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| 1 | Lignin Biosynthesis Studies in Plant Tissue Cultures显示文摘Lignin, a phenolic polymer abundant in cell walls of certain cell types, has given challenges to scientists studying its structure or biosynthesis. In plants lignified tissues are distributed between other, non-lignified tissues. Characterization of native lignin in the cell wall has been difficult due to the highly cross-linked nature of the wall components. Model systems, like plant tissue cultures with tracheary element differentiation or extracellular lignin formation, have provided useful information related to lignin structure and several aspects of lignin formation. For example, many enzyme activities in the phenylpropanoid pathway have been first identified in tissue cultures. This review focuses on studies where the use of plant tissue cultures has been advantageous in structural and biosynthesis studies of lignin, and discusses the validity of tissue cultures as models for lignin biosynthesis. | Anna Krknen Sanna Koutaniemi | 2010 | Journal of Integrative Plant Biology2010，52，2： | 9 |
| 2 | 颞骨恶性肿瘤诊治的国外研究进展显示文摘颞骨恶性肿瘤是较少见的头颈肿瘤,最常见的病理类型是鳞状细胞癌。由于发病率低,加之局部解剖复杂,易累及周围重要结构,且缺乏统一的分期方案,因此其诊治极富挑战性,且仍存颇多争议。本文总结国外文献中关于颞骨恶性肿瘤的诊断、治疗及预后方面的研究进展,并展望未来的发展方向。 | 钟时勋 左汶奇 Mario Sanna | 2020 | 中华耳科学杂志2020，18，2： | 5 |
| 3 | Laparoscopic hysterectomy as optimal approach for 5400 grams uterus with associated polycythemia: A case report显示文摘BACKGROUND Uterine myomas are the most common benign gynecological soft tissue tumors in women but polycythemia associated with these tumors is rare.Polycythemia is significantly associated with risk of venous thromboembolism(VTE),which is further increased in case of a large pelvic mass and obesity.Here we report the surgical challenges in the case of an obese patient with a giant fibromatous uterus and associated polycythemia.CASE SUMMARY A 42-year-old obese woman was referred to our department for treatment for a huge fibromatous uterus.She suffered of pelvic pressure and abdominal distension and reported severe dyspnea from several months.Laboratory analyses including hemoglobin(Hb)19.2 g/dL and hematocrit(Hct)59.7%were indicative of polycythemia.Arterial blood gas analysis showed arterial oxygen pressure(pO2)of 81.5 mmHg.Abdominal computed tomography confirmed a giant fibromatous uterus measuring 28.2 cm×17 cm×25 cm.To reduce the thromboembolic risk,the patient underwent low molecular weight heparin,phlebotomy twice before surgery,and we opted for a laparoscopic hysterectomy.The uterus weighed 5400 g and the histology confirmed a diagnosis of leiomyoma.We did not find increased erythropoietin levels in the supernatant of the myomatous uterine tissue.There were no complications.On postoperative day 1,the Hb and the Hct levels normalized to 13.3 g/dL and 41.7%,respectively.Arterial blood gas analysis after surgery showed a pO2 of 144.7 mmHg.These results suggested the diagnosis of myomatous erythrocytosis syndrome.The patient was discharged on the second postoperative day in very good condition with no symptoms.CONCLUSION We believe this is the first reported laparoscopic hysterectomy in a patient with a giant uterus,polycythemia and obesity.Multiple VTE risk factors warranted a laparoscopic approach. | Antonio Macciò Giacomo Chiappe Fabrizio Lavra Elisabetta Sanna Romualdo Nieddu Clelia Madeddu | 2019 | World Journal of Clinical Cases2019，7，19： | 5 |
| 4 | Norway spruce(Picea abies) laccases:Characterization of a laccase in a lignin-forming tissue culture显示文摘Secondarily thickened cell walls of water-conducting vessels and tracheids and support-giving sclerenchyma cells contain lignin that makes the cell wal s water impermeable and strong. To what extent laccases and peroxidases contribute to lignin biosynthesis in muro is under active evaluation. We performed an in silico study of Norway spruce(Picea abies(L.)Karst.) laccases utilizing available genomic data. As many as 292 laccase encoding sequences(genes, gene fragments, and pseudogenes) were detected in the spruce genome. Out of the 112 genes annotated as laccases, 79 are expressed at some level. We isolated five full-length laccase c DNAs from developing xylem and an extracellular lignin-forming cell culture of spruce. In addition, we purified and biochemically characterized one culture medium laccase from the lignin-forming cell culture.This laccase has an acidic p H optimum(p H 3.8–4.2) for coniferyl alcohol oxidation. It has a high af finity to coniferyl alcohol with an apparent K m value of 3.5 m M; however, the laccase has a lowe catalytic ef ficiency(V max/K m) for coniferyl alcohol oxidation compared with some purified culture medium peroxidases. The properties are discussed in the context of the information already known about laccases/coniferyl alcohol oxidases o coniferous plants. | Sanna Koutaniemi Heli A.Malmberg Liisa K.Simola Teemu H.Teeri Anna K?rk?nen | 2015 | Journal of Integrative Plant Biology2015，57，4： | 4 |
