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| 1 | The Deep-Time Digital Earth program:data-driven discovery in geosciences显示文摘Current barriers hindering data-driven discoveries in deep-time Earth(DE)include:substantial volumes of DE data are not digitized;many DE databases do not adhere to FAIR(findable,accessible,interoperable and reusable)principles;we lack a systematic knowledge graph for DE;existing DE databases are geographically heterogeneous;a significant fraction of DE data is not in open-access formats;tailored tools are needed.These challenges motivate the Deep-Time Digital Earth(DDE)program initiated by the International Union of Geological Sciences and developed in cooperation with national geological surveys,professional associations,academic institutions and scientists around the world.DDE’s mission is to build on previous research to develop a systematic DE knowledge graph,a FAIR data infrastructure that links existing databases and makes dark data visible,and tailored tools for DE data,which are universally accessible.DDE aims to harmonize DE data,share global geoscience knowledge and facilitate data-driven discovery in the understanding of Earth’s evolution. | Chengshan Wang Robert MHazen Qiuming Cheng Michael HStephenson Chenghu Zhou Peter Fox Shu-zhong Shen Roland Oberhansli Zengqian Hou Xiaogang Ma Zhiqiang Feng Junxuan Fan Chao Ma Xiumian Hu Bin Luo Juanle Wang Craig M.Schiffries | 2021 | National Science Review2021，8，9： | 14 |
| 2 | Topic discovery and evolution in scientific literature based on content and citations显示文摘Researchers across the globe have been increasingly interested in the manner in which important research topics evolve over time within the corpus of scientific literature. In a dataset of scientific articles, each document can be considered to comprise both the words of the document itself and its citations of other documents. In this paper, we propose a citationcontent-latent Dirichlet allocation(LDA) topic discovery method that accounts for both document citation relations and the content of the document itself via a probabilistic generative model. The citation-content-LDA topic model exploits a two-level topic model that includes the citation information for ‘father' topics and text information for sub-topics. The model parameters are estimated by a collapsed Gibbs sampling algorithm. We also propose a topic evolution algorithm that runs in two steps: topic segmentation and topic dependency relation calculation. We have tested the proposed citation-content-LDA model and topic evolution algorithm on two online datasets, IEEE Transactions on Pattern Analysis and Machine Intelligence(PAMI) and IEEE Computer Society(CS), to demonstrate that our algorithm effectively discovers important topics and reflects the topic evolution of important research themes. According to our evaluation metrics, citation-content-LDA outperforms both content-LDA and citation-LDA. | Hou-kui ZHOU Hui-min YU Roland HU | 2017 | Frontiers of Information Technology & Electronic Engineering2017，18，10： | 5 |
| 3 | Topic evolution based on the probabilistic topic model: a review显示文摘 | Houkui ZHOU Huimin YU Roland HU | 2017 | Frontiers of Computer Science2017，11，5： | 4 |
| 4 | In ovo leptin administration affects hepatic lipid metabolism and microRNA expression in newly hatched broiler chickens显示文摘Background: A leptin-like immunoreactive substance has been found in chicken eggs and has been implicated in serving as a maternal signal to program offspring growth and metabolism. In the present study, we investigated the effects of in ovo leptin administration on hatch weight, serum and hepatic concentrations of metabolites and hormones, as well as on the expression of genes involved in hepatic lipid metabolism and the predicted microRNAs (miRNAs) targeting the affected genes. To this end we injected fertile eggs with either 0.5 μg of recombinant murine leptin or vehicle (PBS) before incubation. Results: Prenatally leptin-exposed chicks showed lower hatch weight, but higher liver