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| 1 | Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution显示文摘The speed of high-resolution optical imaging has been a rate-limiting factor for meso-scale mapping of brain structures and functional circuits,which is of fundamental importance for neuroscience research.Here,we describe a new microscopy method of Volumetric Imaging with Synchronized on-the-fly-scan and Readout(VISo R)for high-throughput,high-quality brain mapping.Combining synchronized scanning beam illumination and oblique imaging over cleared tissue sections in smooth motion,the VISo R system effectively eliminates motion blur to obtain undistorted images.By continuously imaging moving samples without stopping,the system achieves high-speed 3D image acquisition of an entire mouse brain within1.5 hours,at a resolution capable of visualizing synaptic spines.A pipeline is developed for sample preparation,imaging,3D image reconstruction and quantification.Our approach is compatible with immunofluorescence methods,enabling flexible cell-type specific brain mapping and is readily scalable for large biological samples such as primate brains.Using this system,we examined behaviorally relevant whole-brain neuronal activation in 16 c-Fos-sh EGFP mice under resting or forced swimming conditions.Our results indicate the involvement of multiple subcortical areas in stress response.Intriguingly,neuronal activation in these areas exhibits striking individual variability among different animals,suggesting the necessity of sufficient cohort size for such studies. | Hao Wang Qingyuan Zhu Lufeng Ding Yan Shen Chao-Yu Yang Fang Xu Chang Shu Yujie Guo Zhiwei Xiong Qinghong Shan Fan Jia Peng Su Qian-Ru Yang Bing Li Yuxiao Cheng Xiaobin He Xi Chen Feng Wu Jiang-Ning Zhou Fuqiang Xu Hua Han Pak-Ming Lau Guo-Qiang Bi | 2019 | National Science Review2019，6，5： | 7 |
| 2 | Recent advances in developing small-molecule inhibitors against SARS-CoV-2显示文摘The COVID-19 pandemic caused by the novel SARS-CoV-2 virus has caused havoc across the entire world.Even though several COVID-19 vaccines are currently in distribution worldwide,with others in the pipeline,treatment modalities lag behind.Accordingly,researchers have been working hard to understand the nature of the virus,its mutant strains,and the pathogenesis of the disease in order to uncover possible drug targets and effective therapeutic agents.As the research continues,we now know the genome structure,epidemiological and clinical features,and pathogenic mechanism of SARS-CoV-2.Here,we summarized the potential therapeutic targets involved in the life cycle of the virus.On the basis of these targets,small-molecule prophylactic and therapeutic agents have been or are being developed for prevention and treatment of SARS-CoV-2 infection. | Rong Xiang Zhengsen Yu Yang Wang Lili Wang Shanshan Huo Yanbai Li Ruiying Liang Qinghong Hao Tianlei Ying Yaning Gao Fei Yu Shibo Jiang | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 3 |
| 3 | Denitrification of nitrate contaminated groundwater with a fiber-based biofilm reactor显示文摘 | Qinghong Wang Chuanping Feng Yingxin Zhao Chunbo Hao | 2008 | Bioresource Technology2008，，7： | 1 |
| 4 | Denitrification of nitrate contaminated groundwater with a fiber-based biofilm reactor显示文摘 | Qinghong Wang Chuanping Feng Yingxin Zhao Chunbo Hao | 2008 | Bioresource Technology2008，，7： | 1 |
| 5 | Preparation and magnetic property analysisi of monodisperse Co-Zn ferrite nanospheres显示文摘 | Hou Chenyi Yu Hao Zhang Qinghong | 2010 | J Alloy Compd2010，491，12： | 1 |
