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| 1 | Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China显示文摘长期的肝炎 B 是在中国的一个主要健康问题。自从 1992,通用种痘节目在中国改变了肝炎 B 病毒感染的传染病学从高度到中等地方性。在中国的最流行的肝炎 B 病毒种类是遗传型 B 和 C,而在西方的省的那些是遗传型 D 和 C/D 混血儿。长期的肝炎 B 在中国提出重担到社会。不同治疗策略被探索了以一种划算的方式改进耐心的结果。然而,因为通常低的收入和有限资源,有对抵抗的一个低基因障碍的抗病毒的药仍然广泛地在中国被使用。个性化的抗病毒的治疗仔细与翻译的药被联系,它在 genomics,有免疫力的 biomarkers,和纤维变性上从研究利用信息。这些研究的结果在进一步改进治疗结果是关键的。 | Rui Yu Rong Fan Jinlin Hou | 2014 | Frontiers of Medicine2014，8，2： | 43 |
| 2 | Genome-scale profiling of circulating cell-free DNA signatures for early detection of hepatocellular carcinoma in cirrhotic patients显示文摘Dear Editor,Hepatocellular carcinoma(HCC)is the second most deadly cancer worldwide.1 Cirrhosis of different causes predisposes patients to HCC,increasing the annual HCC incidence by 2%–4%.1 The development of cirrhosis facilitates a series of genetic or epigenetic changes,resulting in the formation of dysplastic nodules,a premalignant stage in HCC.1 HCC diagnosis at an early stage contributes to an improved prognosis with the possibility of curative treatment.Due to the low accuracy of current diagnostic methods,it is urgently needed to explore new non-invasive strategies for early HCC diagnosis in cirrhotic patients. | Lei Chen Ghassan K.Abou-Alfa Bo Zheng Jing-Feng Liu Jian Bai Lu-Tao Du Yun-Song Qian Rong Fan Xiao-Long Liu Lin Wu Jin-Lin Hou Hong-Yang Wang The PreCar Team | 2021 | Cell Research2021，31，5： | 20 |
| 3 | Effect of acupuncture at Neiguan (PC 6) on cardiac function using echocardiography in myocardial ischemia rats induced by isoproterenol显示文摘OBJECTIVE: To investigate the effect of acupuncture at Neiguan(PC 6) on cardiac function using echocardiography in rat models of myocardial ischemia(MI) induced by isoproterenol(ISO).METHODS: Twenty-seven Sprague-Dawley rats were randomly assigned to normal, model, and acupuncture groups. The model and acupuncture groups were given injections of ISO(85 mg/kg) to establish the MI model. After model establishment,the acupuncture group was treated with acupuncture at Neiguan(PC 6) for 30 min. Echocardiography was used to monitor diastolic and systolic function for 30 min starting from the time after the acupuncture needles were removed. Changes in the length of left ventricular internal diameter at end-diastole(LVIDd), length of left ventricular internal diameter at end-systole(LVIDs), the ratio of mitral peak velocity at early diastole and atrial contraction(E/A), ejection fraction(EF), fractional shortening(FS), and stroke volume(SV) were measured.RESULTS: Compared with the model group at 0and 15 min after needles were removed, the means of LVIDd and LVIDs were significantly lower(P <0.01) and E/A, EF, FS, and SV significantly higher(P < 0.01) in the acupuncture group. In the acupuncture group, the means of LVIDd and LVIDs15 min after the needles were removed were significantly higher(P < 0.01) than those at 0 min. The means of E/A, EF, FS, and SV significantly decreased(P < 0.01) from 0 to 15 min in the acupuncture group.CONCLUSION: These findings indicate that acupuncture at Neiguan(PC 6) can affect cardiac function by increasing left ventricular diastolic and systolic function in MI rat models, but the effect only lasts for 15 min. | Wang Songzi Ren Lu Jia Lianqun Gu Zhongyue Fan Xu Chen Wenna Hou Ping Liang Fanrong Rong Peijing Ma Tieming Liu Xulai Chen Yiguo | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 12 |
