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| 1 | Cementation of sand grains based on carbonate precipitation induced by microorganism显示文摘Microbes can produce 2 3 CO_3^(2-)in an environment conductive to precipitation,so the incompact sands will be consolidated.This technology is environmentally friendly not only because it gives strength to the sand body,but also it allows water to penetrate into the sand body,which is unlike silicate cement that will destroy the ecosystem of the earth.After comparing the activity of three kinds of bacteria,the most suitable one was chosen for the study.However,the activity of this bacterium was still not high enough for the purpose,so it was purified.A suitable program for the consolidation and cementation of sands was also found in the experiment.The compressive strength and the porosity of the cemented sand body were tested to characterize the cementation effectiveness.XRD analysis showed that a new phase of calcite was produced between sand grains.The content of calcite was detected by TG.The study showed that the precipitation program was quite important to obtain a sound cemented sand body in addition to the activity of the bacteria. | QIAN ChunXiang,PAN QingFeng &WANG RuiXing Jiangsu Key Laboratory of Construction Materials,School of Materials Science&Engineering,Southeast University,Nanjing 211189,China | 2010 | Science China(Technological Sciences)2010，53，8： | 34 |
| 2 | A cementation method of loose particles based on microbe-based cement显示文摘Microbe-based cement has been widely reported in recent literatures. It is a new method of consolidating loose fine particles, which relies on the bacterially induced formation of a compatible carbonate precipitation around individual particles and at particle-particle contacts. Materials and cementation procedure are two major factors that influence the cementation performance of microbe-based cement. Besides, there are some other factors related to the performance, such as pH, temperature, metabolism activity, the flushed times of bacterial solution, concentration of substrate and calcium ion, etc., which affect consolidation function. The assessment methods for cementation process are carried out by various techniques. The performance of consolidation loose grains based on microbe-based cement is tested with the help of experiment. In this paper a review is presented on the cementation mechanism of microbe-based cement, techniques utilized to monitor cementation process, the consolidated performance by microbe-based cement and bond factors. | RONG Hui QIAN ChunXiang WANG RuiXing | 2011 | Science China(Technological Sciences)2011，54，7： | 8 |
| 3 | Study on soil solidification based on microbiological precipitation of CaCO_3显示文摘The soil solidifying technology started booming from the 1940s and formed an integrated cross-discipline.This paper aimed to study the effect and mechanism of soil solidification by microorganisms.Soil specimens treated by different methods were designed.Then the compressive strengths of these specimens on day 7 were tested and the situ bacteria culturing technique in soil was investigated.Finally the mechanism of soil solidification by microorganisms was explored according to the decomposition rate of substrate,pH value and the SEM and XRD analysis.Experimental results showed that the soil could be solidified by filling enhancement and precipitation of microorganisms.The compressive strength increased with bacteria A but decreased with substrate B,and soil specimen got a higher strength with bacteria situ cultured.The suitable pH value for bacteria A was 8–9,and the delay of lime addition could make substrate decomposition more completely,lower the influence by the existence of substrate,and improve the strength.In XRD and SEM images,precipitation of CaCO3 could be speculated. | LU WangJie,QIAN ChunXiang & WANG RuiXing School of Materials Science & Engineering,Jiangsu Key Laboratory for Construction Materials,Southeast University,Nanjing 210089,China | 2010 | Science China(Technological Sciences)2010，53，9： | 6 |
| 4 | Efficient Computational Method for the Non-Probabilistic Reliability of Linear Structural Systems显示文摘The non-probabilistic reliability in higher dimensional situations cannot be calculated efficiently using traditional methods, which either require a large amount of calculation or cause significant error. In this study, an efficient computational method is proposed for the calculation of non-probabilistic reliability based on the volume ratio theory, specifically for linear structural systems. The common expression for non-probabilistic reliability is obtained through formula derivation with the amount of computation considerably reduced. The compatibility between non-probabilistic and probabilistic safety measures is demonstrated through the Monte Carlo simulation. The high efficiency of the presented method is verified by several numerical examples. | Ruixing Wang Xiao jun Wang Lei Wang Xianjia Chen | 2016 | Acta Mechanica Solida Sinica2016，29，3： | 5 |
