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| 1 | Positioning accuracy assessment for the 4GEO/5IGSO/2MEO constellation of COMPASS显示文摘Determined to become a new member of the well-established GNSS family,COMPASS(or BeiDou-2) is developing its capabilities to provide high accuracy positioning services.Two positioning modes are investigated in this study to assess the positioning accuracy of COMPASS' 4GEO/5IGSO/2MEO constellation.Precise Point Positioning(PPP) for geodetic users and real-time positioning for common navigation users are utilized.To evaluate PPP accuracy,coordinate time series repeatability and discrepancies with GPS' precise positioning are computed.Experiments show that COMPASS PPP repeatability for the east,north and up components of a receiver within China's Mainland is better than 2 cm,2 cm and 5 cm,respectively.Apparent systematic offsets of several centimeters exist between COMPASS precise positioning and GPS precise positioning,indicating errors remaining in the treatments of COMPASS measurement and dynamic models and reference frame differences existing between two systems.For common positioning users,COMPASS provides both open and authorized services with rapid differential corrections and integrity information available to authorized users.Our assessment shows that in open service positioning accuracy of dual-frequency and single-frequency users is about 5 m and 6 m(RMS),respectively,which may be improved to about 3 m and 4 m(RMS) with the addition of differential corrections.Less accurate Signal In Space User Ranging Error(SIS URE) and Geometric Dilution of Precision(GDOP) contribute to the relatively inferior accuracy of COMPASS as compared to GPS.Since the deployment of the remaining 1 GEO and 2 MEO is not able to significantly improve GDOP,the performance gap could only be overcome either by the use of differential corrections or improvement of the SIS URE,or both. | ZHOU ShanShi CAO YueLing ZHOU JianHua HU XiaoGong TANG ChengPan LIU Li GUO Rui HE Feng CHEN JunPing WU Bin | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，12： | 31 |
| 2 | Precise orbit determination for geostationary satellites with multiple tracking techniques显示文摘A new precise orbit determination (POD) strategy based on the combination of satellite laser ranging (SLR) and C-band transfer ranging for geostationary satellites (GEO) is presented.Two approaches to calibrate ranging biases of the C-band ranging system are proposed,namely the two tracking system co-location comparison and the combined POD method,with calibration accuracies estimated to be 0.5 ns and 1 ns respectively.Using data from a C-band tracking network in China,POD experiments indicate that meter-level POD accuracy is achievable for GEO.Root-mean-square (RMS) of the post-fit C-band ranging data is about 0.205 m.The radial component errors of POD are evaluated with SLR data from a station in Beijing,with residual RMS of 0.133 m.Orbital overlapping experiments show the total orbit error is a few meters.Computations of SLR residuals also suggest that for 2-hour prediction,the predicted radial error is about 0.373 m. | GUO Rui HU XiaoGong TANG Bo HUANG Yong LIU Li CHENG LiuCheng HE Feng | 2010 | Chinese Science Bulletin2010，55，8： | 24 |
| 3 | Antipyretic and anti-inflammatory activities of Thais luteostoma extracts and underlying mechanisms显示文摘Thais luteostoma has been utilized as a crude drug whose shell and soft tissue have been widely used for the treatment of heat syndrome in China for thousands of years. The present study was designed to investigate the antipyretic and anti-inflammatory activities of T. luteostoma. T. luteostoma was divided into shell(TLSH) and soft tissue(TLST) samples in the present study. The rat model of yeast-induced fever was used to investigate their antipyretic effects; and the rat model of hind paw edema induced by carrageenan was utilized to study their anti-inflammatory activities, and at the same time, the concentration variations of