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| 1 | The Influence of Phacoemulsification on Corneal Endothelia Cells at Varying Blood Glucose Levels显示文摘Purpose:To investigate the influence of phacoemulsification on corneal endothelial cells in diabetes patients and normal controls. Methods:Phacoemulsification and intraocular lens implantation were performed on 75 patients with diabetic cataract (126 eyes) who were divided into two groups: Trial group 1 (Glu≤6 mmol/L); Trial group 2 (Glu 6-10 mmol/L) and 65 nondiabetic controls (112 eyes).The density and percentage of hexagonal cells and coefficient of variation of the corneal endothelia were measured before surgery and 1 day,1 month and 3 months postoperatively. Results: There was no statistical difference in the density and percentage of hexagonal cells and coefficient of variation of the corneal endothelia prior to phacoemulsification.(P>0.05) between the three groups.The density and percentage of hexagonal cells of the corneal endothelia decreased significantly after surgery in all three groups(P<0.05),while the Coefficient of variation increased in all groups(P<0.05). The rate of loss of corneal endothelial cells in the diabetic groups was significantly higher than for the control group (P<0.05), the percentage of hexagonal cells in the diabetic groups was significantly lower than for the control group (P<0.05), and the coefficient of variation in the diabetic groups was significantly higher than for the control group (P<0.05) at 1 day, 1 month and 3 months post-operatively. There was no statistical difference between the two diabetic groups in terms of these post-operative measurements. Conclusion:The corneal endothelium of diabetic patients is more prone to damage from phacoemulsification. It is advisable to evaluate the corneal endothelium routinely prior to phacoemulsification, particularly in diabetic persons. | RuiMing Yang Xiangyin Sha Mingbing Zeng Yingqian Tan Yu Zheng Feihong Fan | 2011 | Eye Science2011，26，2： | 14 |
| 2 | Ce-doped LiNi_(1/3)Co_((1/3-x/3))Mn_(1/3)Ce_(x/3)O_2 cathode materials for use in lithium ion batteries显示文摘LiNi1/3Co1/3Mn1/3O2 and Ce-doped LiNi1/3Co1/3Mn1/3O2 cathode materials were synthesized by a co-precipitation method and solid phase synthesis and characterized using X-ray diffraction(XRD) and scanning electron microscopy(SEM).The results indicated that the resultant cathode materials with different Ce content all had a good layer structure and high crystallinity.Electrochemical performance testing of the cathode materials showed that the discharge capacity increased with increasing Ce content while the initial reversible capacity attenuation decreased with Ce doping.When the Ce content of the cathode materials is x=0.2,and the current charge and discharge rate is a constant 0.2 C,the discharge capacity maintained 91% of its initial capacity after cycling 50 times. | ZHANG YingJie XIA ShuBiao ZHANG YanNan DONG Peng YAN Yuxing YANG RuiMing | 2012 | Chinese Science Bulletin2012，57，32： | 8 |
| 3 | Peripheral CD4^(+) T cell signatures in predicting the responses to anti-PD-1/PD-L1 monotherapy for Chinese advanced non-small cell lung cancer显示文摘Limited benefit population of immune checkpoint inhibitors makes it urgent to screen predictive biomarkers for stratifying the patients.Herein,we have investigated peripheral CD4^(+) T cell signatures in advanced non-small cell lung cancer(NSCLC)patients receiving anti-PD-1/PD-L1 treatments.It was found that the percentages of IFN-γand IL-17A secreting naïve CD4^(+) T cells(Tn),and memory CD4^(+) T cells(Tm)expressing PD-1,PD-L1 and CTLA-4 were significantly higher in responder(R)than non-responder(NonR)NSCLC patients associated with a longer progression free survival(PFS).Logistic regression analysis revealed that the baseline IFN-γ-producing CD4^(+) Tn cells and PD-1^(+)CD4^(+) Tm cells were the most significant signatures with the area under