|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Correlation of E-selectin gene polymorphisms with risk of ischemic stroke A meta-analysis显示文摘OBJECTIVE: To investigate the association of E-selectin S128R polymorphisms with ischemic stroke. DATA SOURCES: A computer-based online search was conducted in PubMed, Elsevier, Ovid Database, the China National Knowledge Infrastructure, and Wanfang Database between January 1998 and December 2010. STUDY SELECTION: Case-controlled studies addressing the association of the E-selectin polymorphism and ischemic stroke were included in this review. The genotype distribution complied with the Hardy-Weinberg genetic equilibrium. The included reports were evaluated by two authors for strict quality screening. Meta-analysis software, REVMAN 5.1, was used to investigate heterogeneity, pooled odds ratio (OR) and 95% confidence interval (CI) in individual studies. MAIN OUTCOME MEASURES: Genotype and allele distributions at the E-selectin S128R site. RESULTS: Six case-controlled studies were included after screening and application of inclusion and exclusion criteria. There was no heterogeneity in the genotype and allele frequencies, and no publication bias was found. Meta-analysis of the pooled data showed that the OR value of the (AC+CC)/AA genotype was 1.93 (95% CI: 1.55-2.41, Z = 5.80, P < 0.000 01), and the OR for the C/A allele was 1.80 (95% CI: 1.47-2.22, Z = 5.59, P < 0.000 01) in the ischemic stroke group, compared with control group. Results of pooled data in Chinese subjects showed that the OR value of (AC+CC)/AA was 2.36 (95% CI: 1.68-3.31, Z = 4.99, P < 0.000 01), and the OR value of the C/A allele was 2.25 (95% CI: 1.63-3.12, Z = 4.89, P < 0.000 01). CONCLUSION: Polymorphism of E-selectin S128R was significantly associated with susceptibility to ischemic stroke; the AC and CC genotypes as well as the C allele may be factors associated with susceptibility to ischemic stroke. | Qingli Sun Yu Fu Aping Sun Yanhong Shou Mei Zheng Xiaogang Li Dongsheng Fan | 2011 | Neural Regeneration Research2011，6，22： | 46 |
| 3 | Optical property and spectroscopy studies on the selected lubricating oil in the terahertz range显示文摘The optical property and spectroscopy of selected kinds of lubricating oil are studied based on the terahertz time-domain spectroscopy (THz-TDS) in the spectral range of 0.3-1.6 THz. The samples are classified by their characteristics via the near-infrared spectrum. The experimental results reveal that lubricating oil is more sensitive in the range of terahertz than in the near-infrared,and the specific kinds of lubricating oil can be identified according to their different spectral features in the terahertz range. The THz-TDS technology applied to lubricating oil analysis has potentially significant impact on the petroleum field. | TIAN Lu ZHOU QingLi JIN Bin ZHAO Kun ZHAO SongQing SHI YuLei ZHANG CunLin | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，12： | 25 |
| 4 | Comparison of the Δ^(12) fatty acid desaturase gene between high-oleic and normal-oleic peanut genotypes显示文摘Δ12 fatty acid desaturase gene has been targeted as a logical candidate controlling the high oleate trait in peanut seeds.By RT-PCR method,the full-length cDNAs of Δ12 fatty acid desaturase gene were isolated from peanut(Arachis hypogaea L.) genotypes with normal and high ratio of oleic to linoleic acid,which were designated AhFAD2B and AhFAD2B',respectively.Sequence alignment of their coding regions revealed that an extra A was inserted at the position +442 bp of AhFAD2B' sequence of high oleic acid genotypes,which resulted in the shift of open reading frame and a truncated protein AhFAD2B',with the loss of one histidine box involved in metal ion complex required for the reduction of oxygen.Analysis of transcript level showed that the expression of Δ12 fatty acid desaturase gene in high oleic acid genotype was slightly lower than that in normal genotype.The enzyme activity experiment of yeast(Saccharomyces cerevisiae) cell transformed with AhFAD2B or AhFAD2B' proved that only AhFAD2B gene product showed significant Δ12 fatty acid desaturase activity,but AhFAD2B' gene product did not.These results suggested that the change of AhFAD2B' gene sequence resulted in lower activity or deactivation of Δ12 fatty acid desaturase in high oleic acid genotype. | ShanlinYu Lijuan Pan Qingli Yang Ping Min Zengkai Ren Hongsheng Zhang | 2008 | Journal of Genetics and Genomics2008，35，11： | 23 |
