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| 1 | Zircon chronology and REE geochemistry of granulite xenolith at Hannuoba显示文摘The lower crustal xenolith of mafic two_pyroxene granulite (the majority) and hypersthene granulite in the Cenozoic basalt at Hannuoba have the characteristics of igneous blastic structure and granulite facies metamorphic recrystallization. Study on the zircon chronology and REE geochemistry of granulite xenolith shows that the underplating of basic magma into the lower crust during late Mesozoic led to the formation of mafic accumulate, which further through metamorphism of granulite facies formed the high_density and high_velocity crustal bottom layer at the lower crust. This suggests that the underplating of mantle magma is the important way for the vertical overgrowth of continental crust since the Phanerozoic and provides new evidence for crust_mantle interaction. | Qicheng Fan Ruoxin Liu Huimin Li Ni Li Jianli Sui Zhuoran Lin | 1998 | Chinese Science Bulletin1998，43，18： | 22 |
| 2 | A new distinct geminivirus causes soybean stay-green disease显示文摘Dear Editor,Plant viruses make up almost half of the plant disease-causing pathogens,affecting crop yields and the global economy(Savary et al.,2019).Soybean(Glycine max)is one of the most valuable legume crops in the world,supplying 25%of the global edible oil and two-thirds of the global concentrated protein for livestock feeding.Recently,the outbreak of soybean stay-green syndrome with delayed leaf senescence(stay-green),flat pods,and increased number of abnormal seeds has swept the soybean production in the Huang-Huai-Hai region of China,resulting in huge yield losses(Xu et al.,2019).This disease has become an epidemic and prominent problem in soybean production and is still expanding its geography,including North America,posing a serious threat to soybean production(Harbach et al.,2016;Zhang et al.,2016;Li et al.,2019).However,the cause of soybean stay-green syndrome remains obscure. | Ruixiang Cheng Ruoxin Mei Rong Yan Hongyu Chen Dan Miao Lina Cai Jiayi Fan Gairu Li Ran Xu Weiguo Lu Yu Gao Wenwu Ye Shuo Su Tianfu Han Junyi Gai Yuanchao Wang Xiaorong Tao Yi Xu | 2022 | Molecular Plant2022，15，6： | 6 |
| 3 | Construction of MDS block diffusion matrices for block ciphers and hash functions显示文摘Dear editor,Block ciphers are one of the most important building blocks in many cryptosystems.Modern block ciphers are often iterations with several rounds,where each round comprises a(nonlinear)confusion layer and a(linear)diffusion layer.The diffusion layer plays a significant role in block | Ruoxin ZHAO Rui ZHANG Yongqiang LI Baofeng WU | 2016 | Science China(Information Sciences)2016，59，9： | 3 |
| 4 | Improved accuracy of the NPL-CsF2 primary frequency standard: evaluation of distributed cavity phase and microwave lensing frequency shifts显示文摘 | Ruoxin Li Kurt Gibble Krzysztof Szymaniec | 2011 | Metrologia2011，，5： | 1 |
| 5 | Revealing the Distribution of Aggregation-Induced Emission Nanoparticles via Dual-Modality Imaging with Fluorescence and Mass Spectrometry显示文摘Aggregation-induced emission nanoparticles(AIE NPs)are widely used in the biomedical field.However,understanding the biological process of AIE NPs via fluorescence imaging is challenging because of the strong background and poor penetration depth.Herein,we present a novel dual-modality imaging strategy that combines fluorescence imaging and label-free laser desorption/ionization mass spectrometry imaging(LDI MSI)to map and quantify the biodistribution of AIE NPs(TPAFN-F127 NPs)by monitoring the intrinsic photoluminescence and mass spectrometry signal of the AIE molecule.We discovered that TPAFN-F127 NPs were predominantly distributed in the liver and spleen,and most gradually excreted from the body after 5 days.The accumulation and retention of TPAFN-F127 NPs in tumor sites were also confirmed in a tumor-bearing mouse model.As a proof of concept,the suborgan distribution of TPAFN-F127 NPs in the spleen was visualized by LDI MSI,and the results revealed that TPAFN-F127 NPs were mainly distributed in the red pulp of the spleen with extremely high concentrations within the marginal zone.The in vivo toxicity test demonstrated that TPAFN-F127 NPs are nontoxic for a long-term exposure.This dual-modality imaging strategy provides some insights into the fine distribution of AIE NPs and might also be extended to other polymeric NPs to evaluate their distribution and drug release behaviors in vivo. | Liucheng Mao Yuming Jiang Hui Ouyang Yulin Feng Ruoxin Li Xiaoyong Zhang Zongxiu Nie Yen Wei | 2021 | Research2021，，1： | 1 |
