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| 1 | Cell-based drug delivery systems for biomedical applications显示文摘 | Teng Li He Dong Can Zhang Ran Mo | 2018 | Nano Research2018，11，10： | 3 |
| 2 | Collaborative assembly-mediated siRNA delivery for relieving inflammation-induced insulin resistance显示文摘Obesity plays a primary causative role in insulin resistance and hyperglycemia that contributes to type 2 diabetes.Excess lipid storage in the liver renders activation of the resident macrophages and chronic secretion of inflammatory mediators,therefore causing or aggravating insulin resistance.Herein,we develop collaborative assemblies using a“one-pot”synthesis method for macrophage-specific delivery of small interfering RNAs(siRNAs)that target the inflammatory proteins.Ternary nanocomplex(NC)composed of the siRNA molecule,a synthetic thiol-bearing methacrylated hyaluronic acid(sm-HA)and protamine forms through an electrostatic-driven physical assembly,which is chemically crosslinked to acquire the collaboratively assembled nanocapsule(cNC)concurrently.The obtained cNC displays significantly higher stability than NC.Functional moieties as flexible assembly units can be easily equipped on cNC for long circulation,active targeting,or controlled siRNA release.cNC-F decorated with folic acid,a macrophage-targeting ligand promotes the siRNA accumulation in the activated macrophages in the liver of the obese mouse model.cNC-F loaded with siRNA targeting inflammatory indicators efficiently control the macrophage inflammatory response by reducing the expression of the inflammatory proteins(>40%reduction)and ameliorating the insulin resistance symptoms of the obese mice. | Shiyang Shen Li Zhang Mengru Li Zhizi Feng Huixia Li Xiao Xu Shiqi Lin Ping Li Can Zhang Xiaojun Xu Ran Mo | 2020 | Nano Research2020，13，11： | 2 |
| 3 | 1-Pbps orbital angular momentum fibre-optic transmission显示文摘Space-division multiplexing(SDM),as a main candidate for future ultra-high capacity fibre-optic communications,needs to address limitations to its scalability imposed by computation-intensive multi-input multi-output(MIMO)digital signal processing(DSP)required to eliminate the crosstalk caused by optical coupling between multiplexed spatial channels.By exploiting the unique propagation characteristics of orbital angular momentum(OAM)modes in ring core fibres(RCFs),a system that combines SDM and C+L band dense wavelength-division multiplexing(DWDM)in a 34 km 7-core RCF is demonstrated to transport a total of 24960 channels with a raw(net)capacity of 1.223(1.02)Peta-bit s−1(Pbps)and a spectral efficiency of 156.8(130.7)bit s−1 Hz−1.Remarkably for such a high channel count,the system only uses fixed-size 4×4 MIMO DSP modules with no more than 25 time-domain taps.Such ultra-low MIMO complexity is enabled by the simultaneous weak coupling among fibre cores and amongst non-degenerate OAM mode groups within each core that have a fixed number of 4 modes.These results take the capacity of OAM-based fibre-optic communications links over the 1 Pbps milestone for the first time.They also simultaneously represent the lowest MIMO complexity and the 2nd smallest fibre cladding diameter amongst reported few-mode multicore-fibre(FM-MCF)SDM systems of>1 Pbps capacity.We believe these results represent a major step forward in SDM transmission,as they manifest the significant potentials for further up-scaling the capacity per optical fibre whilst keeping MIMO processing to an ultra-low complexity level and in a modularly expandable fashion. | Junyi Liu Jingxing Zhang Jie Liu Zhenrui Lin Zhenhua Li Zhongzheng Lin Junwei Zhang Cong Huang Shuqi Mo Lei Shen Shuqing Lin Yujie Chen Ran Gao Lei Zhang Xiaobo Lan Xinlun Cai Zhaohui Li Siyuan Yu | 2022 | Light(Science & Applications)2022，11，8： | 1 |
| 4 | Effect of non -invasive positive pressure ventilation (NIPPV) onmortality in patients with acute cardiogenic pulmonary oedema: a meta-analysis显示文摘 | Peter J V Mo ran J L Phillips-Hughes J | 2006 | Lancet2006，367，9517： | 1 |
