood's cross-section was analyzed. The longer the exposure time is, the greater the effect of density will impose on the distribution of temperature, but the moisture content has no effect. | ZHANG Jin LIU ZengHui XU YiXiang MA ShuWei XU QingFeng | 2012 | Science China(Technological Sciences)2012，55，12： | 8 |
| 9 | Carbon-supported Fe/Co-N electrocatalysts synthesized through heat treatment of Fe/Co-doped polypyrrole-polyaniline composites for oxygen reduction reaction显示文摘In this paper,we synthesized cathode catalysts(PANI-PPYR,Fe/PANI-PPYR,Co/PANI-PPYR and Fe-Co/PANI-PPYR)with high performance oxygen reduction by using a simple heat treatment process.These catalysts were fabricated by directly calcining the Fe and/or Co doped polyaniline(PANI)-polypyrrole(PPYR)composites.Their electrocatalytic activity for ORR both in acidic and in alkaline media was investigated by voltammetric techniques.Among the prepared catalysts,Co/PANI-PPYR presents the most positive ORR onset potential of 0.62 V(vs.SCE)in 0.5 mol/L H2SO4 solution or?0.09 V(vs.SCE)in 1 mol/L NaOH solution.In addition,the Co/PANI-PPYR catalyst shows the largest limiting-diffusion current density for ORR,which is 4.3 mA/cm2@0.2 V(vs.SCE)in acidic and 2.3 mA/cm2@?0.3 V(vs.SCE)in alkaline media.In acidic media,a four-electron reaction of ORR on the Co/PANI-PPYR and Fe/PANI-PPYR catalysts is more dominant than a two-electron reaction.In alkaline media,however,a four-electron and a two-electron mechanisms are co-present for the ORR on all the prepared catalysts.Co/PANI-PPYR catalyst also presents good electrocatalytic activity stability for ORR both in acidic and in alkaline media. | YI QingFeng ZHANG YuHui LIU XiaoPing YANG YaHui | 2014 | Science China Chemistry2014，57，5： | 8 |
| 10 | Massive cranium from Harbin in northeastern China establishes a new Middle Pleistocene human lineage显示文摘It has recently become clear that several human lineages coexisted with Homo sapiens during the late Middle and Late Pleistocene.Here,we report an archaic human fossil that throws new light on debates concerning the diversification of the Homo genus and the origin of H.sapiens.The fossil was recovered in Harbin city in northeastern China,with a minimum uranium-series age of 146 ka.This cranium is one of the best preserved Middle Pleistocene human fossils.Its massive size,with a large cranial capacity(1,420 mL)falling in the range of modern humans,is combined with a mosaic of primitive and derived characters.It differs from all the other named Homo species by presenting a combination of features,such as long and low cranial vault,a wide and low face,large and almost square orbits,gently curved but massively developed supraorbital torus,flat and low cheekbones with a shallow canine fossa,and a shallow palate with thick alveolar bone supporting very large molars.The excellent preservation of the Harbin cranium advances our understanding of several less-complete late Middle Pleistocene fossils from China,which have been interpreted as local evolutionary intermediates between the earlier species Homo erectus and later H.sapiens.Phylogenetic analyses based on parsimony criteria and Bayesian tip-dating suggest that the Harbin cranium and some other Middle Pleistocene human fossils from China,such as those from Dali and Xiahe,form a third East Asian lineage,which is a part of the sister group of the H.sapiens lineage.Our analyses of such morphologically distinctive archaic human lineages from Asia,Europe,and Africa suggest that the diversification of the Homo genus may have had a much deeper timescale than previously presumed.Sympatric isolation of small populations combined with stochastic long-distance dispersals is the best fitting biogeographical model for interpreting the evolution of the Homo genus. | Xijun Ni Qiang Ji Wensheng Wu Qingfeng Shao Yannan Ji Chi Zhang Lei Liang Junyi Ge Zhen Guo Jinhua Li Qiang Li Rainer Grun Chris Stringer | 2021 | The Innovation2021，2，3： | 6 |