| 5 | Therapeutic effects and molecular mechanisms of anti-fibrosis herbs and selenium on rats with hepatic fibrosis显示文摘AIM:To study the therapeutic effects of anti-fibrosis herbs and selenium on hepatic fibrosis induced by carbon tetrachloride (CCl4) in rats and the underlining molecular mechanisms.METHODS:Fifty-three Wistar rats were randomly divided into:normal control group, model control group, colchicine group, anti-fibrosis herbs group (AF group) and anti-fibrosis herbs plus selenium group (AS group).The last four groups were administered with CCl4 at the beginning of experiment to induce hepatic fibrosis. Then colchicine, anti-fibrosis herbs and selenium were used to treat them. The normal control group and the model control group were given normal saline at the same time. At the end of the 6^th week, rats in each group were sacrificed. Blood and tissue specimens were taken. Serum indicators (ALT, AST, HA, LN) were determined and histopathological changes were graded. Lymphocyte CD4 and CD8 were examined by flow cytometry. Expression of TGF-β1 and NF-κB was detected by immunohistochemistry and expression of TGF-β1 mRNA was detected by semiquantified RT-PCR.RESULTS: Histological grading showed much a smaller degree of hepatic fibrogenesis in AS group and AF group than that in colchicine group and model control group.The serum content of ALT, AST, HA and LN in AF group and AS group were significantly lower than that in colchicine group (ALT:65.8±26.5, 67.3±18.4 and 96.2±20.9 in AF, AS and colchicine groups respectively; AST: 150.8±34.0, 154.6±27.3 and 215.8±24.6 respectively; HA: 228±83, 216±58 and 416±135 respectively; LN:85.9±15.0, 80.6±18.6 and 106.3±14.2 respectively) (P<0.05). The level of CD4 and CD4/CD8 ratio in AF group and AS group was significantly higher that those in cochicine group (CD4:50.8±3.8, 52.6±3.4 and 40.2±2.1 in AF, AS and colchicine groups respectively;CD4/CD8 ratio:1.45,1.46 and 1.26, respectively (P<0.05).The expression level of NF-κB and TGF-β1 in the liver tissues of AF and AS treatment groups was markedly decreased compared with that in cochicine group, and TGF-β1 mRNA was also markedly decreased (1.07±0.31 and 0.98±0.14 vs2.34±0.43, P<0.05).CONCLUSION: Anti-fibrosis herbs and selenium have beneficial effects on hepatic fibrosis in rats by enhancing immunity and inhibiting NF-κB and TGF-β1 expressions. | Yu-TongHe Dian-WuLiu Li-YuDing QingLi Yong-HongXiao | 2004 | World Journal of Gastroenterology2004，10，5： | 19 |
| 6 | Land Use Effects on Soil Organic Carbon, Microbial Biomass and Microbial Activity in Changbai Mountains of Northeast China显示文摘Land use changes are known to alter soil organic carbon(SOC) and microbial properties, however, information about how conversion of natural forest to agricultural land use as well as plantations affects SOC and microbial properties in the Changbai Mountains of Northeast China is meager. Soil carbon content, microbial biomass carbon(MBC), basal respiration and soil carbon mineralization were studied in five selected types of land use: natural old-growth broad-leaved Korean pine mixed forest(NF); spruce plantation(SP) established following clear-cutting of NF; cropland(CL); ginseng farmland(GF) previously under NF; and a five-year Mongolian oak young forest(YF) reforested on an abandoned GF, in the Changbai Mountains of Northeast China in 2011. Results showed that SOC content was significantly lower in SP, CL, GF, and YF than in NF. MBC ranged from 304.4 mg/kg in CL to 1350.3 mg/kg in NF, which was significantly higher in the soil of NF than any soil of the other four land use types. The SOC and MBC contents were higher in SP soil than in CL, GF, and YF soils, yielding a significant difference between SP and CL. The value of basal respiration was also higher in NF than in SP, CL, GF, and YF. Simultaneously, higher values of the metabolic quotient were detected in CL, GF, and YF soils, indicating low substrate utilization of the soil microbial community compared with that in NF and SP soil. The values of cumulative mineralized carbon and potentially mineralized carbon(C0) in NF were significantly higher than those in CL and GF, while no significant difference was observed between NF and SP. In addition, YF had higher values of C0 and C mineralization rate compared with GF. The results indicate that conversion from NF into agricultural land(CL and GF) uses and plantation may lead to a reduction in soil nutrients(SOC and MBC) and substrate utilization efficiency of the microbial community. By contrast, soils below SP were more conducive to the preservation of soil organic matter, which was reflected in the comparison of microbial indicators among CL, GF, and YF land uses. This study can provide data for evaluating soils nutrients under different land use types, and serve as references for the rational land use of natural forest in the study area. | FANG Xiangmin WANG Qingli ZHOU Wangming ZHAO Wei WEI Yawei NIU Lijun DAI Limin | 2014 | Chinese Geographical Science2014，24，3： | 16 |