the central neurotransmitter [prostaglandin E2(PGE2) and cyclic adenosine monophosphate(cA MP)], inflammatory mediators [tumor necrosis factor(TNFα), interleukin-1β(IL-1), interleukin-2(IL-2) and interleukin-6(IL-6)] and ion(Na+ and Ca2+) were also tested. The results showed that TLSH and TLST extracts significantly inhibited yeast-induced pyrexia in rats(P < 0.05), and exhibited more lasting effects as compared to aspirin, and TLSH had the better antipyretic activity than TLST, and that TLSH and TLST could significantly prevent against carrageenan induced paw edema in rats(P < 0.05); and markedly reduced levels of PGE2, cA MP, TNFα, IL-1β, IL-2, IL-6, and Na+/Ca2+. In fever model, TLST could significantly reduce the levels of PGE2(P < 0.01) in rats' homogenate and TNFα(P < 0.05), IL-1β(P < 0.01) in the plasma than TLSH, whereas TLSH could reduce the content of IL-2(P < 0.01) and IL-6(P < 0.01) in plasma and increase the content of Ca2+(P < 0.01) in plasma and homogenate more significantly than TLST. In conclusion, T. luteostoma extract has antipyretic and anti-inflammatory activities, which may be mediated through the suppression of production of PGE2, c AMP, Na+/Ca2+, TNFα, IL-1β, IL-2, and IL-6. | LIU Xin TANG Yu-Ping LIU Rui JIN Yi GUO Jian-Ming ZHAO Jin-Long DING Shao-Xiong LIN Xiang-Zhi LIN Ru-Rong DUAN Jin-Ao | 2015 | Chinese Journal of Natural Medicines2015，13，3： | 15 |
| 4 | Significant value of 18F-FDG-PET/CT in diagnosing small cervical lymph node metastases in patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy显示文摘Background: Little is known about the nature of metaistasis to small cervical lymph nodes(SCLNS) in the patients with nasopharyngeal carcinoma(NPC)examined by using 18-fluoro-2-deoxy-glucose(^(18)F-FDG) positron emission tomography/computed tomography(PET/CT).The present study aimed to evaluate the diagnostic values of PET/CT in identifying metastasis in SCLNs in NPC patients.Methods: Magnetic resonance images(MRI) and PET/CT scans for 470 patients with newly diagnosed, non-distant metastatic NPC were analyzed. Metastatic rates of SCLNs were defined by the positive number of SCLNs on PET/CT scans and total number of SCLNs on MRI scans. Receiver operating characteristic curve was applied to compare PET/CT-determined stage with MRI-determined stage.Results: In total, 2082 SCLNs were identified, with 808(38.8%) ≥ 5 and < 6 mm in diameter(group A), 526(25.3%)≥ 6 and < 7 mm in diameter(group B),374(18.0%)≥ 7 and < 8 mm in diameter(group C), 237(11.4%) ≥8 and<9 mm in diameter(group D),and 137(6.5%) ≥ 9 and <10 mm in diameter(group E).The overall metastatic rates examined by using PET/CT for groups A, B,C,D, and E were 3.5%, 8.0%, 31.3%, 60.0%, and 83.9%, respectively(P< 0.001). In level IV/Vb, the metastatic rate for nodes ≥ 8 mm was 84.6%. PET/CT examination resulted in modification of N category and overall stage for 135(28.7%) and 46(9.8%) patients, respectively. The areas under curve of MRIdetermined and PET/CT-determined overall stage were 0.659 and 0.704 for predicting overall survival, 0.661 and 0.711 for predicting distant metastasis-free survival, and 0.636 and 0.663 for predicting disease-free survival.Conclusions: PET/CT was more effective than MRI in identifying metastatic SCLNs, and the radiologic diagnostic criteria for metastatic lymph nodes in level IV/Vb should be re-defined. | Hao Peng Lei Chen Ling-Long Tang Wen-Fei Li Yan-Ping Mao Rui Guo Yuan Zhang Li-Zhi Liu Li Tian Xu Zhang Xiao-Ping Lin Ying Guo Ying Sun Jun Ma | 2017 | Chinese Journal of Cancer2017，36，12： | 14 |