| 4 | Influences of Technological Parameters on Smelting-separation Process for Metallized Pellets of Vanadium-bearing Titanomagnetite Concentrates显示文摘The smelting-separation process for metallized pellets of vanadium-bearing titanomagnetite concentrates was studied.The influences of smelting temperature,smelting time,and the basicity of the metallized pellet on vanadium and iron recovery were investigated.The characteristics of titanium slag were analyzed using X-ray diffraction,energy dispersive spectroscopy,and mineralographic microscopic analysis.The results demonstrate that appropriate increases in smelting temperature and smelting time can improve the vanadium and iron recovery from metallized pellets and are beneficial for the slag-iron separation.Although increasing the basicity of the metallized pellet can considerably improve the vanadium and iron recovery,the TiO_2 grade of titanium slag was decreased.Under the optimal conditions,90.17% of vanadium and 92.98% of iron in the metallized pellet were recovered,and the TiO_2 grade of titanium slag was 55.01%.It was found that anosovite,augite,spinel,glassiness,and metallic iron were the main mineral phases of the titanium slag. | En-hui WU Rong ZHU Shao-li YANG Lan MA Jun LI Jing HOU | 2016 | Journal of Iron and Steel Research(International)2016，23，7： | 11 |
| 5 | Transcutaneous Auricular Vagus Nerve Stimulation: From Concept to Application显示文摘Whether in the West or the East,the connection between the ear and the rest of the body has been explored for a long time.Especially in the past century or more,the relevant theoretical and applied research on the ear has greatly promoted the development of ear therapy,and finally the concept of transcutaneous auricular vagus nerve stimulation(taVNS)has been proposed.The purpose of taVNS is to treat a disease non-invasively by applying electrical current to the cutaneous receptive field formed by the auricular branch of the vagus nerve in the outer ear.In the past two decades,taVNS has been a topic of basic,clinical,and transformation research.It has been applied as an alternative to drug treatment for a variety of diseases.Based on the rapid understanding of the application of taVNS to human health and disease,some limitations in the development of this field have also been gradually exposed.Here,we comprehensively review the origin and research status of the field. | Yu Wang Shao-Yuan Li Dan Wang Mo-Zheng Wu Jia-Kai He Jin-Ling Zhang Bin Zhao Li-Wei Hou Jun-Ying Wang Lei Wang Yi-Fei Wang Yue Zhang Zi-Xuan Zhang Pei-Jing Rong | 2021 | Neuroscience Bulletin2021，37，6： | 10 |
| 6 | DNA barcoding of 18 species of Bovidae显示文摘Genetic divergences of mitochondrial cytochrome c oxidase subunit I genes,known as DNA barcodes,have been used in species identification in the animal kingdom.Barcodes can assist field workers and taxonomists to determine groups in need of taxa analysis,and facilitate the recognition of appropriate populations and scales for conservation planning.In this study,18 species of Bovidae were selected to evaluate the effectiveness of DNA barcoding for species differentiation.The results showed that all but 2 species had unique DNA barcodes.The mean intraspecific variation was 0.63%,yielding a threshold of 6.3% for flagging putative species.The results supported the inference that barcode variation within species of mammals is somewhat higher than within other animal groups.The present study validated the effectiveness of barcoding for the identification of bovid species. | CAI YanSen ZHANG Liang SHEN FuJun ZHANG WenPing HOU Rong YUE BiSong LI Jing ZHANG ZhiHe | 2011 | Chinese Science Bulletin2011，56，2： | 10 |
