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| 1 | Indole alkaloid sulfonic acids from an aqueous extract of Isatis indigotica roots and their antiviral activity显示文摘Six new indole alkaloid sulfonic acids(1–6), together with two analogues(7 and 8) that were previously reported as synthetic products, were isolated from an aqueous extract of the Isatis indigotica root. Their structures including the absolute configurations were determined by spectroscopic data analysis, combined with enzyme hydrolysis and comparison of experimental circular dichroism and calculated electronic circular dichroism spectra. In the preliminary assay, compounds 2 and 4 showed antiviral activity against Coxsackie virus B3 and influenza virus A/Hanfang/359/95(H3N2), respectively. | Lingjie Meng Qinglan Guo Yufeng Liu Minghua Chen Yuhuan Li Jiandong Jiang Jiangong Shi | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 14 |
| 2 | Aromatic compounds from an aqueous extract of “ban lan gen” and their antiviral activities显示文摘A pair of new diphenyl glycerol ether enantiomers(-)-l and(+)-l and two new methyl benzamidobenzoates 2 and 3,named(-)-(R)-and(+)-(S)-isatindigotrioic acid[(-)-l and(+)-l]and isatindigoticamides A(2) and B(3),respectively,were isolated from an aqueous decoction of the roots of Isatis indigotica(ban lan gen).Their structures were elucidated by spectroscopic data analysis including2 D NMR experiments.The absolute configurations of(-)-l and(+)-l were assigned based on the CD exciton chirality method.Compounds 2 and 3 exhibited antiviral activities against HSV-1 with IC_(50)values of 4.87 and 25.87μmol/L,respectively.Compound 2 was also found active against Coxsackie virus B3 and LPS-induced NO production. | Yufeng Liu Minghua Chen Qinglan Guo Yuhuan Li Jiandong Jiang Jiangong Shi | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 8 |
| 3 | Sulfur-enriched alkaloids from the root of Isatis indigotica显示文摘Five new sulfur-enriched alkaloids isatithioetherins A–E(1–5), and two pairs of scalemic enantiomers(t)-and( à)-isatithiopyrin B(6 a and 6 b) and isoepigoitrin and isogoitrin(7 a and 7 b), along with the known scalemic enantiomers epigoitrin and goitrin(8 a and 8 b), were isolated and characterized from an aqueous extract of the Isatis indigotica roots. Their structures were determined by extensive spectroscopic data analysis, including 2 D NMR and theoretical calculations of electronic circular dichroism(ECD) spectra based on the quantum-mechanical time-dependent density functional theory(TDDFT). Compounds 1–5 represent a novel group of sulfur-enriched alkaloids, biogenetically originating from stereoselective assemblies of epigoitrin-derived units. Isolation and structure characterization of 6 a and 6 b support the postulated biosynthetic pathways for the diastereomers 9 a and 9 b via a rare thio-Diels–Alder reaction. Compounds 2 and 4 showed antiviral activity against the influenza virus A/Hanfang/359/95(H3 N2, IC500.60 and 1.92 μmol/L) and the herpes simplex virus 1(HSV-1, IC503.70 and 2.87 μmol/L), and 2 also inhibited Coxsackie virus B3(IC500.71 μmol/L).& 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license(http://gffzzeb6f7f563f66445dhkknxbwubkov96pwx.ffgz.tsg.suse.edu.cn/licenses/by-nc-nd/4.0/). | Qinglan Guo Chengbo Xu Minghua Chen Sheng Lin Yuhuan Li Chenggen Zhu JiANDong Jiang Yongchun Yang Jiangong Shi | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 8 |
| 4 | Isatindolignanoside A, a glucosidic indole-lignan conjugate from an aqueous extract of the Isatis indigotica roots显示文摘A glucosidic indole-lignan conjugate with a novel carbon skeleton, named isatindolignanoside A(1), was isolated from an aqueous extract of the Isatis indigotica roots 'ban lan gen'. Its structure was elucidated by comprehensive analysis of spectroscopic data, including J-and NOESY correlation-based configurational analysis, circular dichroism(CD) data, enzyme hydrolysis, and theoretical ECD calculation. In a preliminary assay, compound 1 showed antiviral activity against Coxsackie virus B3. This compound is the first example of natural product having a structural feature of conjugation between indole and lignan units, and its biosynthetic pathway is postulated. | Lingjie Meng Qinglan Guo Minghua Chen JiANDong Jiang Yuhuan Li Jiangong Shi | 2018 | Chinese Chemical Letters2018，29，8： | 7 |
