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| 1 | Dendritic Cells Transduced with SOCS1 Gene Exhibit Regulatory DC Properties and Prolong Allograft Survival显示文摘SOCS1 is a key regulator of cytokine signaling and is important for maintaining balance in the immune system. It is thought to participate in negative feedback loops in cytokine signaling and may be an important signal for the regulation of dendritic cell (DC) maturation. However, it remains unclear whether DCs transduced with SOCS1 exhibit characteristics of regulatory DCs and induce allogeneic T-cell hyporesponsiveness. In this study, we constructed adenoviral vector coding SOCS1 (Ad-SOCS1) that can efficiently increase SOCS1 gene expression in bone marrow-derived dendritic cells. DCs transduced with Ad-SOCS1 (DC-SOCS1) expressed low levels of costimulatory and MHC molecules, were resistant to maturation and activation stimulation, induced allogeneic T-cell hyporesponsiveness, and promoted the generation of regulatory-like T cells in vitro. DC-SOCS1 pretreatment significantly prolonged the survival of allografts and led to a substantial increase in the generation of regulatory T cells. Our data suggest that SOCS1 inhibits DC maturation and induces regulatory DC generation, therefore possessing therapeutic potential to prevent rejection in organ transplantation. | Hong Fu Shaohua Song Fang Liu Zhijia Ni Xiaoyun Shen Liang Xiao Guoshan Ding Quanxing Wang | 2009 | Cellular & Molecular Immunology2009，6，2： | 20 |
| 2 | ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer显示文摘 | Shunrong Ji Yi Qin Si Shi Xiangyuan Liu Hongli HU Hu Zhou Jing Gao Bo Zhang Wenyan Xu Jiang Liu Dingkong Liang Liang Liu Chen Liu Jiang Long Haijun Zhou Paul J Chiao Jin Xu Quanxing Ni Daming Gao Xianjun Yu | 2015 | Cell Research2015，25，5： | 19 |
| 3 | Human BDCA2^+CD123^+CD56^+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset显示文摘树枝状的房间(DC ) 包括二个机能上地不同的子集:plasmacytoid DC (pDCs ) 和 myeloid DC (mDCs ) 。pDCs 被专攻类型的快速、巨大的分泌物我响应通过使用费的 nucleic 酸的干扰素(IFN-I ) 相似受体(TLR )-7 或 TLR-9。在这份报告,我们描绘了 CD56 < 啜 class= “ a-plus-plus ” >+ DC 人口包括 CD123 和 BDCA2 表示典型 pDC 标记,但是生产与 pDCs 作比较的少得多 IFN-I。另外, CD56 < 啜 class= “ a-plus-plus ” > 和由介绍的染色体宽的 transcriptional 的 mDCs 然而并非 pDCs 的 + DC 簇。因此, CD56 < 啜 class= “ a-plus-plus ” >+ DC 机能上地由在 TLR4 刺激和 priming na 之上生产 IL-12 类似于 mDCs ? 没有优先的激活的 ve T 房间。这些数据建议 CD56 < 啜 class= “ a-plus-plus ” >+ DC 代表与一些 pDC 特征混合的一个新奇 mDC 子集。CD4 < 啜 class= “ a-plus-plus ” >+ CD56 < 啜 class= “ a-plus-plus ” >+ hematological 恶意作为 blastic plasmacytoid 被分类树枝状的房间瘤(BPDCN ) 由于它 pDCs 的典型分子的表示。然而,我们证明 BPDCN 接近 CD56 < 啜 class= “ a-plus-plus ” >+ DC 比由介绍的全球基因表示的 pDCs。因此,我们建议 CD4 < 啜 class= “ a-plus-plus ” >+ CD56 < 啜 class= “ a-plus-plus ” >+ 瘤可以是 CD56 的一个肿瘤对应物 < 啜 class= “ a-plus-plus ” >+ mDCs 然而并非 pDCs。 | Haisheng Yu Peng Zhang Xiangyun Yin Zhao Yin QuanxinG Shi Ya Cui Guanyuan Liu Shouli Wang Pier Paolo Piccaluga Taijiao Jiang Liguo Zhang | 2015 | Protein & Cell2015，6，4： | 6 |
| 4 | Energy sources identify metabolic phenotypes n pancreatic cancer显示文摘 | Chen Liang Yi Qin Bo Zhang Shunrong Ji Si Shi Wenyan Xu Jiang Liu Jinfeng Xiang Dingkong Liang Qiangsheng Hu Liang Liu Chen Liu Guopei Luo Quanxing Ni Jin xu Xianjun Yu | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 3 |
| 5 | Metabolic tumor burden is associated with major oncogenomic alterations and serum tumor markers in patients with resected pancreatic cancer显示文摘 | Si Shi Shunrong Ji Yi Qin Jin Xu Bo Zhang Wenyan Xu Jiang Liu Jiang Long Chen Liu Liang Liu Quanxing Ni Xianjun Yu | 2015 | Cancer Letters2015，，2： | 1 |
| 6 | Computer Simulation of Heat Transfer in Regenerative Chambers of Self- Preheating Hot Blast Stoves显示文摘 | Zhong Liangcai Liu Quanxing Wang Wenzhong | 2004 | ISIJ International2004，44，5： | 1 |
| 7 | Adsorption of trichloroethylene and benzene vapors onto hypercrosslinked polymeric resin显示文摘 | Peng Liu Chao Long Qifen Li Hongming Qian Aimin Li Quanxing Zhang | 2008 | Journal of Hazardous Materials2008，，1： | 1 |
| 8 | Adsorption of naphthalene onto the carbon adsorbent from waste ion exchange resin: Equilibrium and kinetic characteristics显示文摘 | Chao Long JunDong Lu Aimin Li Dabo Hu Fuqiang Liu Quanxing Zhang | 2007 | Journal of Hazardous Materials2007，，3： | 1 |