| 11 | Molecular characteristics of the omp A gene of serotype B Chlamydia trachomatis in Qinghai Tibetan primary school students显示文摘To study the molecular characteristics of Chlamydia trachomatis, the major outer membrane protein gene(omp A) of C. trachomatis from primary school students with trachoma residing in the Qinghai Tibetan area was sequenced and compared with the same serotype in Gen Bank. In Jianshetang Primary School and Galeng Central Primary School in the Galeng Tibetan Township of Qinghai Haidong Sala Autonomous County, scraped samples were collected from the upper tarsal conjunctiva and lower conjunctival sac of both eyes of 45 students with trachoma, stored at 4°C, and transported to Beijing Tongren Hospital by air within 24 h. The samples were screened for C. trachomatis by real-time PCR. The omp A gene from the C. trachomatis-positive samples was amplified by nested PCR. The serotype was confirmed by National Center for Biotechnology Information(NCBI) BLAST search and homology analysis. The entire omp A gene sequence was compared with the corresponding gene sequences of serotype B strains available in Gen Bank. Of the 45 students aged 6–13 years with trachoma, 26 C. trachomatis-positive students were identified by the initial real-time PCR screening(average age,(9.09±1.63) years; sex ratio, 1.0), accounting for 57.78%(26/45). The cycle threshold values for real-time PCR were 16.79–37.77. Half(13/26) of C. trachomatis-positive students had a bacterial copy number of >105. The compliance rate of the omp A gene sequences with the C. trachomatis serotype B strains in Gen Bank was up to 99%. Two novel genetic mutations were found when the omp A gene was compared with those of the 11 serotype B strains in Gen Bank. The two non-synonymous mutations were located at(i) position 271 in the second constant domain, an adenine(A) to guanine(G) substitution(ACT?GCT), changing the amino acid at position 91 from threonine to alanine(Thr?Ala) in all 26 strains; and(ii) position 887 in the fourth variable domain, a cytosine(C) to thymine(T) substitution(GCA?GTA), changing the amino acid at residue 296 from alanine to valine(Ala?Val) in four of the 26 strains. Six mutations were identified relative to ATCC VR-573. The strains could be divided into two gene clusters according to the mutation at nucleotide position 887: CQZ-1(China Qinghai Tibetan-1) and CQZ-2(China Qinghai Tibetan-2). We thus detected two novel serotype B mutant strains of C. trachomatis among study subjects with trachoma. | Xue Li Shaoya Zhang Qingfeng Liang Mei Wang Ailian Hu Xiuyuan Li Benshan Yang Mingxin Zhang Ningli Wang Xinxin Lu | 2016 | Science China(Life Sciences)2016，59，6： | 6 |
| 12 | Zeolitic Imidazolate Framework 8-Derived Au@ZnO for Efficient and Robust Photocatalytic Degradation of Tetracycline显示文摘Summary of main observation and conclusion Tetracycline (TC) and other antibiotics accumulated in groundwater and soil pollute ecological environment and threaten human health. Gold nan oparticles doped on photocatalysts are able to enhance the photodegradation efficiency during removing these antibiotics, but preparation of Au nanoparticles of well-dispersion on photocatalysts remains challenging. In this work, zeolite imidazolate (ZIF-8) was employed as the precursor to prepare Au@ZnO photocatalyst via impregnation and in-situ reduction method to efficiently degrade the tetracycline in the aqueous solution. Au nanoparticles are of 10 nm in size and uniformly dispersed on the surfaces of ZnO microstructures. The as-prepared Au@ZnO is able to remove 85.5% of TC of 0.010 mg/mL within 2h, presenting higher photocatalytic activity than pure ZnO catalyst. Most importantly, the catalyst shows its superior stability after five cycles without structure and activity changing. The mechanism of the photocatalytic degradation was discussed in detail. | Bijun Gao Jin Zhou Hongliang Wang Guping Zhang Jinghui He Qingfeng Xu Najun Li Dongyun Chen Hua Li Jianmei Lu | 2019 | Chinese Journal of Chemistry2019，37，2： | 6 |