| 5 | A nano-silver inkjet conductive ink with excellent adhesion显示文摘 | Ran Jun Mo Lixin Li Wenbo | 2013 | Applied Mechanics and Materials2013，262，： | 1 |
| 6 | Clinical features and predictors of clinical outcomes in K orean patients with C rohn’s disease: A K orean A ssociation for the S tudy of I ntestinal D iseases multicenter study显示文摘 | Chang Mo Moon Dong Il Park Eun Ran Kim Young‐Ho Kim Chang Kyun Lee Suck‐Ho Lee Jae Hak Kim Kyu‐Chan Huh Sung‐Ae Jung Soon Man Yoon Hyun Joo Song Hyun Joo Jang You Sun Kim Kang‐Moon Lee Jeong Eun Shin | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 7 | The concentration of deepsea gas hydrates from down hole electrical resistivity logs andlaboratory data显示文摘 | Hyndman R D Yuan T Mo ran K | 1999 | Earth and Planetary Science Letters1999，172，： | 1 |
| 8 | Estimating crop water deficit using the relation between surface air temperature and spectral vegetation index 显示文摘 | Mo ran M S Clarke T R Inoue Y | 1994 | Remote Sensing of Environment1994，49，： | 1 |
| 9 | The mechanism of enhancement on oral absorption of paclitaxel by N-octyl-O-sulfate chitosan micelles显示文摘 | Ran Mo Xiang Jin Nan Li Caoyun Ju Minjie Sun Can Zhang Qineng Ping | 2011 | Biomaterials2011，，20： | 1 |
| 10 | Quality and Internal characteristics of Huanghua pears treated with different kind of coating during storage 显示文摘 | Zhou Ran Mo Yun | 2008 | Posthavarvest Biology and Technology2008，，49： | 1 |
| 11 | Quality and internal characteristics of Huanghua pears ( Pyrus pyrifolia Nakai, cv. Huanghua) treated with different kinds of coatings during storage显示文摘 | Ran Zhou Yun Mo Yunfei Li Yanyun Zhao Guixiang Zhang Yunsheng Hu | 2007 | Postharvest Biology and Technology2007，，1： | 1 |
| 12 | Aged hematopoietic stem cells entrap regulatory T cells to create a prosurvival microenvironment显示文摘Although DNA mutation drives stem cell aging,how mutation-accumulated stem cells obtain clonal advantage during aging remains poorly understood.Here,using a mouse model of irradiation-induced premature aging and middle-aged mice,we show that DNA mutation accumulation in hematopoietic stem cells(HSCs)during aging upregulates their surface expression of major histocompatibility complex class II(MHCII).MHCII upregulation increases the chance for recognition by bone marrow(BM)-resident regulatory T cells(Tregs),resulting in their clonal expansion and accumulation in the HSC niche.On the basis of the establishment of connexin 43(Cx43)-mediated gap junctions,BM Tregs transfer cyclic adenosine monophosphate(cAMP)to aged HSCs to diminish apoptotic priming and promote their survival via activation of protein kinase A(PKA)signaling.Importantly,targeting the HSC–Treg interaction or depleting Tregs effectively prevents the premature/physiological aging of HSCs.These findings show that aged HSCs use an active self-protective mechanism by entrapping local Tregs to construct a prosurvival niche and obtain a clonal advantage. | Weinian Liao Chaonan Liu Ke Yang Jun Chen Yiding Wu Shuzhen Zhang Kuan Yu Lisha Wang Li Ran Mo Chen Fang Chen Yang Xu Song Wang Fengchao Wang Qian Zhang Jinghong Zhao Lilin Ye Changhong Du Junping Wang | 2023 | Cellular & Molecular Immunology2023，20，10： | 0 |
| 13 | A New Route for the Rapid Synthesis of Metal–Organic Frameworks at Room Temperature显示文摘Rapid synthesis of metal–organic frameworks(MOFs),especially high-valence MOFs at roomtemperature without external energy,is a challenging topic.In this work,a stable radical solution has been discovered.Various MOFs with versatile metal nodes and ligands were rapidly synthesized at room temperature in the absence of external energy.Especially,MOFs with conjugated ligands achieved instantaneous architecture(in less than 1 s)and quantitative yield.Radicals in the solution play a crucial role in the accelerated kinetics,and the new radical route paves a cyclic pathway for the MOF synthesis.The mechanism has been thoroughly investigated by electron paramagnetic resonance,in situ proton nuclear magnetic resonance,X-ray absorption spectra,in situ small-angle X-ray scattering-wide-angle X-ray scattering,and density functional theory calculations. | Pei Zhang Xinchen Kang Liming Tao Lirong Zheng Junfeng Xiang Ran Duan Jikun Li Peng Chen Xueqing Xing Guang Mo Zhonghua Wu Buxing Han | 2023 | CCS Chemistry2023，5，6： | 0 |