| 7 | Expression Detection of DMRTs and Two sox9 Genes in Takifugu rubripes (Tetraodontidae, Vertebrata)显示文摘Sex determination and sex differentiation are important phenomena in fish, but the mechanisms of sex determination in Takifugu rubripes are poorly understood. In our study, the expression patterns of genes for DMRTs (DMRT1, DMRT2 and DMRT3), sox9a and sox9b in T. rubripes tissues were verified with the Reverse Transcription (RT)-PCR detection. It is showed that DMRT1 expressions in testis and ovaries were much lower, and no expressions were found in muscle, blood and tailfin. However, expressions for DMRT2 and DMRT3 were not found in the tissues stated above. Transcripts of sox9a were detected in muscle, fin, ovary and testis, but not in blood, whereas sox9b expression was only detected in ovary. The expression patterns of DMRTs, sox9a and sox9b in T. rubripes gonads suggest that these genes may not be sex-specific. | SHEN Xueyan CUI Jianzhou YANG Guanpin GONG Qingli GU Qianqun | 2007 | Journal of Ocean University of China2007，6，2： | 15 |
| 8 | Effects of augmentation of liver regeneration recombinant plasmid on rat hepatic fibrosis显示文摘AIM: To investigate the effects of eukaryotic expression of plasmid on augmentation of liver regeneration (ALR) in rat hepatic fibrosis and to explore their mechanisms. METHODS: Ten rats were randomly selected from 50Wistar rats as normal control group. The rest were administered intraperitoneally with porcine serum twice weekly. After 8 wk, they were randomly divided into:model control group, colchicine group (Col), first ALR group (ALR1), second ALR group (ALR2). Then colchicine ALR recombinant plasmid were used to treat them respectively. At the end of the 4th wk, rats were killed.Serum indicators were detected and histopathological changes were graded. Expression of type Ⅰ, Ⅲ, collagen and TIMP-1 were detected by immunohisto-chemistry and expression of TIMP-1 mRNA was detected by semiquantified RT-PCR.RESULTS: The histologic examination showed that the degree of the rat hepatic fibrosis in two ALR groups was lower than those in model control group. Compared with model group, ALR significantly reduced the serum levels of ALT,AST, HA, LN, PCⅢ and Ⅳ (P<0.05). Immunohistochemical staining showed that expression of type Ⅰ, Ⅲ, collagen and TIMP-1 in two ALR groups was ameliorated dramatically compared with model group (Ⅰ collagen: 6.94±1.42, 5.80±1.66and 10.83±3.58 in ALR1, ALR2 and model groups, respectively;Ⅲ collagen: 7.18±1.95, 4.50±1.67 and 10.25±2.61,respectively; TIMP-1: 0.39±0.05, 0.20±0.06 and 0.53±0.12,respectively, P<0.05 or P<0.01). The expression level of TIMP-1 mRNA in the liver tissues was markedly decreased in two ALR groups compared with model group (TIMP-1mRNA/β-actin: 0.89±0.08, 0.65±0.11 and 1.36±0.11 in ALR1, ALR2 and model groups respectively, P<0.01).CONCLUSION: ALR recombinant plasmid has beneficial effects on rat hepatic fibrosis by enhancing regeneration of injured liver cells and inhibiting TIMP-1 expressions. | QingLi Dian-WuLiu Li-MeiZhang BingZhu Yu-TongHe Yong-HongXiao | 2005 | World Journal of Gastroenterology2005，11，16： | 12 |
| 9 | Field experiment of subgrade vibration induced by passing train in a seasonally frozen region of Daqing显示文摘The vibration characteristics and attenuation of the subgrade caused by passing trains in a seasonally frozen region of Daqing, China are investigated. Three fi eld experiments were conducted during different times through the year, in normal, freezing and thawing periods, respectively, and the influence of the season, train speed and train type, is described in this paper. The results show that: (1) the vertical component is the greatest among the three components of the measured vibration near the rail track, and as the distance to the railway track increases, the dominant vibration depends on the season. (2) Compared with the vibration in the normal period, the