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| 1 | Long-term prognostic impact of circulating tumour cells in gastric cancer patients显示文摘AIM To analyse the long-term prognostic impact of circulating tumour cells(CTCs) in gastric cancer patients who underwent surgery. METHODS A 7.5-m L peripheral vein blood sample was obtained from each patient with treatment-negative gastric adenocarcinoma before surgery. OBP-401, a telomerasespecific, replication-selective, oncolytic adenoviral agent carrying the green fluorescent protein gene, was used to label CTCs. Correlations between the number of CTCs and clinical end points were evaluated. RESULTS The median follow-up period of the surviving patients with gastric cancer was 60 mo. The CTC number tended to increase concomitantly with disease progression. The overall survival of patients with more than five CTCs in 7.5-m L of peripheral blood was lower than that of patients with five or less CTCs, although the difference was not significant(P = 0.183). A significant difference in relapse-free survival was found between patients with more than five and those with five or less CTCs(P = 0.034).CONCLUSION A lower number of CTCs was correlated with higher relapse-free survival rates in patients. Detection of CTCs using OBP-401 may be useful for predicting prognosis in gastric cancer. | Hiroaki Ito Jun Sato Yukio Tsujino Noriko Yamaguchi Satoshi Kimura Keigo Gohda Katsuhiro Murakami Manabu Onimaru Tohru Ohmori Fumihiro Ishikawa Haruhiro Inoue | 2016 | World Journal of Gastroenterology2016，22，46： | 8 |
| 2 | Feasibility of gastric endoscopic submucosal dissection with continuous low-dose aspirin for patients receiving dual antiplatelet therapy显示文摘BACKGROUND Endoscopic submucosal dissection(ESD) for gastric neoplasms during continuous low-dose aspirin(LDA) administration is generally acceptable according to recent guidelines. This retrospective study aimed to investigate the effect of continuous LDA on the postoperative bleeding after gastric ESD in patients receiving dual antiplatelet therapy(DAPT).AIM To investigate the feasibility of gastric ESD with continuous LDA in patients with DAPT.METHODS A total of 597 patients with gastric neoplasms treated with ESD between January2010 and June 2017 were enrolled. The patients were categorized according to type of antiplatelet therapy(APT).RESULTS The postoperative bleeding rate was 6.9%(41/597) in all patients. Patients were divided into the following two groups: no APT(n = 443) and APT(n = 154). APT included single-LDA(n = 95) and DAPT(LDA plus clopidogrel, n = 59)subgroups. In the single-LDA and DAPT subgroups, 56 and 39 patients were received continuous LDA, respectively. The bleeding rate with continuous singleLDA(10.7%) was similar to that with discontinuous single-LDA(10.3%)(P >0.99). Although the bleeding rate with continuous LDA in patients receiving DAPT(23.1%) was higher than that with discontinuous LDA in patients receiving DAPT(5.0%), no significant difference was observed(P = 0.141).CONCLUSION The bleeding rate with continuous LDA in patients receiving DAPT was not statistically different from that with discontinuous LDA in patients receiving DAPT. Therefore, continuous LDA administration may be acceptable for ESD in patients receiving DAPT, although patients should be carefully monitored for possible bleeding. | Hideaki Harada Satoshi Suehiro Daisuke Murakami Ryotaro Nakahara Takuya Nagasaka Tetsuro Ujihara Ryota Sagami Yasushi Katsuyama Kenji Hayasaka Yuji Amano | 2019 | World Journal of Gastroenterology2019，25，4： | 6 |