| 14 | Infection of wild-type mice by SARS-CoV-2 B.1.351 variant indicates a possible novel cross-species transmission route显示文摘COVID-19 is identified as a zoonotic disease caused by SARS-CoV-2,which also can cross・transmit to many animals but not mice.Genetic modifications of SARS-CoV-2 or mice enable the mice susceptible to viral infection.Although neither is the natural situation,they are currently utilized to establish mouse infection models.Here we report a direct contact transmission of SARS-CoV-2 variant B.1.351 in wild-type mice.The SARS-CoV-2(B.1.351)re plicated efficiently and induced significant pathological changes in lungs and tracheas,accompanied by elevated proinflammatory cytokines in the lungs and sera.Mechanistically,the receptor-binding domain(RBD)of SARS-CoV-2(B.1.351)spike protein turned to a high binding affinity to mouse angiotensin-converting enzyme 2(mACE2),allowing the mice highly susceptible to SARS-CoV-2(B.1.351)infection.Our work suggests that SARS-CoV-2(B.1.351)expands the host range and therefore increases its transmission route without adapted mutation.As the wild house mice live with human populations quite closely,this possible transmission route could be potentially risky.In addition,because SARS-CoV-2(B.1.351)is one of the major epidemic strains and the mACE2 in laboratory-used mice is naturally expressed and regulated,the SARS-CoV-2(B.1.351)/mice could be a much convenient animal model system to study COVID-19 pathogenesis and evaluate antiviral inhibitors and vaccines. | Ting Pan Ran Chen Xin He Yaochang Yuan Xiaohui Deng Rong Li Haiping Yan Shumei Yan Jun Liu Yiwen Zhang Xiantao Zhang Fei Yu Mo Zhou Changwen Ke Xiancai Ma Hui Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 15 | Synthesis of ultrafine dual-phase structure in CrFeCoNiAl_(0.6)high entropy alloy via solid-state phase transformation during sub-rapid solidification显示文摘High entropy alloys(HEAs)with superb mechanical properties have been traditionally produced by solid-ification and subsequent heat treatment,In this paper,we demonstrate a new route via one-step process using sub-rapid cooling.Under proper cooling rates,the CrFeCoNiAl^(0.6) HEA could form ultrafineFCC+BCC dual-phase structure.By varying cooling rate,we can control the fraction of the BCC phaseand refinement of FCC microstructures that have tunable mechanical properties in yield strength and hardness ranging from~580 to~1460 MPa and~260 to~550 Hv.We show that the structure-property-processing relation originates from the sideplate microstructures formed during fast cooling that havespecific crystallographic orientation relationship between the FCC and BCC phases and chemical segrega tion.This work provides a new setting for better understanding of the solid-state phase transformation in HEAs under sub-rapid solidification conditions as well as a novel method for development of high-performance HEAs. | Chen Chen Yanzhou Fan Wei Wang Hang Zhang Jialiang Hou Ran Wei Tao Zhang Tan Wang Mo Li Shaokang Guan Fushan Li | 2022 | Journal of Materials Science & Technology2022，，18： | 0 |
| 16 | Mid1ip1b modulates apical reorientation of non-centrosomal microtubule organizing center in epithelial cells显示文摘In most kinds of animal cells,the centrosome serves as the main microtubule organizing center(MTOC)that nucleates microtubule arrays throughout the cytoplasm to maintain cell structure,cell division and intracellular transport.Whereas in epithelial cells,non-centrosomal MTOCs are established in the apical domain for generating asymmetric microtubule fibers and cilia in epithelial cells for the organ morphogenesis during embryonic development.However,the mechanism by which MTOCs localize to the apical domain in epithelial cells remains largely