| 9 | Adsorption of reactive dyes onto polymeric adsorbents: effect of pore structure and surface chemistry group of adsorbent on adsorptive properties显示文摘 | Chao Long Zhaoyang Lu Aimin Li Wei Liu Zhenmao Jiang Jinlong Chen Quanxing Zhang | 2004 | Separation and Purification Technology2004，，1： | 1 |
| 10 | Adsorption of phenolic compounds from aqueous solutions by a water-compatible hypercrosslinked polymeric adsorbent显示文摘 | Aimin Li Quanxing Zhang Gencheng Zhang Jinlong Chen Zhenghao Fei Fuqiang Liu | 2002 | Chemosphere2002，，9： | 1 |
| 11 | Dual nanocomposite multihollow polymer microspheres prepared by suspension polymerization based on a multiple pickering emulsion显示文摘 | Quanxing Gao Chaoyang Wang Hongxia Liu etal | 2010 | Polymer Chemistry2010，1，： | 1 |
| 12 | Influence of infection rate and migration on extinction of disease in spatial epidemics显示文摘 | Guiquan Sun Quanxing Liu Zhen Jin | 2010 | Journal of Theoretical Biology2010，264，： | 1 |
| 13 | Blood Neutrophil–Lymphocyte Ratio Predicts Survival in Patients with Advanced Pancreatic Cancer Treated with Chemotherapy显示文摘 | Guopei Luo Meng Guo Zuqiang Liu Zhiwen Xiao Kaizhou Jin Jiang Long Liang Liu Chen Liu Jin Xu Quanxing Ni Xianjun Yu | 2015 | Annals of Surgical Oncology2015，，： | 1 |
| 14 | Molecular Mechanism Underlying Lymphatic Metastasis in Pancreatic Cancer显示文摘 | Zhiwen Xiao Guopei Luo Chen Liu Chuntao Wu Liang Liu Zuqiang Liu Quanxing Ni Jiang Long Xianjun Yu Sonshin Takao | 2014 | BioMed Research International2014，，： | 1 |
| 15 | Molecular Mechanism Underlying Lymphatic Metastasis in Pancreatic Cancer显示文摘 | Zhiwen Xiao Guopei Luo Chen Liu Chuntao Wu Liang Liu Zuqiang Liu Quanxing Ni Jiang Long Xianjun Yu Sonshin Takao | 2014 | BioMed Research International2014，，： | 1 |
| 16 | A New Amine-modified Hypercrosslinked Polymeric Adsorbent for Removing Phenolic Compounds from Aqueous Solutions显示文摘 | Aimin Li Quanxing Zhang Haisuo Wu Zhicai Zhai Fuqiang Liu Zhenghao Fei Chao Long Zhaolian Zhu Jinlong Chen | 2009 | Adsorption Science & Technology2009，，10： | 1 |
| 17 | Prehistoric damaging earthquake promoted the decline of'Heluo Ancient State'in Early China显示文摘The emergence of the'Ancient State'is considered an important stage in the discourse on human civilizations.Based on its complex and hierarchical social structure,the Shuanghuaishu site of Henan Province is regarded as an'Ancient state',specifically the'Heluo Ancient State'.The site is situated in the middle reaches of the Yellow River region and played a key role in prehistoric China.However,the reasons behind its decline are unclear.Here,we conducted an integrated investigation of the archaeological excavations and archaeoseismic analyses at the Shuanghuaishu site.We identified paleoseismic remains within paleo-artificial moats,which were formed owing to off-fault structures of soil liquefaction,hillslope landslides,and related ground fractures,along with shake-related wall disruption and building collapse in the residential zone.Charcoal dating was conducted to constrain the age for this earthquake event,which was determined to be approximately 5.0 cal kyr BP.Furthermore,based on the practical curve for earthquake-induced liquefaction,the preliminary estimate of the magnitude of this paleo seismic event is greater than M_(s)5.9-6.0.We propose that the Shuanghuaishu site experienced a recession after the earthquake event,which may have influenced the continuous development of the'Heluo Ancient State'as a regional center settlement. | Xiu HU Peng LU Youli LI Duowen MO Wanfa GU Qingri LIU Ailun GUO Panpan CHEN Hui WANG Yan TIAN Xu WANG Yayi HU Jiqin ZHANG Zhen WANG Quanxing LUO Junjie XU | 2023 | Science China Earth Sciences2023，66，5： | 0 |
