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| 1 | Novel Strategy for Synthesis of High Quality CdTe Nanocrystals in Aqueous Solution显示文摘A novel aqueous route for the synthesis of high-quality CdTe nanocrystals(NCs) is presented in this article. With both glutathione(GSH) and cysteine[n(GSH):n(cysteine)=1:3] as stabilizers, high-quality CdTe NCs with controllable photoluminescence(PL) wavelength from 500 to 630 nm can be prepared within 4 h. As-prepared CdTe NCs show higher photoluminescence quantum yields(PLQY) compared with CdTe NCs prepared via other aqueous methods. When the fluorescent emission peak appeared in orange-red window, the PLQY reaches 70% or above at room temperature without any post-preparative treatment. | YAN Yu-xi MU Ying FENG Guo-dong ZHANG Lei ZHU Lin-lin XU Ling YANG Rui JIN Qin-han | 2008 | Chemical Research in Chinese Universities2008，24，1： | 21 |
| 2 | Electrochemical performance of a nickel-rich LiNi0.6Co0.2Mn0.2O2 cathode material for lithium-ion batteries under different cut-off voltages显示文摘A spherical-like Ni_(0.6)Co_(0.2)Mn_(0.2)(OH)_2 precursor was tuned homogeneously to synthesize LiNi_(0.6)Co_(0.2)Mn_(0.2)O_2 as a cathode material for lithium-ion batteries.The effects of calcination temperature on the crystal structure,morphology,and the electrochemical performance of the as-prepared LiNi_(0.6)Co_(0.2)Mn_(0.2)O_2 were investigated in detail.The as-prepared material was characterized by X-ray diffraction,scanning electron microscopy,laser particle size analysis,charge–discharge tests,and cyclic voltammetry measurements.The results show that the spherical-like LiNi_(0.6)Co_(0.2)Mn_(0.2)O_2 material obtained by calcination at 900°C displayed the most significant layered structure among samples calcined at various temperatures,with a particle size of approximately 10 μm.It delivered an initial discharge capacity of 189.2 m Ah×g^(-1) at 0.2C with a capacity retention of 94.0% after 100 cycles between 2.7 and 4.3 V.The as-prepared cathode material also exhibited good rate performance,with a discharge capacity of 119.6 m Ah×g^(-1) at 5C.Furthermore,within the cut-off voltage ranges from 2.7 to 4.3,4.4,and 4.5 V,the initial discharge capacities of the calcined samples were 170.7,180.9,and 192.8 m Ah×g^(-1),respectively,at a rate of 1C.The corresponding retentions were 86.8%,80.3%,and 74.4% after 200 cycles,respectively. | Kai-lin Cheng Dao-bin Mu Bo-rong Wu Lei Wang Ying Jiang Rui Wang | 2017 | International Journal of Minerals,Metallurgy and Materials2017，24，3： | 14 |
| 3 | One-stop strategy for treatment of atrial fibrillation:feasibility and safety of combining catheter ablation and left atrial appendage closure in a single procedure显示文摘Background:Catheter ablation is effective in restoring sinus rhythm and left atrial appendage closure(LAAC)is increasingly used for stroke prevention in patients with atrial fibrillation(AF).We aimed to observe the feasibility and safety of performing AF ablation and LAAC in a single(one-stop)procedure.Methods:Consecutive AF patients who underwent the combined procedure of AF ablation and LAAC with WATCHMAN device between March 2017 and September 2018 were prospectively enrolled.Baseline and intra-procedural parameters were evaluated.Three-month and subsequent 1-year follow-up were performed in all and earlier-enrolled subjects,respectively.Results:A total of 178 AF patients(94 males,68.9±8.1 years)underwent the one-stop procedure with CHA2DS2-VASc score 3.3±1.5 and HAS-BLED score 1.6±1.0,respectively.Pulmonary vein isolation was achieved in all patients while additional linear ablation was applied if the operator deemed necessary,yielding immediate ablation success rate of 98.9%(176/178).In the subsequent LAAC,satisfactory seal(residual leak<5 mm)was achieved in all patients.One stroke and four cardiac perforations occurred peri-operatively.At 3-month follow-up,sinus rhythm and satisfactory seal were maintained in 153/178(86.0%)and 