| 6 | PROX1 restrains ferroptosis via SCD transcription activation in colorectal cancer显示文摘Colorectal cancer(CRC)is one of the most commonly diagnosed cancers and the second most common cause of cancer-related mortality worldwide.Although several therapeutic approaches have been developed for CRC in recent years,the prognosis of patients who develop chemotherapy resistance remains poor.Ferroptosis is an iron and lipid reactive oxygen species(ROS)-dependent form of programmed cell death,and it is distinct from other forms of regulatory cell death at multiple levels[1].Ferroptosis is regulated by a complex network and is a research hotspot as a promising therapeutic target in human cancers. | Ruoxin Zhang Dakui Luo Zezhi Shan Yufei Yang Yi Qin Qingguo Li Xinxiang Li | 2023 | Acta Biochimica et Biophysica Sinica2023，55，4： | 0 |
| 7 | circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer显示文摘Background:Circular RNAs(circRNAs)generated by back-splicing of precursor mRNAs(pre-mRNAs)are often aberrantly expressed in cancer cells.Accumulating evidence has revealed that circRNAs play a critical role in the progression of several cancers,including colorectal cancer(CRC).However,the current understandings of the emerging functions of circRNAs in CRC lipid metabolism and the underlying molecular mechanisms are still limited.Here,we aimed to explore the role of circCAPRIN1 in regulating CRC lipid metabolism and tumorigenesis.Methods:circRNA microarray was performed with three pairs of tumor and non-tumor tissues from CRC patients.The expression of circRNAs were determined by quantitative PCR(qPCR)and in situ hybridization(ISH).The endogenous levels of circRNAs in CRC cells were manipulated by transfection with lentiviruses overexpressing or silencing circRNAs.The regulatory roles of circRNAs in the occurrence of CRC were investigated both in vitro and in vivo using gene expression array,RNA pull-down/mass spectrometry,RNA immunoprecipitation assay,luciferase reporter assay,chromatin immunoprecipitation analysis,and fluorescence in situ hybridization(FISH).Results:Among circRNAs,circCAPRIN1 was most significantly upregulated in CRC tissue specimens.circCAPRIN1 expression was positively correlated with the clinical stage and unfavorable prognosis of CRC patients.Downregulation of circCAPRIN1 suppressed proliferation,migration,and epithelial-mesenchymal transition of CRC cells,while circCAPRIN1 overexpression had opposite effects.RNA sequencing and gene ontology analysis indicated that circCAPRIN1 upregulated the expressions of genes involved in CRC lipid metabolism.Moreover,circCAPRIN1 promoted lipid synthesis by enhancing Acetyl-CoA carboxylase 1(ACC1)expression.Further mechanistic assays demonstrated that circCAPRIN1 directly bound signal transducer and activator of transcription 2(STAT2)to activate ACC1 transcription,thus regulating lipid metabolism and facilitating CRC tumorigenesis.Conclusions:These findings revealed the oncogenic role and mechanism of circCAPRIN1 in CRC.circCAPRIN1 interacted with STAT2 to promote CRC tumor progression and lipid synthesis by enhancing the expression of ACC1.circCAPRIN1 may be considered as a novel potential diagnostic and therapeutic target for CRC patients. | Yufei Yang Dakui Luo Yang Shao Zezhi Shan Qi Liu Junyong Weng Weijing He Ruoxin Zhang Qingguo Li Ziliang Wang Xinxiang Li | 2023 | Cancer Communications2023，43，1： | 0 |