| 7 | Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress显示文摘在细胞的 ubiquitin (Ub ) 的改变动态平衡,作为 Ub 知道强调,展示并且影响处于多重条件的细胞的回答,然而,内在的机制不完全地被理解。这里,我们报导 autophagy 受体 p62/sequestosome-1 与结合酶, UBE2D2 和 UBE2D3 的 E2 Ub 交往。内长的 p62 在 Ub 动态平衡的 upregulation 期间经历 E2 依赖的 ubiquitylation,一个条件作为 Ub + 应力称为,那对由 bortezomib 的 Ub overexpression,热吃惊或延长 proteasomal 抑制内在,化学疗法的药。p62 的 Ubiquitylation 破坏 p62 的 UBA 领域的 dimerization,解放它的能力认出为选择 autophagy 的 polyubiquitylated 货物。我们进一步证明这机制可能为在 Ub + 压力条件之上的 autophagy 激活是批评的。机制的描述和在察觉到 Ub 应力并且控制选择 autophagy 的 p62 的规章的角色能帮助理解并且调制细胞的回答到许多内长、环境的挑战,潜在地对 autophagy 相关的病为治疗学的策略的发展打开一条新大街。 | Hong Peng Jiao Yang Guangyi Li Qing You Wen Han Tianrang Li Darning Gao Xiaoduo Xie Byung-Hoon Lee Juan Du Jian Hou Tao Zhang Hai Rao Ying Huang Qinrun Li Rong Zeng Lijian Hui Hongyan Wang Qin Xia Xuemin Zhang Yongning He Masaaki Komatsu Ivan Dikic Daniel Finley Ronggui Hu | 2017 | Cell Research2017，27，5： | 9 |
| 8 | Hypoglycemic activity of puerarin through modulation of oxidative stress and mitochondrial function via AMPK显示文摘Hyperglycemia is the dominant phenotype of diabetes and the main contributor of diabetic complications. Puerarin is widely used in cardiovascular diseases and diabetic vascular complications. However, little is known about its direct effects on diabetes. The aim of our study is to investigate its antidiabetic effect in vivo and in vitro, and explore the underlying mechanism. We used type I diabetic mice induced by streptozotocin to observe the effects of puerarin on glucose metabolism. In addition, oxidative stress and hepatic mitochondrial respiratory activity were evaluated in type I diabetic mice. In vitro, glucose consumption in Hep G2 cells was assayed along with the q PCR detection of glucogenesis genes expression. Moreover, ATP production was examined and phosphorylation of AMPK was determined using Western blot. Finally, the molecular docking was performed to predict the potential interaction of puerarin with AMPK utilizing program Lib Dock of Discovery Studio 2018 software. The results showed that puerarin improved Hep G2 glucose consumption and upregulated the glucogenesis related genes expression. Also, puerarin lowered fasting and fed blood glucose with improvement of glucose tolerance in type I diabetic mice. Further mechanism investigation showed that puerarin suppressed oxidative stress and improved hepatic mitochondrial respiratory function with enhancing ATP production and activating phosphorylation of AMPK. Docking study showed that puerarin interacted with AMPK activate site and enhancing phosphorylation. Taken together, these findings indicated that puerarin exhibited the hypoglycemic effect through attenuating oxidative stress and improving mitochondrial function via AMPK regulation, which may serve as a potential therapeutic option for diabetes treatment. | HOU Bi-Yu ZHAO Yue Rong MA Peng XU Chun-Yang HE Ping YANG Xiu-Ying ZHANG Li QIANG Gui-Fen DU Guan-Hua | 2020 | Chinese Journal of Natural Medicines2020，18，11： | 9 |
| 9 | Late recurrent high degree atrioventricular block after percutaneous closure of a perimembranous ventricular septal defect显示文摘高度心房与心室的块(HDAVB ) 是 perimembranous 的 transcatheter 闭合的严肃的复杂并发症室的氏族的缺点(PMVSD ) 。我们报导开发了短暂 HDAVB 的一个病人在在过程以后的 PMVSD 和有的周期性的 HDAVB 42 月的 transcathter 闭合以后的七天。 | YANG Rong SHENG Yan-hui CAO Ke-jiang ZOU Jiang-gang ZHANG Hao HOU Xiao-feng XU Di YONG Yong-hong ZHOU Lei KONG Xiang-qing | 2011 | Chinese Medical Journal2011，，19： | 8 |