vertical and longitudinal vibrations increase while the lateral vibration decreases in the freezing period. However, in the thawing period, the vertical and longitudinal vibrations decrease, and the lateral vibration increases. (3) As train speeds increase, the subgrade vibration increases. (4) The vibration induced by a freight train is greater than by a passenger train. These observations provide a better understanding of the vibration and dynamic stability of the subgrade and may be useful in developing criteria for railway and building construction in cold regions. | Ling Xianzhang Zhang Feng Zhu Zhanyuan Ding Lin Hu Qingli | 2009 | Earthquake Engineering and Engineering Vibration2009，8，1： | 12 |
| 10 | Aqueous extract of Taxus Chinensis (Pilger) Rehd inhibits lung carcinoma A549 cells through the epidermal growth factor receptor/mitogen-activated protein kinase pathway in vitro and in vivo显示文摘OBJECTIVE:To explore the anticancer mechanismof aqueous extract of Taxus Chinensis (Pilger) Rehd (AETC).METHODS: The serum pharmacological method was used to avoid interference from administration of the crude medicinal herbs. Eight purebred New Zealand rabbits were used for preparation of serum containing various concentrations of AETC. Forty-eightBalb/c-nu mice were used for in vivo experiments. The effects of serum containing AETC on the proliferation of A549 cells and expression levels of the epidermal growth factor receptor/mitogen-activated protein kinase(EGFR/MAPK) pathway-related proteins in vitro were investigated. Additionally, the effects on the growth of A549 xenografts in nudemice,and expression levels of the EGFR/MAPK pathway-related proteins in the xenografts,were investigated.RESULTS: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT) assay revealed that the serum containing AETC significantly decreased the viability of A549 cells in a dose-dependent manner.Western blot showed that the serum containing various concentrations of AETC strongly reduced the levels of phospho-Jun N-terminal kinase(p-JNK) and phospho-extracellular signal-regulated kinase1/2(ERK1/2) while it increased the level of p-p38. However, no significant effects on the expression levels of JNK, ERK1/2, and p38 MAPK were found. In addition, an anticancer effect from AETC was observed invivo in the Balb/c-nu mice bearing A549xenografts.CONCLUSION: AETC has significant effects on the growth of A549 xenografts and on the activity of the EGFR/MAPK pathway. Therefore, AETC may be beneficial in lung carcinoma treatment. | Qijin Shu Minhe Shen Binbin Wang Qingli Cui Xiaoying Zhou Luming Zhu | 2014 | Journal of Traditional Chinese Medicine2014，34，3： | 10 |
| 11 | Spectrum features of commercial derv fuel oils in the terahertz region显示文摘Characteristic spectra in the 0.5-2.5 terahertz (THz) range of three commercial derv fuel oils have been obtained using THz time-domain spectroscopy and calculated using density functional theory.The simulated results and experimental absorption curves suggest that the skeleton vibration is predominant in the THz region,and the absorption bumps of diesels are a superposition of various components.The investigation demonstrates that different diesels can be distinguished using THz time-domain spectroscopy and THz technology is a promising method to detect the composition and properties of diesels via chemical analysis. | ZHAO Hui ZHAO Kun TIAN Lu ZHAO SongQing ZHOU QingLi SHI YuLei ZHAO DongMei ZHANG CunLin | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，2： | 8 |
| 12 | Protection of Mice from Lethal Endotoxemia by Chimeric Human BPI-Fcγ1 Gene Delivery显示文摘To evaluate the potentiality of applying gene therapy to endotoxemia in high-risk patients, we investigated the effects of transferring an adeno-associated virus serotype 2 (AAV2)-mediated BPI-Fcγ1 gene on protecting mice from challenge of lethal endotoxin. The chimeric BPI-Fcγ1 gene consists of two parts, one encods functional N-terminus (1 to 199 amino acidic residues) of human BPI, which is a bactericidal/permeability-increasing protein, and the other encodes Fc segment of human immunoglobulin G1(Fcγ1). Our results indicated that the target protein could be expressed and secreted into the serum of the gene-transferred mice. After lethal endotoxin challenge, the levels of endotoxin and TNF-αin the gene-transferred mice were decreased. The survival rate of the BPI-Fcγ1 gene-transferred mice was markedly increased. Our data suggest that AAV2-mediated chimeric BPI-Fcγ1 gene delivery can potentially be used clinically for the protection and treatment of endotoxemia and endotoxic shock in high-risk individuals. | Chen Li Jing Li Zhe Lv Xinghua Guo Qinghua Chen Qingli Kong Yunqing An | 2006 | Cellular & Molecular Immunology2006，3，3： | 7 |