| 3 | Endoscopic submucosal dissection for small submucosal tumors of the rectum compared with endoscopic submucosal resection with a ligation device显示文摘AIM To evaluate the efficacy and safety of endoscopic submucosal dissection(ESD) for small rectal submucosal tumors(SMTs).METHODS Between August 2008 and March 2016, 39 patients were treated with endoscopic submucosal resection with a ligation device(ESMR-L)(n = 21) or ESD(n = 18) for small rectal SMTs in this study. Twenty-five lesions were confirmed by histological evaluation of endoscopic biopsy prior to the procedure, and 14 lesions were not evaluated by endoscopic biopsy. The results for the ESMR-L group and the ESD group were retrospectively compared, including baseline characteristics and therapeutic outcomes.RESULTS The rate of en bloc resection was 100% in both groups. Although the rate of complete endoscopic resectionwas higher in the ESD group than in the ESMR-L group(100% vs 95.2%), there were no significant differences between the two groups(P = 0.462). In one patient in the ESMR-L group with a previously biopsied tumor, histological complete resection with a vertical margin involvement of carcinoid tumor could not be achieved, whereas there was no incomplete resection in the ESD group. The mean length of the procedure was significantly greater in the ESD group than in the ESMR-L group(14.7 ± 6.4 min vs 5.4 ± 1.7 min, P < 0.05). The mean period of the hospitalization was also significantly longer in the ESD group than in the ESMR-L group(3.7 ± 0.9 d vs 2.8 ± 1.5 d, P < 0.05). Postoperative bleeding was occurred in one patient in the ESMR-L group.CONCLUSION Both ESMR-L and ESD were effective for treatment of small rectal SMTs. ESMR-L was simpler to perform than ESD and took less time. | Hideaki Harada Satoshi Suehiro Daisuke Murakami Ryotaro Nakahara Takanori Shimizu Yasushi Katsuyama Yasunaga Miyama Kenji Hayasaka Shigetaka Tounou | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，2： | 5 |
| 4 | Survival of geriatric patients after percutaneous endoscopic gastrostomy in Japan显示文摘AIM: To examine the long term survival of geriatric patients treated with percutaneous endoscopic gastrostomy (PEG) in Japan. METHODS: We retrospectively included 46 Japanese community and tertiary hospitals to investigate 931 consecutive geriatric patients (≥ 65 years old) with swallowing difficulty and newly performed PEG between Jan 1st 2005 and Dec 31st 2008. We set death as an outcome and explored the associations among patient’s characteristics at PEG using log-rank tests and Cox proportional hazard models. RESULTS: Nine hundred and thirty one patients were followed up for a median of 468 d. A total of 502 deaths were observed (mortality 53%). However, 99%, 95%, 88%, 75% and 66% of 931 patients survived more than 7, 30, 60 d, a half year and one year, respectively. In addition, 50% and 25% of the patients survived 753 and 1647 d, respectively. Eight deaths were considered as PEG-related, and were associated with lower serum albumin levels (P = 0.002). On the other hand, among 28 surviving patients (6.5%), PEG was removed. In a multivariate hazard model, older age [hazard ratio (HR), 1.02; 95% confidence interval (CI), 1.00-1.03; P = 0.009], higher C-reactive protein (HR, 1.04; 95% CI: 1.01-1.07; P = 0.005), and higher blood urea nitrogen (HR, 1.01; 95% CI: 1.00-1.02; P = 0.003) were significant poor prognostic factors, whereas higher albumin (HR, 0.67; 95% CI: 0.52-0.85; P = 0.001), female gender (HR, 0.60; 95% CI: 0.48-0.75; P < 0.001) and no previous history of ischemic heart disease (HR, 0.69; 95% CI: 0.54-0.88, P = 0.003) were markedly better prognostic factors. CONCLUSION: These results suggest that more than half of geriatric patients with PEG may survive longer than 2 years. The analysis elucidated prognostic factors. | Yutaka Suzuki Seryna Tamez Akihiko Murakami Akihiko Taira Akihiro Mizuhara Akira Horiuchi Chie Mihara Eiji Ako Hirohito Muramatsu Hitoshi Okano Hitoshi Suenaga Kazuaki Jomoto Junya Kobayashi Katsunari Takifuji Kazuhiro Akiyama Koh Tahara Koji Onishi Makoto Shimazaki Masami Matsumoto Masashi Ijima Masato Murakami Masato Nakahori Michiaki Kudo Michio Maruyama Mikako Takahashi Naohiro Washizawa Shigeru Onozawa Satoshi Goshi Satoyoshi Yamashita Shigeki Ono Shin Imazato Shinji Nishiwaki Shuichirou Kitahara Takao Endo Takao Iiri Takeshi Nagahama Takuto Hikichi Tatsuya Mikami Tetsuo Yamamoto Tetsushi Ogawa Tomoko Ogawa Tomoyuki Ohta Toshifumi Matsumoto Toshiroh Kura Tsutomu Kikuchi Tsuyoshi Iwase Tsuyotoshi Tsuji Yukio Nishiguchi Mitsuyoshi Urashima | 2010 | World Journal of Gastroenterology2010，16，40： | 4 |
| 5 | Hilar cholangiocarcinoma with intratumoral calcification: A case report显示文摘This report describes a rare case of hilar cholangiocarcinoma with intratumoral calcification that mimicked hepatolithiasis. A 73-year-old man presented to a local hospital with a calcified lesion in the hepatic hilum. At first,hepatolithiasis was diagnosed,and he underwent endoscopic stone extraction via the transpapillary route. This treatment strategy failed due to biliary stricture. He was referred to our hospital,and further examination suggested the existence of cholangiocarcinoma. He underwent left hepatectomy with caudate lobectomy and extrahepatic bile duct resection. Pathological examination revealed hilar cholangiocarcinoma with intratumoral calcification,while no stones were found. To the best of our knowledge,only one case of calcified hilar cholangiocarcinoma has been previously reported in the literature. Here,we report a rare case of calcified hilar cholangiocarcinoma and reveal its clinicopathologic features. | Kazuho Inoko Takahiro Tsuchikawa Takehiro Noji Yo Kurashima Yuma Ebihara Eiji Tamoto Toru Nakamura Soichi Murakami Keisuke Okamura Toshiaki Shichinohe Satoshi Hirano | 2015 | World Journal of Gastroenterology2015，21，38： | 2 |
| 6 | PiggyBac transposon-mediated gene delivery efficiently generates stable transfectants derived from cultured primary human deciduous tooth dental pulp cells(HDDPCs) and HDDPC-derived iPS cells显示文摘The ability of human deciduous tooth dental pulp cells(HDDPCs) to differentiate into odontoblasts that generate mineralized tissue holds immense potential for therapeutic use in the field of tooth regenerative medicine. Realization of this potential depends on efficient and optimized protocols for the genetic manipulation of HDDPCs. In this study, we demonstrate the use of a Piggy Bac(PB)-based gene transfer system as a method for introducing nonviral transposon DNA into HDDPCs and HDDPC-derived inducible pluripotent stem cells. The transfection efficiency of the PB-based system was significantly greater than previously reported for electroporation-based transfection of plasmid DNA. Using the neomycin resistance gene as a selection marker, HDDPCs were stably transfected at a rate nearly 40-fold higher than that achieved using conventional methods. Using