| 10 | Mechanism of exogenous nucleic acids and their precursors improving the repair of intestinal epithelium after 7-irradiation in mice显示文摘AIM To clone expressed genes associated withrepair of irradiation-damaged mice intestinalgland cells treated by small intestinal RNA,andto explore the molecular mechanism ofexogenous nucleic acids improving repair ofintestinal crypt.METHODS The animal mode of test group andcontrol group was established,forty-five micebeing irradiated by γ ray were treated with smallintestinal RNA as test group,forty mice beingirradiated by γ ray were treated withphysiological saline as control group,five micewithout irradiation were used as normal control,their jejunal specimens were collectedrespectively at 6h,12h,24h,4d and 8d afterirradiation.Then by using LD-PCR based onsubtractive hybridization,these gene fragmentsdifferentially expressed between test group andcontrol group were obtained,and then werecloned into T vectors as well as beingsequenced.Obtained sequences were screenedagainst.GeneBank,if being new sequences,they were submitted to GeneBank.RESULTS Ninety clones were associated withrepair of irradiation-damaged intestinal glandcells treated by intestinal RNA.These clonesfrom test group of 6h,12h,24h,4d and 8dwere respectively 18,22,25,13,12.By screening against GeneBank,18 of which werenew sequences,the others were dramaticallysimilar to the known sequences,mainly similarto hsp,Nmi,Dutt1,alkaline phosphatase,homeobox,anti-CEA ScFv antibody,arginine/serine kinase and BMP-4,repA.Eighteen genefragments were new sequences,their acceptnumbers in GeneBank were respectivelyAF240164-AF240181.CONCLUSION Ninety clones were obtained tobe associated with repair of irradiation-damagedmice intestinal gland cells treated by smallintestinal RNA,which may be related toabnormal expression of genes and matchedproteins of hsp,Nmi,Duttl,Na,K-ATPase,alkalineph-osphatase,glkA,single strandedreplicative centromeric gene as well as 18 newsequences. | Da Xiang Cui~1 Guei Ying Zeng~2 Feng Wang~1 Jun Rong Xu~1 Dong Qing Ren~2 Yan Hai Guo~1 Fu Rong Tian~2 Xiao Jun Yan~1 Yu Hou~1 Cheng Zhi Su~1 1 Institute of Genetic Diagnosis of the Fourth Military Medical University,Xi’an 710032,China 2 Department of Irradiation Medicine of the Fourth Military Medical University,Xi’an 710032,China | 2000 | World Journal of Gastroenterology2000，6，5： | 8 |
| 11 | Xiaoyaosan improves depressive-like behaviors by regulating the NLRP3 signaling pathway in the rat cerebral cortex显示文摘Objective:To observe changes in the molecular expression of the NLR Family Pyrin Domain Containing Protein 3(NLRP3)pathway in depressed rats after treatment with Xiaoyaosan,and identify the regulatory mechanism of this compound.Methods:Male SpragueeD awley rats were randomly divided into five groups with 12 rats in each group,including the control group,model group,Fluoxetine group,Xiaoyaosan group,and MCC950 group.A depression model was generated by chronic immobilization stress(induced by 3 h of restraint immobilization every day),and the drugs were administered at the same time in each group for 21 days.The effects of Xiaoyaosan on behavioral changes of depressed rats were observed through macroscopic characterization,body mass,open field experiments,and a sucrose preference test.The m RNA and protein expression of the NLRP3 signaling pathway was examined by fluorescence real-time quantitative PCR and Western blot assays.Results:The Xiaoyaosan group,Fluoxetine group,and MCC950 group rats showed improved depressive behavior and an increased weight of sucrose water consumption.The protein and mRNA expression levels of NLRP3,Caspase-1,and IL-1 b were also decreased in the Fluoxetine,Xiaoyaosan,and MCC950 groups.Conclusion:NLRP3,Caspase-1,and IL-1 b protein and mRNA expression levels were increased in the cortex of depressed rats,while Xiaoyaosan protected cortical tissue in these rats by decreasing NLRP3,Caspase-1,and IL-1 b protein and mRNA expression. | Cong Chen Rong Yu Zhe Xue Zhiyi Yan Qinlai Bian Yajing Hou Yunzhi Chen Yueyun Liu Jiaxu Chen | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，3： | 5 |