| 8 | Effectively Modulating Oxygen Vacancies in Flower‑Likeδ‑MnO_(2)Nanostructures for Large Capacity and High‑Rate Zinc‑Ion Storage显示文摘In recent years,manganese-based oxides as an advanced class of cathode materials for zinc-ion batteries(ZIBs)have attracted a great deal of attentions from numerous researchers.However,their slow reaction kinetics,limited active sites and poor electrical conductivity inevitably give rise to the severe performance degradation.To solve these problems,herein,we introduce abundant oxygen vacancies into the flower-likeδ-MnO_(2)nanostructure and effectively modulate the vacancy defects to reach the optimal level(δ-MnO_(2)-x-2.0).The smart design intrinsically tunes the electronic structure,guarantees ion chemisorption-desorption equilibrium and increases the electroactive sites,which not only effectively accelerates charge transfer rate during reaction processes,but also endows more redox reactions,as verified by first-principle calculations.These merits can help the fabricatedδ-MnO_(2)-x-2.0 cathode to present a large specific capacity of 551.8 mAh g^(-1) at 0.5 A g^(-1),high-rate capability of 262.2 mAh g^(-1) at 10 A g^(-1) and an excellent cycle lifespan(83%of capacity retention after 1500 cycles),which is far superior to those of the other metal compound cathodes.In addition,the charge/discharge mechanism of theδ-MnO_(2)-x-2.0 cathode has also been elaborated through ex situ techniques.This work opens up a new pathway for constructing the next-generation high-performance ZIBs cathode materials. | Yiwei Wang Yuxiao Zhang Ge Gao Yawen Fan Ruoxin Wang Jie Feng Lina Yang Alan Meng Jian Zhao Zhenjiang Li | 2023 | Nano-Micro Letters2023，15，12： | 0 |
| 9 | “Living”fluorophores:thermo-driven reversible ACQ-AIE transformation and ultra-sensitive in-situ monitor for dynamic Diels-Alder reactions显示文摘Organic fluorophores play essential roles in both academic and applied fields.Most of the fluorescent molecules can be divided into aggregation-caused quenching(ACQ)and aggregation-induced emission(AIE)types based on the diverse emission properties in solution and aggregated states.Currently,a large part of studies focuses on the ACQ-to-AIE one-way transformation and the complex synthesis of chemical bonds is inevitable in all existing methods.To maximize the advantages of ACQ and AIE types fluorophores and avoid complex chemosynthesis,we propose a facile strategy first realizing the reversible ACQAIE transformation with the dynamic Diels-Alder(DA)reactions.Besides,the fluorescent platform can monitor DA reactions in microscale ultra-sensitively and quantitively.The dynamic covalent bonds can help to develop novel fluorophores creatively,and the reversible ACQ-AIE platform is expected to offer fresh insights into the dynamic covalent chemistry. | Danning Hu Hongye Huang Ruoxin Li Jinying Yuan Yen Wei | 2022 | Science China Chemistry2022，65，8： | 0 |
| 10 | Significance of K-Ar age of bimodal volcanic rocks at Wangtian'e volcano,Changbaishan area显示文摘Wangtian’ e volcano, about 30 km south of Tianchi volcano is another large scale volcano center on the south slope of Changbaishan with its nearly 4 000 km^2 area of volcanic rocks distributed over the border area of the Chinese side. Based on the field occurrence, petrology and K-Ar age dating of its volcanic rocks, it can be shown that the Wangtian’e volcano had experienced two developing stages of shield forming and cone forming, while its volcanic activities can be divided into three periods: Changbai period (? —2.87 Ma), Wangtian’e period (2.69—2.41 Ma) and Hongtoushan period (2.12 Ma). Its petrographic change goes from trachybasalt→basaltic trachyandesite, trachyte→alkalic rhyolite, with a feature of bimodal volcanic rock combination similar to yet a bit different from that of Tianchi volcano, and is a new scene for study of volcanic magma evaluation of Changbaishan volcanoes. | Qicheng Fan Ruoxin Liu Daming Li Qi Li | 1999 | Chinese Science Bulletin1999，44，7： | 0 |
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