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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Direct versus indirect line of sight(los) stabilization显示文摘 | KENNED Y P J RHONDA L | 2003 | IEEE Transactions on Control Systems Technology2003，11，： | 1 |
| 3 | Mitochondrial DNA sequence heteroplasmy in the Grand Duke of Russia Georgij Romanov establishes the authenticity of the remains of Tsar Nicholas II显示文摘 | Pavel L I Mark J W Rhonda K R | 1996 | Nat Genet1996，12，： | 1 |
| 4 | A review of operations management studies using scale development techniques显示文摘 | Rhonda L Hensley | 1999 | Journal of Operations Management1999，17，： | 1 |
| 5 | Safety, tolerability, and antibody responses in humans after sequential immunization with a PfCSP DNA vaccine followed by the recombinant protein vaccine RTS,S/AS02A显示文摘 | Judith E Epstein Yupin Charoenvit Kent E Kester Ruobing Wang Rhonda Newcomer Steve Fitzpatrick Thomas L Richie Nadia Tornieporth D.Gray Heppner Chris Ockenhouse Victoria Majam Carolyn Holland Esteban Abot Harini Ganeshan Mara Berzins Trevor Jones C.Nicole | 2004 | Vaccine2004，，13： | 1 |
| 6 | Direct Versus Indirect Line of Sight (LOS) Stabilization显示文摘 | Peter J Kennedy Rhonda L Kennedy | | 0，，01： | 1 |
| 7 | Strategic Supply chain Planning显示文摘 | Rhonda R Lummus Robert J Vokurka Karen L Alber | 1998 | Production & Inventory Management Journal1998，39，3： | 1 |
| 8 | CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression显示文摘 | Brown Rhonda L Reinke Lauren M Damerow Marin S Perez Denise Chodosh Lewis A Yang Jing Cheng Chonghui | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 9 | Rela- tionships among internet use, personality and social support 显示文摘 | Rhonda J Swickert James B Hittner Jamic L Harris | 2002 | Computer in human behavior2002，，18： | 1 |
| 10 | Estimating the relationship be- tween measured wind speed and overturning truck cra- shes using a binary logic model显示文摘 | Rhonda K Y Joel L | 2007 | Accident Analysis and Prevention2007，39，3： | 1 |
| 11 | Silica sol as a nanoglue: flexible synthesis of composite aerogels显示文摘 | Morris Catherine A Anderson Michele L Stroud Rhonda M | 1999 | Science1999，284，： | 1 |
| 12 | Direct versus indirect line of sight(los) stabilization显示文摘 | KENNEDY P J RHONDA L | 2003 | IEEE Transactions on Control Systems Technology2003，11，： | 1 |
| 13 | Intermittent PTH(1–84) is osteoanabolic but not osteoangiogenic and relocates bone marrow blood vessels closer to bone‐forming sites显示文摘 | Rhonda Prisby Alain Guignandon Arnaud Vanden‐Bossche Fabrice Mac‐Way Marie‐Thérèse Linossier Mireille Thomas Norbert Laroche Luc Malaval Max Langer Zoltz‐Andrei Peter Fran?oise Peyrin Laurence Vico Marie‐Hélène Lafage‐Proust | 2011 | J Bone Miner Res2011，，11： | 1 |
| 14 | Direct Versus Indirect Line of Sight(LOS) Stabilization显示文摘 | Kennedy Peter J Kennedy Rhonda L | 2003 | IEEE Transactions on ControlSystems Technology2003，11，1： | 1 |
| 15 | The Relative Importance of Food, Atmosphere, and Fairness of Wait, The Case of a Full-service RestmJrant 显示文摘 | Joanne M S Rhonda L H | 2004 | Cornell Hotel and Restaurant Administration Quarterly2004，45，3： | 1 |
| 16 | The Influence of Cotyledons in Axillay and Adventitious Shoot Rroduction from Cotyledonaty Nodes of Cucumis satvus L(cucumber)显示文摘 | Rhonda L Gambley WA Dodd | 1991 | Exp Bot1991，42，242： | 1 |
| 17 | CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression显示文摘 | Brown Rhonda L Reinke Lauren M Damerow Marin S Perez Denise Chodosh Lewis A Yang Jing Cheng Chonghui | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 18 | The meaning of hope and social support in patients receiving chemotherapy显示文摘 | Mattioli Jennifer L Repinski Rhonda Chappy Sharon L | 2008 | Oncology Nursing Forum2008，35，5： | 1 |
| 19 | The meaning of hope and social support in patients receiving chemotherapy显示文摘 | Mattioli Jennifer L Repinski Rhonda Chappy Sharon L | 2008 | Oncology Nursing Forum2008，35，5： | 1 |
| 20 | Comparison of Effects of Nisoldipine -Extended Release and Amlodipine in Patients With Systemic Hypertension and Chronic Stable Angina Pectoris显示文摘 | Carl J Pepine Rhonda M Cooper-DeHoff Robert J Weiss Michael Koren Neville Bittar Udho Thadani Margaret C Minkwitz Eric L Michelson Howard G Hutchinson | 2003 | The American Journal of Cardiology2003，，3： | 1 |
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