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| 1 | Discovery of the highly depleted N-MORB-type volcanic rocks: new evidence for the Mianlue paleo-ocean显示文摘The highly depleted N-MORB-type volcanic rocks have been discovered in Mianlue mélange of Qinling orogenic belt, central China. These mafic rocks are associated with the meta-peridotites, showing LREE-depleted pattern, similar to N-MORB and typical ophiolites. It is indicated that an ancient ocean existed in the Mianlue area of Qinling orogenic belt during the late Paleozoic. | Jifeng Xu Xueyuan Yu Xianhua Li Yinwen Han Jihu Shen Benren Zhang | 1998 | Chinese Science Bulletin1998，43，6： | 7 |
| 2 | Correlation and analysis of well-log sequence with Milankovitch cycles as rulers: A case study of coal-bearing strata of late Permian in western Guizhou显示文摘Based on the well-logging data of typical wells of Zhijin,Panxian and Weining areas in western Guizhou,the well-logging data GR of late Permian coal-bearing strata were processed and wavelet transform technique was used to carry out the sequence stratigraphy division and correlation.The study mainly focuses on the controlling effects which Milankovitch had on high frequency sequence,Milankovitch cycle can be used as a ruler of sequence stratigraphy division and correlation to ensure the scientifcity and the unity of sequence stratigraphy division.According to well-logging signal of the ideal Milankovitch cycle,the corresponding relation between the wavelet scales and the cycles is determined by wavelet analysis.Through analyzing analog signals of subsequence sets to search the corresponding relation between various system tracts and the features of time-frequency,the internal features of wavelet transform scalogram could be made clearly.According to ideal model research,features of Milankovitch curves and wavelet spectrum can be seen clearly and each well can be classifed into four third-order sequences and two system tracts.At the same time Milankovitch cycle can realize the division and correlation of stratigraphic sequence in a quick and convenient way. | Yuan Xuexu Guo Yinghai Yu Jifeng Shen Yulin Shao Yubao | 2013 | International Journal of Mining Science and Technology2013，23，4： | 6 |
| 3 | mRNA expression of Rho GTPase-related signaling molecules during rat hippocampal development显示文摘BACKGROUND:Rho GTPase family members have been shown to participate in neurite growth by regulating the neuronal cytoskeleton.However,there are very few reports of developmental roles of signaling molecules related to Rho GTPases. OBJECTIVE:To investigate messenger ribonucleic acid mRNA expression of signaling molecules associated with Rho GTPases,including Rho-A,Rac-1,collapsin response mediator protein 1(CRMP-1),and tubulin(53(Tubβ3) during rat hippocampus development. DESIGN,TIME AND SETTING:A non-randomized,controlled,animal experiment,based on different developmental stages of the rat hippocampus,was performed at the Guangdong Key Laboratory of Tissue Construction and Detection,Institute of Clinical Anatomy,Southern Medical University between December 2005 and July 2007. MATERIALS:Trizol reagent was purchased from Invitrogen,USA.RNA PCR kit(AMV) Ver 3.0 and 150 bp DNA Ladder Marker were purchased from TaKaRa,Japan.Unless otherwise specified,all other reagents were purchased from Sigma-Aldrich,USA. METHODS:Twenty-five Sprague Dawley rats were assigned to five groups(n = 5) according to developmental stages:embryonic(embryonic 15 days),neonatal(postnatal 5 days),juvenile (postnatal 1 month),adult(postnatal 3 months),and senile(postnatal 18 months). MAIN OUTCOME MEASURES:Detection of mRNA expression of Rho-A,Rac-1,CRMP-1,and Tubβ3 during various hippocampal developmental stages by reverse-transcription polymerase chain reaction. RESULTS:Hippocampal mRNA expression of Rho-A,as well as Rac-1,reached peak levels at embryonic,juvenile,and senile stages,and was relatively less during neonatal and adult stages. mRNA expression of Rac-1 was greater than Rho-A during each hippocampal developmental stage. CRMP-1 mRNA expression levels were as follows:embryonic>neonatal>juvenile>adultneonatal>juvenile>adult = senile. CONCLUSION:Rho-A and Rac-1 shared similar expression profiles,which demonstrated similar variations during the entire rat hippocampus developmental process.However,Rac-1 mRNA expression remained greater than Rho-A.Both CRMP-1 and Tubβ3 mRNA expression profiles gradually declined during hippocampal development from embryonic to adult stages.Tubβ3 mRNA expression arrested during the adult stage,and CRMP-1 mRNA expression increased during the senile stage. | Guoqing Guo Jifeng Zhang Li Xin Jing Chen Weizai Shen Lin Yuan Shizhen Zhong | 2009 | Neural Regeneration Research2009，4，10： | 2 |