this system, it was also possible to introduce two constructs simultaneously into a single cell. The resulting stable transfectants, expressing td Tomato and enhanced green fluorescent protein, exhibited both red and green fluorescence. The established cell line did not lose the acquired phenotype over three months of culture. Based on our results, we concluded that PB is superior to currently available methods for introducing plasmid DNA into HDDPCs. There may be significant challenges in the direct clinical application of this method for human dental tissue engineering due to safety risks and ethical concerns. However, the high level of transfection achieved with PB may have significant advantages in basic scientific research for dental tissue engineering applications, such as functional studies of genes and proteins. Furthermore, it is a useful tool for the isolation of genetically engineered HDDPC-derived stem cells for studies in tooth regenerative medicine. | Emi Inada Issei Saitoh Satoshi Watanabe Reiji Aoki Hiromi Miura Masato Ohtsuka Tomoya Murakami Tadashi Sawami Youichi Yamasaki Masahiro Sato | 2015 | International Journal of Oral Science2015，7，3： | 2 |
| 7 | Simultaneous removal of dissolved organic matter and bromide from drinking water source by anion exchange resins for controlling disinfection by-products显示文摘Anion exchange resins(AERs) with different properties were evaluated for their ability to remove dissolved organic matter(DOM) and bromide, and to reduce disinfection by-product(DBP) formation potentials of water collected from a eutrophic surface water source in Japan. DOM and bromide were simultaneously removed by all selected AERs in batch adsorption experiments. A polyacrylic magnetic ion exchange resin(MIEX) showed faster dissolved organic carbon(DOC) removal than other AERs because it had the smallest resin bead size. Aromatic DOM fractions with molecular weight larger than 1600 Da and fluorescent organic fractions of fulvic acid- and humic acid-like compounds were efficiently removed by all AERs. Polystyrene AERs were more effective in bromide removal than polyacrylic AERs. This result implied that the properties of AERs, i.e. material and resin size, influenced not only DOM removal but also bromide removal efficiency. MIEX showed significant chlorinated DBP removal because it had the highest DOC removal within 30 min, whereas polystyrene AERs efficiently removed brominated DBPs, especially brominated trihalomethane species. The results suggested that, depending on source water DOM and bromide concentration,selecting a suitable AER is a key factor in effective control of chlorinated and brominated DBPs in drinking water. | Athit Phetrak Jenyuk Lohwacharin Hiroshi Sakai Michio Murakami Kumiko Oguma Satoshi Takizawa | 2014 | Journal of Environmental Sciences2014，26，6： | 2 |
| 8 | Molecular dynamics simulation of the formation of sp3 hybridized bonds in hydrogenated diamondlike carbon deposition processes 显示文摘 | Murakami Yasuo Horiguchi Seishi Hamaguchi Satoshi | 2010 | Physical Review E2010，81，04： | 1 |
| 9 | 猪隐秘杆菌型出血性坏死性脾炎显示文摘六月龄去势公猪表现昏睡、食欲不振、站立困难。尸检发现脾脏边缘呈多重出血灶。从脾脏、肾脏、肌肉和肝脏中分离出革兰氏阳性杆菌,对分离株(TO16177)的16S rDNA基因序列比较分析发现,其可能与未发表过的隐秘杆菌属HJ57-14E菌株(登记号:gi18873551)(比较675bp个碱基,相似性达99.7%)为同一个属。脾脏组织切片的组织学检查发现呈广泛性坏死和炎症,其中革兰氏阳性杆菌显而易见。肝脏中可见多病灶的坏死斑。免疫组织化学检测发现,分离株与抗化脓性隐秘杆菌属(Arcanobacterium pyogenes)和内氏放线菌(Actinomyces naeslundii)的多克隆抗体具有交叉反应,且与后者的交叉反应更强烈。相似的反应也见于扁桃体的化脓灶中分离株,偶尔也见于脾脏和淋巴结中的分离株。本研究结果表明,这种未公开发布的隐秘杆菌属的细菌会引起生长肥育猪多器官功能衰竭,而后继发急性出血性坏死性脾炎。 | 任彬(译) 常飞(校) Takemi OHBA Tomoyuki Shibahara Hideki Kobayashi Masanori Kubo Ariko Takaahima ShigenoriImai Satoshi Murakami Koichi Kadota | 2007 | 国外畜牧学(猪与禽)2007，，4： | 1 |