| 5 | Patients'perspectives on smoking and inflammatory bowel disease:An online survey in collaboration with European Federation of Crohn's and Ulcerative Colitis Associations显示文摘BACKGROUNDSmoking has detrimental effects on Crohn’s disease (CD) activity while data onulcerative colitis (UC) are conflicting. Little is known about the use and impact ofalternative smoking products in inflammatory bowel diseases (IBD).AIMTo understand the patients’ perceptions of the impact of smoking on their IBDand to assess differences between CD and UC patients.METHODSThe questionnaire was developed by Philip Morris Products SA in cooperationwith European Federation of Crohn's and Ulcerative Colitis Associations. Thefinal survey questionnaire consisted of 41 questions divided in 8 categories: (1)Subject screener;(2) Smoking history;(3) Background information;(4) IBD diseasebackground;(5) Current disease status;(6) Current therapeutics and medications;and (7) Current nicotine/cigarettes use and awareness of the impacts of smokingon IBD. The questionnaire was submitted online from 4th November 2019 to 11th March 2020 through the European Federation of Crohn's and Ulcerative ColitisAssociations website to IBD patients who were current smokers or had a historyof smoking.RESULTSIn total 1050 IBD patients speaking nine languages participated to the survey.Among them, 807 (76.9%) patients declared to have ever smoked or consumed analternative smoking product, with a higher proportion of current cigarettesmokers among CD patients (CD: 63.1% vs UC: 54.1%, P = 0.012). About twothirdsof the participants declared to have ever stopped cigarette smoking andrestarted (67.0%), with a significantly higher proportion among UC patientscompared to CD patients (73.1% vs 62.0%, P = 0.001). We also found significantdifferences between CD and UC patients in the awareness of the healthconsequences of smoking in their disease and in the perceived impact of smokingon disease activity, for both cigarettes and alternative smoking products.CONCLUSIONThis survey found significant differences between CD and UC patients in bothawareness and perception of the impact of smoking on their disease. Furtherefforts should be done to encourage smoking cessation for all IBD patients,including UC patients. | Catherine Le Berre Laura Loy Sanna Lönnfors Luisa Avedano Daniele Piovani | 2020 | World Journal of Gastroenterology2020，26，29： | 4 |
| 6 | Successful outcome after combined chemotherapeutic and surgical management in a case of esophageal cancer with breast and brain relapse显示文摘Esophageal cancer (EC) is a highly lethal disease. Approximately 50% of patients present with metastatic EC and most patients with localized EC will have local recurrence or develop metastases, despite potentially curative local therapy. The most common sites of distant recurrence are represented by lung, liver and bone while brain and breast metastases are rare. Usually patients with advanced disease are not treated aggressively and their median survival is six months. We report a woman patient who developed breast and brain metastases after curative surgery. We treated her with a highly aggressive chemotherapeutic and surgical combination resulting in a complete remission of the disease even after 11-year follow-up. We think that in super selected patients with more than one metastasis, when functional status is good and metastases are technically resectable, a surgical excision may be considered as a salvage option and chemotherapy should be delivered to allow a systemic control. | Davide Adriano Santeufemia Gianfranca Piredda Giovanni Maria Fadda Paolo Cossu Rocca Salvatore Costantino Giovanni Sanna Maria Giuseppa Sarobba Maria Antonietta Pinna Carlo Putzu Antonio Farris | 2006 | World Journal of Gastroenterology2006，12，34： | 4 |
| 7 | 应用扩大迷路入路技术治疗巨大听神经瘤36例显示文摘 | 唐志辉 蓝明权 胡宝华 Mario Sanna | 2005 | 中华耳鼻咽喉头颈外科杂志2005，40，9： | 4 |
| 8 | Prevalence and prognosis of synchronous colorectal cancer: A Dutch population-based study显示文摘 | Sanna A. Mulder Ries Kranse Ronald A. Damhuis Johannes H.W. de Wilt Rob J.Th. Ouwendijk Ernst J. Kuipers Monique E. van Leerdam | 2011 | Cancer Epidemiology2011，，5： | 3 |