curve(AUC)value reaching 0.849.This was further validated in another anti-PD-1 monotherapy cohort.Conversely,high percentage of CTLA-4^(+)CD4^(+) Tm cells was associated with a shorter PFS in patients receiving anti-PD-L1 monotherapy.Our study therefore elucidates the significance of functional CD4^(+) Tn and Tm subpopulations before the treatment in predicting the responses to anti-PD-1 treatment in Chinese NSCLC patients.The fact that there display distinct CD4^(+) T cell signatures in the prediction to anti-PD-1 and anti-PD-L1 monotherapy from our study provides preliminary evidence on the feasibility of anti-PD-1 and anti-PD-L1 combination therapy for advanced NSCLC patients. | Liliang Xia Hui Wang Mingjiao Sun Yi Yang Chengcheng Yao Sheng He Huangqi Duan Weimin Xia Ruiming Sun Yaxian Yao Zhiwei Chen Qiong Zhao Hong Li Shun Lu Ying Wang | 2021 | Science China(Life Sciences)2021，64，10： | 7 |
| 4 | Sedimentary Evolution of the Qinghai-Tibet Plateau in Cenozoic and its Response to the Uplift of the Plateau显示文摘We have studied the evolution of the tectonic lithofacies paleogeography of Paleocene-Eocene, Oligocene, Miocene, and Pliocene of the Qinghai-Tibet Plateau by compiling data regarding the type, tectonic setting, and lithostratigraphic sequence of 98 remnant basins in the plateau area. Our results can be summarized as follows. (1) The Paleocene to Eocene is characterized by uplift and erosion in the Songpan-Garzê and Gangdisê belts, depression (lakes and pluvial plains) in eastern Tarim, Qaidam, Qiangtang, and Hoh Xil, and the Neo-Tethys Sea in the western and southern Qinghai-Tibet Plateau. (2) The Oligocene is characterized by uplift in the Gangdisê-Himalaya and Karakorum regions (marked by the absence of sedimentation), fluvial transport (originating eastward and flowing westward) in the Brahmaputra region (marked by the deposition of Dazhuka conglomerate), uplift and erosion in western Kunlun and Songpan-Garzê, and depression (lakes) in the Tarim, Qaidam, Qiangtang, and Hoh Xil. The Oligocene is further characterized by depressional littoral and neritic basins in southwestern Tarim, with marine facies deposition ceasing at the end of the Oligocene. (3) For the Miocene, a widespread regional unconformity (ca. 23 Ma) in and adjacent to the plateau indicates comprehensive uplift of the plateau. This period is characterized by depressions (lakes) in the Tarim, Qaidam, Xining-Nanzhou, Qiangtang, and Hoh Xil. Lacustrine facies deposition expanded to peak in and adjacent to the plateau ca. 18-13 Ma, and north-south fault basins formed in southern Tibet ca. 13-10 Ma. All of these features indicate that the plateau uplifted to its peak and began to collapse. (4) Uplift and erosion occurred during the Pliocene in most parts of the plateau, except in the Hoh Xil-Qiangtang, Tarim, and Qaidam. The continuous uplift and intensive taphrogeny in the plateau divided the original large basin into small basins, deposition of lacustrine facies decreased considerably, and boulderstone accumulated, indicating a response to the overall uplift of the plateau. Here, we discuss the evolution of tectonic lithofacies paleogeography in Cenozoic and its response to the tectonic uplift of the Qinghai-Tibet Plateau in relation to the above characteristics. We have recognized five major uplift events, which occurred during 58-53 Ma, 45-30 Ma, 25-20 Ma, 13-7 Ma, and since 5 Ma. The results presented here indicate that the paleogeomorphic configurations of the Qinghai-Tibet Plateau turned over during the late Miocene, with high elevations in the east during the pre-Miocene switching to high contours in the west at the end of Miocene. | ZHANG Kexin WANG Guocan XU Yadong LUO Mansheng JI Junliang XIAO Guoqiao WANG An SONG Bowen LIANG Yinpin JIANG Shangsong CAO Kai CHEN Fenning CHEN Ruiming YANG Yongfeng | 2013 | Acta Geologica Sinica(English Edition)2013，87，2： | 6 |