unknown.Here,we show that Mid1ip1b has a close interaction with g-tubulin protein,the central component of MTOC,and modulates lumen opening of the neural tube,gut,intestine,and kidney of zebrafish.Knockdown or dominant negative effect of Mid1ip1b resulted in failure of lumen formation of the organs as aforementioned.Moreover,the non-centrosomal MTOCs were unable to orientate to the apical domain in Mid1ip1b knockdown epithelial cells,and the centrosomal MTOCs were inaccurately placed in the apical domain,resulting in defective formation of asymmetric microtubules and misplacement of cilia in the apical domain.These data uncover a molecule that controls the proper localization of MTOCs in the apical domain in epithelial cells for organ morphogenesis during embryonic development. | Xin Zhou Chun Xiao Yu Li Yanna Shang Dongqin Yin Siying Li Bo Xiang Ran Lu Yi Ji Yang Wu Wentong Meng Hongyan Zhu Jin Liu Huozhen Hu Xianming Mo Hong Xu | 2018 | Journal of Genetics and Genomics2018，45，8： | 0 |
| 17 | An endolysin gene from Candidatus Liberibacter asiaticus confers dual resistance to huanglongbing and citrus canker显示文摘The most damaging citrus diseases are Huanglongbing(HLB)and citrus canker,which are caused by Candidatus Liberibacter asiaticus(CaLas)and Xanthomonas citri pv.citri(Xcc),respectively.Endolysins from bacteriophages are a possible option for disease resistance in plant breeding.Here,we report improvement of citrus resistance to HLB and citrus canker using the LasLYS1 and LasLYS2 endolysins from CaLas.LasLYS2 demonstrated bactericidal efficacy against several Rhizobiaceae bacteria and Xcc,according to inhibition zone analyses.The two genes,driven by a strong promoter from Cauliflower mosaic virus,35S,were integrated into Carrizo citrange via Agrobacterium-mediated transformation.More than 2 years of greenhouse testing indicated that LasLYS2 provided substantial and long-lasting resistance to HLB,allowing transgenic plants to retain low CaLas titers and no obvious symptoms while also clearing CaLas from infected plants in the long term.LasLYS2 transgenic plants with improved HLB resistance also showed resistance to Xcc,indicating that LasLYS2 had dual resistance to HLB and citrus canker.A microbiome study of transgenic plants revealed that the endolysins repressed Xanthomonadaceae and Rhizobiaceae populations in roots while increasing Burkholderiaceae and Rhodanobacteraceae populations,which might boost the citrus defense response,according to transcriptome analysis.We also found that Lyz domain 2 is the key bactericidal motif of LasLYS1 and LasLYS2.Four endolysins with potential resistance to HLB and citrus canker were found based on the structures of LasLYS1 and LasLYS2.Overall,the work shed light on the mechanisms of resistance of CaLas-derived endolysins,providing insights for designing endolysins to develop broad-spectrum disease resistance in citrus. | Lanzhen Xu Kaiqing Mo Danlu Ran Juanjuan Ma Lehuan Zhang Yijia Sun Qin Long Guojin Jiang Xiaochun Zhao Xiuping Zou | 2023 | Horticulture Research2023，10，9： | 0 |
| 18 | Neurons generated from carcinoma stem cells support cancerprogression显示文摘Recent evidences show that nervous system acts as a crucial part of cancer microenvironment.Infiltration of nerve fibers into cancer microenvironment has an important active role in cancer progression.The stimulations of both cancer growth and metastasis by members of nervous system such as neurons and glial cells have been demonstrated.However,how the nervous system is built in cancer is largely unknown.Here we show that a fraction of cancer stem cells(CSCs)derived from patients with gastric carcinoma and colorectal carcinoma are capable of producing neurons that are involved in tumor neurogenesis and tumor growth.Cancer stem cell monoclone derived from a single cancer stem cell was able to generate neurons including sympathetic and parasympathetic neurons to take part in the nervous system in cancer tissues.Knocking down the neural cell generating capability of the human CSCs inhibited the growth of xenograft tumors in mouse model.Our data demonstrate that human CSCs are able to produce one of most important components in the cancer microenvironment that are required for cancer development and progression. | Ran Lu Chuanwen Fan Wenqi Shangguan Yuan Liu Yu Li Yanna Shang Dongqin Yin Shengliang Zhang Qiaorong Huang Xue Li Wentong Meng Hong Xu Zongguang Zhou Jiankun Hu Weimin Li Lunxu Liu Xianming Mo | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 0 |