| 5 | Prognostic value of plasma Epstein-Barr virus DNA level during posttreatment follow-up in the patients with nasopharyngeal carcinoma having undergone intensity-modulated radiotherapy显示文摘Background: The value of Epstein-Barr virus(EBV) DNA assay during posttreatment follow-up of the patients with nasopharyngeal carcinoma(NPC) presenting with different pretreatment plasma EBV DNA levels remains unclear. In the present study, we aimed to evaluate the prognostic value of plasma EBV DNA assay during posttreatment followup in the patients with NPC who have undergone intensity-modulated radiotherapy.Methods: The medical records of 385 NPC patients treated with intensity-modulated radiotherapy between November 2009 and February 2012 were reviewed. All patients underwent plasma EBV DNA assays before treatment, within3 months after treatment, and then every 3-12 months during posttreatment follow-up period. The recurrence rates for patients with different pretreatment and posttreatment follow-up plasma EBV DNA levels were analyzed.Results: Of the 385 patients, 267(69.4%) had detectable pretreatment plasma EBV DNA(> 0 copy/mL) and 93(24.2%) had detectable posttreatment EBV DNA during a median follow-up of 52.8 months(range 9.3-73.8 months).Detectable EBV DNA during posttreatment follow-up was found in 14.4%(17/118) and 28.5%(76/267) of patients with undetectable and detectable pretreatment EBV DNA, respectively, and was significantly associated with tumor recurrence in both patient groups. EBV DNA was detectable in 12.8%(40/313) of patients who remained disease-free,56.4%(22/39) of patients with locoregional recurrence alone, and 93.9%(31/33) of patients with distant metastasis as the first recurrence event(P < 0.001); 6.5%(19/292) of patients with undetectable EBV DNA and 57.0%(53/93) of patient with detectable EBV DNA during posttreatment follow-up experienced tumor recurrence. Compared with other cut-off values, the cut-off value of 0 copy/mL for EBV DNA during posttreatment follow-up had the highest area under the ROC curve(AUC) value(0.804,95% confidence interval 0.741-0.868) for predicting tumor recurrence(sensitivity, specificity, and accuracy: 73.6%, 87.2%, and 84.7%, respectively).Conclusion: Plasma EBV DNA level during posttreatment follow-up is a good marker for predicting distant metastasis but not locoregional recurrence in the patients with NPC irrespective of the pretreatment EBV DNA levels. | Wen-Fei Li Yuan Zhang Xiao-Bin Huang Xiao-Jing Du Ling-Long Tang Lei Chen Hao Peng Rui Guo Ying Sun Jun Ma | 2017 | Chinese Journal of Cancer2017，36，11： | 12 |
| 6 | A highly conductive and stretchable wearable liquid metal electronic skin for long-term conformable health monitoring显示文摘Conventional rigid electronics are usually unconformable with soft skins and tend to fail in accurate physiological monitoring and precise treatment. Electronic skins(e-Skins) made by conductive and stretchable materials offer mechanical compliance for fabricating flexible and conformable wearables. Compared to common organic or inorganic conductive materials, gallium-based liquid metals alone own superior conductivity and compliance. Here, we demonstrate a highly conductive and stretchable electronic skin with liquid metal circuits(LMCs) embedded in silicone rubber film, which are functionalized for physiological signals monitoring. Through the designs of serpentine structure, LMCs maintained good electrical conductivity and functionality under over 100% strain. Also, a wearable electrocardiogram(ECG) recording device was fabricated and tested. The device was able to acquire steady signals during real-time measurement of physical activities. The proposed liquid metal e-Skin can be further extended to conformable bio-integrated healthcare devices and intelligent health monitoring networks. | GUO Rui WANG XueLin YU WenZhuo TANG JianBo LIU Jing | 2018 | Science China(Technological Sciences)2018，61，7： | 10 |