| 5 | Ship collision impact on the structural load of an offshore wind turbine显示文摘When a maintenance and operations ship is berthing,there is a chance the ship may collide into the wind turbine.When these ships collide into wind turbine structures,this can result in significant changes to the foundation and structure of the wind turbine.In this paper,the structural load of a 4 MW offshore wind turbine was analyzed during a collision with an operations and maintenance ship.The variations in the wind speeds on hub height,waves,and the sea currents were measured.The dynamic simulation of the wind turbine was carried out using the test data as the input parameters.As a result,the load condition of the turbine without a collision was obtained.Finally,the measured turbine load was compared with the simulation results.This study shows that the collision of the operation and the maintenance ship increases the bending moments at the tower’s bottom and the blade’s roots. | Haikun Jia Shiyao Qin Ruiming Wang Yang Xue Deyi Fu Anqing Wang | 2020 | Global Energy Interconnection2020，3，1： | 4 |
| 6 | Role of Retinal Nerve Fiber Layer Thickness and Optic Disk Measurement by OCT onEarly Diagnosis of Glaucoma显示文摘Purpose:.Glaucoma is an eye disease that can lead to irreversible optic nerve damage and cause blindness. Optical coherence tomography.(OCT) allows an early diagnosis of glaucoma by the measurements of the retinal nerve fiber and optic disc parameters.A retrospective study was designed to analyze the effects of the measurement of the retinal nerve fiber layer(RNFL) thickness and the optic disc tomography by spectraldomain OCT on the early diagnosis of suspected glaucoma and primary open angle glaucoma(POAG).Methods:.This was a clinical case-control study. The RNFL thickness around the optic disc and optic disk tomographic parameters of the control(n=51, 98 eyes), suspected glaucoma(n=81,.146 eyes), and POAG groups(n=55, 106 eyes) were measured by OCT. The parameters included superior, inferior, nasal and temporal mean RNFL thickness,.disc area(DA), cup area(CA), rim area(RA), disc volume(DV),cup volume(CV), rim volume(RV), cup / disc area ratio(CA / DA), rim / disc area ratio(RA / DA), cup / disc volume ratio(CV / DV) and rim / disc volume ratio(RV / DV).Results: Superior, nasal, and mean RNFL parameters, DA,CA,RA, DV, CV, CA / DA, RA / DA, CV / DV and RV / DV significantly differed among three groups by single-factorial ANOVA. Inferior and temporal RNFL thickness significantly differed between the control and POAG groups. No significant difference was observed in RV among three groups. In the POAG group,.the maximum area under the ROC curve(AROC) of mean RNFL thickness was 0.845. The maximum AROC of optic disk parameters was RA / DA(0.998), followed by CA / DA(0.997). The AROC of CA, RA, CV, and DV were all > 0.900.Conclusion:.OCT may serve as a useful diagnostic modality in distinguishing suspected glaucoma from POAG. | Zanmei Hua Qiuyun Fang Xiangyin Sha Ruiming Yang Zuopeng Hong | 2015 | Eye Science2015，30，1： | 3 |
| 7 | Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos显示文摘Dear Editor,Newly discovered characteristics like'collateral effect'or trans-cleavage in CRISPR-Cas13 and CRISPR-Cas12 systems have enabled their usage in nucleic acid detection(Gootenberg et al.2017,2018;Chen et al.2018).The collateral RNA cleavage of Cas13a has been reported to be harmful for cell development(Wang et al.2019;Buchman et al.2020).As a representative gene editor of CRISPR-Cas12 system,CRISPR-Cas12a(Cpf1)holds great potential for therapeutic applications in the future(Zetsche et al.2015;Koo et al.2018;Campa et al.2019). | Yu Wei Yingsi Zhou Yajing Liu Wenqin Ying Ruiming Lv Qimeng Zhao Haibo Zhou Erwei Zuo Yidi Sun Hui Yang Changyang Zhou | 2021 | Protein & Cell2021，12，9： | 2 |
| 8 | Nanostruc- tured TiN powder prepared via an integrated mechanical and thermal activation 显示文摘 | Ren Ruiming Yang Zhenguo Shaw Leon L | 2000 | Mater Sci Eng2000，286，： | 1 |