| 5 | Six sigma robust design optimization for thermal protection system of hypersonic vehicles based on successive response surface method显示文摘Lightweight design is important for the Thermal Protection System(TPS) of hypersonic vehicles in that it protects the inner structure from severe heating environment. However, due to the existence of uncertainties in material properties and geometry, it is imperative to incorporate uncertainty analysis into the design optimization to obtain reliable results. In this paper, a six sigma robust design optimization based on Successive Response Surface Method(SRSM) is established for the TPS to improve the reliability and robustness with considering the uncertainties. The uncertain parameters related to material properties and thicknesses of insulation layers are considered and characterized by random variables following normal distributions. By employing SRSM, the values of objective function and constraints are approximated by the response surfaces to reduce computational cost. The optimization is an iterative process with response surfaces updating to find the true optimal solution. The optimization of the nose cone of hypersonic vehicle cabin is provided as an example to illustrate the feasibility and effectiveness of the proposed method. | Jingjing ZHU Xiaojun WANG Haiguo ZHANG Yuwen LI Ruixing WANG Zhiping QIU | 2019 | Chinese Journal of Aeronautics2019，32，9： | 4 |
| 6 | Quercetin promotes human epidermal stem cell proliferation through the estrogen receptor/β-catenin/c-Myc/cyclin A2 signaling pathway显示文摘Skin epidermal stem cells(EpSCs)play an important role in wound healing.Quercetin is a phytoestrogen reported to accelerate skin wound healing,but its effect on EpSCs is unknown.In this study,we investigated the effect of quercetin on human EpSC proliferation and explored the underlying mechanisms.We found that quercetin at 0.1~1μM significantly promoted EpSC proliferation and increased the number of cells in S phase.The pro-proliferative effect of quercetin on EpSCs was confirmed in cultured human skin tissue.Mechanistic studies showed that quercetin significantly upregulated the expressions ofβ-catenin,c-Myc,and cyclins A2 and E1.Inhibitor forβ-catenin or c-Myc significantly inhibited quercetin-induced EpSC proliferation.Theβ-catenin inhibitor XAV-939 suppressed quercetin-induced expressions ofβ-catenin,c-Myc,and cyclins A2 and E1.The c-Myc inhibitor 10058-F4 inhibited the upregulation of c-Myc and cyclin A2 by quercetin.Pretreatment of EpSCs with estrogen receptor(ER)antagonist ICI182780,but not the G protein-coupled ER1 antagonist G15,reversed quercetin-induced cell proliferation and upregulation ofβ-catenin,c-Myc,and cyclin A2.Collectively,these results indicate that quercetin promotes EpSC proliferation through ER-mediated activation ofβ-catenin/c-Myc/cyclinA2 signaling pathway and ER-independent upregulation of cyclin E1 and that quercetin may accelerate skin wound healing through promoting EpSC proliferation.As EpSCs are used not only in clinic to treat skin wounds but also as seed cells in skin tissue engineering,quercetin is a useful reagent to expand EpSCs for basic research,skin wound treatment,and skin tissue engineering. | Zhaodong Wang Guangliang Zhang Yingying Le Jihui Ju Ping Zhang Dapeng Wan Qiang Zhao Guangzhe Jin Hao Su Jinwei Liu Jiaxuan Feng Yi Fu Ruixing Hou | 2020 | Acta Biochimica et Biophysica Sinica2020，52，10： | 3 |
| 7 | Deficiency of two-pore segment channel 2 contributes to systemic lupus erythematosus via regulation of apoptosis and cell cycle显示文摘Background:Systemic lupus erythematosus(SLE)is a complex autoimmune disease,and the mechanism of SLE is yet to be fully elucidated.The aim of this study was to explore the role of two-pore segment channel 2(TPCN2)in SLE pathogenesis.Methods:Quantitative reverse transcription polymerase chain reaction(qRT-PCR)was used to detect the expression ofTPCN2 in SLE.We performed a loss-of-function assay by lentiviral construct in Jurkat and THP-1 cell.Knockdown ofTPCN2 were confirmed at the RNA level by qRT-PCR and protein level by Western blotting.Cell Count Kit-8 and flow cytometry were used to analyze the cell proliferation,apoptosis,and