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| 1 | The Inhibitory Effect of Oridonin on the Growth of Fifteen Human Cancer Cell Lines显示文摘OBJECTIVE To study the inhibitory effect of oridonin on the growth of cancer cells. METHODS Fifteen human cancer cell lines were subjected to various concentrations of oridonin in culture medium. The inhibitory rate of cell growth was measured by the MTT assay, and compared with a negative con- trol and 5-Fu-positive control. RESULTS The 50% inhibiting concentration (IC50) and maximal inhibition (Imax) of oridonin shown by studying the growth of the cancer cell lines were as follows: leukemias (HL60 cells: 3.9 μg/ml and 73.8%, K562 cells: 4.3 μg/ml and 76.2%); esophageal cancers(SHEEC cells: 15.4 μg/ml and 99.2%, Eca109 cells: 15.1 μg/ml and 84.6%, TE1 cells: 4.0 μg/ml and 70.2%); gastric cancers (BGC823 cells: 7.6 μg/ml and 98.7%, SGC7901 cells: 12.3 μg/ml and 85.7%); colon cancers (HT29 cells: 13.6 μg/ml and 97.2%, HCT cells: 14.5 μg/ml and 96.5%); liver cancers (Bel7402 cells: 15.2 μg/ml and 89.2%, HepG2 cells: 7.1 μg/ml and 88.3%); pancreatic cancer (PC3 cells: 11.3 μg/ml and 68.4%); lung cancer (A549 cells: 18.6 μg/ml and 98.0% ); breast cancer (MCF7 cells: 18.4 μg/ml and 84.7%); uterine cervix cancer (Hela cells: 13.7 μg/ml and 98.5%). CONCLUSION Oridonin had a relatively wide anti-tumor spectrum, and a relatively strong inhibitory effect on the growth of the 15 human cancer cells. Inhibitory effects were concentration dependent. | Junhui Chen Shaobin Wang Dongyang Chen Guisheng Chang Qingfeng Xin Shoujun Yuan Zhongying Shen | 2007 | Chinese Journal of Clinical Oncology2007，4，1： | 32 |
| 2 | Mathematical rules for synergistic,additive,and antagonistic effects of multi-drug combinations and their application in research and development of combinatorial drugs and special medical food combinations显示文摘Multi-drug(or multi-element)combinations are often prescribed in the practice of clinical medicine and as foods for special medical purposes.The main motivations for these combinations are that most diseases contain multiple related targets and an appropriate combination can maximize benefits while minimizing adverse reactions.As such,it is especially important to derive mathematical models for their quantitative calculation.In this paper,we introduce mathematical rules for the synergistic,additive,and antagonistic effects of multi-drug combinations developed in our laboratory.We have established a“onebelt,one-line”model and provide examples of the quantitative calculation of the synergistic,additive,and antagonistic effects of a combination of multiple components.We also explain how to scientifically and precisely determine the intensity of these synergies,additions and antagonisms,as well as their corresponding dose ranges,thereby laying a solid theoretical foundation for market listing combinatorial drugs and foods for special medical purposes. | Shoujun Yuan Haoyu Chen | 2019 | Food Science and Human Wellness2019，8，2： | 2 |
| 3 | Staged microvascular anastomosis training program for novices:transplantation of both kidneys from one rat donor显示文摘 | Zhou Shoujun Li Enchun He Jun Weng Guobin Yuan Hexing Hou Jianquan | 2014 | Chinese Medical Journal2014，，4： | 2 |
| 4 | Use of gamma-irradiation pretreatment for enhancement of anaerobic digestibility of sewage sludge显示文摘The effects of γ-irradiation pretreatment on anaerobic digestibility of sewage sludge was investigated in this paper.Parameters like solid components,soluble components,and biogas production of anaerobic digestion experiment for sewage sludge were measured.The values of these parameters were compared before and after γ-irradiation pretreatment.Total solid(TS),volatile solid(VS),suspended solid(SS),volatile suspended solid(VSS),and average floc size of samples decreased after cirradiation treatment.Besides,floc size distribution of sewage sludge shifted from 80–100 mm to 0–40 mm after γ-irradiation treatment at the doses from 0 to 30 kGy,which indicated the disintegration of sewage sludge.Moreover,microbe cells of sewage sludge were ruptured by γ-irradiation treatment,which resulted in the release of cytoplasm and increase of soluble chemical oxygen demand(SCOD).Both sludge disintegration and microbe cells rupture enhanced the subsequent anaerobic digestion process,which was demonstrated by the increase of accumulated biogas production.Compared with digesters fed with none irradiated sludge,the accumulated biogas production increased 44,98,and 178 mL for digesters fed sludge irradiated at 2.48,6.51,and 11.24 kGy,respectively.The results indicated that γ-irradiation pretreatment could effectively enhance anaerobic digestibility of sewage sludge,and correspondingly,could accelerate hydrolysis process,shorten sludge retention time of sludge anaerobic digestion process. | Shoujun YUAN Zheng ZHENG Yanyan MU Xin YU Yongfu ZHAO | 2008 | Frontiers of Environmental Science & Engineering2008，2，2： | 2 |