| 12 | Effect of Rotational Tillage on Soil Aggregates, Organic Carbon and Nitrogen in the Loess Plateau Area of China显示文摘In rain-fed semi-arid agroecosystems, continuous conventional tillage can cause serious problems in soil quality and crop production, whereas rotational tillage (no-tillage and subsoiling) could decrease soil bulk density, and increase soil aggregates and organic carbon in the 0-40 cm soil layer. A 3-year field study was conducted to determine the effect of tillage practices on soil organic carbon (SOC), total nitrogen (TN), water-stable aggregate size distribution and aggregate C and N sequestration from 0 to 40 cm soil in semi-arid areas of southern Ningxia. Three tillage treatments were tested: no-tillage in year 1, subsoiling in year 2, and no-tillage in year 3 (NT-ST-NT); subsoiling in year 1, no-tillage in year 2, and subsoiling in year 3 (ST-NT-ST); and conventional tillage over years 1-3 (CT). Mean values of soil bulk density in 0-40 cm under NT-ST-NT and ST-NT-ST were significantly decreased by 3.3% and 6.5%, respectively, compared with CT, while soil total porosity was greatly improved. Rotational tillage increased SOC, TN, and water-stable aggregates in the 0-40 cm soil, with the greatest effect under ST-NT-ST. In 0-20 and 20-40 cm soils, the tillage effect was confined to the 2-0.25 mm size fraction of soil aggregates, and rotational tillage treatments obtained significantly higher SOC and TN contents than conventional tillage. No significant differences were detected in SOC and TN contents in the >2 mm and <0.25 mm aggregates among all treatments. In conclusion, rotational tillage practices could significantly increase SOC and TN levels, due to a fundamental change in soil structure, and maintain agroecosystem sustainability in the Loess Plateau area of China. | HOU Xian-Qing LI Rong JIA Zhi-Kuan HAN Qing-Fang | 2013 | Pedosphere2013，23，4： | 5 |
| 13 | Highly active catalyst for vinyl acetate synthesis by modified activated carbon显示文摘从修改的激活的碳被准备的新锌醋酸盐催化剂向乙烯基醋酸盐的合成展出了极端活动。激活的碳被硝酸,讽刺和 peroxyacetic 酸(泛美航空公司) 修改。特定的区域,结构, pH 和由修正的搬运人的表面酸味组上的效果被讨论。羰基总计,在激活的碳的 carboxyl 组被 peroxyacetic 酸处理增加。新催化剂的生产率比用未经治疗的激活的碳准备的催化剂的高是 14.58% 。在羰基和 carboxyl 组(m) 和催化剂生产率(P) 的数量之间的关系是 P = 1.83 + 2.26 × 10 −3*e3.17m 。反应机制被建议。 | Chun Yan Hou Liang Rong Feng Fa Li Qiu | 2009 | Chinese Chemical Letters2009，20，7： | 5 |
| 14 | Intranasal insulin ameliorates neurological impairment after intracerebral hemorrhage in mice显示文摘In Alzheimer’s disease and ischemic stroke,intranasal insulin can act as a neuroprotective agent.However,whether intranasal insulin has a neuroprotective effect in intracerebral hemorrhage and its potential mechanisms remain poorly understood.In this study,a mouse model of autologous blood-induced intracerebral hemorrhage was treated with 0.5,1,or 2 IU insulin via intranasal delivery,twice per day,until 24 or 72 hours after surgery.Compared with saline treatment,1 IU intranasal insulin treatment significantly reduced hematoma volume and brain edema after cerebral hemorrhage,decreased blood-brain barrier permeability and neuronal degeneration damage,reduced neurobehavioral deficits,and improved the survival rate of mice.Expression levels of p-AKT and p-GSK3βwere significantly increased in the perihematoma tissues after intranasal insulin therapy.Our findings suggest that intranasal insulin therapy can protect the neurological function of mice after intracerebral hemorrhage through the AKT/GSK3βsignaling pathway.The study was approved by the Ethics Committee of the North Sichuan Medical College of China(approval No.NSMC(A)2019(01))on January 7,2019. | Yuan Zhu Yi Huang Jin Yang Rong Tu Xin Zhang Wei-Wei He Chang-Yue Hou Xiao-Ming Wang Ju-Ming Yu Guo-Hui Jiang | 2022 | Neural Regeneration Research2022，17，1： | 5 |