| 6 | Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner显示文摘Myeloid-derived suppressor cells(MDSCs)are well known for their capacity to suppress antitumor T-cell responses,but their effects on B-cell function and antibody production remain unclear.Here,we found that MDSCs that accumulated around the germinal center in the spleen of tumor-bearing mice co-located with B cells.In the presence of MDSCs,the antibody reaction to a surrogate antigen was significantly enhanced in mice,especially the immunoglobulin(Ig)A subtype.Co-culture with MDSCs promoted both proliferation and differentiation of B cells into IgA-producing plasma cells in vitro.Interestingly,the cross talk between MDSCs and B cells required cell-cell contact.MDSCs from tumor necrosis factor receptor(TNFR)2^(−/−)mice,but not from TNFR1^(−/−)mice,failed to promote B-cell responses.Further investigation suggested that interleukin-10 and transforming growth factor-β1 were crucial for the MDSC-mediated promotion of IgA responses.These results demonstrate a novel mechanism of MDSC-mediated immune regulation during tumor growth. | Xia Xu Qinghong Meng Ulrike Erben Peigang Wang Rainer Glauben Anja A Kühl Hao Wu Chung Wah Ma Minghua Hu Yuanyuan Wang Wei Sun Junying Jia Xinyi Wu Wei Chen Britta Siegmund Zhihai Qin | 2017 | Cellular & Molecular Immunology2017，14，7： | 1 |
| 7 | Fabrication and characterization of superporous celiulose bead for high-speed protein chromatography 显示文摘 | Wang Dongmei Hao Gang Shi Qinghong Sun Yan | 2007 | Journal of ChromatographyA2007，1146，： | 1 |
| 8 | Self‑Assembly of Binderless MXene Aerogel for Multiple‑Scenario and Responsive Phase Change Composites with Ultrahigh Thermal Energy Storage Density and Exceptional Electromagnetic Interference Shielding显示文摘The severe dependence of traditional phase change materials(PCMs)on the temperature-response and lattice deficiencies in versatility cannot satisfy demand for using such materials in complex application scenarios.Here,we introduced metal ions to induce the self-assembly of MXene nanosheets and achieve their ordered arrangement by combining suction filtration and rapid freezing.Subsequently,a series of MXene/K^(+)/paraffin wax(PW)phase change composites(PCCs)were obtained via vacuum impregnation in molten PW.The prepared MXene-based PCCs showed versatile applications from macroscale technologies,successfully transforming solar,electric,and magnetic energy into thermal energy stored as latent heat in the PCCs.Moreover,due to the absence of binder in the MXene-based aerogel,MK3@PW exhibits a prime solar-thermal conversion efficiency(98.4%).Notably,MK3@PW can further convert the collected heat energy into electric energy through thermoelectric equipment and realize favorable solar-thermal-electric conversion(producing 206 mV of voltage with light radiation intensity of 200 mw cm^(−2)).An excellent Joule heat performance(reaching 105℃with an input voltage of 2.5 V)and responsive magnetic-thermal conversion behavior(a charging time of 11.8 s can achieve a thermal insulation effect of 285 s)for contactless thermotherapy were also demonstrated by the MK3@PW.Specifically,as a result of the ordered arrangement of MXene nanosheet self-assembly induced by potassium ions,MK3@PW PCC exhibits a higher electromagnetic shielding efficiency value(57.7 dB)than pure MXene aerogel/PW PCC(29.8 dB)with the same MXene mass.This work presents an opportunity for the multi-scene response and practical application of PCMs that satisfy demand of next-generation multifunctional PCCs. | Chuanbiao Zhu Yurong Hao Hao Wu Mengni Chen Bingqing Quan Shuang Liu Xinpeng Hu Shilong Liu Qinghong Ji Xiang Lu Jinping Qu | 2024 | Nano-Micro Letters2024，16，3： | 0 |
| 9 | The role and potential of attapulgite in catalytic pyrolysis of refinery waste activated sludge显示文摘Pyrolysis is a promising technology for the treatment of refinery waste activated sludge(rWAS).In this study,attapulgite as a natural clay was used to enhance the pyrolysis of rWAS.The yields,characteristics of pyrolytic products,pyrolytic kinetics and mechanisms were investigated.The attapulgite improved the conversion of rWAS into non-condensable gases and pyrolytic liquids.The bio-oil quality improved and the biochar yield reduced.The average activation energy of Stage Ⅰ(230-400℃)and Stage Ⅱ(400-500℃)decreased by 36.5%and 49.7%,respectively,compared to rWAS alone.Al_(2)O_(3)and Fe_(2)O_(3)in attapulgite enhanced the dealkylation reaction and cracking of C-C bonds.The content of the gasoline( | Qinghong Wang Kanghong Hao Chelsea Benally Yue Kou Zhexuan An Mohamed Gamal El-Din Chunmao Chen | 2022 | Petroleum Science2022，19，1： | 0 |
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