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| 1 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 2 | Inheritance of tomato late blight resistance derived from LA1033 and identification of molecular markers 显示文摘 | Rebecca C R | 2001 | nort-Science2001，35，3： | 1 |
| 3 | A comparison of chemical pretreatment methods for improving saceharification of cotton stalks显示文摘 | Rebecca A S Ye C Ratna R | 2007 | Bioresource Technology2007，98，16： | 1 |
| 4 | Metronomic therapy for refractory/relapsed lymphoma:The PEP-C low-dose oral combination chemotherapy regimen显示文摘 | Morton C Gia R Rebecca L | 2012 | Hematology2012，17，： | 1 |
| 5 | Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis 显示文摘 | Kerrie B Todd C S Rebecca B R | 2005 | Carcinogenesis2005，26，： | 1 |
| 6 | Structural basis of caspase inhibition by XIAP:differential roles of linker versus the BIR domain显示文摘 | Huang Y Park Y C Rebecca L R | 2001 | Cell2001，104，5： | 1 |
| 7 | Palmitoylation and trafficking of GAD65 are impaired in a cellular model of Huntington' s disease显示文摘 | Daniel B R Rebecca T L Mark H M C | 2012 | Bioehem J2012，442，1： | 1 |
| 8 | Live Tissue Intrinsic Emission Microscopy Using Multiphoton Excited Native Fluorescence and Second Harmonic Generation 显示文摘 | ZIPFEL W R REBECCA M W RICHARD C | 2003 | Proc Natl Acad Sci2003，100，12： | 1 |
| 9 | Programming infant gut microbiota: influence of dietary and environmental factors显示文摘 | Tatiana Milena Marques Rebecca Wall R Paul Ross Gerald F Fitzgerald C Anthony Ryan Catherine Stanton | 2010 | Current Opinion in Biotechnology2010，，2： | 1 |
| 10 | Evaluation of achromogenic agar for detection of group B Streptococcus inpregnant women 显示文摘 | Robin R C Carol J W Rebecca A J | 2010 | J Clin Microbiol2010，48，9： | 1 |
| 11 | Micropropagation of Gymea Lily (Doryanthes excelsa Corr(e)a) from New South Wales,Australia显示文摘 | ADAM M R C REBECCA F | 2007 | Plant Cell Tiss Organ Cult2007，88，2： | 1 |
| 12 | Prevalence of transmitted drug resistance associated mutations and HIV-1 subtypes in new HIV-1 diagnoses, U.S.–2006显示文摘 | William H Wheeler Rebecca A Ziebell Helena Zabina Danuta Pieniazek Joseph Prejean Ulana R Bodnar Kristen C Mahle Walid Heneine Jeffrey A Johnson H Irene Hall | 2010 | AIDS2010，，8： | 1 |
| 13 | Antigenic and genetic characteristics of swine - origin 2009 A ( HI N1 ) influenza viruses circulating in humans 显示文摘 | REBECCA J G TODD C D COLIN A R | 2009 | Science2009，22，： | 1 |
| 14 | Inheritance of tomato late blight resistance derived from Lycopersicon esculentum LA1033 and identification of Molecular markers 显示文摘 | Rebecca C L Garbner R G | 2001 | Hort Science2001，35，3： | 1 |
| 15 | Zinc protoporphyrin/heme ratio for diagnosis of preanemic iron deficiency 显示文摘 | REBECCA L TIMOTHY R H MAURICE C L | 1999 | Pediatrics1999，104，3： | 1 |
| 16 | Inheritance of tomato late blight resistance derived from Lycopersicon esculentum LA1033 and identification of Molecular makers显示文摘 | REBECCA C L GARBNER R G | 2001 | Hort Science2001，35，3： | 1 |
| 17 | Identification of human remains by immobilized sequence-specific oligonucleotide probe analysis mtDNA hypervariable regions Ⅰ and Ⅱ 显示文摘 | Matthew N G Cassandra D C Rebecca L R | 2003 | Forensic Sci2003，44，3： | 1 |
| 18 | A comparison of chemical pretreatment methods for improving saccharification of cotton stalks显示文摘 | Rebecca A S Ye C Ratna R | 2007 | Bioresource Technology2007，98，16： | 1 |
| 19 | Mapping of NRAGE domains reveals clues to cell viability in BMP signaling 显示文摘 | Jennifer A R Rebecca A C Joshua S H | 2010 | Apoptosis2010，15，1： | 1 |
| 20 | A comparison of chemical pretreatment methods for improving saccharification of cotton stalks显示文摘 | Rebecca A S Ye C Ratna R | 2007 | Bioresource Technology2007，98，16： | 1 |
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