| 13 | Improving the stability and bioavailability of tea polyphenols by encapsulations:a review显示文摘Tea polyphenols(TPPs)have attracted significant research interest due to their health benefits.However,TPPs are sensitive to certain environmental and gastrointestinal conditions and their oral bioavailability was found to be very low.Delivery systems made of food-grade materials have been reported to improve the shelf-life,bioavailability and bioefficacy of TPPs.This review discusses the chemistry of TPPs;the setbacks of TPPs for application;and the strategies to counteract application limitations by rationally designing delivery systems.An overview of different formulations used to encapsulate TPPs is provided in this study,such as emulsion-based systems(liposome,nanoemulsion,double emulsion,and Pickering emulsion)and nano/microparticles-based systems(protein-based,carbohydrate-based,and bi-polymer based).In addition,the stability,bioavailability and bioactivities of encapsulated TPPs are evaluated by various in vitro and in vivo models.The current findings provide scientific insights in encapsulation approaches for the delivery of TPPs,which can be of great value to TPPs-fortified food products.Further explorations are needed for the encapsulated TPPs in terms of their applications in the real food industry as well as their biological fate and functional pathways in vivo. | Zhiya Yin Ting Zheng Chi-Tang Ho Qingrong Huang Qingli Wu Man Zhang | 2022 | Food Science and Human Wellness2022，11，3： | 7 |
| 14 | Digitally determining forest inventory units with an ecological classification system显示文摘Management-level forest resource data in China were obtained with a combination of two forest inventories. However, inconsistencies in the spatial attributes of forest data vary between the two inventory types and between two inventories of the same type. The inconsistencies make it inconvenient for long-term forest management planning with digital technologies. Ecological Land Types (ELTs) and Ecological Land Type Phases (ELTPs) have been mapped in selected forestry regions in northeast China, where important forest industries are located. The boundaries of ELTs are determined by geomorphic conditions, which are quantified by Digital Elevation Models (DEM); ELTPs are classified by overlaying ELTs with forest vegetation data layers that are obtained with both remotely sensed and ground data. The ELTPs represent the divisions of land in terms of both natural and human-induced forest conditions, and therefore they are reliable units for forest inventories and management. This paper introduces a case study for digitally determining forest inventory units in Benxi City, Liaoning Province, northeast China. The general objective of the study was to explain how a compatible forest inventory system should be designed and why the compatible forest inventory system was significant to digital forestry in China. | TANG Una, WANG Qingli, Guofan Shao, DAI Limin, WANG Shunzhong, LI Xiufen & XU Dong Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China Graduate University of Chinese Academy of Sciences, Beijing 100101, China Department of Forestry and Natural Resources, Purdue University, West Lafayette, IN 47907, USA | 2006 | Science China(Technological Sciences)2006，49，z1： | 6 |
| 15 | Expression of transforming growth factor-α and hepatitis B surface antigen in human hepatocellular carcinoma tissues and its significance显示文摘AIM:To evaluate the expression of transforming growthfactor-alpha (TGF-α) and hepatitis B surface antigen (HBsAg) in human hepatocellular carcinoma (HCC) tissues and its significance.METHODS:Seventy specimens of HCC tissues were detected by immunohistochemical method. Five specimens of normal human liver tissues were used as control.RESULTS: The TGF-o~ positive expression rates in HCC and its surrounding tissues were 74.3%(52/70) and 88.1%(52/59), respectively. TGF-α positive granules were mainly in the cytoplasm and fewer existed on the karyotheca. The TGF-α positive expressing rate in well differentiated HCC was significantly higher than that in moderately and poorly differentiated HCC (P<0.05).The TGF-α positive