178/178(100%)patients,respectively.One stroke and one delayed cardiac tamponade occurred,while no device-related thrombus or device migration was observed.During the 1-year follow-up for the earlier enrolled subjects,52/72(72.2%)of the patients maintained sinus rhythm.There was no stroke or systemic embolism observed.Conclusion:Combining catheter ablation and LAAC in a single procedure can be successfully and safely performed in non-valvular AF patients of Chinese population. | Mu Chen Zhi-Quan Wang Qun-Shan Wang Jian Sun Peng-Pai Zhang Xiang-Fei Feng Wei Li Ying Yu Bo Liu Bin-Feng Mo Rui Zhang Mei Yang Chang-Qi Gong Ming-Zhe Zhao Yi-Chi Yu Yan Zhao Qiu-Fen Lu Yi-Gang Li | 2020 | Chinese Medical Journal2020，，12： | 11 |
| 4 | Apogossypolone, a novel inhibitor of anfiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro显示文摘有限治疗选择为好攻击的前列腺癌症是可得到的。Gossypol 被报导了在癌症的许多类型举办一项有势力 anticancer 活动。它能增加癌症房间的敏感到 alkylating 代理人,减少 multidrug 抵抗和减少转移。它是否能在癌症房间导致 autophagy,还没是坚定的。这里,我们在 vitro 在人的前列腺癌症房间线 PC3 和 LNCaP 上调查了 apogossypolone (ApoG2 ) 和(?)-gossypol 的 antiproliferative 活动。到 ApoG2 的 PC-3 和 LNCaP 房间的暴露导致了 autophagy 的几个特定的特征特征,包括在酸的小囊的细胞器的细胞质和形成的膜的液泡的外观。联系 autophagy 的 LC3-II 和 beclin-1 的表示在治疗以后在两根房间线增加了。有 3-methyladenine 的 autophagy 的抑制支持了两种房间类型的 apoptosis。一起拿,这些数据证明 autophagy 的那正式就职能在人的前列腺癌症房间对 apoptosis 代表防卫机制。 | Xian-Qing Zhang Xiao-Feng Huang Xing-Bin Hu Yong-Hua Zhan Qun-Xing An Shi-Ming Yang Ai-Jun Xia Jing Yi Rui Chen Shi-Jie Mu Dao-Cheng Wu | 2010 | Asian Journal of Andrology2010，12，5： | 10 |
| 5 | Automatic Test Method Research on the Word Part of Document Format Translator显示文摘 | MU Yongmin WANG Rui ZHANG Zhihua DING Yuan WU Miao | 2013 | Chinese Journal of Electronics2013，22，1： | 7 |
| 6 | Co-Estimation of State of Charge and Capacity for Lithium-Ion Batteries with Multi-Stage Model Fusion Method显示文摘Lithium-ion batteries(LIBs)have emerged as the preferred energy storage systems for various types of electric transports,including electric vehicles,electric boats,electric trains,and electric airplanes.The energy management of LIBs in electric transports for all-climate and long-life operation requires the accurate estimation of state of charge(SOC)and capacity in real-time.This study proposes a multistage model fusion algorithm to co-estimate SOC and capacity.Firstly,based on the assumption of a normal distribution,the mean and variance of the residual error from the model at different ageing levels are used to calculate the weight for the establishment of a fusion model with stable parameters.Secondly,a differential error gain with forward-looking ability is introduced into a proportional–integral observer(PIO)to accelerate convergence speed.Thirdly,a fusion algorithm is developed by combining a multistage model and proportional–integral–differential observer(PIDO)to co-estimate SOC and capacity under a complex application environment.Fourthly,the convergence and anti-noise performance of the fusion algorithm are discussed.Finally,the hardware-in-the-loop platform is set up to verify the performance of the fusion algorithm.The validation results of different aged LIBs over a wide range of temperature show that the presented fusion algorithm can realize a high-accuracy estimation of SOC and capacity with the relative errors within 2%and 3.3%,respectively. | Rui Xiong Ju Wang Weixiang Shen Jinpeng Tian Hao Mu | 2021 | Engineering2021，7，10： | 5 |
| 7 | 左旋棉酚对前列腺癌PC-3细胞增殖的体内外抑制作用显示文摘本文研究左旋棉酚在体内外对前列腺癌PC-3细胞的抗增殖活性,并阐明其可能的分子机制。使用MTT法测定了细胞的生长与活性,用TUNEL与透射电镜检测了细胞的凋亡,用免疫组织化学技术检测了肿瘤组织中PCNA、Bcl-2、CD31、caspase-3与caspase-8的表达。结果表明左旋棉酚的IC。值为4.74mgmL-1。在体内实验中,给予荷瘤裸鼠左旋棉酚(〉5mgkg-1),每日一次,共7天,结果发现左旋棉酚以剂量依赖方式显著抑制肿瘤生长,免疫组化分析发现左旋棉酚增强caspase-3与caspase-8的表达,降低PCNA、Bcl-2、与CD31的表达。结果提示左旋棉酚可以通过诱导前列腺癌细胞凋亡和抑制血管生成而起到抗肿瘤作用。 | Xian-Qing Zhang Xiao-Feng Huang Shi-Jie Mu Qun-Xing An Ai-Jun Xia Rui Chen Dao-Cheng Wu | 2010 | Asian Journal of Andrology2010，12，3： | 4 |
