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| 1 | 肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)显示文摘The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells. | Maria Stella Carro Wei Keat Lim Mariano Javier Alvarez Robert J. Bollo Evan Y. Snyder Erik P. Sulman Sandrine L. Anne Fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea Califano Antonio Iavarone | 2010 | 中华神经外科疾病研究杂志2010，9，1： | 16 |
| 2 | A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C显示文摘 | Chun-Tao Wai Joel K. Greenson Robert J. Fontana John D. Kalbfleisch Jorge A. Marrero Hari S. Conjeevaram Anna S.-F. Lok | 2003 | Hepatology2003，，2： | 11 |
| 3 | 基于MaxEnt模型的小兴安岭东北虎潜在生境适宜性评价显示文摘小兴安岭是东北虎的历史分布区之一,近年来东北虎数次重返小兴安岭,预示了小兴安岭东北虎种群恢复的可能性。为了探明小兴安岭作为东北虎栖息地的适宜程度,本文以我国小兴安岭及俄罗斯联邦阿穆尔州、犹太自治州为整体研究区域,利用该区域内东北虎出现点数据,采用MaxEnt模型,以植被、气候、地形、积雪4类环境数据为基础,分析自然环境条件下小兴安岭东北虎潜在生境的适宜性及空间分布。结果显示:小兴安岭东北虎潜在适宜生境面积为0.96×10~4~1.03×10~4 km^2,主要位于小兴安岭北部和东部,中部、西部和东南部有少量分散适宜生境;次适宜生境面积为2.46×10~4~2.76×10~4 km^2,主要位于适宜生境周边区域;叶灌层差异、蒸散量、归一化植被指数、叶面积指数等植被相关因素及降水季节性、最冷季降水量等气候因素是影响东北虎栖息地适宜程度的主要环境特征变量。小兴安岭仍具备东北虎种群生存的自然条件。 | 朱世兵 曲艺 Yachmennikova Anna Kotlov Ivan Sandlerskiy Robert Rozhnov Viatcheslav Hernandez-Blanco Jose Antonio 张士芳 刘应竹 张弘强 | 2020 | 兽类学报2020，40，4： | 10 |
| 4 | 2013 ESH/ESC Guidelines for the management of arterial hypertension显示文摘 | Giuseppe Mancia Robert Fagard Krzysztof Narkiewicz Josep Redon Alberto Zanchetti Michael B?hm Thierry Christiaens Renata Cifkova Guy De Backer Anna Dominiczak Maurizio Galderisi Diederick E. Grobbee Tiny Jaarsma Paulus Kirchhof Sverre E. Kjeldsen Stéphane | 2013 | European Heart Journal2013，，28： | 5 |
| 5 | Role of cannabinoids in chronic liver diseases显示文摘Cannabinoids are a group of compounds acting pri-marily via CB1 and CB2 receptors.The expression of cannabinoid receptors in normal liver is low or absent.However,many reports have proven up-regulation of the expression of CB1 and CB2 receptors in hepatic myofibroblasts and vascular endothelial cells,as well as increased concentration of endocannabinoids in liver in the course of chronic progressive liver diseases.It has been shown that CB1 receptor signalling exerts profibrogenic and proinflammatory effects in liver tis-sue,primarily due to the stimulation of hepatic stellate cells,whereas the activation of CB2 receptors inhibits or even reverses liver fibrogenesis.Similarly,CB1 re-ceptor stimulation contributes to progression of liver steatosis.In end-stage liver disease,the endocannabi-noid system has been shown to contribute to hepatic encephalopathy and vascular effects,such as portal hypertension,splanchnic vasodilatation,relative pe-ripheral hypotension and probably cirrhotic cardiomy-opathy.So far,available evidence is based on cellular cultures or animal models.Clinical data on the effects of cannabinoids in chronic liver diseases are limited.However,recent studies have shown the contribution of cannabis smoking to the progression of liver fibrosis and steatosis.Moreover,controlling CB1 or CB2 signal-ling appears to be an attractive target in managing liver diseases. | Anna Parfieniuk Robert Flisiak | 2008 | World Journal of Gastroenterology2008，14，40： | 5 |
| 6 | Levels and trends of poly-and perfluoroalkyl substances in the Arctic environment-An update显示文摘Poly-and perfluoroalkyl substances(PFASs)are important environmental contaminants globally and in the early 2000s they were shown to be ubiquitous contaminants in Arctic wildlife.Previous reviews by Butt et al.and Letcher et al.have covered studies on levels and trends of PFASs in the Arctic that were available to 2009.The purpose of this review is to focus on more recent work,generally published between 2009 and 2018,with emphasis on PFASs of emerging concern such as perfluoroalkyl carboxylates(PFCAs)and short-chain perfluoroalkyl sulfonates(PFSAs)and their precursors.Atmospheric measurements over the period 2006e2014 have shown that fluorotelomer alcohols(FTOHs)as well as perfluorobutanoic acid(PFBA)and perfluoroctanoic acid(PFOA)are the most prominent PFASs in the arctic atmosphere,all with increasing concentrations at Alert although PFOA concentrations declined at the Zeppelin Station(Svalbard).Results from ice cores show generally