| 5 | Constructing Odd-Variable Rotation Symmetric Boolean Functions with Optimal Algebraic Immunity and High Nonlinearity显示文摘Rotation symmetric Boolean functions(RSBFs) have attracted widespread attention due to their good cryptographic properties. We present a new construction of RSBFs with optimal algebraic immunity on odd number of variables. The nonlinearity of the new function is much higher than other best known RSBFs with optimal algebraic immunity. The algebraic degree of the constructed n-variable RSBF can achieve the upper bound n-1 when n/2 is odd or when n/2 is a power of 2 for n≥11.In addition, the constructed function can possess almost perfect immunity to fast algebraic attacks for n=11, 13, 15. | ZHAO Qinglan HAN Gang ZHENG Dong LI Xiangxue | 2019 | Chinese Journal of Electronics2019，28，1： | 4 |
| 6 | Experimental study of separation of ammonia synthesis vent gas by hydrate formation显示文摘Termodynamic data on methane hydrate formation in the presence of ammonia are very important for upgrading of ammonia synthesis vent gas using hydrate formation. This paper is focused on the formation conditions of methane hydrate in the presence of ammonia and the effects of gas-liquid ratio and temperature on the separation of vent gas by hydrate formation. Equilibrium data for methane hydrate within an ammonia mole concentration range from 1% to 5 % were obtained. The experimental results indicated that ammonia has an inhibitive effect on hydrate formation. The higher the ammonia concentration, the higher is the pressure reguired for methane hydrate formation would be. The primary experimental results showed that when volume ratio of gas to liquid was 80:1 and temperature was 283.15 K, total mole fraction of (H2+N2) in gas phase could reach 96.9 %. | Dong Taibin Wang Leiyan Liu Aixian Guo Xuqiang Ma Qinglan Li Guowen Sun Qiang | 2009 | Petroleum Science2009，6，2： | 3 |
| 7 | Activation pressure studies with an iron-based catalyst for slurry Fischer-Tropsch synthesis显示文摘Fischer-Tropsch synthesis(FTS) was carried out with an industrial iron-based catalyst(100Fe/5Cu/6K/16SiO 2,by weight) under the baseline conditions in a stirred tank slurry reactor(STSR) . The effects of activation pressure on the catalyst activity and selectivity were investigated. It was found that iron phase compositions,textural properties,and FTS performances of the catalysts were strongly dependent on activation pressure. The high activation pressure retards the carburization. M ssbauer effect spectroscopy(MES) results indicated that the contents of the iron carbides clearly decrease with the increase of activation pressure,especially for the activation pressure increasing from 1.0 MPa to 1.5 MPa,and the reverse trend is observed for superparamagnetic Fe 3+(spm) . The higher content of Fe 3+(spm) results in the higher amount of CO 2 in tail gas when the catalyst is reduced at higher pressure. The catalyst activity decreases with the increase of activation pressure. The high quantity of iron carbides is necessary to obtain high FTS activity. However,the activity of the catalyst activated in syngas can not be predicted solely from the fraction of the carbides. It is concluded that activation with syngas at the lower pressure would be the most desirable for the better activity and stability on the iron-based catalyst. | Qinglan Hao Liang Bai Hongwei Xiang Yongwang Li | 2009 | Journal of Natural Gas Chemistry2009，18，4： | 2 |
| 8 | Synthesis and characterization of 1-ferrocenecarboxy silatranes and crystal structures of FcC (CH3)2CHCOOSi(OCH 2CH2)3N and p-FcC6H4COOSi (OCH2CH2) 3N显示文摘 | Li C Qinglan X Lijuan S | 2003 | J Organomet Chem2003，678，1： | 1 |
| 9 | MULTI-FLORET SPIKELET 4(MFS4)Regulates Spikelet Development and Grain Size in Rice显示文摘In rice,the spikelet is the basic unit of inflorescence,and its development is important for determining the grain yield and quality.We reported a rice spikelet mutant multi-floret spikelet 4(mfs4)which resulted in the production of extra floral organs or a whole extra floret,and elongated sterile lemmas.The results suggested that the mutation of the MFS4 gene interfered with spikelet meristem determinacy and floral organ identity.In addition,the plant height and the grain length and width in the mfs4 mutant were all less than those in the wild type.Using the bulked segregant analysis method,the MFS4 gene was localized in a 557-kb region on the long arm of chromosome 1.Sequence analysis showed that there was a C-base deletion at the open reading frame of LOC_Os01g67430.Further