| 8 | Substantial transition to clean household energy mix in rural China显示文摘The household energy mix has significant impacts on human health and climate,as it contributes greatly to many health-and climate-relevant air pollutants.Compared to the well-established urban energy statistical system,the rural household energy statistical system is incomplete and is often associated with high biases.Via a nationwide investigation,this study revealed high contributions to energy supply from coal and biomass fuels in the rural household energy sector,while electricity comprised∼20%.Stacking(the use of multiple sources of energy)is significant,and the average number of energy types was 2.8 per household.Compared to 2012,the consumption of biomass and coals in 2017 decreased by 45%and 12%,respectively,while the gas consumption amount increased by 204%.Increased gas and decreased coal consumptions were mainly in cooking,while decreased biomass was in both cooking(41%)and heating(59%).The time-sharing fraction of electricity and gases(E&G)for daily cooking grew,reaching 69%in 2017,but for space heating,traditional solid fuels were still dominant,with the national average shared fraction of E&G being only 20%.The non-uniform spatial distribution and the non-linear increase in the fraction of E&G indicated challenges to achieving universal access to modern cooking energy by 2030,particularly in less-developed rural and mountainous areas.In some non-typical heating zones,the increased share of E&G for heating was significant and largely driven by income growth,but in typical heating zones,the time-sharing fraction was<5%and was not significantly increased,except in areas with policy intervention.The intervention policy not only led to dramatic increases in the clean energy fraction for heating but also accelerated the clean cooking transition.Higher income,higher education,younger age,less energy/stove stacking and smaller family size positively impacted the clean energy transition. | Guofeng Shen Rui Xiong Yanlin Tian Zhihan Luo Bahabaike Jiangtulu Wenjun Meng Wei Du Jing Meng Yuanchen Chen Bing Xue Bin Wang Yonghong Duan Jia Duo Fenggui Fan Lei Huang Tianzhen Ju Fenggui Liu Shunxin Li Xianli Liu Yungui Li Mu Wang Ying Nan Bo Pan Yanfang Pan Lizhi Wang Eddy Zeng Chao Zhan Yilin Chen Huizhong Shen Hefa Cheng Shu Tao | 2022 | National Science Review2022，9，7： | 4 |
| 9 | Poly-PR in C9ORF72-Related Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Causes Neurotoxicity by Clathrin-Dependent Endocytosis显示文摘GGGGCC repeat expansions in the C9 ORF72 gene are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia(c9 ALS/FTD). It has been reported that hexanucleotide repeat expansions in C9 ORF72 produce five dipeptide repeat(DPR) proteins by an unconventional repeat-associated non-ATG(RAN)translation. Within the five DPR proteins, poly-PR and poly-GR that contain arginine are more toxic than the other DPRs(poly-GA, poly-GP, and poly-PA). Here, we demonstrated that poly-PR peptides transferred into cells by endocytosis in a clathrin-dependent manner, leading to endoplasmic reticulum stress and cell death. In SH-SY5 Y cells and primary cortical neurons, poly-PR activated JUN amino-terminal kinase(JNK) and increased the levels of p53 and Bax. The uptake of poly-PR peptides by cells was significantly inhibited by knockdown of clathrin or by chlorpromazine, an inhibitor that blocks clathrin-mediated endocytosis. Inhibition of clathrin-dependent endocytosis by chlorpromazine significantly blocked the transfer of poly-PR peptides into cells, and attenuated poly-PRinduced JNK activation and cell death. Our data revealed that the uptake of poly-PR undergoes clathrin-dependentendocytosis and blockade of this process prevents the toxic effects of synthetic poly-PR peptides. | Rui Wang Xingyun Xu Zongbing Hao Shun Zhang Dan Wu Hongyang Sun Chenchen Mu Haigang Ren Guanghui Wang | 2019 | Neuroscience Bulletin2019，35，5： | 4 |