increasing deposition of PFCAs on the Devon Ice cap in the Canadian arctic while declining fluxes were found in a glacier on Svalbard.An extensive dataset exists for long-term trends of long-chain PFCAs that have been reported in Arctic biota with some datasets including archived samples from the 1970s and 1980s.Trends in PFCAs over time vary among the same species across the North American Arctic,East and West Greenland,and Svalbard.Most long term time series show a decline from higher concentrations in the early 2000s.However there have been recent(post 2010)increasing trends of PFCAs in ringed seals in the Canadian Arctic,East Greenland polar bears and in arctic foxes in Svalbard.Annual biological sampling is helping to determine these relatively short term changes.Rising levels of some PFCAs have been explained by continued emissions of long-chain PFCAs and/or their precursors and inflows to the Arctic Ocean,especially from the North Atlantic.While the effectiveness of biological sampling for temporal trends in long-chain PFCAs and PFSAs has been demonstrated,this does not apply to the C4eC8ePFCAs,perfluorobutane sulfonamide(FBSA),or perfluorobutane sulfonate(PFBS)which are generally present at low concentrations in biota.In addition to air sampling,sampling abiotic media such as glacial cores,and annual sampling of lake waters and seawater would appear to be the best approaches for investigating trends in the less bioaccumulative PFASs. | Derek Muir Rossana Bossi Pernilla Carlsson Marlene Evans Amila De Silva Crispin Halsall Cassandra Rauert Dorte Herzke Hayley Hung Robert Letcher Frank Riget Anna Roos | 2019 | Emerging Contaminants2019，5，1： | 3 |
| 7 | A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C显示文摘 | Chun-Tao Wai Joel K. Greenson Robert J. Fontana John D. Kalbfleisch Jorge A. Marrero Hari S. Conjeevaram Anna S.-F. Lok | 2003 | Hepatology2003，，2： | 3 |
| 8 | α-Fetoprotein, Des-γ Carboxyprothrombin, and Lectin-Bound α-Fetoprotein in Early Hepatocellular Carcinoma显示文摘 | Jorge A. Marrero Ziding Feng Yinghui Wang Mindie H. Nguyen Alex S. Befeler Lewis R. Roberts K. Rajender Reddy Denise Harnois Josep M. Llovet Daniel Normolle Jackie Dalhgren David Chia Anna S. Lok Paul D. Wagner Sudhir Srivastava Myron Schwartz | 2009 | Gastroenterology2009，，1： | 3 |
| 9 | The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor显示文摘 | Anne E. Powell Yang Wang Yina Li Emily J. Poulin Anna L. Means Mary K. Washington James N. Higginbotham Alwin Juchheim Nripesh Prasad Shawn E. Levy Yan Guo Yu Shyr Bruce J. Aronow Kevin M. Haigis Jeffrey L. Franklin Robert J. Coffey | 2012 | Cell2012，，1： | 2 |
| 10 | Mitigating nitrous oxide emissions from agricultural soils by precision management显示文摘Nitrous oxide(N2O)emissions make up a significant part of agricultural greenhouse gas emissions.There is an urgent need to identify new approaches to the mitigation of these emissions with emerging technology.In this short review four approaches to precision managements of agricultural systems are described based on examples of work being undertaken in the UK and New Zealand.They offer the opportunity for N2 O mitigation without any reduction in productivity.These approaches depend upon new sensor technology,modeling and spatial information with which to make management decisions and interventions that can both improve agricultural productivity and environmental protection. | Robert M.REES Juliette MAIRE Anna FLORENCE Nicholas COWAN Ute SKIBA Tony van der WEERDEN Xiaotang JU | 2020 | Frontiers of Agricultural Science and Engineering2020，7，1： | 2 |
| 11 | Des-gamma carboxyprothrombin can differentiate hepatocellular carcinoma from nonmalignant chronic liver disease in american patients显示文摘 | Jorge A. Marrero Grace L. Su Wei Wei Dawn Emick Hari S. Conjeevaram Robert J. Fontana Anna S. Lok | 2003 | Hepatology2003，，5： | 2 |
| 12 | Recent US Food and Drug Administration warnings on hepatitis B reactivation with immune‐suppressing and anticancer drugs: Just the tip of the iceberg?显示文摘 | Adrian M. Bisceglie Anna S. Lok Paul Martin Norah Terrault Robert P. Perrillo Jay H. Hoofnagle | 2015 | Hepatology2015，，2： | 2 |