| 15 | Ionic liquid modified GC electrode for the direct electrochemistry of chloroperoxidase显示文摘Chloroperoxidase (CPO ) 被 konjac glucomannan (KGM ) 在 1-butyl-3-methyl imidazolium tetrafluoroborate 上使不能调动[BMIM ][BF4 ]/Nafion 修改的玻璃质的碳电极。使不能调动的 CPO 的电气化学的行为被周期的 voltammetry 调查。结果证明 CPO 成功地在 GCE 上被使不能调动并且与正式潜力经历了快直接电子转移反应在 ? 0.3 V 对 SCE。修改电极为 O2 和 H2O2 的 electrocatalytical 减小显示出一项好催化活动。 | Liu Yang Xia Qin Wu Rong Wang Zhong Qing Lu Wen Jing Hou He Xing Li | 2008 | Chinese Chemical Letters2008，19，12： | 5 |
| 16 | Copper transportion of WD protein in hepatocytes from Wilson disease patients in vitro显示文摘AIM: To study the effect of copper transporting P-type ATPase in copper metabolism of hepatocyte and pathogenesis of Wilson disease (WD).METHODS: WD copper transporting properties in some organelles of the cultured hepatocytes were studied from WD patients and normal controls. These cultured hepatocytes were incubated in the media of copper 15mg.L-1 only, copper 15 mg. L-1 with vincristine (agonist of P-type ArPase) 0.5mg. L-1, or copper 15 mg. L-1 withvanadate (antagonist of P-type ATPase) 18.39 mg. L-1separately. Microsome (endoplasmic reticulum and Golgi apparatus), lysosome, mitochondria, and cytosol were isolated by differential centrifugation. Copper contents in these organelles were measured with atomic absorption spectrophotometer, and the influence in copper transportion of these organelles by vanadate and vincristine were comparatively analyzed between WD patients and controls.WD copper transporting P-type ATPase was detected by SDS-PAGE in conjunction with Western blot in liver samples of WD patients and controls.RESULTS: The specific WD proteins (Mr155 000 lanes) were expressed in human hepatocytes, including the control and WD patients. After incubation with medium containing copper for 2 h or 24 h, the microsome copper concentration in WD patients was obviously lower than that of controls,and the addtion of vanadate or vincristine would change the copper transporting of microsomes obviously. When incubated with vincristine, levels of copper in microsome were significantly increased, while incubated with vanadate,the copper concentrations in microsome were obviously decreased. The results indicated that there were Wdproteins, the copper transportion P-type ATPase in the microsome of hepatocytes. WD patients possessed abnormal copper transporting function of WD protein in the microsome, and the agonist might correct the defect of copper transportion by promoting the activity of copper transportion P-type ATPase.CONCLUSION: Copper transportion P-type ATPase plays an important role in hepatocytic copper metabolism.Dysfunction of hepatocytic WD protein copper transportion might be one of the most important factors for WD. | Guo-Qing Hou~1 Xiu-Ling Liang~2 Rong Chen~2 Li-Wen Tang~3 Ying Wang~2 Ping-Yi Xu~2 Ying-Ru Zhang~2 Cui-Hua Ou~2 1 Department of Neurology.Guangzhou First Municipal People’s Hospital,Guangzhou Medical College,Guangzhou 510180,Guangdong Province.China2 Department of Neurology.First Affiliated Hospital.Sun Yat-Sen University of Medical Sciences.Guangzhou 510080.Guangdong Province.China3 Department of Pharmacology,University of Kentucky.Lexington,KY 40506.USA | 2001 | World Journal of Gastroenterology2001，7，6： | 4 |
