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| 1 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 2 | Auricular Acupuncture with Laser 显示文摘 | Regina R Gerhard L Frank B | 2013 | Evid Based Complement Ahernat Med2013，2013，98： | 1 |
| 3 | Making sense of safety显示文摘 | Regina B | 2005 | The Science Teacher2005，72，9： | 1 |
| 4 | Susceptibility to Vibrio cholerae Infection in a Cohort of Household Contacts of Patients with Cholera in Bangladesh显示文摘 | Jason B Harris Regina C LaRorocque Fahima Chowdhury | 2008 | Plos Neglected Tropical Diseases2008，2，4： | 1 |
| 5 | Role of mast cells and pro-inflammatory mediators on the intestinal secretion induced by cholera toxin显示文摘 | Marcos F.G Rocha José E.P Aguiar José J.C Sidrim Raimundo B Costa Regina F.G Feitosa Ronaldo A Ribeiro Aldo A.M Lima | 2003 | Toxicon2003，，2： | 1 |
| 6 | Follicular mucinosis, a critical reappraisal of clinicopathologic feature and association with mycosis fungoides and sezary syndrome 显示文摘 | Cerroni L Regina FP Back B | 2002 | Arch Dermatol2002，138，： | 1 |
| 7 | Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis显示文摘BACKGROUND Hepatitis C virus(HCV)infection is responsible for a chronic liver inflammation,which may cause end-stage liver disease and hepatocellular carcinoma.Apolipoprotein E(protein:ApoE,gene:APOE),a key player in cholesterol metabolism,is mainly synthesized in the liver and APOE polymorphisms may influence HCV-induced liver damage.AIM To determine whether APOE alleles affect outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation(OLT).METHODS This was a cohort study in which 179 patients,both genders and aged 34-70 years,were included before or after(up to 10 years follow-up)OLT.Liver injury severity was assessed using different criteria,including METAVIR and models for endstage liver disease.APOE polymorphisms were analyzed by quantitative real-time polymerase chain reaction.RESULTS The APOE3 allele was the most common(67.3%).In inflammation severity of biopsies from 89 OLT explants and 2 patients in pre-transplant,the degree of severe inflammation(A3F4,0.0%)was significantly less frequent than in patients with minimal and moderate degree of inflammation(≤A2F4,16.2%)P=0.048,in patients carrying the APOE4 allele when compared to non-APOE4.In addition,a significant difference was also found(≤A2F4,64.4%vs A3F4,0.0%;P=0.043)and(A1F4,57.4%vs A3F4,0.0%;P=0.024)in APOE4 patients when compared to APOE3 carriers.The fibrosis degree of the liver graft in 8 of 91 patients and the lack of the E4 allele was associated with more moderate fibrosis(F2)(P=0.006).CONCLUSION Our results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients. | José Carlos Rodrigues Nascimento Lianna C Pereira Juliana Magalhães C Rêgo Ronaldo P Dias Paulo Goberlânio B Silva Silvio Alencar C Sobrinho Gustavo R Coelho Ivelise Regina C Brasil Edmilson F Oliveira-Filho James S Owen Pierluigi Toniutto Reinaldo B Oriá | 2021 | World Journal of Gastroenterology2021，27，11： | 1 |
| 8 | Compliance with hepatitis B virus vaccination and risk of occupational exposure to blood and other body fluids in intensive care department personnel in Brazil显示文摘 | Vania F.C Manso Kézia F Castro Sirley M Matos Ana Luiza N Junqueira Sandra B Souza Márcia M Sousa Regina M.B Martins Sheila A Teles | 2003 | AJIC: American Journal of Infection Control2003，，7： | 1 |
| 9 | The use of mediation and ontology technologies for software component information retrieval显示文摘 | REGINA M M B MARA M CLAUDIA M L W | 2001 | ACM Sigsoft Software Engineering Notes2001，26，3： | 1 |
| 10 | Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis 显示文摘 | Jens-Michael J Regina FH Anke B | 2004 | J Invest Dermato12004，122，6： | 1 |
| 11 | Bactericidal activity of LFchimera is stronger and less sensitive to ionic strength than its constituent lactoferricin and lactoferrampin peptides显示文摘 | Jan G M B Regina A Kamran N | 2009 | Biochimie2009，91，： | 1 |
| 12 | Selenium in Biology: Facts and Medical Perspectives显示文摘 | Josef K?hrle Regina Brigelius-Flohé August B?ck Roland G?rtner Ortwin Meyer Leopold Flohé | 2000 | Biological Chemistry (-)2000，，9： | 1 |
| 13 | Activation of platelet-rich plasma using thrombin receptor agonist peptide 显示文摘 | Regina L Andrea B David P | 2005 | Oral Maxillofac Surg2005，63，4： | 1 |
| 14 | Multiple isoforms of starch branching enzyme-I in wheat:lack of the major SBE-I isoform does not alter starch phenotype显示文摘 | REGINA A KOSAR-HASHEMI B LI Z | 2004 | Funct Plant Biol2004，31，6： | 1 |
| 15 | A cross-sectional analysis of the prevalence of dental anxiety and its relation to the oral health-related quality of life in patients with dental treatment needs at a university clinic in Switzerland 显示文摘 | Vanessa G Renzo B Regina MS | 2012 | Gerodontology2012，29，1： | 1 |
| 16 | Mrp1 multidrug resistance-associated protein and P-glycoprotein expression in rat brain microvessel endothelial cells显示文摘 | Regina A Koman A Piciotti M El Hafny B Center MS Bergmann R Couraud PO Roux F | 1998 | J of Neurochem1998，71，： | 1 |
| 17 | Reduction of SO2 on different carbons 显示文摘 | Eduardo Humeres Moreira Regina F P M Peruch Maria da Oliria B | 2002 | Carbon2002，40，： | 1 |
| 18 | Effects of stareh synthase IIa gene dosage on grain, protein and starch in endosperm of wheat 显示文摘 | Konik-Rose C Thistleton J Chanvrier H Tan I Halley P Gidley hi Kosar-Hashemi B Wang H Larroque O Ikea J McMaugh S Regina A Rahman S Morell M Li Z | 2007 | Theoretical and Ap- plied Genetics2007，115，8： | 1 |
| 19 | NO synthesis inhibition decreases cortical Ach release and impairs retention of a conditioned response显示文摘 | Silvia R K Regina S B Reni K | 2001 | Brain Res2001，894，1： | 1 |
| 20 | Adipocyte differen- tiation:a transcriptional regulatory cascade显示文摘 | Regina P B Jae B K Hu E D | 1996 | Current Opinion in Cell Biology1996，8，6： | 1 |
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