| 7 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 8 | Revisiting the sex pheromone of the fall armyworm Spodoptera frugiperda,a new invasive pest in South China显示文摘The fall armyworm Spodoptera frugiperda is a worldwide serious agricultural pest,and recently invaded South China.Sex pheromone can be employed to monitor its population dynamics accurately in the field.However,the pheromone components previously reported by testing different geographic populations and strains are not consistent.On the basis of confirming that the S.frugiperda population from Yunnan Province belonged to the com strain,we analyzed the potential sex pheromone components in the pheromone gland extracts of females using gas chromatography coupled with electroan-tennographic detection(GC-EAD),gas chromatography coupled with mass spectrometry(GC-MS)and electroantennography(EAG).The results show that(Z)-9-tetradecenal acetate(Z9-14:Ac),(Z)-11-hexadecenyl acetate(Z11-16:Ac),(Z)-7-dodecenyl acetate(Z7-12:Ac)or(E)-7-dodecenyl acetate(E7-12:Ac)with a ratio of 100:15.8:3.9 induced EAD responses to varying degrees:Z9-14:Ac elicited a strong EAD response,Z7-12:Ac or E7-12:Ac elicited a small but clear EAD response,while Z11-16:Ac elicited a weak EAD response.Further single sensillum recording(SSR)showed that Z9-14:Ac and Z7-12:Ac induced dose-dependent activities in two types(A and B)of sensilla in male antennae,respectively,while the sensilla in response to E7-12:Ac and Z11-16:Ac was not recorded.Finally,wind tunnel tests reveal that Z9-14:Ac and Z7-12:Ac are two principal sex pheromone components of the tested population. | Nan-Ji Jiang Bao-Tong Mo Hao Guo Jun Yang Rui Tang Chen-Zhu Wang | 2022 | Insect Science2022，29，3： | 8 |
| 9 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 10 | In situ hybridization assay of androgen receptor gene in hepatocarcinogenesis显示文摘NTRODUCTIONItiswelknownthatsexhormoneplaysanimportantroleinregulationofcelgrowth,organdevelopmentandcarcinogenesis.Butthemost... | ZHAO Guo Qiang, XUE Ling, XU Hong Yu, TANG Xi Ming, HU Rui De and DONG Jun | 1998 | World Journal of Gastroenterology1998，4，6： | 7 |
| 11 | Applications of two-way satellite time and frequency transfer in the BeiDou navigation satellite system显示文摘A two-way satellite time and frequency transfer(TWSTFT) device equipped in the BeiDou navigation satellite system(BDS)can calculate clock error between satellite and ground master clock. TWSTFT is a real-time method with high accuracy because most system errors such as orbital error, station position error, and tropospheric and ionospheric delay error can be eliminated by calculating the two-way pseudorange difference. Another method, the multi-satellite precision orbit determination(MPOD)method, can be applied to estimate satellite clock errors. By comparison with MPOD clock estimations, this paper discusses the applications of the BDS TWSTFT clock observations in satellite clock measurement, satellite clock prediction, navigation system time monitor, and satellite clock performance assessment in orbit. The results show that with TWSTFT clock observations, the accuracy of satellite clock prediction is higher than MPOD. Five continuous weeks of comparisons with three international GNSS Service(IGS) analysis centers(ACs) show that the reference time difference between BeiDou time(BDT) and golbal positoning system(GPS) time(GPST) realized IGS ACs is in the tens of nanoseconds. Applying the TWSTFT clock error observations may obtain more accurate satellite clock performance evaluation in the 104 s interval because the accuracy of the MPOD clock estimation is not sufficiently high. By comparing the BDS and GPS satellite clock performance, we found that the BDS clock stability at the 103 s interval is approximately 10.12, which is similar to the GPS IIR. | ShanShi Zhou XiaoGong Hu Li Liu Rui Guo LingFeng Zhu ZhiQiao Chang ChengPan Tang XiuQiang Gong Ran Li Yang Yu | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，10： | 6 |