weight relative to the body weight, compared to the control group. In ovo leptin treatment increased the hepatic content and serum concentration of leptin in newly hatched chickens. The hepatic contents of triglycerides (TG) and total cholesterol (Tch) were decreased, whereas the serum levels of TG, Tch and apolipoprotein B (ApoB) were increased. The hepatic mRNA expression of sterol regulator element binding protein 1 (SREBP-1c), SREBP-2, hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and cholesterol 7α-hydroxylase 1 (CYP7A1) was significantly up-regulated, as was the protein content of both SREBP-1c and SREBP-2 in hepatic nuclear extracts of leptin-treated chickens. Moreover, out of 12 miRNAs targeting SREBP-1c and/or HMGCR, five were significantly up-regulated in liver of leptin-treated chicks, including gga-miR-200b and gga-miR-429, which target both SREBP-1c and HMGCR. Conclusions: These results suggest that leptin in ovo decreases hatch weight, and modifies hepatic leptin secretion and lipid metabolism in newly hatched broiler chickens, possibly via microRNA-mediated gene regulation. | Yan Hu Rui Zhang Yanhong Zhang Jing Li Roland Grossmann Ruqian Zhao | 2012 | Journal of Animal Science and Biotechnology2012，3，2： | 3 |
| 5 | Mechanism of variations in environmental magnetic proxies of lake sediments from Nam Co, Tibet during the Holocene显示文摘High-resolution environmental records from the Tibetan Plateau are essential to understand past global climatic and environmental changes. Magnetic minerals in lake sediments are important proxies to reconstruct environmental and climatic changes. Nam Co (lake) is a typical great lake in the transitional region of southwest monsoon in the Tibetan Plateau. Previous studies have extensively focused on geochemistry, microfossils, sedimentology and biochemistry analysis of Nam Co, which provides sound interpretation of paleoclimatic and paleoenvironmental changes. However, up to now, no systematic environmental magnetic studies have been carried out. Therefore, high-resolution and systematic magnetic studies combined with geochemical parameters were carried on lake sediments of core NC 08/01 from Nam Co for the Holocene period (11.3 cal ka BP) in order to explore how magnetic properties of the sediments respond to climatic changes. Based on variations of magnetic proxies, the sequence can be separated into 3 units. Unit 1 (236-199 cm, 11.3-7.8 cal ka BP) contains dominantly coarse-grained magnetite with homogeneous grain size. A positive correlation between magnetite and Ti strongly suggests that these coarse-grained detrital magnetites reflect detrital input signals due to insignificant effects of postdepositional dissolution processes on these coarse-grained magnetite particles. For Unit 2 (198-102 cm, 7.8-2.1 cal ka BP), magnetic grain size is finer and the corresponding concentration of magnetite is also reduced. This is mainly due to significant dissolution of these fine-grained detrital magnetite particles, which were transported under reduced water flow conditions during this period. For Unit 3 (101-0 cm, 2.1-0 cal ka BP), the bulk magnetic properties are dominated by a mixture of single domain biogenic magnetite and detrital magnetite. The concentration of magnetic minerals is not correlated with the Ti content. In conclusion, the preservation of magnetic minerals in the lake sediment and thus the corresponding magnetic properties are related to the initial grain size. Combination of magnetic properties (including variation of grain size and concentration) and other proxies of detrital inputs (e.g. Ti) can be used to infer the variation of redox conditions in Nam Co. These results provide a viable framework for reconstructing the paleoenvironmental changes of this lake. | SU YouLiang GAO Xing LIU QingSong HU PengXiang DUAN ZongQi JIANG ZhaoXia WANG JunBo ZHU LiPing DOBERSCHüTZ Stefan MUSBACHER Roland DAUT Gerhard HABERZETTL Torsten | 2013 | Chinese Science Bulletin2013，58，13： | 2 |