| 13 | A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid–liquid phase separation to promote oncogenic YAP signaling显示文摘Long noncoding RNAs(lncRNAs)are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development.Liquid–liquid phase separation(LLPS)occurs in a wide range of biological processes,while its role in signal transduction remains largely undeciphered.In this study,we uncovered a lipid-associated lncRNA,small nucleolar RNA host gene 9(SNHG9)as a tumor-promoting lncRNA driving liquid droplet formation of Large Tumor Suppressor Kinase 1(LATS1)and inhibiting the Hippo pathway.Mechanistically,SNHG9 and its associated phosphatidic acids(PA)interact with the C-terminal domain of LATS1,promoting LATS1 phase separation and inhibiting LATS1-mediated YAP phosphorylation.Loss of SNHG9 suppresses xenograft breast tumor growth.Clinically,expression of SNHG9 positively correlates with YAP activity and breast cancer progression.Taken together,our results uncover a novel regulatory role of a tumor-promoting lncRNA(i.e.,SNHG9)in signal transduction and cancer development by facilitating the LLPS of a signaling kinase(i.e.,LATS1). | Rui-Hua Li Tian Tian Qi-Wei Ge Xin-Yu He Cheng-Yu Shi Jun-Hong Li Zhen Zhang Fang-Zhou Liu Ling-Jie Sang Zuo-Zhen Yang Ya-Zhuo Liu Yan Xiong Qingfeng Yan Xu Li Huai-Qiang Ju Jian Liu Liang-Jing Wang Jian-Zhong Shao Wenqi Wang Tianhua Zhou Aifu Lin | 2021 | Cell Research2021，31，10： | 6 |
| 14 | Advancement toward Polymer Electrolyte Membrane Fuel Cells at Elevated Temperatures显示文摘Elevation of operational temperatures of polymer electrolyte membrane fuel cells(PEMFCs)has been demonstrated with phosphoric acid-doped polybenzimidazole(PA/PBI)membranes.The technical perspective of the technology is simplified construction and operation with possible integration with,e.g.,methanol reformers.Toward this target,significant efforts have been made to develop acid-base polymer membranes,inorganic proton conductors,and organic-inorganic composite materials.This report is devoted to updating the recent progress of the development particularly of acid-doped PBI,phosphate-based solid inorganic proton conductors,and their composite electrolytes.Long-term stability of PBI membranes has been well documented,however,at typical temperatures of 160℃.Inorganic proton-conducting materials,e.g.,alkali metal dihydrogen phosphates,heteropolyacids,tetravalent metal pyrophosphates,and phosphosilicates,exhibit significant proton conductivity at temperatures of up to 300℃ but have so far found limited applications in the form of thin films.Composite membranes of PBI and phosphates,particularly in situ formed phosphosilicates in the polymer matrix,showed exceptionally stable conductivity at temperatures well above 200℃.Fuel cell tests at up to 260℃ are reported operational with good tolerance of up to 16%CO in hydrogen,fast kinetics for direct methanol oxidation,and feasibility of nonprecious metal catalysts.The prospect and future exploration of new proton conductors based on phosphate immobilization and fuel cell technologies at temperatures above 200℃ are discussed. | Jin Zhang David Aili Shanfu Lu Qingfeng Li and San Ping Jiang | 2020 | Research2020，，1： | 6 |
| 15 | The next generation models for crops and agro-ecosystems显示文摘Growth in population, decrease in arable land area, and change in climate are endangering our food security. Precision agriculture has the potential to increase crop productivity thorough tailored agricultural practices for different growing areas. Many models of crops and agro-ecosystems capable of predicting interaction between plants and environments have been developed for precision agriculture. Currently, there are several representative categories of crop and agro-ecosystem models, including the de Wit school models, the DSSAT series models and the APSIM series models, which have contributed substantially to improvement of agricultural practices. However, these models are weak in predicting performances of crops under environmental and genetic perturbations are generally weak, which severely limits the application of these models in guiding precision agriculture. We need to develop the next generation crop and agro-ecosystems models with a high level of mechanistic basis, which can be integrated with high throughput data and can predict the heterogeneity of environmental factors inside canopy and dynamic canopy photosynthesis. In developing such a model close collaboration is inevitably required among scientists from different disciplines. The successful development and application of such models will undoubtedly advance precision agriculture through providing better agronomical practices tailored for different growing environments. These models will also form a basis to identify breeding targets for increased productivity at given location with given soil and climatic conditions. | ZHU XinGuang ZHANG GuiLian THOLEN Danny WANG Yu XIN ChangPeng SONG QingFeng | 2011 | Science China(Information Sciences)2011，54，3： | 6 |