| 9 | Mapping of wheat stripe rust resistance gene Yr041133 by BSR-Seq analysis显示文摘Puccinia striiformis Westend. f. sp. tritici(Pst) pathotype CYR34 is widely virulent and prevalent in China.Here, we report identification of a strpie rust resistance(Yr) gene, designated Yr041133, in winter wheat line 041133. This line produced a hypersensitive reaction to CYR34 and conferred resistance to 13 other pathotypes. Resistance to CYR34 in line 041133 was controlled by a single dominant gene. Bulked segregant RNA sequencing(BSR-Seq) was performed on a pair of RNA bulks generated by pooling resistant and susceptible recombinant inbred lines. Yr041133 was mapped to a 1.7 c M genetic interval on the chromosome arm 7 BL that corresponded to a 0.8 Mb physical interval(608.9–609.7 Mb) in the Chinese Spring reference genome. Based on its unique physical location Yr041133 differred from the other Yr genes on this chromosome arm. | Yahui Li Ruiming Lin Jinghuang Hu Xiaohan Shi Dan Qiu Peipei Wu Gebremedhin Habteab Goitom Siqi Wang Hongjun Zhang Li Yang Hongwei Liu Qiuhong Wu Jingzhong Xie Yang Zhou Zhiyong Liu Hongjie Li | 2022 | The Crop Journal2022，10，2： | 1 |
| 10 | Erythropoietin Ameliorates Renal Ischemia and Reperfusion Injury via Inhibiting Tubulointerstitial Inflammation显示文摘 | Linkun Hu Cheng Yang Tian Zhao Ming Xu Qunye Tang Bin Yang Ruiming Rong Tongyu Zhu | 2012 | Journal of Surgical Research2012，，1： | 1 |
| 11 | Polymorphic Transformation and Powder Characteristics of TiO2 During High Energy Milling显示文摘 | REN Ruiming YANG Zhengguo | 2000 | Journal of Materials Science2000，35，： | 1 |
| 12 | Correlation between aortic/carotid atherosclerotic plaques and cerebralinfarction显示文摘 | Baojun Wang Shaoli Sun Guorong Liu Yuechun Li Jiangxia Pang Jingfen Zhang Lijuan Yang Ruiming Li Hui Zhang Changchun Jiang Xiue Li | 2013 | Experimental and Therapeutic Medicine2013，，2： | 1 |
| 13 | Automatically de-tect and track infrared small targets with kernel Fukunaga-Koontz transform and Kalman prediction 显示文摘 | Ruiming Liu Erqi Liu Jie Yang | 2007 | APPLIEDOPTICS2007，46，31： | 1 |
| 14 | Automatic extraction of infrared small target based on support vector regression and adaptive region growing algorithm显示文摘 | LIU Ruiming YANG Lei LIU Erqi | 2007 | Optical Engineering2007，46，4： | 1 |
| 15 | Infrared Small Target Detection with Kernel Fukunaga-Koontz Transform显示文摘 | Liu Ruiming Liu Erqi Yang Jie | 2007 | Measurement Science and Technology2007，18，9： | 1 |
| 16 | Relationship between Foxp3-3279(rs376158) Polymorphism and Dust Mite Allergic Conjunctivitis显示文摘Purpose:To investigate the genotyping of Foxp3-3279(A /C,rs376158) genes in patients with dust mite-induced allergic conjunctivitis from Guangdong province and to explore the association between these genes and the susceptibility to dust mite allergic conjunctivitis.Methods:.In total,.80 patients with dust mite allergic conjunctivitis and 103 healthy Han Chinese were enrolled in the study and received genotyping of Foxp3-3279(A / C,rs376158)by PCR-SSP technique.Results: Genotype frequency of Foxp3-3279 AA,.CA,.and CC in patients with dust mite allergic conjunctivitis were 1.25%,25.00% and 73.75%,respectively. Gene frequency of C and A in patients with dust mite allergic conjunctivitis were 86.25%and 13.75% with no significant difference from healthy counterparts(both P>0.05).Conclusion:.Foxp3-3279 polymorphisms did not significantly differ between patients with dust mite allergic conjunctivitis and healthy controls, implying that this genetic locus is probably not an independent risk factor of the underlying pathogenesis of dust mite allergic conjunctivitis. | Ruiming Yang He Lai Xiangyin Sha Shengqiang Chen Yingqian Tan Weifang Chen Zhiping Liu | 2014 | Eye Science2014，29，3： | 0 |