| 10 | Structural and molecular basis for foot-andmouth disease virus neutralization by two potent protective antibodies显示文摘Dear Editor,Foot-and-mouth disease(FMD)is an economically devastating and highly contagious viral disease of cloven-hoofed animals with a global distribution.The causative agent,FMD virus(FMDV)is a small non-enveloped RNA virus,belonging to the Aphthoviruses genus within Picornaviridae family(Tuthill et al.,2010).Control of FMD has been largely reliant on vaccinations with inactivated virus vaccines.However,significant antigenic diversity within FMDV serotypes and inability of the vaccines to induce immune protection for a long duration of time impinge on the efficacy of available vaccines.The roles of neutralizing antibodies(NAbs)as the principal protective components of the immune responses to FMDV vaccination or infection have been well established(Pay and Hingley,1987;Juleff et al.,2009).Passive immunization of NAbs has also been demonstrated to be effective in curing FMD and many viral diseases(Harmsen et al.,2007;Qiu et al.,2018).A deep understanding of the molecular basis for viral neutralization by antibodies and the identification of key viral epitopes would aid in the development of potent rationally designed broad-spectrum vaccine. | Hu Dong Pan Liu Manyuan Bai Kang Wang Rui Feng Dandan Zhu Yao Sun Suyu Mu Haozhou Li Michiel Harmsen Shiqi Sun Xiangxi Wang Huichen Guo | 2022 | Protein & Cell2022，13，6： | 3 |
| 11 | Effect of potential HONO sources on peroxyacetyl nitrate(PAN)formation in eastern China in winter显示文摘As an important secondary photochemical pollutant,peroxyacetyl nitrate(PAN)has been studied over decades,yet its simulations usually underestimate the corresponding observations,especially in polluted areas.Recent observations in north China found unusually high concentrations of PAN during wintertime heavy haze events,but the current model still cannot reproduce the observations,and researchers speculated that nitrous acid(HONO)played a key role in PAN formation.For the first time we systematically assessed the impact of potential HONO sources on PAN formation mechanisms in eastern China using the Weather Research and Forecasting/Chemistry(WRF-Chem)model in February of 2017.The results showed that the potential HONO sources significantly improved the PAN simulations,remarkably accelerated the RO x(sum of hydroxyl,hydroperoxyl,and organic peroxy radicals)cycles,and resulted in 80%–150%enhancements of PAN near the ground in the coastal areas of eastern China and 10%–50%enhancements in the areas around 35–40°N within 3 km during a heavy haze period.The direct precursors of PAN were aldehyde and methylglyoxal,and the primary precursors of PAN were alkenes with C>3,xylenes,propene and toluene.The above results suggest that the potential HONO sources should be considered in regional and global chemical transport models when conducting PAN studies. | Jingwei Zhang Yitian Guo Yu Qu Yong Chen Ruipeng Yu Chaoyang Xue Rui Yang Qiang Zhang Xingang Liu Yujing Mu Jing Wang Can Ye Haihan Zhao Qiangqiang Sun Ziwen Wang Junling An | 2020 | Journal of Environmental Sciences2020，32，8： | 3 |
| 12 | DNA methylation patterns of banana leaves in response to Fusarium oxysporum f. sp. cubense tropical race 4显示文摘Fusarium wilt of banana, which is caused by Fusarium oxysporum f. sp. cubense tropical race 4(Foc TR4), is a serious soil-borne fungal disease. Now, the epigenetic molecular pathogenic basis is elusive. In this study, with methylation-sensitive amplification polymorphism(MSAP) technique, DNA methylation was compared between the leaves inoculated with Foc TR4 and the mock-inoculated leaves at different pathogenic stages. With 25 pairs of primers, 1 144 and 1 255 fragments were amplified from the infected and mock-inoculated leaves, respectively. DNA methylation was both changed and the average methylated CCGG sequences were 34.81 and 29.26% for the infected and the mock-inoculated leaves. And DNA hypermethylation and hypomethylation were induced by pathogen infection during all pathogenic stages. Further, 69 polymorphic fragments were sequenced and 29 of them showed sequence similarity to genes with known functions. And RT-PCR results of four genes indicated that their expression patterns were consistent with their methylation patterns. Our results suggest that DNA methylation plays important roles in pathogenic response to Foc TR4 for banana. | LUO Jing-yao PAN Xiao-lei PENG Tie-cheng CHEN Yun-yun ZHAO Hui MU Lei PENG Yun HE Rui TANG Hua | 2016 | Journal of Integrative Agriculture2016，15，12： | 2 |