| 5 | Modelling loop-top X-ray source and reconnection outflows in solar flares with intense lasers显示文摘 | Zhong Jiayong Li Yutong Wang Xiaogang Wang Jiaqi Dong Quanli Xiao Chijie Wang Shoujun Liu Xun Zhang Lei An Lin Wang Feilu Zhu Jianqiang Gu Yuan He Xiantu Zhao Gang Zhang Jie | 2010 | Nature Physics2010，，12： | 1 |
| 6 | Impact of roxarsone on the UASB reactor performance and its degradation显示文摘 | Mengchuan Shui Feng Ji Rui Tang Shoujun Yuan Xinmin Zhan Wei Wang Zhenhu Hu | 2016 | Frontiers of Environmental Science & Engineering2016，10，6： | 1 |
| 7 | Modelling loop-top X-ray source and reconnection outflows in solar flares with intense lasers显示文摘 | Zhong Jiayong Li Yutong Wang Xiaogang Wang Jiaqi Dong Quanli Xiao Chijie Wang Shoujun Liu Xun Zhang Lei An Lin Wang Feilu Zhu Jianqiang Gu Yuan He Xiantu Zhao Gang Zhang Jie | 2010 | Nature Physics2010，，12： | 1 |
| 8 | Influence of arsanilic acid, Cu2+, PO43- and their interaction on anaerobic digestion of pig manure显示文摘 | Ping He Guangxue Wu Rui Tang Peilun Ji Shoujun Yuan Wei Wang Zhenhu Hu | 2018 | Frontiers of Environmental Science & Engineering2018，12，2： | 0 |
| 9 | Anomalous-plasmoid-ejection-induced secondary magnetic reconnection: modeling solar flares and coronal mass ejections by laser–plasma experiments显示文摘The driving mechanism of solar flares and coronal mass ejections is a topic of ongoing debate, apart from the consensus that magnetic reconnection plays a key role during the impulsive process. While present solar research mostly depends on observations and theoretical models, laboratory experiments based on high-energy density facilities provide the third method for quantitatively comparing astrophysical observations and models with data achieved in experimental settings.In this article, we show laboratory modeling of solar flares and coronal mass ejections by constructing the magnetic reconnection system with two mutually approaching laser-produced plasmas circumfused of self-generated megagauss magnetic fields. Due to the Euler similarity between the laboratory and solar plasma systems, the present experiments demonstrate the morphological reproduction of flares and coronal mass ejections in solar observations in a scaled sense,and confirm the theory and model predictions about the current-sheet-born anomalous plasmoid as the initial stage of coronal mass ejections, and the behavior of moving-away plasmoid stretching the primary reconnected field lines into a secondary current sheet conjoined with two bright ridges identified as solar flares. | Quanli Dong Dawei Yuan Shoujun Wang Xun Liu Yutong Li Xiaoxuan Lin Huigang Wei Jiayong Zhong Shaoen Jiang Yongkun Ding Bobin Jiang Kai Du Yongjian Tang Mingyang Yu Xiantu He Neng Hua Zhanfeng Qiao Kuixi Huang Ming Chen Jianqiang Zhu Gang Zhao Zhengming Sheng Jie Zhang | 2013 | High Power Laser Science and Engineering2013，1，1： | 0 |
| 10 | Aggravation of membrane fouling and methane leakage by a three-phase separator in an external anaerobic ceramic membrane bioreactor显示文摘The three-phase separator is a critical component of high-rate anaerobic bioreactors due to its significant contribution in separation of biomass, wastewater, and biogas. However, its role in an anaerobic membrane bioreactor is still not clear. In this study, the distinction between an external anaerobic ceramic membrane bioreactor (EAnCMBR) unequipped (R1) and equipped (R2) with a three-phase separator was investigated in terms of treatment performance, membrane fouling, extracellular polymers of sludge, and microbial community structure. The results indicate that the COD removal efficiencies of Rl and R2 were 98.2%±0.4% and 98.1%±0.4%, respectively, but the start-up period of R2 was slightly delayed. Moreover, the membrane fouling rate of R2 (0.4 kPa/d) was higher than that of Rl (0.2 kPa/d). Interestingly, the methane leakage from R2 (0.1 L/d) was 20 times higher than that from Rl (0.005 L/d). The results demonstrate that the three-phase separator aggravated the membrane fouling rate and methane leakage in the EAnCMBR. Therefore, this study provides a novel perspective on the effects of a three-phase separator in an EAnCMBR. | Chao Pang Chunhua He Zhenhu Hu Shoujun Yuan Wei Wang | 2019 | Frontiers of Environmental Science & Engineering2019，13，4： | 0 |
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