| 12 | Famitinib in combination with concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 1, open-label, dose-escalation Study显示文摘Background:Famitinib is a tyrosine kinase inhibitor against multiple targets,including vascular endothelial growth factor receptor 2/3,platelet-derived growth factor receptor,and stem cell factor receptor(c-kit).Previous studies have demonstrated anti-tumour activities of famitinib against a wide variety of advanced-stage solid cancers.We aimed to determine the safety and efficacy of famitinib with concurrent chemoradiotherapy(CCRT)in patients with locoregionally advanced nasopharyngeal carcinoma(NPC).We also evaluated the feasibility of contrast-enhanced ultrasound(D-CEUS)as a predictor of early tumour response to famitinib and to correlate functional parameters with clinical efficacy.Methods:The trial was conducted in subjects with stage III or IVa-b NPC using a 3+3 design of escalating fami-tinib doses.Briefly,subjects received 2 weeks of famitinib monotherapy followed by 7 weeks of famitinib plus CCRT.D-CEUS of the neck lymph nodes was performed at day 0,8 and 15 after famitinib was administered before starting concurrent chemoradiotherapy.End points included safety,tolerability and anti-tumour activity.Results:Twenty patients were enrolled(six each for 12.5,16.5 and 20 mg and two for 25 mg).Two patients in the 25 mg cohort developed dose-limiting toxicities,including grade 4 thrombocytopenia and grade 3 hypertension.The most common grade 3/4 adverse events were leukopenia,neutropenia and radiation mucositis.D-CEUS tests showed that more than 60%of patients achieved a perfusion parameter response after 2 weeks taking famitinib alone,and the parameter response was associated with disease improvement.In the famitinib monotherapy stage,three patients(15%)showed partial responses.The complete response rate was 65%at the completion of treatment and 95%3 months after the treatment ended.After a median follow-up of 44 months,the 3-year progression-free survival(PFS)and distant metastasis-free survival were 70%and 75%,respectively.Subjects with a decrease of perfusion parameter response,such as peak intensity decreased at least 30%after 1 week of famitinib treatment,had higher 3-year PFS(90.9%vs.44.4%,95%CI 73.7%-100%vs.11.9%-76.9%,P<0.001)than those with an increase or a reduction of less than 30%.Conclusions:The recommended famitinib dose for phase II trial is 20 mg with CCRT for patients with local advanced NPC.D-CEUS is a reliable and early measure of efficacy for famitinib therapies.Further investigation is required to confirm the effects of famitinib plus chemoradiotherapy. | Qiuyan Chen Linquan Tang Na Liu Feng Han Ling Guo Shanshan Guo Jianwei Wang Huai Liu Yanfang Ye Lu Zhang Liting Liu Pan Wang Yingqin Li Qingmei He Xiaoqun Yang Qingnan Tang Yang Li YuJing Liang XueSong Sun Chuanmiao Xie Yunxian Mo Ying Guo Rui Sun Haoyuan Mo Kajia Cao Xiang Guo Musheng Zeng Haiqiang Mai Jun Ma | 2018 | Cancer Communications2018，38，1： | 6 |
| 13 | Functional identification of the terpene synthase family involved in diterpenoid alkaloids biosynthesis in Aconitum carmichaelii显示文摘Aconitum carmichaelii is a high-value medicinal herb widely used across China,Japan,and other Asian countries.Aconitine-type diterpene alkaloids(DAs)are the characteristic compounds in Aconitum.Although six transcriptomes,based on short-read next generation sequencing technology,have been reported from the Aconitum species,the terpene synthase(TPS)corresponding to DAs biosynthesis remains unidentified.We apply a combination of Pacbio isoform sequencing and RNA sequencing to provide a comprehensive view of the A.carmichaelii transcriptome.Nineteen TPSs and five alternative splicing isoforms belonging to TPS-b,TPS-c,and TPS-e/f subfamilies were identified.In vitro enzyme reaction analysis functional identified two sesqui-TPSs and twelve di TPSs.Seven of the TPS-c subfamily genes reacted with GGPP to produce the intermediate ent-copalyl diphosphate.Five Ac KSLs separately reacted with ent-CPP to produce ent-kaurene,ent-atiserene,and ent-13-epi-sandaracopimaradie:a new diterpene found in Aconitum.Ac TPSs gene expression in conjunction DAs content analysis in different tissues validated that ent-CPP is the sole precursor to all DAs biosynthesis,with Ac KSL1,Ac KSL2 s and Ac KSL3-1 responsible for C20 atisine and napelline type DAs biosynthesis,respectively.These data clarified the molecular basis for the C20-DAs biosynthetic pathway in A.carmichaelii and pave the way for further exploration of C19-DAs biosynthesis in the Aconitum species. | Liuying Mao Baolong Jin Lingli Chen Mei Tian Rui Ma Biwei Yin Haiyan Zhang Juan Guo Jinfu Tang Tong Chen Changjiangsheng Lai Guanghong Cui Luqi Huang | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 6 |