cell cycle ofTPCN2-deficient cells.In addition,gene expression profile ofTPCN2-deficient cells was analyzed by RNA sequencing(RNA-seq).Results:TPCN2 knockdown with short hairpin RNA(shRNA)-mediated lentiviruses inhibited cell proliferation,and induced apoptosis and cell-cycle arrest of G2/M phase in both Jurkat and THP-1 cells.We analyzed the transcriptome of knockdown-TPCN2-Jurkat cells,and screened the differential genes,which were enriched for the G2/M checkpoint,complement,and interleukin-6-Janus kinase-signal transducer and activator of transcription pathways,as well as changes in levels of forkhead box O,phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin,and T cell receptor pathways;moreover,TPCN2 significantly influenced cellular processes and biological regulation.Conclusion:TPCN2 might be a potential protective factor against SLE. | Keke Li Jingkai Xu Ke Xue Ruixing Yu Chengxu Li Wenmin Fei Xiaoli Ning Yang Han Ziyi Wang Jun Shu Yong Cui | 2022 | Chinese Medical Journal2022，，4： | 2 |
| 8 | Dynamic rupture of metal sheet subjected to laser irradiation and tangential subsonic airflow显示文摘To reproduce the premature rupture process of metal sheet subjected to laser irradiation with subsonic airflow,which is an interesting phenomenon observed in the experiments given by Lawrence Livermore National Laboratory,a coupled numerical model considering the interaction and evolution of metal elastoplastic deformation and aerodynamic pressure profile is presented.With the thermal elastoplastic constitutive relationship and failure criterion,the simulated failure modes and dynamic rupture process are basically consistent with the experimental results,indicating plastic flow and multiple fracturing is the main failure mechanism.Compared with the case of non-airflow,subsonic airflow not only accelerates deformation,but also turns the bugle deformation,plastic strain and rupture mode into asymmetric. | Xiaodong Xing Te Ma Ruixing Wang Chenyu Cao Hongwei Song Chenguang Huang | 2018 | Theoretical & Applied Mechanics Letters2018，8，4： | 2 |
| 9 | On the expected discounted penalty function for risk process with tax显示文摘 | Wang Wenyuan Ming Ruixing Hu Yijun | 2011 | Statistics and Probability Letters2011，81，： | 1 |
| 10 | Corrosion protection of cement-based building materials by surface deposition of CaCO3 by bacillus pasteurii 显示文摘 | Qian Chunxiang Wang Jianyun Wang Ruixing | 2009 | MaterSciEngC2009，29，4： | 1 |
| 11 | Corrosion protection of cement-based building materials by surface deposition of CaCO 3 by Bacillus pasteurii显示文摘 | Qian Chunxiang Wang Jianyun Wang Ruixing Cheng Liang | 2008 | Materials Science & Engineering C2008，，4： | 1 |
| 12 | Mitochondrial DNA haplogroup N is associated good outcome of gastric cancer显示文摘 | Cuiju Wang Yingnan Wang Huiying Wang Ruixing Zhang Zhanjun Guo | 2014 | Tumor Biology2014，，12： | 1 |
| 13 | Construction of an artificial intelligence system in dermatology: effectiveness and consideration of Chinese Skin Image Database (CSID)显示文摘After more than 60 years of development,artificial intelligence(AI)has been widely used in various fields.Especially in recent years,with the development of deep learning,AI has made many remarkable achievements in the medical field.Dermatology,as a clinical discipline with morphology as its main feature,is particularly suitable for the development of AI.The rapid development of skin imaging technology has helped dermatologists to assist in the diagnosis of diseases and has greatly improved the accuracy of diagnosis.Skin imaging data have natural big data attributes,which is important for AI research.The establishment of the Chinese Skin Image Database(CSID)has solved many problems such as isolated data islands and inconsistent data quality.Based on the CSID,many pioneering achievements have been made in the research and development of AI-assisted decision-making software,the establishment of expert organizations,personnel training,scientific research,and so on.At present,there are still many problems with AI in the field of dermatology,such as clinical validation,medical device licensing,interdisciplinary,and standard formulation,which urgently need to be solved by joint efforts of all parties. | Chengxu Li Wenmin Fei Yang Han Xiaoli Ning Ziyi Wang Keke Li Ke Xue Jingkai Xu Ruixing Yu Rusong Meng Feng Xu Weimin Ma Yong Cui | 2021 | Intelligent Medicine2021，1，2： | 1 |
