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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Clinical implication of 14-3-3 epsilon expression in gastric cancer显示文摘AIM:To evaluate for the first time the protein and mRNA expression of 14-3-3εin gastric carcinogenesis.METHODS:14-3-3εprotein expression was determined by western blotting,and mRNA expression was examined by real-time quantitative RT-PCR in gastric tumors and their matched non-neoplastic gastric tissue samples.RESULTS:Authors observed a significant reduction of 14-3-3εprotein expression in gastric cancer(GC)samples compared to their matched non-neoplastic tissue.Reduced levels of 14-3-3εwere also associated with diffuse-type GC and early-onset of this pathology.Our data suggest that reduced 14-3-3εmay have a role in gastric carcinogenesis process.CONCLUSION:Our results reveal that the reduced 14-3-3εexpression in GC and investigation of 14-3-3ε interaction partners may help to elucidate the carcino-genesis process. | Mariana Ferreira Leal Danielle Queiroz Calcagno Smia Demachki Paulo Pimentel Assumpo Roger Chammas Rommel Rodríguez Burbano Marília de Arruda Cardoso Smith | 2012 | World Journal of Gastroenterology2012，18，13： | 6 |
| 3 | Two-dimensional control of light with light on metasurfaces显示文摘The ability to control the wavefront of light is fundamental to focusing and redistribution of light,enabling many applications from imaging to spectroscopy.Wave interaction on highly nonlinear photorefractive materials is essentially the only established technology allowing the dynamic control of the wavefront of a light beam with another beam of light,but it is slow and requires large optical power.Here we report a proof-of-principle demonstration of a new technology for two-dimensional(2D)control of light with light based on the coherent interaction of optical beams on highly absorbing plasmonic metasurfaces.We illustrate this by performing 2D all-optical logical operations(AND,XOR and OR)and image processing.Our approach offers diffractionlimited resolution,potentially at arbitrarily-low intensity levels and with 100 THz bandwidth,thus promising new applications in space-division multiplexing,adaptive optics,image correction,processing and recognition,2D binary optical data processing and reconfigurable optical devices. | Maria Papaioannou Eric Plum João Valente Edward TF Rogers Nikolay I Zheludev | 2016 | Light(Science & Applications)2016，5，1： | 3 |
| 4 | Lessons from look-back in acute liver failure? A single centre experience of 3300 patients显示文摘 | William Bernal Anna Hyyrylainen Amit Gera Vinod K. Audimoolam Mark J.W. McPhail Georg Auzinger Mohammed Rela Nigel Heaton John G. O’Grady Julia Wendon Roger Williams | 2013 | Journal of Hepatology2013，，1： | 2 |
| 5 | Blockade of PD1 and TIM3 Restores Innate and Adaptive Immunity in Patients with Acute Alcoholic Hepatitis显示文摘 | Lee J.L. Markwick Antonio Riva Jennifer M. Ryan Helen Cooksley Elena Palma Tom H. Tranah Godhev K. Manakkat Vijay Nikhil Vergis Mark Thursz Alex Evans Gavin Wright Sarah Tarff John O’Grady Roger Williams Debbie L. Shawcross Shilpa Chokshi | 2014 | Gastroenterology2014，，： | 2 |
| 6 | Combined aerobic and resistance exercise improves glycemic control and fitness in type 2 diabetes显示文摘 | Andrew Maiorana Gerard O'Driscoll Carmel Goodman Roger Taylor Daniel Green | 2002 | Diabetes Research and Clinical Practice2002，，2： | 2 |
| 7 | Clostridium perfringens beta-toxin forms potential-dependent, cation-selective channels in lipid bilayers 显示文摘 | Shatursky O Bayles R Rogers M | 2000 | Infect Immun2000，68，10： | 1 |
| 8 | Transgene and mitochondrial DNA are indicators of efficient composting of transgenic pig carcasses显示文摘 | Dave Murray Roy G. Meidinger Serguei P. Golovan John P. Phillips Ivan P. O’Halloran Ming Z. Fan Roger R. Hacker Cecil W. Forsberg | 2006 | Bioresource Technology2006，，9： | 1 |
| 9 | Liquid clathrate formation in ionic liquid-aromatic mixtures显示文摘 | HOLBREY J D REICHERT W M NIEUWENHUYZEN M SHEPPARD O HARDACRE C ROGERS R D | 2003 | Chem Commun2003，，47： | 1 |
| 10 | J Intelligent Material Systems and Structure显示文摘 | | 1996 | 7:1231996，7，： | 1 |
| 11 | Sensitivity of megavohage photon beam Monte-Carlo simulations to electron beam and other parameters 显示文摘 | SHEIKH-BAGHERI D ROGERS D W O | 2002 | Medical Physics2002，29，3： | 1 |
| 12 | Valuing moving barrier options显示文摘 | Rogers L C G Zane O | 1997 | Journal of Computational Finance1997，9，： | 1 |
| 13 | Isolation and Characterization of Novel Psychrophilic, Neutrophilie, Fe-Oxidizing, Chemolithoautotrophic α-and β-Proteobacteria from the Deep Sea 显示文摘 | Edwards K J Rogers D R Wirsen C O | 2003 | Applied and Environmental Microbiology2003，69，5： | 1 |
| 14 | The Toxicology of Perfluorooctanoate显示文摘 | Gerald L. Kennedy John L. Butenhoff Geary W. Olsen John C. O’Connor Andrew M. Seacat Roger G. Perkins Lisa B. Biegel Sandra R. Murphy David G. Farrar | 2004 | Critical Reviews in Toxicology2004，，4： | 1 |
| 15 | The Economics of Small Worlds显示文摘 | Jackson M O Rogers B W | 2005 | Joumal of the European Economic Association2005，3，2： | 1 |
| 16 | Dissociation of cognitive and emotional empathy in Adults with Asperger syndrome: Using the Multifaceted Empathy Test (MET)显示文摘 | Dziobek I Rogers K Fleck S Bahnemann M Heekeren H Wolf O Convit A | 2008 | Journal of Autism and Developmental Disorders2008，38，： | 1 |
| 17 | Monte Carlo simulation of a typical ^60 Co therapy source显示文摘 | MORA G M MAIO A ROGERS D W O | 1999 | Med Phys1999，26，11： | 1 |
| 18 | Cloning by functional expression of a member of the glutamate recep- tor family显示文摘 | Hollmann M O'Shea-Greenfield A Rogers SW | 1989 | Nature1989，342，6250： | 1 |
| 19 | Meeting Strangers and Friends of Friends:How Random Are Social Networks?显示文摘 | JACKSON M O ROGERS B W | 2007 | American Economic Review2007，97，3： | 1 |
| 20 | Pore types in the Barnett and Woodford gas shales: Contribution to under-standing gas storage and migration pathways in fine- grained rocks显示文摘 | Roger M S Neal R O'B | 2011 | AAPG2011，，： | 1 |
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