| 17 | Research on organic matters in the drinking water of Kaschin-Beck disease area显示文摘Organic matters in drinking water of Kaschin-Beck disease areas were extracted. Then analyses and characterization were performed by means of multiply chemical and physical methods. The results did not show the obvious difference in the frame structure of humic substances and the structure of rmcromolecular compounds in the drinking water of disease and non-disease areas, but the difference in the contents of some micromolecular compounds and radicals. The investigation also includes the preliminary research on the photoreaction of drinking water from disease and non-disease areas and the accumulation of natural organic matter in the bone of tested animals. | Wang Wenhua, Yang Chunlin, Qi Ruiming, Wang Zijian and Peng AnResearch center for Eco-Environmental Sciences.Chinese Academy of Sciences,Beijing 100083,China. | 1991 | Journal of Environmental Sciences1991，3，4： | 0 |
| 18 | Hertz-rate metropolitan quantum teleportation显示文摘Quantum teleportation can transfer an unknown quantum state between distant quantum nodes,which holds great promise in enabling large-scale quantum networks.To advance the full potential of quantum teleportation,quantum states must be faithfully transferred at a high rate over long distance.Despite recent impressive advances,a high-rate quantum teleportation system across metropolitan fiber networks is extremely desired.Here,we demonstrate a quantum teleportation system which transfers quantum states carried by independent photons at a rate of 7.1±0.4 Hz over 64-km-long fiber channel.An average single-photon fidelity of≥90.6±2.6%is achieved,which exceeds the maximum fidelity of 2/3 in classical regime.Our result marks an important milestone towards quantum networks and opens the door to exploring quantum entanglement based informatic applications for the future quantum internet. | Si Shen Chenzhi Yuan Zichang Zhang Hao Yu Ruiming Zhang Chuanrong Yang Hao Li Zhen Wang You Wang Guangwei Deng Haizhi Song Lixing You Yunru Fan Guangcan Guo Qiang Zhou | 2023 | Light(Science & Applications)2023，12，6： | 0 |
| 19 | Flexible all-organic photodetectors via universal water-assisted transfer printing显示文摘Transfer printing of small-molecular organic semiconductors often faces challenges due to surface adhesion mismatch.Here,we developed a sacrificing-layer-assisted transfer printing technique for the deposition of smallmolecular thin films.High-boiling-point ethylene glycol(EG)was doped in aqueous solution poly(3,4-ethylenedioxythiophene)polystyrene sulfonate(PEDOT:PSS)as the sacrificing layer to manipulate residual water in film,which allowed chlorobenzene solution to spontaneously spread and form uniform film. | Yang Tang Ruiming Li Rui Sun Jie Min Qianqian Lin Chuluo Yang Guohua Xie | 2023 | The Innovation2023，4，4： | 0 |
| 20 | Experimental Study on the Characteristics of Water Vapor Generation from Gas-washing Bottle and Injector显示文摘Gas-washing and water injection are two commonly used methods in generating certain moisture content in gas flow stream, but the control accuracy of these methods remains uncertain. The purpose of the study is to investigate the characteristic of water vapor generation of the two methods. The temperature and humidity recorder and FTIR gas analyzer have been adopted to monitor the moisture content in tests. It has been revealed that, in gas-washing process, the moisture content in gas stream is well below saturation, and long time is required before moisture content stabilized after water bath temperature or carrier gas flow rate changed. Water injection pump could directly control the amount of water injected into gas stream. However, the moisture content generated in this way is not stable but oscillates in cycles, whose frequency and magnitude are closely related to water injection amount. | WANG Zhipeng WANG Lang ZHAO Angran CHENG Shuhao YANG Ruiming ZHUOYuqun TONG Huiling | 2019 | Journal of Thermal Science2019，28，1： | 0 |
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