| 19 | Incorporation of a Toll-like receptor 2/6 agonist potentiates mRNA vaccines against cancer and infectious diseases显示文摘mRNA vaccines have emerged rapidly in recent years as a prophylactic and therapeutic agent against various diseases including cancer and infectious diseases.Improvements of mRNA vaccines have been underway,among which boosting of efficacy is of great importance.Pam2Cys,a simple synthetic metabolizable lipoamino acid that signals through Toll-like receptor(TLR)2/6 pathway,eliciting both humoral and cellular adaptive immune responses,is an interesting candidate adjuvant.To investigate the enhancement of the efficacies of mRNA vaccines by Pam2Cys,the adjuvant was incorporated into mRNA-lipid nanoparticles(LNPs)to achieve co-delivery with mRNA.Immunization with the resulting mRNA-LNPs(Pam2Cys)shaped up the immune milieu in the draining lymph nodes(dLNs)through the induction of IL-12 and IL-17,among other cytokines.Antigen presentation was carried out mainly by migratory and dLNresident conventional type 2 DCs(cDC2s)and significantly more potent antitumor responses were triggered in both prophylactic and therapeutic tumor models in a CD4^(+) and CD8^(+) T cell-dependent fashion.Accompanying memory antitumor immunity was also established.Moreover,the vaccine also stimulated much more robust humoral and cellular immunity in a surrogate COVID-19 prophylactic model.Last but not the least,the new vaccines exhibited good preliminary safety profiles in murine models.These facts warrant future development of Pam2Cys-incorporated mRNA vaccines or relevant mRNA therapeutics for clinical application. | Yangzhuo Gu Jingyun Yang Cai He Tingmei Zhao Ran Lu Jian Liu Xianming Mo Fuqiang Wen Huashan Shi | 2023 | Signal Transduction and Targeted Therapy2023，8，8： | 0 |
| 20 | In-situ TEM study on the evolution of dislocation loops and bubbles in CeO_(2)during Kr^(+)single-beam and Kr^(+)-H_(2)^(+)dual-beam synergetic irradiation显示文摘CeO_(2)is widely used as the nonradioactive surrogate fuel of UO_(2)when studying the irradiation performance of UO_(2).The evolution and characteristics of dislocation loops and bubbles in CeO_(2)foils were studied by in-situ transmission electron microscopy(TEM)observation during 400 ke V Kr^(+)&30 ke V H_(2)^(+)dual-beam synergetic irradiation and 400 ke V Kr^(+)single-beam irradiation at 1073 K.The rotation of the habit plane of dislocation loops induced by above ion irradiation was found in the CeO_(2)for the first time,such as from[211]to[311]and then to[100].The rafted loops were first observed under Kr^(+)&H_(2)^(+)dual-beam synergetic irradiation,which not only had similar[111]direction,but also belonged to perfect dislocation loops(PDLs).The rafted loops were formed not only by the growth of loops that absorbed irradiation defects,but also by the combination of loops.But,this phenomenon of loop rafting was not obvious during Kr single-beam irradiation.It was first found that Kr^(+)irradiation induced the change of Burgers vectors of PDLs.The absorption of large PDLs to small PDLs was also observed.The average size and areal number density of dislocation loops and gas bubbles as a function of irradiation dose were constructed,which showed that the addition of H_(2)^(+)obviously affected the characteristics of dislocation loops and gas bubbles and the swelling of CeO_(2). | Ziqi Cao Guang Ran Zhen Wang Yipeng Li Xiaoyong Wu Lu Wu Xiuyin Huang Huajun Mo | 2022 | Journal of Materials Science & Technology2022，，28： | 0 |
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