| 9 | Evidence to suggest adoption of water exchange deservesbroader consideration:Its pain alleviating impact occurs in90%of investigators显示文摘AIM: To determine variations in colonoscopy real-time insertion pain among investigators using three different insertion techniques.METHODS: From March 2013 through June 2014, 18-85-year-old diagnostic and 50-70-year-old screening patients were enrolled at each center to on-demand sedation colonoscopy with water exchange(WE), water immersion(WI) and insufflation with air or CO2 for insertion and withdrawal [air or carbon dioxide(AICD)]. Data were aggregated for analysis. Primary outcome: Variations in real-time maximum insertion pain(0 = none, 1-2 = discomfort, 10 = worst).RESULTS: One thousand and ninety-one cases analyzed: WE(n = 371); WI(n = 338); AICD(n = 382). Demographics and indications were comparable. The WE group had the lowest real-time maximum insertion pain score, mean(95%CI): WE 2.8(2.6-3.0), WI 3.8(3.5-4.1) and AICD 4.4(4.1-4.7), P < 0.0005. Ninety percent of the colonoscopists were able to use water exchange to significantly decrease maximum insertion pain scores. One investigator had high insertion pain in all groups, nonetheless WE achieved the lowest real-time maximum insertion pain score. WE had the highest proportions of patients with painless unsedated colonoscopy(vs WI, P = 0.013; vs AICD, P < 0.0005); unsedated colonoscopy with only minor discomfort(vs AICD, P < 0.0005), and completion without sedation(vs AICD, P < 0.0005).CONCLUSION: Aggregate data confirm superiority of WE in lowering colonoscopy real-time maximum insertion pain and need for sedation. Ninety percent of investigators were able to use water exchange to significantly decrease maximum insertion pain scores. Our results suggest that the technique deserves consideration in a broader scale. | Sergio Cadoni Mauro Liggi Premysl Falt Stefano Sanna Mariangela Argiolas Viviana Fanari Paolo Gallittu Donatella Mura Maria L Porcedda Vit Smajstrla Matteo Erriu Felix W Leung | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 2 |
| 10 | Impact of urbanization on plant diversity: A case study in built-up areas of Beijing显示文摘Urbanization is developing rapidly in the world, which seriously changes the habitat of organisms and has clearly a nega-tive effect on biodiversity. Preservation of biodiversity is crucial in urban planning and management, which is also an important symbol for the level of greening. Problems such as scarcity of urban green space and plant species have become obstacles to the es-tablishment of ecological friendly cities. However, coexistence of nature and modernization, as well the coordination of economic development and biodiversity, are goals that people are seeking. We have taken the built-up areas of Beijing as a study case and dis-cussed the impacts of urbanization on plant diversity, with the support of fieldwork and SPOT remote sensing data. The results are as follows: 1) in the process of urbanization, exotic plants have been widely introduced, which has affected species composition and the proportion of native plants; it is clear that artificial green spaces always will have a lower level of plant diversity than natural green spaces; 2) functional differences of green space types partially decide their species abundance, so that plant diversity in greenbelts and streets is generally lower than in parks; 3) the spatial variety of plant diversity contributes much to the imbalance of district de-velopment and the planning of different functional zones; this variation is embodied in different ring-belts and directions; 4) habitat fragmentation also affects plant diversity to a great extent; there is a significant positive correlation between high fragmentation and low plant diversity. According our results, some suggestions are proposed, which would be suitable for the preservation of plant di-versity and ecological improvement during urbanization. | LIANG Yao-qin LI Jing-wen LI Jing Sanna Katrina VALIMAKI | 2008 | Forestry Studies in China2008，10，3： | 2 |
| 11 | Vasohibin-1 and vasohibin-2 expression in gastric cancer cells and TAMs显示文摘 | Zhanlong Shen Tuuli Kauttu Hanna Sepp?nen Sanna Vainionp?? Yingjiang Ye Shan Wang Harri Mustonen Pauli Puolakkainen | 2012 | Medical Oncology2012，，4： | 2 |
| 12 | Current role of hepatopancreatoduodenectomy for the management of gallbladder cancer and extrahepatic cholangiocarcinoma:A systematic review显示文摘BACKGROUND Hepatopancreatoduodenectomy(HPD)is the simultaneous combination of hepatic resection,pancreaticoduodenectomy,and resection of the entire extrahepatic biliary system.HPD is not a universally accepted due to high mortality and morbidity rates,as well as to controversial survival benefits.AIM To evaluate the current role of HPD for curative treatment of gallbladder cancer(GC)or extrahepatic cholangiocarcinoma(ECC)invading both the hepatic hilum and the intrapancreatic common bile duct.METHODS A systematic literature search using the PubMed,Web of Science,and Scopus databases was performed to identify studies reporting on HPD,using the following keywords:‘Hepatopancreaticoduodenectomy’,‘hepatopancreatoduodenectomy’,‘hepatopancreatectomy’,‘pancreaticoduodenectomy’,‘hepatectomy’,‘hepatic resection’,‘liver