expression also was observed in intrahepatic bile ducts (part of those were hyperplastic ducts).The HBsAg positive expression rates in HCC and its surrounding tissues were 21.4%(15/70) and 79.7%(47/59), respectively.HBsAg positive granules were in the cytoplasm, inclusion and on the karyotheca.There was a prominent positive correlation between TGF-α and HBsAg expression in HCC surrounding tissues (P<0.05,γ=0.34). TGF-α was usually existed with HBsAg in regenerated and/or dysplastic liver cells.In the five normal liver tissues, TGF-α and HBsAg were not detectable in hepatocytes and bile ducts.CONCLUSION:Hepatitis B virus infection is dosely related with hepatocarcinogenesis.The overexpression of TGF-α in the liver seems to be associated with the regeneration of hepatocytes injured by HBsAg.The continued expression of TGF-α might lead to dysplasia of liver cells and development of HCC. Furthermore, TGF-α might play a role in morphogenesis and regeneration of intrahepatic bile ducts. | JingZhang Wen-LiangWang QingLi QingQiao | 2004 | World Journal of Gastroenterology2004，10，6： | 6 |
| 16 | Carbon Stock of Larch Plantations and Its Comparison with an Old-growth Forest in Northeast China显示文摘The overall goal of this study was to understand carbon(C) stock dynamics in four different-aged Japanese larch(Larix kaempferi) plantations in Northeast China that were established after clear-cutting old-growth Korean pine deciduous forests. Four Japanese larch plantations which were at 10, 15, 21, and 35 years old and an old-growth Korean pine deciduous forest which was 300 years old in Northeast China were selected and sampled. We compared the C pools of biomass(tree, shrub and herb), litterfall(LF), and soil organic carbon(SOC) among them. The biomass C stock of larch plantation at 10, 15, 21, and 35 years old was 26.8, 37.9, 63.6, and 83.2 Mg/ha, respectively, while the biomass C stock of the old-growth Korean pine deciduous forest was 175.1 Mg/ha. The SOC stock of these larch plantations was 172.1, 169.7, 140.3, and 136.2 Mg/ha respectively, and SOC stock of 170.4 Mg/ha in the control of old-growth forest. The biomass C stock increased with stand age of larch plantations, whereas SOC stock decreased with age, and C stock of LF did not change significantly(P > 0.05). The increase of biomass C offset the decline of SOC stock with age, making total carbon stock(TCS) of larch plantations stable from stand ages of 10–35 years. The TCS in larch plantations was much smaller than that in the old-growth forest, suggesting that the conversion of old-growth forests to young larch plantations releases substantial C into the atmosphere. | QI Guang CHEN Hua ZHOU Li WANG Xinchuang ZHOU Wangming QI Lin YANG Yuhua YANG Fengling WANG Qingli DAI Limin | 2016 | Chinese Geographical Science2016，26，1： | 6 |
| 17 | Study on microscope hyperspectral medical imaging method for biomedical quantitative analysis显示文摘A microscopic pushbroom hyperspectral imaging system was developed based on the microscopic technology and spectral imaging technology according to the principle of spectral imager in remote sensing. The basic principle and key technologies of this system were presented and the system per- formance was also analyzed. Some methods and algorithms were proposed to preprocess and nor- malize the microscopic hyperspectral data and retrieve the transmittance spectrum of samples. As a case study, the microscopic hyperspectral imaging system was used to image the retina sections of different rats and get some significant results. Experiment results show that the system can be used for the quantitative assessment and evaluating the effect of medication in biomedical research. | LI QingLi XUE YongQi XIAO GongHai ZHANG JingFa | 2008 | Chinese Science Bulletin2008，53，9： | 5 |
| 18 | Overview of particulate air pollution and human health in China: Evidence, challenges, and opportunities显示文摘Ambient particulate matter(PM)pollution in China continues to be a major public health challenge.With the release of the new WHO air quality guidelines in 2021,there is an urgent need for China to contemplate a revision of air quality standards(AQS).In the recent decade,there has been an increase in epidemiological studies on PM in China.A comprehensive evaluation of such epidemiological evidence among the Chinese population is central for revision of the AQS in China and in other developing countries with similar air pollution problems.We thus conducted a systematic review on the epidemiological literature of PM published in the recent decade. | Qingli Zhang Xia Meng Su Shi Lena Kan Renjie Chen Haidong Kan | 2022 | The Innovation2022，3，6： | 5 |