| 6 | International experts consensus guidelines on robotic liver resection in 2023显示文摘The robotic liver resection(RLR)has been increasingly applied in recent years and its benefits shown in some aspects owing to the technical advancement of robotic surgical system,however,controversies still exist.Based on the foundation of the previous consensus statement,this new consensus document aimed to update clinical recommendations and provide guidance to improve the outcomes of RLR clinical practice.The guideline steering group and guideline expert group were formed by 29 international experts of liver surgery and evidence-based medicine(EBM).Relevant literature was reviewed and analyzed by the evidence evaluation group.According to the WHO Handbook for Guideline Development,the Guidance Principles of Development and Amendment of the Guidelines for Clinical Diagnosis and Treatment in China 2022,a total of 14 recommendations were generated.Among them were 8 recommendations formulated by the GRADE method,and the remaining 6 recommendations were formulated based on literature review and experts’opinion due to insufficient EBM results.This international experts consensus guideline offered guidance for the safe and effective clinical practice and the research direction of RLR in future. | Rong Liu Mohammed Abu Hilal Go Wakabayashi Ho-Seong Han Chinnusamy Palanivelu Ugo Boggi Thilo Hackert Hong-Jin Kim Xiao-Ying Wang Ming-Gen Hu Gi Hong Choi Fabrizio Panaro Jin He Mikhail Efanov Xiao-Yu Yin Roland S Croner Yu-Man Fong Ji-Ye Zhu Zheng Wu Chuan-Dong Sun Jae Hoon Lee Marco V Marino Iyer Shridhar Ganpati Peng Zhu Zi-Zheng Wang Ke-Hu Yang Jia Fan Xiao-Ping Chen Wan Yee Lau | 2023 | World Journal of Gastroenterology2023，29，32： | 2 |
| 7 | Determination of absorption characteristics of AG337, a novel thymidylate synthase inhibitor, using a perfused rat intestinal model 显示文摘 | Hu M Roland K Chen J | 1998 | J Pharm Sci1998，87，7： | 1 |
| 8 | Morphological changes of placental syncytium and their implications for the pathogenesis of preeclampsia显示文摘 | Roland CS Hu J Ren CE | 2016 | Cell Mol Life Sci2016，73，2： | 1 |
| 9 | Probabilistic hypergraph based hash codes for social image search显示文摘With the rapid development of the Internet, recent years have seen the explosive growth of social media. This brings great challenges in performing efficient and accurate image retrieval on a large scale. Recent work shows that using hashing methods to embed high-dimensional image features and tag information into Hamming space provides a powerful way to index large collections of social images. By learning hash codes through a spectral graph partitioning algorithm, spectral hashing(SH) has shown promising performance among various hashing approaches. However, it is incomplete to model the relations among images only by pairwise simple graphs which ignore the relationship in a higher order. In this paper, we utilize a probabilistic hypergraph model to learn hash codes for social image retrieval. A probabilistic hypergraph model offers a higher order repre-sentation among social images by connecting more than two images in one hyperedge. Unlike a normal hypergraph model, a probabilistic hypergraph model considers not only the grouping information, but also the similarities between vertices in hy-peredges. Experiments on Flickr image datasets verify the performance of our proposed approach. | Yi XIE Hui-min YU Roland HU | 2014 | Journal of Zhejiang University-Science C(Computers and Electronics)2014，15，7： | 1 |
| 10 | Determination of absorption characteristics of AG337, a novel thymidylate synthase inhibitor, using a perfused rat intestinal model显示文摘 | HU M ROLAND K GE L | 1998 | J Pharm Sci1998，87，7： | 1 |
| 11 | Determination of absorption characteristics of AG337, a novel thymidylate synthase inhibitor, using a perfused rat intestinal model 显示文摘 | Hu M Roland K Ge L | 1998 | J Pharm Sci1998，87，： | 1 |
| 12 | Determination of absorption characteristics of AG337, a novel thymidylate synthase inhibitor, using a perfused rat intestinal model显示文摘 | Hu M Roland K Ge L | 1998 | J Pharm Sci1998，87，： | 1 |