| 13 | Gastric stump cancer after distal gastrectomy for benign gastric ulcer in a population‐based study显示文摘 | Jesper Lagergren Anna Lindam Robert M. Mason | 2012 | Int J Cancer2012，，6： | 2 |
| 14 | A randomized controlled trial of pretransplant antiviral therapy to prevent recurrence of hepatitis C after liver transplantation显示文摘 | Gregory T. Everson Norah A. Terrault Anna S. Lok Del R. Rodrigo Robert S. Brown Sammy Saab Mitchell L. Shiffman Abdullah M.S. Al‐Osaimi Laura M. Kulik Brenda W. Gillespie James E. Everhart | 2013 | Hepatology2013，，5： | 2 |
| 15 | The Role of Synthetic Biology in Atmospheric Greenhouse Gas Reduction: Prospects and Challenges显示文摘The long atmospheric residence time of CO2 creates an urgent need to add atmospheric carbon drawdown to CO2 regulatory strategies.Synthetic and systems biology(SSB),which enables manipulation of cellular phenotypes,offers a powerful approach to amplifying and adding new possibilities to current land management practices aimed at reducing atmospheric carbon.The participants(in attendance:Christina Agapakis,George Annas,Adam Arkin,George Church,Robert Cook-Deegan,Charles DeLisi,Dan Drell,Sheldon Glashow,Steve Hamburg,Henry Jacoby,Henry Kelly,Mark Kon,Todd Kuiken,Mary Lidstrom,Mike MacCracken,June Medford,Jerry Melillo,Ron Milo,Pilar Ossorio,Ari Patrinos,Keith Paustian,Kristala Jones Prather,Kent Redford,David Resnik,John Reilly,Richard J.Roberts,Daniel Segre,Susan Solomon,Elizabeth Strychalski,Chris Voigt,Dominic Woolf,Stan Wullschleger,and Xiaohan Yang)identified a range of possibilities by which SSB might help reduce greenhouse gas concentrations and which might also contribute to environmental sustainability and adaptation.These include,among other possibilities,engineering plants to convert CO2 produced by respiration into a stable carbonate,designing plants with an increased root-to-shoot ratio,and creating plants with the ability to self-fertilize.A number of serious ecological and societal challenges must,however,be confronted and resolved before any such application can be fully assessed,realized,and deployed. | Charles DeLisi Aristides Patrinos Michael MacCracken Dan Drell George Annas Adam Arkin George Church Robert Cook-Deegan Henry Jacoby Mary Lidstrom Jerry Melillo Ron Milo Keith Paustian John Reilly Richard J.Roberts Daniel Segrè Susan Solomon Dominic Woolf Stan D.Wullschleger Xiaohan Yang | 2020 | BioDesign Research2020，，1： | 2 |
| 16 | NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States显示文摘 | Jorge A. Marrero Robert J. Fontana Grace L. Su Hari S. Conjeevaram Dawn M. Emick Anna S. Lok | 2002 | Hepatology2002，，6： | 2 |
| 17 | 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)显示文摘 | Giuseppe Mancia Guy De Backer Anna Dominiczak Renata Cifkova Robert Fagard Giuseppe Germano Guido Grassi Anthony M Heagerty Sverre E Kjeldsen Stephane Laurent Krzysztof Narkiewicz Luis Ruilope Andrzej Rynkiewicz Roland E Schmieder Harry AJ Struijker Boudi | 2007 | Journal of Hypertension2007，，6： | 2 |
| 18 | Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document显示文摘 | Giuseppe Mancia Stéphane Laurent Enrico Agabiti-Rosei Ettore Ambrosioni Michel Burnier Mark J Caulfield Renata Cifkova Denis Clément Antonio Coca Anna Dominiczak Serap Erdine Robert Fagard Csaba Farsang Guido Grassi Hermann Haller Anthony Heagerty Sverre | 2009 | Journal of Hypertension2009，，： | 2 |
| 19 | Antiproliferative and Proapoptotic Activity of Sunitinib on Endothelial and Anaplastic Thyroid Cancer Cells via Inhibition of Akt and ERK1/2 Phosphorylation and by Down-Regulation of Cyclin-D1显示文摘 | Teresa Di Desidero Anna Fioravanti Paola Orlandi Bastianina Canu Riccardo Giannini Nicla Borrelli Shan Man Ping Xu Gabriella Fontanini Fulvio Basolo Robert S. Kerbel Giulio Francia Romano Danesi Guido Bocci | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，9： | 2 |
| 20 | 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)显示文摘 | Giuseppe Mancia Guy De Backer Anna Dominiczak Renata Cifkova Robert Fagard Giuseppe Germano Guido Grassi Anthony M Heagerty Sverre E Kjeldsen Stephane Laurent Krzysztof Narkiewicz Luis Ruilope Andrzej Rynkiewicz Roland E Schmieder Harry AJ Struijker Boudi | 2007 | Journal of Hypertension2007，，6： | 2 |
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