| 14 | Reliability design optimization of composite structures based on PSO together with FEA显示文摘The present work aims to develop a method for reliability-based optimum design of composite structures. A procedure combining particle swarm optimization (PSO) and finite element analysis (FEA) has been proposed. Numerical examples for the reliability design optimization (RDO) of a laminate and a composite cylindrical shell are worked out to demonstrate the effectiveness of the method. Then a design for composite pressure vessels is studied. The advantages and necessity of RDO over the conventional equi-strength design are addressed. Examples show that the proposed method has good stability and is efficient in dealing with the probabilistic optimal design of composite structures. It may serve as an effective tool to optimize other complicated structures with uncertainties. | Chen Jianqiao Tang Yuanfu Ge Rui An Qunli Guo Xiwei | 2013 | Chinese Journal of Aeronautics2013，26，2： | 6 |
| 15 | Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats显示文摘Curcumin improves the learning and memory deficits in rats induced by the gp120 V3 loop. The present study cultured rat hippocampal neurons with 1 nM gp120 V3 loop and 1 μM curcumin for 24 hours. The results showed that curcumin inhibited the gp120 V3 loop-induced mitochondrial membrane potential decrease, reduced the mRNA expression of the pro-apoptotic gene caspase-3, and attenuated hippocampal neuronal injury. | Zheng Gong Lijuan Yang Hongmei Tang Rui Pan Sai Xie Luyan Guo Junbin Wang Qinyin Deng Guoyin Xiong Yanyan Xing Jun Dong | 2012 | Neural Regeneration Research2012，7，3： | 5 |
| 16 | Hardware-in-the-loop simulation for the contact dynamic process of flying objects in space显示文摘在地面上的一个严肃环境,自从人首先由飞目标探索了空间,在空间的零严肃的环境的二个飞的目标的接触过程的模拟是一个挑战性的问题。Hardware-in-the-loop (HIL ) 模拟是一个重要、有效的方法在空间测试真实停靠机制的可用性,可靠性,和安全。为 HIL 模拟系统有四个主要问题:能够高频率反应,高运动精确,高速度,和快速的加速的模拟器的设计;为模拟失真的赔偿;为 HIL 模拟进程的一个控制模型的设计;并且试验性的确认。这里,我们与 6-DOF 3-3 建议一个新奇 HIL 模拟器系统垂直平行机制和 3-DOF 3-PRS 平行机制;发现模拟失真的原则;为模拟器的力量测量系统,动态反应,和结构的动力学介绍失真赔偿模型;并且为 HIL 模拟过程提供一个控制模型。二种实验在被动未受潮的有弹性的杆和停靠机制上被执行测试他们的表演并且验证 HIL 模拟器的有效性和可用性。在这份报纸建议的 HIL 模拟系统为开发停靠的空格是有用的, berthing, refueling,修理,升级,搬运,并且 rescuing 技术。 | GAO Feng QI ChenKun REN AnYe ZHAOXianChao CAO Rui SUN Qiao WANG Qian HU Yan HE Jun JIN ZhenLin LIU RenQiang ZHANG Yong GUO WeiZhong HU ZhenYu TANG Ping NI Bo JING QianFeng WANG WeiJun GAO Peng | 2016 | Science China(Technological Sciences)2016，59，8： | 4 |
| 17 | Effects of octreotide on glucose transporter type 2expression in obese rat small intestine显示文摘AIM:To investigate the effects of the somatostatin analogue,octreotide,on maltose and sucrase activities and expression of glucose transporter type 2(GLUT2) in obese rat intestinal mucosa.METHODS:We divided 49 Sprague-Dawley rats into a group of 31 high fat diet-induced obese rats and a group of 18 normal controls.The obese rats were separated into an octreotide treated group of 16 rats and an obese group of 15.The intervention group was injected with octreotide at 40μg/kg body weight every 12 h for 8 d.Rat body weight was measured weekly to calculate Lee's index.After euthanization,maltase and sucrase activities in the small intestine were measuredby activity assays,and the fasting plasma glucose level was measured.The expression of GLUT2 in small intestinal mucosa was analyzed by immunohistochem-istry,reverse transcriptase polymerase chain reaction and Western blotting assays.RESULTS:Body weight,Lee's index,fasting plasma glucose level,maltase activity in small intestinal mucosa,mucosa and apical GLUT2,GLUT2 mRNA and protein expression levels were all significantly higher in the obese group than