| 13 | Comparative study of metal oxides and phosphate modification with different mechanisms over g-C_(3)N_(4) for visible-light photocatalytic degradation of metribuzin显示文摘In this work,a comparative study of three frequently employed modification techniques to g-C_(3)N_(4)(CN)nanosheets for the photocatalytic degradation of metribuzin(MET)under visible-light irradiation has been carried out in detail.The modification methods were coupling TiO_(2)nanoparticles(TO)as electron acceptors,nano-sized Fe_(2)O_(3)(FO)to construct a Z-scheme nanocomposite,and phosphate(HP)modification to promote O_(2)adsorption.The steady-state and transient-state surface photovoltage spectra and transient photoluminescence(PL)spectra confirmed that all the three modification techniques enhanced the charge separation with prolonged lifetimes and presented degradation activities in the order of TO/CN[FO/CN[HP/CN.The TO/CN nanocomposite showed the highest photocatalytic activity for MET degradation,with a sixfold higher rate than bulk CN.Liquid chromatography–tandem mass spectrometry and radical trapping experiments indicated that the increased activity was related to the synergetic effect of two radicals(·O^(2-) and ·OH)involved in the photocatalytic degradation pathway,which was different from the·OH radical-dominated pathway of bulk CN.This work reveals the importance of charge separation and the influence of the radical pathway and provides guidance for the design of high-efficiency photocatalysts. | Rui Yan Amir Zada Lei Sun Zhi-Jun Li Zhi-Yuan Mu Shuang-Ying Chen Fan Yang Jian-Hui Sun Lin-Lu Bai Yang Qu Li-Qiang Jing | 2022 | Rare Metals2022，41，1： | 2 |
| 14 | Implementation of a reference-scaled average bioequivalence approach for highly variable generic drug products of agomelatine in Chinese subjects显示文摘The aim of this study was to apply the reference-scaled average bioequivalence(RSABE)approach to evaluate the bioequivalence of 2 formulations of agomelatine,and to investigate the pharmacokinetic properties of agomelatine in Chinese healthy male subjects.This was performed in a single-dose,randomized-sequence,open-label,four-way crossover study with a one-day washout period between doses.Healthy Chinese males were randomly assigned to receive 25 mg of either the test or reference formulation.The formulations were considered bioequivalent if 90% confidence intervals(CIs)for the log-transformed ratios and ratio of geometric means(GMR)of AUC and C_(max) of agomelatine were within the predetermined bioequivalence range based on RSABE method.Results showed that both of the90% CIs for the log-transformed ratios of AUC and C_(max) of 7-desmethyl-agomelatine and 3-hydroxyagomelatine were within the predetermined bioequivalence range.The 90% CIs for natural logtransformed ratios of C_(max) ,AUC_(0–t)and AUC_(0–∞) of agomelatine(104.42–139.86,101.33–123.83 and97.90–117.94)were within the RSABE acceptance limits,and 3-hydroxy-agomelatine(105.55–123.03,101.95–109.10 and 101.72–108.70)and 7-desmethyl-agomelatine(104.50–125.23,102.36–111.50 and101.62–110.64)were within the FDA bioequivalence definition intervals(0.80–1.25 for AUC and0.75–1.33 for C_(max)).The RSABE approach was successful in evaluating the bioequivalence of these two formulations. | Fang Tang Rui Zhou Zeneng Cheng Guoping Yang Aiqiao Chen Zhi Liu Hongyi Tan Shuang Yang Sanwang Li Lingli Mu Peng Yu | 2016 | Acta Pharmaceutica Sinica B2016，6，1： | 2 |