| 19 | Analysis on Nutrient Compositions and Nutritional Quality of Lota lota( Linnaeus) Muscle显示文摘In order to evaluate the nutritional quality of Lota lota(Linnaeus) muscle,the common nutrient components,amino acid composition and fatty acid composition in muscle of wild Lota lota(captured in Hailang reaches of Mudan River) were determined by routine methods. The results showed that the contents of moisture,crude protein,crude fat and ash were 81. 82%,15. 93%,0. 44% and 1. 06% in fresh muscle of Lota lota,respectively. Totally 17 amino acids,including seven kinds of essential amino acids(EAA),were detected in dry muscle of Lota lota(Linnaeus),accounting for 72. 43% of total dry muscle. The content of EAA was 29. 82%,accounting for 41. 17% of TAA,meeting the amino acid composition of high-quality protein standard required by Food and Agriculture Organization /Word Health Organization(FAO /WHO). There were four delicious amino acids(DAA) in dry muscle,accounting for 28. 34% of total dry weight.The percentage of DAA to TAA was 39. 13% in dry muscle. The contents of C20:5n- 3(EPA) and C22:6n- 3(DHA) in dry muscle were 8. 65% and 20. 32%respectively,which were significantly higher than that of the artificially cultured fish species,such as Oxyeleotris marmorata(EPA:2. 24%,DHA:4. 74%),Spinibarbus sinensis(EPA:0. 87%,DHA:3. 08%) and Glossogobius giuris(EPA: 3. 94%,DHA: 8. 10%). Based on the amino acids score(AAS) and chemical score(CS),the first limited amino acid in Lota lota(Linnaeus) was sulfur-containing amino acid(methionine + cysteine). The essential amino acids index(EAAI) of Lota lota(Linnaeus) was 62.58. It is concluded that Lota lota(Linnaeus) is abundant in amino acids and high-unsaturated fatty acids,and rational in composition of amino acids. Thus,Lota lota(Linnaeus) is a high quality freshwater fish with high nutritional value and health value,possessing good exploitation and utilization prospects. | Xu Gefeng Wang Yuyu Bai Qingli Li Xiaolong Jia Zhonghe | 2014 | Animal Husbandry and Feed Science2014，6，4： | 5 |
| 20 | Segregation during crystal growth from melt and absorption cross section determination by optical absorption method显示文摘Segregation during crystal growth from melt under two conditions is studied by using crystal mass,which can be measured easily,as an independent variable,and a method to determine the effective segregation coefficient and absorption cross section of optical dopant is given.When the segregated solute disperses into the whole or just a part of melt homogenously,the concentration CS in solid interface will change by different formulas.If the crystal growth interface is conical and segregated solute disperses into melt in total or part,the solute concentration at r=2/3R,where r is the distance from the growth cross section center and R the crystal radius,is independent on the shape of the crystal growth interface,and its variation at r=2/3R can be regarded as the result from crystal growth in flat interface.With CS variation formula in solid and absorption cross section σ for optical dopant,the absorption coefficients along the crystal growth direction can be calculated,and the corresponding experimental value can be obtained through the crystal optical absorption spectra.By minimizing the half sum,whose independent variables are k,ΔW or σ,of the difference square between the calculated and experimental absorp-tion coefficients from one or more absorption peaks along the crystal growth di-rection,k and σ,or k and ΔW,can be determined at the same time through the Levenberg-Marquardt iteration method.Finally,the effective segregation coefficient k,ΔW and absorption cross sections of Nd:GGG were determined,the results fitted by two formula gave more closed effective segregation coefficient,and the value ΔW also indicates that the segregated dopant had nearly dispersed into the whole melt.Experimental results show that the method to determine effective segregation coefficient k,ΔW and absorption cross sections σ is convenient and reliable,and the two segregation formulas can describe the segregation during the crystal growth from melt relatively commendably. | ZHANG QingLi YIN ShaoTang SUN DunLu WAN SongMing | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，5： | 5 |
您所在的机构暂未开通此部分的功能，请联系管理员