| 14 | Inhibition of Cancer Cell Migration and Glycolysis by Terahertz Wave Modulation via Altered Chromatin Accessibility显示文摘Metastasis and metabolic disorders contribute to most cancer deaths and are potential drug targets in cancer treatment. However, corresponding drugs inevitably induce myeloid suppression and gastrointestinal toxicity. Here, we report a nonpharmaceutical and noninvasive electromagnetic intervention technique that exhibited long-term inhibition of cancer cells. Firstly, we revealed that optical radiation at the specific wavelength of 3.6 μm (i.e., 83 THz) significantly increased binding affinity between DNA and histone via molecular dynamics simulations, providing a theoretical possibility for THz modulation- (THM-) based cancer cell intervention. Subsequent cell functional assays demonstrated that low-power 3.6 μm THz wave could successfully inhibit cancer cell migration by 50% and reduce glycolysis by 60%. Then, mRNA sequencing and assays for transposase-accessible chromatin using sequencing (ATAC-seq) indicated that low-power THM at 3.6 μm suppressed the genes associated with glycolysis and migration by reducing the chromatin accessibility of certain gene loci. Furthermore, THM at 3.6 μm on HCT-116 cancer cells reduced the liver metastasis by 60% in a metastatic xenograft mouse model by splenic injection, successfully validated the inhibition of cancer cell migration by THM in vivo. Together, this work provides a new paradigm for electromagnetic irradiation-induced epigenetic changes and represents a theoretical basis for possible innovative therapeutic applications of THM as the future of cancer treatments. | Lan Suno Yangmei Li Yun Yu Peiliang Wang Shengquan Zhu KaijieWu Yan Liu Ruixing Wang Li Min Chao Chan | 2022 | Research2022，，4： | 0 |
| 15 | A novel method of Newton iteration-based interval analysis for multidisciplinary systems显示文摘A Newton iteration-based interval uncertainty analysis method(NI-IUAM) is proposed to analyze the propagating effect of interval uncertainty in multidisciplinary systems. NI-IUAM decomposes one multidisciplinary system into single disciplines and utilizes a Newton iteration equation to obtain the upper and lower bounds of coupled state variables at each iterative step.NI-IUAM only needs to determine the bounds of uncertain parameters and does not require specific distribution formats. In this way, NI-IUAM may greatly reduce the necessity for raw data. In addition, NI-IUAM can accelerate the convergence process as a result of the super-linear convergence of Newton iteration. The applicability of the proposed method is discussed, in particular that solutions obtained in each discipline must be compatible in multidisciplinary systems. The validity and efficiency of NI-IUAM is demonstrated by both numerical and engineering examples. | Lei Wang Chuang Xiong RuiXing Wang XiaoJun Wang Di Wu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，9： | 0 |
| 16 | Release of deposited MnO2 nanoparticles from aqueous surfaces显示文摘Changes in solution chemistry and transport conditions can lead to the release of deposited MnO2 nanoparticles from a solid interface,allowing them to re-enter the aqueous environment.Understanding the release behavior of Mn02 nanoparticles from naturally occurring surfaces is critical for better prediction of the transport potential and environmental fate of Mn02 nanoparticles.In this study,the release of Mn02 nanoparticles was investigated using a quartz crystal microbalance with dissipation monitoring(QCM-D),and different environmental surface types,solution pH values and representative macromolecular organics were considered.Mn02 nanoparticles were first deposited on crystal sensors at elevated NaN03 concentrations before being rinsed with double-deionized water to induce their remobilization.The results reveal that the release rate of Mn02 depends on the surface type,in the decreasing order:SiO2>Fe304>Al2 O3,resulting from electrostatic interactions between the surface and particles.Moreover,differences in solution pH can lead to variance in the release behavior of Mn02 nanoparticles.The release rate from surfaces was significantly higher at pH 9.8 that at 4.5,indicating that alkaline conditions were more favorable for the mobilization of Mn02 in the aquatic environment.In the presence of macromolecular organics,bovine serum albumin(BSA)can inhibit the release of Mn02 from the surfaces due to attractive forces.In presence of humic acid(HA)and sodium alginate(SA),the Mn02 nanoparticles were more likely to be mobile,which may be associated with a large repulsive barrier imparted by steric effects. | Hainan Wang Ruixing Huang Chengxue Ma Xiaoling Li Caihong Liu Qiang He Zhengsong Wu Jun Ma Xiaoliu Huangfu | 2020 | Journal of Environmental Sciences2020，32，4： | 0 |
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