| 15 | Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study显示文摘Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women. | ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang | 2021 | Biomedical and Environmental Sciences2021，34，1： | 2 |
| 16 | Theil Utility Based Multi-Device Cooperation Mechanism for Service Quality Equilibrium in Ubiquitous Stub Environments显示文摘An approach to make heterogeneous devices cooperate with each other to provide ubiquitous service remains a longstanding challenge in ubiquitous environments. In addition, when multi-user request ubiquitous services simultaneously, the arbitrariness in resource allocation process easily leads to non-equilibrium of qualities of multiuser's services. Thus, How to design an effective heterogeneous devices cooperation mechanism that meet the QoS requirements and also equilibrate QoS among multi-user's services becomes a very tough problem. In the paper, Equilibrium Index and Theil Utility function are imported to establish a multidevice equilibrium cooperation model, which is benefit for resource allocation in ubiquitous environments. Then a Theil-Equilibrium based Cooperation Mechanism for multi-service is proposed. Firstly, in order to simplify calculating, a dimensionless processing is introduced. After that, a cooperation approach with Theil-Utility Heuristic algorithm is designed to choose the best solution for the simplified model. At last, the mechanism is simulated in a smart home scenario. The simulation results show that this mechanism outperforms non-equilibrium method by improving almost 40% in internal equilibrium with just reducing 0-2% in the total utility ofall the requested ubiquitous services. These data show that the proposed mechanism performs well in equilibrating qualities of multi-user's ubiquitous services. | RUI Lanlan MU Nan GUO Shaoyong QIU Xuesong ZHANG Jie | 2014 | China Communications2014，11，6： | 2 |
| 17 | Inhibitory effect of a new gossypol derivative apogossypolone (ApoG2) on xenograft of human prostate cancer cell line PC-3显示文摘Objective: To investigate the inhibitory effect of apogossypolone (ApoG2) on prostate cancer cell line PC-3 in vivo, and explore its mechanism. Methods: The models of transplantation tumors in Balb/c nu/nu mice were established via subcutaneous injection of PC-3 cells and the tumor-transplanted mice were divided into 4 groups: control group and three ApoG2 treatment groups, with 10 mice in each group. Volumes of the tumor were estimated every 2 d and the morphology of tumor tissues was observed. Immunohistochemistry was employed to observe the expression of Bcl-2, PCNA, CD31, caspase-3 and caspase-8 in tumor tissues. Results: ApoG2 (2.5 mg/kg-10 mg/kg) given intraperitoneally once a day can obviously inhibit the growth of subcutaneous prostatic carcinoma implant. The tumor volume decreased obviously when the treatment dosage was bigger than 5.0 mg/kg (P<0.01). Meanwhile, ApoG2 decreased the expression of PCNA and CD31, and enhanced the expression of caspases-3, caspase-8 in tumor tissues. Conclusion: ApoG2 exert an inhibitory effect on prostatic carcinoma possibly by inducing apoptosis and inhibiting tumor angiogenesis. | Zhang Xianqing Huang Xiaofeng Mu Shijie Chen Rui An Qunxing Xia Aijun Wu Daocheng | 2009 | Journal of Medical Colleges of PLA(China)2009，24，5： | 2 |
| 18 | Advances and key focus areas in gastric cancer immunotherapy:A comprehensive scientometric and clinical trial review(1999-2023)显示文摘BACKGROUND Gastric cancer(GC)is the sixth most common cancer and third leading cause of cancer-related deaths worldwide.Current treatments mainly rely on surgery-and chemotherapy-based systemic;however,the prognosis remains poor for advanced disease.Recent studies have suggested that immunotherapy has significant potential in cancer therapy;thus,GC immunotherapy may improve quality of life and survival for patients with this disease.AIM To provide a comprehensive