| 18 | Glutamine deprivation induces ferroptosis in pancreatic cancer cells显示文摘Ferroptosis is a type of programmed cell death closely related to amino acid metabolism.Pancreatic cancer cells have a strong dependence on glutamine,which serves as a carbon and nitrogen substrate to sustain rapid growth.Glutamine also aids in self-protection mechanisms.However,the effect of glutamine on ferroptosis in pancreatic cancer remains largely unknown.Here,we aim to explore the association between ferroptosis and glutamine deprivation in pancreatic cancer.The growth of pancreatic cancer cells in culture media with or without glutamine is evaluated using Cell Counting Kit-8.Reactive oxygen species(ROS)are measured by 2′,7′-dichlorodihydrofluorescein diacetate staining.Ferroptosis is assessed by BODIPY-C11 dye using confocal microscopy and flow cytometry.Amino acid concentrations are measured using ultrahigh-performance liquid chromatography-tandem mass spectrometry.Isotope-labelled metabolic flux analysis is performed to track the metabolic flow of glutamine.Additionally,RNA sequencing is performed to analyse the genetic alterations.Glutamine deprivation inhibits pancreatic cancer growth and induces ferroptosis both in vitro and in vivo.Additionally,glutamine decreases ROS formation via glutathione production in pancreatic cancer cells.Interestingly,glutamine inhibitors(diazooxonorleucine and azaserine)promotes ROS formation and ferroptosis in pancreatic cancer cells.Furthermore,ferrostatin,a ferroptosis inhibitor,rescues ferroptosis in pancreatic cancer cells.Glutamine deprivation leads to changes in molecular pathways,including cytokine-cytokine receptor interaction pathways(CCL5,CCR4,LTA,CXCR4,IL-6R,and IL-7R).Thus,exogenous glutamine is required for the detoxification of ROS in pancreatic cancer cells,thereby preventing ferroptosis. | Zhiwen Xiao Shengming Deng He Liu Ruijie Wang Yu Liu Zhengjie Dai Wenchao Gu Quanxing Ni Xianjun Yu Chen Liu Guopei Luo | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 0 |
| 19 | Description of adsorption equilibrium of PAHs on hypercrosslinked polymeric adsorbent using Polanyi potential theory显示文摘In this research,static adsorption of three polycyclic aromatic hydrocarbons(PAHs),naphthalene,acenaphthene,and fluorene,from aqueous solutions onto hypercrosslinked polymeric adsorbent within the temperature range of 288-308 K is investigated.Several isotherm equations are correlated with the equilibrium data,and the experimental data is found to fit the Polanyi-Dubinin-Manes model best within the entire range of concentrations,providing evidence that pore-filling is the dominating sorption mechanism for PAHs.The study shows that the molecular size of adsorbates has distinct in-fluence on adsorption capacity of hypercrosslinked polymeric adsorbent for the PAHs;the larger the adsorbate molecular size,the lower the adsorption equilibrium capacity.Based on the Polanyi-Dubinin-Manes model,the molecular size of adsorbates was introduced to adjust the adsorbate molar volume.Plots of qv vs.(σε /Vs) are collapsed to a single correlation curve for different adsorbates on hypercrosslinked polymeric resin. | LONG Chao LI AiMin HU DaBo LIU FuQiang ZHANG QuanXing | 2008 | Science China Chemistry2008，51，6： | 0 |
| 20 | Attenuated plasmodium sporozoite expressing MAGE-A3 induces antigen-specific CD8+ T cell response against lung cancer in mice显示文摘Objective: Cancer vaccines that rely on tumor antigen-specific CD8^+ T cell responses, are promising anti-cancer adjuvant immunotherapies. This study investigated whether genetically attenuated Plasmodium sporozoite(GAS) could be used as a novel vector to induce antigen-specific CD8^+ T cell responses against lung cancer.Methods: We constructed GAS/MAGE-A3, a recombinant GAS engineered to express the lung cancer-specific antigen, melanomaassociated antigen 3(MAGE-A3), and assessed its therapeutic effects against lung cancer.Results: Robust parasite-specific CD8αlow CD11ahigh and CD49dhigh CD11ahigh CD4^+ T cell responses as well as a MAGE-A3-specific CD8^+ T cell response were induced in GAS/MAGE-A3-immunized mice. Adoptive transfer of GAS/MAGE-A3-induced CD8^+ T cells from HLA-A2 transgenic mice into lung cancer-bearing nude mice inhibited tumor growth and prolonged survival.Conclusions: These findings demonstrate that GAS/MAGE-A3 induces a strong MAGE-A3-specific CD8^+ T cell response against lung cancer in vivo, and indicate that GAS is a novel and efficacious antigen delivery vector for antitumor immunotherapy. | Dong Zhou Hong Zheng Quanxing Liu Xiao Lu Xufeng Deng Li Jiang Bing Hou Yong Fu Feng Zhu Yan Ding Wenyue Xu Jigang Dai | 2019 | Cancer Biology & Medicine2019，16，2： | 0 |
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