resection’,‘Whipple procedure’,‘bile duct cancer’,‘gallbladder cancer’,and‘cholangiocarcinoma’.RESULTS This updated systematic review,focusing on 13 papers published between 2015 and 2020,found that rates of morbidity for HPD have remained high,ranging between 37.0%and 97.4%,while liver failure and pancreatic fistula are the most serious complications.However,perioperative mortality for HPD has decreased compared to initial experiences,and varies between 0%and 26%,although in selected center it is well below 10%.Long term survival outcomes can be achieved in selected patients with R0 resection,although 5–year survival is better for ECC than GC.CONCLUSION The present review supports the role of HPD in patients with GC and ECC with horizontal spread involving the hepatic hilum and the intrapancreatic bile duct,provided that it is performed in centers with high experience in hepatobiliarypancreatic surgery.Extensive use of preoperative portal vein embolization,and preoperative biliary drainage in patients with obstructive jaundice,represent strategies for decreasing the occurrence and severity of postoperative complications.It is advisable to develop internationally-accepted protocols for patient selection,preoperative assessment,operative technique,and perioperative care,in order to better define which patients would benefit from HPD. | Alessandro Fancellu Valeria Sanna Giulia Deiana Chiara Ninniri Davide Turilli Teresa Perra Alberto Porcu | 2021 | World Journal of Gastrointestinal Oncology2021，13，6： | 2 |
| 13 | Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses显示文摘His-tRNA synthetase (HARS) is targeted by autoantibodies in chronic and acute inflammatory anti-Jo-1-positive antisynthetase syndrome. The extensive activation and migration of immune cells into lung and muscle are associated with interstitial lung disease, myositis, and morbidity. It is unknown whether the sequestration of HARS is an epiphenomenon or plays a causal role in the disease. Here, we show that HARS circulates in healthy individuals, but it is largely undetectable in the serum of anti-Jo-1-positive antisynthetase syndrome patients. In cultured primary human skeletal muscle myoblasts (HSkMC), HARS is released in increasing amounts during their differentiation into myotubes. We further show that HARS regulates immune cell engagement and inhibits CD4+ and CD8+ T-cell activation. In mouse and rodent models of acute inflammatory diseases, HARS administration downregulates immune activation. In contrast, neutralization of extracellular HARS by high-titer antibody responses during tissue injury increases susceptibility to immune attack, similar to what is seen in humans with anti-Jo-1-positive disease. Collectively, these data suggest that extracellular HARS is homeostatic in normal subjects, and its sequestration contributes to the morbidity of the anti-Jo-1-positive antisynthetase syndrome. | Ryan AAdams Cátia Fernandes-Cerqueira Antonella Notarnicola Elisabeth Mertsching Zhiwen Xu Wing-Sze Lo Kathleen Ogilvie Kyle PChiang Jeanette Ampudia Sanna Rosengren Andrea Cubitt David JKing John DMendlein Xiang-Lei Yang Leslie ANangle Ingrid ELundberg Per-Johan Jakobsson Paul Schimmel | 2021 | Cellular & Molecular Immunology2021，18，6： | 2 |
| 14 | Outcomes of Early- and Late-Identified Children at 3 Years of Age: Findings From a Prospective Population-Based Study显示文摘 | Teresa Y. C. Ching Harvey Dillon Vivienne Marnane Sanna Hou Julia Day Mark Seeto Kathryn Crowe Laura Street Jessica Thomson Patricia Van Buynder Vicky Zhang Angela Wong Lauren Burns Christopher Flynn Linda Cupples Robert S. C. Cowan Greg Leigh Jessica Sja | 2013 | Ear and Hearing2013，，5： | 2 |
| 15 | IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and Caspase inhibition 显示文摘 | Sanna MG | 2002 | Mol Cell Biol2002，22，6： | 1 |
| 16 | Genome - wide association study shows BCL11A associated with persistent fetal hemoglobin and Amelioration of the phenotype of beta -thalassemia 显示文摘 | Uda M Galanello R Sanna S | 2008 | Proc Natl Acad Sci U S A2008，105，5： | 1 |
| 17 | 'Isms' in information science: con- structivism, collectivism and constuctionism 显示文摘 | Talja Sanna | 2005 | Journal of Documentation2005，，61： | 1 |
| 18 | Requirement for leptin in induction and progression of experimental autoimmune encephalomyelitis显示文摘 | Matarese G Di Giacomo A Sanna V | 2001 | J Immunol2001，166，10： | 1 |
| 19 | Surgical removal of jugular paragangliomas after stenting of the intratemporal internal carotid artery:a preliminary report显示文摘 | Sanna M Khrais T Menozi R | 2006 | Laryngoscope2006，116，5： | 1 |
| 20 | Renewable Chemical Commodity Feedstocks From Integrated Catalytic Processing of Pyrolysis Oils 显示文摘 | Vispute P T Zhang H Y Sanna A | 2010 | Science2010，330，： | 1 |
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