overview of the knowledge structure and research hotspots of GC immunotherapy.METHODS We conducted a bibliometric analysis of publications on immunotherapy related to GC in the Web of Science Core Collection database.We analyzed 2013 publications from 1999 to February 1,2023,using the VOSviewer and CiteSpace software.We assessed publication and citation distributions using the WoS platform and explored research countries,institutions,journals,authors,references,and keywords(co-occurrence,timeline view,and burst analysis).In addition,we examined 228 trials on immunotherapy,137 on adoptive cell therapy,274 on immune checkpoint inhibitors(ICIs),and 23 on vaccines from ClinicalTrials.gov and the International Clinical Trials Registry Platform.The Impact Index Per Article for the top ten high-cited papers collected from Reference Citation Analysis(RCA)are presented.RESULTS Our bibliometric analysis revealed that the study of immunotherapy in GC has developed rapidly in recent years.China accounted for almost half the publications,followed by the United States.The number of publications in recent years has been growing continuously,and most institutions and authors with the most publications are from China.The main keywords or clusters identified were“tumor microenvironment”,“adoptive immunotherapy”,“dendritic therapy”,and“microsatellite instability”.CONCLUSION Our analysis of 2013 publications indicated that immunotherapy for GC has led to several new developments in recent years.Considerable progress has been made in vaccinations,immune checkpoint therapy,and adoptive cellular therapy.In particular,ICIs and chimeric antigen receptor T-cells are novel options for the treatment of GC.We suggest that the combination of ICIs,chemotherapy,targeted therapy,and other immunotherapies should be the primary research direction in the future. | Yao-Nan Li Bin Xie Ying Zhang Ming-Hua He Yang Xing Dong-Mei Mu Hong Wang Rui Guo | 2023 | World Journal of Gastroenterology2023，29，40： | 2 |
| 19 | Nanoparticle‑Loaded Polarized‑Macrophages for Enhanced Tumor Targeting and Cell‑Chemotherapy显示文摘Cell therapy is a promising strategy for cancer therapy.However,its therapeutic efficiency remains limited due to the complex and immunosuppressive nature of tumor microenvironments.In this study,the“cell-chemotherapy”strategy was presented to enhance antitumor efficacy.M1-type macrophages,which are therapeutic immune cells with both of immunotherapeutic ability and targeting ability,carried sorafenib(SF)-loaded lipid nanoparticles(M1/SLNPs)were developed.M1-type macrophages were used both as therapeutic tool to provide immunotherapy and as delivery vessel to target deliver SF to tumor tissues for chemotherapy simultaneously.M1-type macrophages were obtained by polarizing macrophages using lipopolysaccharide,and M1/SLNPs were obtained by incubating M1-type macrophages with SLNP.Tumor accumulation of M1/SLNP was increased compared with SLNP(p<0.01),which proved M1/SLNP could enhance tumor targeting of SF.An increased ratio of M1-type macrophages to M2-type macrophages,and the CD3^+CD4^+T cells and CD3^+CD8^+T cell quantities in tumor tissues after treatment with M1/SLNP indicated M1/SLNP could relieve the immunosuppressive tumor microenvironments.The tumor volumes in the M1/SLNP group were significantly smaller than those in the SLNP group(p<0.01),indicating M1/SLNP exhibited enhanced antitumor efficacy.Consequently,M1/SLNP showed great potential as a novel cellchemotherapeutic strategy combining both cell therapy and targeting chemotherapy. | Teng Hou Tianqi Wang Weiwei Mu Rui Yang Shuang Liang Zipeng Zhang Shunli Fu Tong Gao Yongjun Liu Na Zhang | 2021 | Nano-Micro Letters2021，13，1： | 1 |
| 20 | Ionic Liquid Assisted Synthesis of Au–Pd Bimetallic Particles with Enhanced Electrocatalytic Activity显示文摘 | Zhonghao Li Rui Li Tiancheng Mu Yuxia Luan | 2013 | Chem. Eur. J2013，，19： | 1 |
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