tests indicated that a wild type copy of LOC_Os01g67430 was able to reverse the mfs4 defects,which indicated that LOC_Os01g67430 was the MFS4 gene.The MFS4 gene encodes a lipase located in the mitochondria and is expressed strongly in the young inflorescence.qRT-PCR results showed that the expression of some genes that were known to regulate spikelet meristem determinacy and grain size were decreased in the mfs4 mutant,which indicated that the MFS4 gene regulates spikelet meristem determinacy and grain size by modulating the expression of these genes. | Wang Yan Zeng Xiaoqin Lu Lu Cheng Qinglan Yang Fayu Huang Mingjiang Xiong Mao Li Yunfeng | 2021 | Rice science2021，28，4： | 1 |
| 10 | Web Resources for Microbial Data显示文摘There are multitudes of web resources that are quite useful for the microbial scientific research community. Here, we provide a brief introduction on some of the most notable microbial web resources and an evaluation of them based upon our own user experience. | Qinglan Sun Li Liu Linhuan Wu Wei Li Quanhe Liu Jianyuan Zhang Di Liu Juncai Ma | 2015 | Genomics, Proteomics & Bioinformatics2015，13，1： | 1 |
| 11 | Organic frameworks confined Cu single atoms and nanoclusters for tandem electrocatalytic CO_(2) reduction to methane显示文摘The electrochemical reduction reaction of carbon dioxide(CO_(2)RR)is considered to be an effective way to realize carbon neutrality.As a type of intensively studied materials,covalent organic frameworks(COFs)with a tunable pore structure and various functional groups are promising catalysts for CO_(2)RR.Herein,COF synthesized by 2,6‐diaminoanthraquinone and 2,4,6‐triformylphloroglucinol is employed to assist the synthesis of electrocatalysts from Cu single atoms(SAs)to nanoclusters by controlling the electrodeposition.A tandem catalyst for CO_(2)‐to‐CH4 conversion is thus achieved by the Cu nanoclusters dispersed among the isolated Cu SAs in the COF network.It is proposed that CO_(2) is first reduced to CO over the atomically isolated Cu SAs,followed by diffusion onto the neighboring Cu nanoclusters for further reduction into CH4.In addition,mechanistic analysis suggests that the coordinated K^(+)ions on the COF network promote the activation of CO_(2) and the adsorption of reaction intermediates,thus realizing the suppressed hydrogen evolution reaction and selective production of CH4.This study presents a new insight of COFs for the confined synthesis of a tunable SA to nanocluster electrocatalysts,disclosing the great potential of COFs in electrocatalysis. | Qinglan Zhao Yian Wang Meng Li Shangqian Zhu Tiehuai Li Jixiang Yang Ting Lin Ernest PDelmo Yinuo Wang Juhee Jang Meng Gu Minhua Shao | 2022 | SmartMat2022，3，1： | 1 |
| 12 | Salvianolic Acid B Attenuates Rat Hepatic Fibrosis via Downregulating Angiotensin II Signaling显示文摘 | Shu Li Lina Wang Xiuchuan Yan Qinglan Wang Yanyan Tao Junxia Li Yuan Peng Ping Liu Chenghai Liu Adair Roberto Soares Santos | 2012 | <journal-title>Evidence-Based Complementary and Alternative Medicine2012，，： | 1 |
| 13 | A Class of Cyclic Queue with Priority Batch Service 显示文摘 | Ma Zili Wang Siming Li Qinglan | 1991 | Applied Mathematical Modelling (S0307- 904X)1991，15，9： | 1 |
| 14 | Protocadherin 17 acts as a tumour suppressor inducing tumour cell apoptosis and autophagy, and is frequently methylated in gastric and colorectal cancers显示文摘 | Xiaotong Hu Xinbing Sui Lili Li Xuefeng Huang Rong Rong Xianwei Su Qinglan Shi Lijuan Mo Xingsheng Shu Yeye Kuang Qian Tao Chao He | 2012 | Pathol2012，，1： | 1 |
| 15 | A class of cyclic queue with priority batch service显示文摘 | Ma Zili Wang Siming Li Qinglan | 1991 | Appl Math Modelling1991，15，9： | 1 |
| 16 | Construction Method of Rail Transit Oriented Metropolitan Area under the Integration of Four Networks显示文摘In the process of metropolitan area integration,the current rail transit development is not enough to support the rapid expansion of the economy and population of the metropolitan area.It is necessary to attach importance to the important role of rail transit as a support system,promote the integrated development of the metropolitan area,and create a metropolitan area on the track.Through the problems in rail transit development,the development concept of “four networks integration” of rail transit is put forward.From multiple aspects of planning,construction and operation,reasonable promotion strategies are proposed,which could provide feasible suggestions for promoting the construction of metropolitan area on the track. | LI Daoyong SONG Sisi CHU Qinglan | 2022 | Journal of Landscape Research2022，14，5： | 0 |