| 16 | Multimetallic AuPd@Pd@Pt core-interlayer-shell icosahedral electrocatalysts for highly efficient oxygen reduction reaction显示文摘Incorporating Pt with core metals into Pt-based core-shell catalysts is regarded as a promising strategy to substantially enhance the catalytic properties towards oxygen reduction reaction(ORR) in fuel cells due to the synergetic effect between distinct metals. In this wok, ultrathin Pt skins with two atomic layers were epitaxially coated on as-prepared icosahedral Au_50Pd_50, Au_60Pd_40 and Au_66Pd_34 nanocrystal seeds,which are constructed with alloyed cores and Pd shells with different thickness. Through electron microscopic characterizations, Pd interlayers with tunable thickness of 3, 6, and 12 atomic layers can be found in the Au_66Pd_34@Pt, Au_60 Pd_40@Pt and Au_50Pd_50@Pt icosahedra, respectively. These icosahedral Au Pd@Pd@Pt nanocrystals show substantially enhanced activities and durabilities in electrocatalytic measurements towards ORR compared to Au_75Pd_25@Pt icosahedra without Pd interlayer and commercial Pt/C catalysts. Specifically, Au_60Pd_40@Pt icosahedra with 6 atomically thick Pd interlayer display the best electrocatalytic performances, whose mass activities before and after durability tests of 50,000 cycles are11.6 and 30.2 times, respectively, as high as that of the commercial Pt/C. | Qingfeng Xu Wenlong Chen Yucong Yan Zhemin Wu Yi Jiang Junjie Li Ting Bian Hui Zhang Jianbo Wu Deren Yang | 2018 | Science Bulletin2018，63，8： | 5 |
| 17 | Single W18O49 nanowires: A multifunctional nanoplatform for computed tomography imaging and photothermal/ photodynamic/radiation synergistic cancer therapy显示文摘联合治疗是通常基于复杂 nanostructures 的利用,多重部件为 photothermal 作为相片热的精力变换器, photo-sensitizers,或剂量 intensifiers 工作的有希望的癌症治疗策略治疗(PTT ) ,光力学的治疗(太平洋夏季时间) ,或放射治疗(RT ) 。在这研究, ultrathin 钨氧化物 nanowires (W 18 O 49) 用一条 solvothermal 途径被综合并且作为多功能的 theranostic nanoplatform 检验了。在 vitro 并且在 vivo,分析证明这些 nanowires 能导致广泛的热 -- 并且汗衫在 980 nm 在附近下面的癌症房间的调停氧的损坏红外线(NIR ) 激光刺激。他们也被显示作为加强在放射治疗期间局部地并且有选择地提高放热精力免职的代理人的放射剂量工作。独自比作导致 NIR 的 PTT/PDT 和 RT, W 18 O 49-based synergistic tri 形式的治疗根除了异种皮移植肿瘤和没有复发被观察在以内一 9 月列在后面起来。而且,钨元素的强壮的 X 光检查变细能力(Z = 74, 4.438 厘米 2???? ?? ?? 佦 ? 畳 ?? 猯扵￣?? | Jianjian Qiu Qingfeng Xiao Xiangpeng Zheng Libo Zhang Huaiyong Xing Dalong Ni Yanyan Liu Shengjian Zhang Qingguo Ren Yanqing Hua Kuaile Zhao Wenbo Bu | 2015 | Nano Research2015，8，11： | 5 |
| 18 | Comparative Analysis of Fractional Vegetation Cover Estimation Based on Multi-sensor Data in a Semi-arid Sandy Area显示文摘The estimation of fractional vegetation cover(FVC) is important for identifying and monitoring desertification, especially in arid and semiarid regions. By using regression and pixel dichotomy models, we present the comparison of Sentinel-2A(S2) multispectral instrument(MSI) and Landsat 8(L8) operational land imager(OLI) data regarding the retrieval of FVC in a semi-arid sandy area(Mu Us Sandland, China, in August 2016). A combination of unmanned aerial vehicle(UAV) high-spatial-resolution images and field plots were used to produce verified data. Based on a normalized difference vegetation index(NDVI) regression model, the results showed that, compared with that of L8, the coefficient of determination(R2) of S2 increased by 26.0%, and the root mean square error(RMSE) and the sum of absolute error(SAE) decreased by 3.0% and 11.4%, respectively. For the ratio vegetation index(RVI) regression model, compared with that of L8, the R2 of S2 increased by 26.0%, and the RMSE and SAE decreased by 8.0% and 20.0%, respectively. When the pixel dichotomy model was used, compared with that of L8, the RMSE of S2 decreased by 21.3%, and the SAE decreased by 26.9%. Overall, S2 performed better than L8 in terms of FVC inversion. Additionally, in this paper, we develop a verified scheme based on UAV data in combination with the object-based classification method. This scheme is feasible and sufficiently robust for building relationships between field data and inversion results from satellite data. Further, the synergy of multi-source sensors(especially UAVs and satellites) is a potential effective way to estimate and evaluate regional ecological environmental parameters(FVC). | LIU Qiuyu ZHANG Tinglong LI Yizhe LI Ying BU Chongfeng ZHANG Qingfeng | 2019 | Chinese Geographical Science2019，29，1： | 4 |
