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| 1 | Circulating inflammatory factors associated with worse long-term prognosis in colorectal cancer显示文摘AIM To investigate association of circulating inflammatory factors at the time of colorectal cancer(CRC) surgery with survival.METHODS Plasma levels from 174 CRC patients(69 females and 105 men), with median age 70 years(range 29-90), localized in the colon(n = 105) or rectum(n = 69), with stage Ⅰ(n = 24), stage Ⅱ(n = 54), stage Ⅲ(n = 67) and stage Ⅳ(n = 29) were measured using commercially available Bio-Plex Pro? Human Chemokine Panel 40-Plex, including 40 different chemokines, cytokines and interleukins. The prognostic association of each inflammatory factor was analysed as CRC-specific and total mortality.RESULTS Out of 174 patients, 66 died during the follow-up, 40 because of CRC specific mortality. High tertile levels of 8 factors were significantly associated with increased CRC-specific mortality, of which CCL1, CCL20, CCL24, CX3CL1, IL-4 and TNF-α remained significant in a multivariate Cox regression analysis. High tertile levels of 14 factors were associated with increased total mortality, of which CCL1, CCL15, CCL20, CX3CL1, CXCL13, IFN-γ, IL-2, IL-4 and IL-10 remained significant after adjustment for clinical covariates. For most of the inflammatory factors the association between higher tertile levels and an increased mortality in general appeared two years after surgery. High tertile levels of TNF-α and CCL24 were exclusively associated with CRC-specific mortality. The distribution of these factors were not associated with TNM stage with exception for CCL20.CONCLUSION High plasma levels of inflammatory factors are associated with increased risk of mortality among CRC patients and could be potential biomarkers for revealing prognosis. | Renate S Olsen Johnny Nijm Roland E Andersson Jan Dimberg Dick Wagsater | 2017 | World Journal of Gastroenterology2017，23，34： | 8 |
| 2 | Dynamical Shannon Entropy and Information Tsallis Entropy in Complex Systems显示文摘 | Renat M Y Natalya A E Faii M G | 2004 | Physica A:Statistical Mechanics and its Applications2004，341，： | 1 |
| 3 | Comparison of Al-induced gene expression in sensitive and tolerant soybean cultivar显示文摘 | Vladimir E Winfriede W Renate M | 2003 | Journal of Experiment Botany2003，54，： | 1 |
| 4 | Ex vivo gene transfer in the years to come显示文摘 | Thomas P Renate E G Ulf M | 2002 | Arthritis Res2002，4，： | 1 |
| 5 | The influence of green space on com- munity attachment of urban and suburban residents显示文摘 | ARNE A RENATE E | 2012 | Urban Forestry : Urban Greening2012，11，1： | 1 |
| 6 | Stress induced ethylene production,ethylene binding,and the response to the ethylene action inhibitor 1-MCP in miniature roses 显示文摘 | Renate Sisler E C Serek M | 2000 | Sci Hort2000，83，： | 1 |
| 7 | Gay and steffen Gay collagen autoantibodies in patients with vascullitis and systemic lupus erythematosus 显示文摘 | Larry W Moreland Renate E | 1991 | J Clin Immunol Imunopathol1991，60，3： | 1 |
| 8 | Active specific immunotherapy for stage II and stage III human colon cancer: a randomised trial显示文摘 | Jan B Vermorken Anke ME Claessen Harm van Tinteren Helen E Gall Renate Ezinga Sybren Meijer Rik J Scheper Chris JLM Meijer Elizabeth Bloemena Janet H Ransom Michael G Hanna Herbert M Pinedo | 1999 | The Lancet . 1999 (9150)1999，，9150： | 1 |
| 9 | Long-time survival with HIV-related pulmonary arterial hypertension: a case report显示文摘 | Serap Alp Renate Schlottmann Torsten T Bauer Wolfgang E Schmidt Andreas Bastian | 2003 | AIDS2003，，11： | 1 |
| 10 | Effects of Sex and Hormone Replacement Therapy Use on the Prevalence ofIsolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance in Subjects With a Family History of Type 2 Diabetes显示文摘 | Renate E Kristina M Jenny Tong | 2006 | Diabetes2006，12，55： | 1 |
| 11 | Two cellular mechanisms explain joint destruction显示文摘 | Gray S Renate E G William J K Mole cular and cellular mechanisms of joint destruction in rheumatoid arthritis | 1993 | Ann Rheum Dis1993，，： | 1 |
| 12 | Relations of Inflammatory Biomarkers and Common Genetic Variants With Arterial Stiffness and Wave Reflection显示文摘 | Renate Schnabel Martin G. Larson Josée Dupuis Kathryn L. Lunetta Izabella Lipinska James B. Meigs Xiaoyan Yin Jian Rong Joseph A. Vita Christopher Newton-Cheh Daniel Levy John F. Keaney Ramachandran S. Vasan Gary F. Mitchell Emelia J. Benjamin | 2008 | Hypertension2008，，6： | 1 |
| 13 | Minerals and trace elements in commercial infant food显示文摘 | Renate M Kristin G Lars E | 2008 | Food and Chemical Toxicology2008，46，10： | 1 |
| 14 | Dose glucagonlike peptide-I receptor agonist therapy add value in the treatment of type 2 diabetes? Focus on exenatide 显示文摘 | Renate E van Genugten Daniel H van Raalte | 2009 | Diabetes Research and Clinical Practice2009，86，： | 1 |
| 15 | Dynamical Shannon Entropy and Information Tsallis Entropy in Complex Systems显示文摘 | Renat M Y Natalya A E Fail M G | 2004 | Physica A: Statistical Mechanics and its Applications2004，341，： | 1 |
| 16 | Expression and function of EZH2 in synovial fibroblasts:epigenetic repression of the Wnt inhibitor SFRP1 in rheumatoid arthritis显示文摘 | MICHELLE T MATTHIAS B RENATE E G | 2011 | Ann Rheum Dis2011，70，： | 1 |
| 17 | IL-4 and IL-10 are both required for the induction of oral tolerance显示文摘 | Luiz V R Renate A M Nancy E M | 1999 | The Journal of Immunology1999，162，： | 1 |
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