in the normal control group(605.61±141.00 vs 378.54±111.75,337.61 ±10.82 vs 318.73±20.10,8.60±1.38 vs 7.33± 0.70,156.01±58.81 vs 50.43±30.49,390 744.2 ±62 469.21 vs 170 546.50±50 646.14,26 740.18 ±3809.60 vs 354.98±57.19,0.26±0.11 vs 0.07 ±0.02,and 2.08±0.59 vs 1.27±0.38,respectively,all P<0.01).Sucrase activity did not differ between the two groups.Octreotide intervention significantly decreased the body weight and fasting plasma glucose level of obese rats(508.27±94.39 vs 605.61±141.00,7.58±1.51 vs 8.60±1.38,respectively,all P<0.05).The intestinal mucosa and apical GLUT2,expression of GLUT2 mRNA and protein were also significantly lower in the octreotide intervention group than in the obese group(269 975.2 ±53 730.94 vs 390 744.2±62 469.21,3758.06± 364.51 vs 26 740.18±3809.60,0.08±0.02 vs 0.26± 0.11,and 1.31±0.27 vs 2.08±0.59,respectively,all P<0.01).CONCLUSION:High fat dietinduced obesity is associated with elevated intestinal maltase activity,GLUT2 expression,and permanent apical GLUT2 in the small intestinal mucosa of rats.Octreotide can inhibit these effects. | Na Wei Rui Liu Yan Ou Xian Li Ou Qiang Wei Guo Cheng-Wei Tang | 2011 | World Journal of Gastroenterology2011，17，39： | 4 |
| 18 | The method and experiment analysis of two-way common-view satellite time transfer for compass system显示文摘Time synchronization between ground and satellites is a key technology for satellite navigation system. With dual-channel satellite, a method called Two-Way Common-View(TWCV) satellite time transfer for Compass system is proposed, which combines both characteristics of satellite common-view and two-way satellite-ground time transfer. By satellite-ground two-way pseudo-range differencing and two stations common-view differencing, this TWCV method can completely eliminate the influence of common errors, such as satellite clock offset, ephemeris errors, troposphere delay and station coordinates errors. At the same time, ionosphere delay related to signal frequency is also weakened significantly. So the precision of time transfer is improved much more greatly than before. In this paper, the basic principle is introduced in detail, the effect of major errors is analyzed and the practical calculation model in the Earth-fixed coordinate system for this new method is provided. Finally, experiment analysis is conducted with actual Compass observing data. The results show that the deviation and the stability of the satellite dual channel can be better than 0.1 ns, and the accuracy of the two-way common-view satellite time transfer can achieve 0.4 ns. All these results have verified the correctness of this TWCV method and model. In addition, we compare this TWCV satellite time transfer with the independent C-band TWSTFT(Two-Way Satellite Time and Frequency Transfer). It shows that the result of the TWCV satellite time transfer is in accordance with the C-band TWSTFT result, which further suggests that the TWCV method is a remote high precision time transfer technique. The research results in this paper are very important references for the development and application of Compass satellite navigation system. | LIU Li TANG GuiFen HAN ChunHao SHI Xin GUO Rui ZHU LingFeng | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，8： | 2 |
| 19 | Immunological features and efficacy of the reconstructed epitope vaccine CtUBE against Helicobacter pylori infection in BALB/c mice model显示文摘 | Le Guo Kunmei Liu Wenfeng Zhao Xiaokang Li Tong Li Feng Tang Rui Zhang Wutong Wu Tao Xi | 2013 | Applied Microbiology and Biotechnology2013，，： | 2 |
| 20 | Efficacy and Safety of Domestic Leuprorelin in Girls with Idiopathic Central Precocious Puberty: A Multicenter,Randomized, Parallel, Controlled Trial显示文摘 | Wen-Jing Li Chun-Xiu Gong Mei-Jie Guo Jie Xing Tang Li Wen-Hui Song Xiao-Ping Luo Di Wu Jian-Ping Liang Bing-Yan Cao Yi Gu Chang Su Xue-Jun Liang Min Liu Rui Wang Feng-Ting Li | 2015 | Chinese Medical Journal2015，，10： | 2 |
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