| 13 | Optimal weighting of bimodal bio- metric information with specific application to audio-visua person identification显示文摘 | Hu Roland Damper R I | 2009 | Information Fusion2009，10，2： | 1 |
| 14 | Transient receptor potential channels as predictive marker and potential indicator of chemoresistance in colon cancer显示文摘Transient receptor potential(TRP)channels are strongly associated with colon cancer development and progression.This study leveraged a multivariate Cox regression model on publicly available datasets to construct a TRP channels-associated gene signature,with further validation of signature in real world samples from our hospital treated patient samples.Kaplan-Meier(K-M)survival analysis and receiver operating characteristic(ROC)curves were employed to evaluate this gene signature’s predictive accuracy and robustness in both training and testing cohorts,respectively.Additionally,the study utilized the CIBERSORT algorithm and single-sample gene set enrichment analysis to explore the signature’s immune infiltration landscape and underlying functional implications.The support vector machine algorithm was applied to evaluate the signature’s potential in predicting chemotherapy outcomes.The findings unveiled a novel three TRP channels-related gene signature(MCOLN1,TRPM5,and TRPV4)in colon adenocarcinoma(COAD).The ROC and K-M survival curves in the training dataset(AUC=0.761;p=1.58e-05)and testing dataset(AUC=0.699;p=0.004)showed the signature’s robust predictive capability for the overall survival of COAD patients.Analysis of the immune infiltration landscape associated with the signature revealed higher immune infiltration,especially an increased presence of M2 macrophages,in high-risk group patients compared to their low-risk counterparts.High-risk score patients also exhibited potential responsiveness to immune checkpoint inhibitor therapy,evident through increased CD86 and PD-1 expression profiles.Moreover,the TRPM5 gene within the signature was highly expressed in the chemoresistance group(p=0.00095)and associated with poor prognosis(p=0.036)in COAD patients,highlighting its role as a hub gene of chemoresistance.Ultimately,this signature emerged as an independent prognosis factor for COAD patients(p=6.48e-06)and expression of model gene are validated by public data and real-world patients.Overall,this bioinformatics study provides valuable insights into the prognostic implications and potential chemotherapy resistance mechanisms associated with TRPs-related genes in colon cancer. | WEI HU THOMAS WARTMANN MARCO STRECKER ARISTOTELIS PERRAKIS ROLAND CRONER ARPAD SZALLASI WENJIE SHI ULF D.KAHLERT | 2024 | Oncology Research2024，32，1： | 0 |
| 15 | 肿瘤再生细胞通过犬尿氨酸转移以及芳香烃受体激活诱导CD8^+T细胞表达PD-1显示文摘文章简介肿瘤免疫治疗是当前肿瘤研究的热点领域之一,通过利用免疫细胞、免疫分子直接或间接杀伤肿瘤细胞,以控制或清除肿瘤,被认为是人类战胜癌症的希望所在。肿瘤免疫治疗主要依赖活化的T细胞杀伤肿瘤细胞. | 刘玉英 梁晓雨 董文茜 Yi Fang Jiadi Lv Tianzhen Zhang Roland Fiskesund Jing Xie Jinyan Liu Xiaonan Yin Xun Jin Degao Chen Ke Tang Jingwei Ma Huafeng Zhang Jing Yu Jun Yan Huaping Liang Siqi Mo Feiran Cheng Yabo Zhou Haizeng Zhang Jing Wang Jingnan Li Yang Chen Bing Cui Zhuo-Wei Hu Xuetao Cao F. Xiao-Feng Qin 黄波 | 2019 | 科学新闻2019，0，2： | 0 |
| 16 | Nicotine gum or patch treatment for smoking cessation and smoking reduction: a multi-centre study in Chinese physicians显示文摘在中国,约 23% 医生(41% 男性, 3% 女性) 当前吸烟。为烟草依赖的 Pharmacotherapy 是可得到的,但是广泛地没在中国被使用。这研究的目的是在在中国保健专业人员吸烟碱口香糖和烟碱补丁的停止上估计有效性和安全。激发停止的 300 个常规吸烟者在中国从六所医院被招募。所有题目是接受烟碱代替治疗,并且他们能选择烟碱口香糖(2 mg 或 4 mg,取决于吸水平的基线) 或为 12 个星期的烟碱补丁(15 mg/16 h ) ,与 12 星期的后续。有限行为支持被提供。在星期 24 点, 2-24 星期连续节制率(由到期的碳一氧化物验证了) 是 17% ,点流行节制率(没有自从以前的访问,吸烟)35% ,和 38% 题目连续地在至少 50% 减少了他们的每日的香烟消费对基线。对处理的依从好,特别地与补丁。没有严肃的不利事件被报导,并且很不利的事件温和或中等。最普通的处理相关的不利事件是胃肠的(口香糖和补丁) 并且本地激怒症状。烟碱补丁和口香糖很好在中国吸烟者被容忍。节制率比得上以前与烟碱代替治疗报导的那些,并且没实质地停止的许多吸烟者减少了他们的香烟消费。 | Dan Xiao Nanshan Zhong Chunxue Bai Qingyu Xiu Canmao Xie Dayi Hu Yun Mao Roland Perfekt Elisabeth Kruse Qing Li John Jiangnan Liu Chen Wang | 2014 | Frontiers of Medicine2014，8，1： | 0 |
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