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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial显示文摘 | Eric Lawitz Fred F Poordad Phillip S Pang Robert H Hyland Xiao Ding Hongmei Mo William T Symonds John G McHutchison Fernando E Membreno | 2013 | The Lancet2013，，： | 5 |
| 4 | High-speed burst-mode packet-capable optical receiver and instant aneous clock recivery for optical bus opreation显示文摘 | Yusuke O Robert G S | 1994 | Journal of Lightwave Technology1994，12，2： | 2 |
| 5 | Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection显示文摘AIM: To test antibiotic-loaded coating for efficacy in reducing bacterial biofilm and development of osteomyelitis in an orthopaedic model of implant infection. METHODS: Phosphatidylcholine coatings loaded with 25% vancomycin were applied to washed and sterilized titanium wires 20 mm in length. A 10 mm segment was removed from rabbit radius(total = 9; 5 coated, 4 uncoated), and the segment was injected with 1 × 106 colony forming units(CFUs) of Staphylococcus aureus(UAMS-1 strain). Titanium wires were inserted throughthe intramedullary canal of the removed segment and into the proximal radial segment and the segment was placed back into the defect. After 7 d, limbs were removed, X-rayed, swabbed for tissue contamination. Wires were removed and processed to determine attached CFUs. Tissue was swabbed and streaked on agar plates to determine bacteriological score.RESULTS: Antibiotic-loaded coatings resulted in significantly reduced biofilm formation(4.7 fold reduction in CFUs; P < 0.001) on titanium wires and reduced bacteriological score in surrounding tissue(4.0 ± 0 for uncoated, 1.25 ± 0.5 for coated; P = 0.01). Swelling and pus formation was evident in uncoated controls at the 7 d time point both visually and radiographically, but not in antibiotic-loaded coatings.CONCLUSION: Active antibiotic was released from coated implants and significantly reduced signs of osteomyelitic symptoms. Implant coatings were well tolerated in bone. Further studies with additional control groups and longer time periods are warranted. Antibiotic-loaded phosphatidylcholine coatings applied at the point of care could prevent implant-associated infection in orthopaedic defects. | Jessica Amber Jennings Karen E Beenken Robert A Skinner Daniel G Meeker Mark S Smeltzer Warren O Haggard Karen S Troxel | 2016 | World Journal of Orthopedics2016，7，8： | 2 |
| 6 | Aggressive surgery for metastatic liver neuroendocrine tumors显示文摘 | Jeffrey A Norton Robert S Warren Mary G Kelly Marlene B Zuraek Robert T Jensen | 2003 | Surgery2003，，： | 2 |
| 7 | Biogenic gas(CH4, N2O, DMS) emission to the atmosphere from near-shore of the North-Western Black Sea显示文摘 | Amouroux D Roberts G Rapsomanikis S | 2002 | Estuarine Coastal & Shelf Science2002，54，3： | 1 |
| 8 | Measurement of the equivalent dose in quartz using a regenerative-dose single aliquot protocol 显示文摘 | Murray A S Roberts R G | 1998 | Radiation Measurements1998，29，： | 1 |
| 9 | A Com- bined Uninterruptible Power Supply and Dynamic Voltage Compensa- tor Using a Flywheel Energy Storage System 显示文摘 | Robert S Weissbach George G Karady Richard G Farmer | 2001 | Transaction on Power Delivery2001，16，2： | 1 |
| 10 | Effects of stunting, diarrhoeal disease, and parasitic infection during infancy on cognition in late childhood: a follow-up study显示文摘 | Douglas S Berkman Andres G Lescano Robert H Gilman Sonia L Lopez Maureen M Black | 2002 | The Lancet2002，，9306： | 1 |
| 11 | Statins and sepsis: multiple modifications at multiple levels显示文摘 | Marius Terblanche Yaniv Almog Robert S Rosenson Terry S Smith Daniel G Hackam | 2007 | The Lancet Infectious Diseases2007，，5： | 1 |
| 12 | Exploring Variation in Active Network Size: Constraints and Ego Characteristics 显示文摘 | Roberts S G B Dunbar R I M Pollet T V | 2009 | Social Networks2009，31，2： | 1 |
| 13 | Waters, national occupational research agenda (NORA) future directions in occupational musculoskeletal disorder health research 显示文摘 | William S Marras Robert G Cutlip Susan E Burt | 2009 | AppliedErgonomics2009，40，： | 1 |
| 14 | Calcineurin controls growth,morphology,and pathogenicity in Aspergillus fumigatus显示文摘 | William J S Robert A C Yohannes G A | 2006 | Eukaryotic Cell2006，5，7： | 1 |
| 15 | All Current-Mode Frequency Selective Circuits显示文摘 | ROBERTS G W SEDRA A S | 1989 | Electronics Letters1989，25，12： | 1 |
| 16 | Treatment of colon and lung cancer patients with ex vivo heat shock protein 70 peptide-activa- ted autologous natural killer cells~ a clinical phase I trial显示文摘 | Stefan S Krause W Robert G | 2004 | Clin Cancer Res2004，10，1： | 1 |
| 17 | Ectopic bone for- mation by 3D porous calcium phosphate-Ti6A14V hybrids produced by perfusion electrodeposition显示文摘 | Chai Y C Kerckhofs G Roberts S J | 2012 | Biomaterials2012，33，16： | 1 |
| 18 | Positive Performance states of athletes: Toward a conceptual understanding of peak performance显示文摘 | Jackson S A Robert G C | 1992 | The Sport Psychologist1992，6，1： | 1 |
| 19 | Determinants of isotopic coupling of CO2 and water vapour within a Quercus petraea forest canopy 显示文摘 | Harwood K G Gillon J S Roberts A | 1999 | Oecologia1999，119，1： | 1 |
| 20 | The value of fast fashion: quick response, enhanced design, and strategic consumer behavior 显示文摘 | CACHON G P ROBERT S | 2011 | Management Science2011，57，4： | 1 |
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