| 17 | SB1 Encoding RING-Like Zinc-Finger Protein Regulates Branch Development as a Transcription Repressor显示文摘Inflorescence structure of rice,including the number and length of branches,and the density of the spikelet,can greatly affect the number of grains per panicle,which is one of the key factors in yield compositions.Here we identified five allelic mutants sb1-1/2/3/4/5 that related to branch development of rice.In these mutants,the branch meristem fate was prolonged sharply,resulting in delay of transition from branches to spikelets,and then increased the numbers of branches and spikelets per panicle.SB1 encodes a nuclear RING-like domain protein of SHI/LRP/SRS family and strongly expressed in branch meristems.The results of protein interaction and chromatin immunoprecipitation further suggested that SB1 directly repressed the expression of DEP1,TAW1,MOC1 and IPA1 by interacting with a co-repressor complex to affect acetylation level of histone H3 on target regions.Thus,we proposed that SB1 is a transcription repressor of branch meristem activity by widely and negatively regulating a series of genes that maintain branch meristem fate. | ZENG Xiaoqin ZHUANG Hui CHENG Qinglan TANG Jun YANG Fayu HUANG Mingjiang WANG Ziyi LI Zhongcheng ZHU Honghui CHEN Rui HE Guanghua LI Yunfeng | 2021 | Rice science2021，28，3： | 0 |
| 18 | Strategies of Building Rail Micro-centers in the New Era显示文摘Taking Beijing as the study object, this paper based on POI service offered by online maps and the results of the 7th population census, used ArchMap for the visualized analysis of population movement and large-scale business in Chaoyang District. Then it proposed that the construction of rail micro-centers should put human concerns on the top priority, enhance the coordinated development between rail microcenters and urban functions, and strengthen its own facilitation. | LI Daoyong CHU Qinglan SONG Sisi | 2022 | Journal of Landscape Research2022，14，6： | 0 |
| 19 | Genome-wide DNA methylation landscape of four Chinese populations and epigenetic variation linked to Tibetan high-altitude adaptation显示文摘DNA methylation(DNAm)is one of the major epigenetic mechanisms in humans and is important in diverse cellular processes.The variation of DNAm in the human population is related to both genetic and environmental factors.However,the DNAm profiles have not been investigated in the Chinese population of diverse ethnicities.Here,we performed double-strand bisulfite sequencing(DSBS)for 32 Chinese individuals representing four major ethnic groups including Han Chinese,Tibetan,Zhuang,and Mongolian.We identified a total of 604,649 SNPs and quantified DNAm at more than 14 million Cp Gs in the population.We found global DNAm-based epigenetic structure is different from the genetic structure of the population,and ethnic difference only partially explains the variation of DNAm.Surprisingly,non-ethnic-specific DNAm variations showed stronger correlation with the global genetic divergence than these ethnic-specific DNAm.Differentially methylated regions(DMRs)among these ethnic groups were found around genes in diverse biological processes.Especially,these DMR-genes between Tibetan and nonTibetans were enriched around high-altitude genes including EPAS1 and EGLN1,suggesting DNAm alteration plays an important role in high-altitude adaptation.Our results provide the first batch of epigenetic maps for Chinese populations and the first evidence of the association of epigenetic changes with Tibetans'high-altitude adaptation. | Zeshan Lin Yan Lu Guoliang Yu Huajing Teng Bao Wang Yajun Yang Qinglan Li Zhongsheng Sun Shuhua Xu Wen Wang Peng Tian | 2023 | Science China(Life Sciences)2023，66，10： | 0 |
| 20 | Effective Classroom Management in Young Learners English Teaching显示文摘Young learners (children from the first year of formal schooling, five or six years old to eleven or twelve years of age) English teaching program is very popular in many places of China, especially in urban areas. Although all the young learners English teachers may use different textbooks, they face a same problem -- classroom management. It is one of | Li Qinglan Wu Junyan & Hou Songshan, Shijiazhuang Mechanical Engineering College | 2004 | 中国英语教学:英文版2004，27，3： | 0 |
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