| 17 | The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes显示文摘 | Juan Chen Zhaokui Cai Meizhu Bai Xiaohua Yu Chao Zhang Changchang Cao Xihao Hu Lei Wang Ruibao Su Di Wang Yingpeng Yao Rong Ye Baidong Hou Yang Yu Shuyang Yu Jinsong Li Yuanchao xue | 2018 | Cell Research2018，28，10： | 4 |
| 18 | Optimal investment for the defined-contribution pension with stochastic salary under a CEV model显示文摘In this paper,we study the optimal investment strategy of defined-contribution pension with the stochastic salary.The investor is allowed to invest in a risk-free asset and a risky asset whose price process follows a constant elasticity of variance model.The stochastic salary follows a stochastic differential equation,whose instantaneous volatility changes with the risky asset price all the time.The HJB equation associated with the optimal investment problem is established,and the explicit solution of the corresponding optimization problem for the CARA utility function is obtained by applying power transform and variable change technique.Finally,we present a numerical analysis. | ZHANG Chu-bing RONG Xi-min ZHAO hui HOU Ru-jing | 2013 | Applied Mathematics(A Journal of Chinese Universities)2013，28，2： | 4 |
| 19 | Microsatellite variability reveals high genetic diversity and low genetic differentiation in a critical giant panda population显示文摘 | Jiandong YANG Zhihe ZHANG Fujun SHEN Xuyu YANG Liang ZHANG Limin CHEN Wenping ZHANG Qing ZHU Rong HOU | 2011 | Current Zoology2011，57，6： | 3 |
| 20 | Microvolt T-wave alternans complemented with electrophysiologic study for prediction of ventricular tachyarrhythmias in patients with arrhythmogenic right ventricular cardiomyopathy: a long-term follow-up study显示文摘Background: The long-term predicted value of microvolt T-wave alternans (MTWA) for ventricular tachyarrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) remains unclear. Our study explored the characteristics of MTWA and its prognostic value when combined with an electrophysiologic study (EPS) in patients with ARVC. Methods: All patients underwent non-invasive MTWA examination with modified moving average (MMA) analysis and an EPS. A positive event was defined as the first occurrence of sudden cardiac death, documented sustained ventricular tachycardia (VT), ventricular fibrillation, or the administration of appropriate implantable cardioverter defibrillator therapy including shock or antitachycardia pacing. Results: Thirty-five patients with ARVC (age 38.6 ± 11.0 years;28 males) with preserved left ventricular (LV) function were recruited. The maximal TWA value (MaxValt) was 17.0 (11.0–27.0)μV. Sustained VT was induced in 22 patients by the EPS. During a median follow-up of 99.9 ± 7.7 months, 15 patients had positive clinical events. When inducible VT was combined with the MaxValt, the area under the curve improved from 0.739 to 0.797. The receiver operating characteristic curve showed that a MaxValt of 23.5 μV was the optimal cutoff value to identify positive events. The multivariate Cox regression model for survival showed that MTWA (MaxValt, hazard ratio [HR], 1.06;95% confidence interval [CI], 1.01–1.11;P = 0.01) and inducible VT (HR, 5.98;95% CI, 1.33–26.8;P = 0.01) independently predicted positive events in patients with ARVC. Conclusions: MTWA assessment with MMA analysis complemented by an EPS might provide improved prognostic ability in patients with ARVC with preserved LV function during long-term follow-up. | She-Liang Xue Xiao-Feng Hou Kang-Yun Sun Yao Wang Zhi-Yong Qian Quan-Peng Wang Si-Peng Shen Hong-Li Yin Rong Zhang Hai-Ping Yin Jian-Gang Zou | 2019 | Chinese Medical Journal2019，，12： | 3 |
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