| 19 | Syndecan-2, negatively regulated by miR-20b-5p, contributes to 5-fluorouracil resistance of colorectal cancer cells via the JNK/ERK signaling pathway显示文摘5-Fluorouracil (5-FU) resistance has been long considered as an obstacle to the efficacy of chemotherapy in colorectal cancer (CRC). In this study, we demonstrated the role of miR-20b-5p-regulated syndecan-2 (SDC2) in 5-FU resistance of CRC cells. 5-FU-resistant SW480 CRC cells were established by treatment of SW480 cells with stepwise increase of 5-FU concentration. The results showed that SDC2 was expressed significantly higher in SW480/5-FU cells than in SW480/WT cells as revealed by quantitative real-time polymerase chain reaction and western blot analysis. MTT assay and BrdU assay showed that SDC2 overexpression led to increased cell survival rate, while SDC2 knockdown reversed the drug resistance of SW480/5-FU cells. Wound healing and transwell invasion assays revealed that knockdown of SDC2 inhibited the migratory and invasive ability of SW480/5-FU cells. Moreover, animal experiments indicated that si-SDC2 plays a suppressive role in tumor growth in vivo. We also confirmed that miR-20b-5p interacted with SDC2, which reversed the effect of SDC2 in SW480/5-FU cells via the c-Jun N-terminal kinase (JNK)/extracellular regulated protein kinases (ERK) signaling pathway. These findings showed that JNK/ERK signaling pathway is involved in miR-20b-5p/SDC2 axis-mediated 5-FU resistance in SW480/5-FU cells, indicating that the miR-20b-5p/SDC2 axis is a potential target for reversing 5-FU resistance in CRC. | Ruheng Hua Yan Zhang Xiyue Yan Dong Tang Xiaolong Li Qingfeng Ni Daorong Wang Jianwei Zhu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，11： | 4 |
| 20 | Targeted disruption of tyrosinase causes melanin reduction in Carassius auratus cuvieri and its hybrid progeny显示文摘The white crucian carp(Carassius auratus cuvieri,WCC) not only is one of the most economically important fish in Asia,characterized by strong reproductive ability and rapid growth rates,but also represents a good germplasm to produce hybrid progenies with heterosis.Gene knockout technique provides a safe and acceptant way for fish breeding.Achieving gene knockout in WCC and its hybrid progeny will be of great importance for both genetic studies and hybridization breeding.Tyrosinase(TYR) is a key enzyme in melanin synthesis.Depletion of tyr in zebrafish and mice results in mosaic pigmentation or total albinism.Here,we successfully used CRISPR-Cas9 to target tyr in WCC and its hybrid progeny(WR) derived from the cross of WCC(♀) and red crucian carp(Carassius auratus red var.,RCC,♂).The level of TYR protein was significantly reduced in mutant WCC.Both the mutant WCC and the mutant WR showed different degrees of melanin reduction compared with the wild-type sibling control fish,resulting from different mutation efficiency ranging from 60% to 90%.In addition,the transcriptional expression profiles of a series of pivotal pigment synthesis genes,i.e.tyrp1,mitfa,mitfb,dct and sox10,were down-regulated in tyr-CRISPR WCC,which ultimately caused a reduction in melanin synthesis.These results demonstrated that tyr plays a key role in melanin synthesis in WCC and WR,and CRISPR-Cas9 is an effective tool for modifying the genome of economical fish.Furthermore,the tyr-CRISPR models could be valuable in understanding fundamental mechanisms of pigment formation in non-model fish. | Qingfeng Liu Yanhua Qi Qiuli Liang Jia Song Junmei Liu Wuhui Li Yuqin Shu Min Tao Chun Zhang Qinbo Qin Jing Wang Shaojun Liu | 2019 | Science China(Life Sciences)2019，62，9： | 4 |
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