| 10 | Effects of receipt of chronic statin therapy before the onset of acute myocardial infarction: A retrospective study in patients undergoing primary percutaneous coronary intervention显示文摘 | Hideki Ishii Satoshi Ichimiya Masaaki Kanashiro Toru Aoyama Yasuhiro Ogawa Ryuichiro Murakami Tetsuya Amano Keiko Naruse Tatsuaki Matsubara Toyoaki Murohara | 2006 | Clinical Therapeutics2006，，11： | 1 |
| 11 | Pooled analysis of the reports of erlotinib after failure of gefitinib for non-small cell lung cancer显示文摘 | Kyoichi Kaira Tateaki Naito Toshiaki Takahashi Eriko Ayabe Rai Shimoyama Rieko Kaira Akira Ono Satoshi Igawa Takehito Shukuya Haruyasu Murakami Asuka Tsuya Yukiko Nakamura Masahiro Endo Nobuyuki Yamamoto | 2009 | Lung Cancer2009，，1： | 1 |
| 12 | Interactions of Ginseng Extract, Ginseng Separated Fractions, and Some Triterepenoid Saponins with Glucose Transporters in Sheep Erythrocytes显示文摘 | Hideo Hasegawa Satoshi Matsumiya Chikgae Murakami Tomonori Kurokawa Ryoji Kasai Sadahiko Ishibashi Kazuo Yamasaki | 1994 | Planta Med1994，，02： | 1 |
| 13 | Severe metabolic acidosis and hypokalemia in a patient with enterovesical fistula显示文摘 | Kazutaka Murakami Makoto Tomita Nahoko Kawamura Midori Hasegawa Kunihiro Nabeshima Yoshiyuki Hiki Satoshi Sugiyama | 2007 | Clinical and Experimental Nephrology2007，，3： | 1 |
| 14 | Synthesis and dual binding character of novel macrocyclic thiourea derivatives 显示文摘 | YASUYUKI OKUMURA SATOSHI MURAKAMI HAJIME MAEDA | 2003 | Tetrahedron Lett2003，44，： | 1 |
| 15 | 静脉注射尼可地尔对短期和长期患有心绞痛的急性ST段抬高型心肌梗塞患者的影响显示文摘(接8月下)在这篇文章的研究中,每组又被分为2个子组:给予52名前驱心绞痛患者安慰剂,给予129名非前驱心绞痛患者尼克地尔治疗,给予56名前驱心绞痛患者尼克地尔治疗,给予131名非前驱心绞痛患者安慰剂。前驱心绞痛被定义为急性心肌梗死前的休息时持续时间少于30分钟的短暂性胸痛。 | Hideki Ishii Satoshi Ichimiya Masaaki Kanashiro Tetsuya Amano Yasuhiro Ogawa Hirotsugu Mitsuhashi Shinichi Sakai Tadayuki Uetani Ryuichiro Murakami Keiko Naruse Toyoaki Murohara Tatsuaki Matsubara 王青 | 2015 | 首都食品与医药2015，22，18： | 1 |
| 16 | Urinary transforming growth factor-beta in patients with glomerular diseases显示文摘 | Murakami K Takemura T Satoshi Hino | 1997 | Pediatr Nephrol1997，11，： | 1 |
| 17 | Concomitant expression of heparin-binding epidermal growth factor-like growth factor mRNA and basic fibroblast growth factor mRNA in myocardial infarction in rats显示文摘 | Akihiro Iwabu Takashi Murakami Shozo Kusachi Keigo Nakamura Syunji Takemoto Issei Komatsubara Satoshi Sezaki Junichi Hayashi Yoshifumi Ninomiya Takao Tsuji | 2002 | Basic Research in Cardiology2002，，3： | 1 |
| 18 | Long term persistence of NS5A inhibitor‐resistant hepatitis C virus in patients who failed daclatasvir and asunaprevir therapy显示文摘 | Satoshi Yoshimi Michio Imamura Eisuke Murakami Nobuhiko Hiraga Masataka Tsuge Yoshiiku Kawakami Hiroshi Aikata Hiromi Abe C. Nelson Hayes Tamito Sasaki Hidenori Ochi Kazuaki Chayama | 2015 | J. Med. Virol2015，，11： | 1 |
| 19 | Postcyclic degradation of strength and stiffness for low plasticity silt显示文摘 | KAZUYA Yasuhara SATOSHI Murakami SONG Byung-woong | 2003 | Journal of Geotechnical and Geoenvironmental Engineering2003，129，8： | 1 |
| 20 | Myriophyllum spicatum -released allelopathic polyphenols inhibiting growth of blue-green algae Microcystis aeruginosa显示文摘 | Satoshi Nakai Yutaka Inoue Masaaki Hosomi Akihiko Murakami | 2000 | Water Research2000，，11： | 1 |
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