| 4 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 5 | A novel distributionbased feature for rapid object detection显示文摘 | Shen Jifeng Sun Changyin Yang Wankou | 2011 | Neurocomputing2011，74，17： | 1 |
| 6 | An Approach on Automatic Test Data Generation with Predicate Constraint Solving Technique显示文摘 | Chen Jifeng Zhu Li Shen Junyi | 2006 | International Journal of Information Technology2006，12，3： | 1 |
| 7 | 吉西他滨联合顺铂或卡铂方案一线治疗晚期非小细胞肺癌的疗效和毒性比较(英文)显示文摘Objective: To compare the efficacy and toxicity between gemcitabine plus cisplatin and plus carboplatin in first-line treatment of advanced non-small cell lung cancer (NSCLC). Methods: Gemcitabine 1000 mg/m2 iv, d1, 8; cisplatin 75 mg/m2 iv, d1, or 25 mg/m2 iv, d1-3; carboplatin AUC = 5 iv, d1; repeated every 21 days. Results: All 76 cases were available for objective response. Gemcitabine + cisplatin (GCis) group: among 33 cases, CR 1 case, PR 13 cases, MR 3 cases, SD 7 cases, PD 9 cases, response rate, disease control rate, time to progress (TTP), median survival time (MST) and 1-, 2-year survival rates were 42.42% (14/33), 72.73% (24/33), 5 months, 14 months and 66.67% (22/33), 12.12% (4/33), respectively; Gemcitabine + carboplatin (GCarb) group: among 43 cases, PR 13 cases, MR 11 cases, SD 7 cases, PD 12 cases, the results while comparing with those of GCis group were 30.23% (13/43), 72.09% (31/43), 4 months, 11 months and 48.84% (21/43), 2.33% (1/43), respectively. Among them, only MST between the two groups had significant statistic difference (χ2 = 2.45, P = 0.017). Mild to modest myelo-suppression as well as nausea and vomiting were observed. Conclusion: Both GCis and GCarb regimens had active and well-tolerated toxicity for advanced NSCLC. Cisplatin-based chemotherapy yields a substantial effective advantage over carboplatin-based regimens. Therefore, carboplatin and cisplatin are not equal-active and that cisplatin-based doublet regimens should remain the standard first-line therapy for patients with advanced NSCLC with good performance status. | Meiqi Shi Bo Shen Guochun Cao Yun Zeng Guohao Xia Jifeng Feng Lin Xu | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，4： | 1 |
| 8 | Fabrication of an electrochemical immunosensor based on a gold-hydroxyapatite nanocomposite-chitosan film显示文摘 | SHEN Guangyu CAI Chenbo YANG Jifeng | 2011 | Electrochim Acta2011，56，24： | 1 |
| 9 | Fast Human Detection Base on Enhanced Variable Size HOG Features显示文摘 | SHEN Jifeng SUN Changyin YANG Wankou | 2011 | ISNN2011，，6676： | 1 |
| 10 | Broadband Fluorescence Guided-Wave in DANS/PMMA Thin Film Waveguides显示文摘The broadband fluorescence guided-waves excited in DANS/PMMA polymer thin film waveguides by an Ar+laser beam were demonstrated in terms of the observation of mlines with colour array.Considering the high brightness of these m-lines observation,we assert that it is a kind of stimulated amplification of fluorescence guided-wave. | WANG Huitian DONG Fengzhong ZHANG Zhanxiang YE Peixian QIU Ling SHEN Jifeng FU Xingfa SHEN Yuquan | 1994 | Chinese Physics Letters1994，11，2： | 0 |
| 11 | The Tianlin Mission:A 6m UV/Opt/IR Space Telescope to Explore Habitable Worlds and the Universe显示文摘It is expected that ongoing and future space-borne planet survey missions including Transiting Exoplanet Survey Satellite(TESS),PLATO and Earth 2.0 will detect thousands of small to medium-sized planets via the transit technique,including over a hundred habitable terrestrial rocky planets.To conduct a detailed study of these terrestrial planets,particularly the cool ones with wide orbits,the exoplanet community has proposed various follow-up missions.The currently proposed European Space Agency mission Ariel is the first step for this purpose,and it is capable of characterization of planets down to warm super-Earths mainly using transmission spectroscopy.The NASA Large Ultraviolet/Optical/Infrared Surveyor mission proposed in the Astro2020 Decadal Survey white paper will endeavor to further identify habitable rocky planets,and is expected to launch around 2045.In the meanwhile,China is funding a concept study of a 6 m class space telescope named Tianlin(a UV/Opt/NIR large aperture space telescope)that aims to start its operation within the next 10–15 yr and last for 5+yr.Tianlin will be primarily aimed at the discovery and characterization of rocky planets in the habitable zones around nearby stars and to search for potential biosignatures mainly using the direct imaging method.Transmission and emission spectroscopy at moderate to high resolution will be carried out as well on a population of exoplanets to strengthen the understanding of the formation and evolution of exoplanets.It will also be utilized to perform in-depth studies of the cosmic web and early galaxies,and constrain the nature of dark matter and dark energy.We describe briefly the primary scientific motivations and main technical considerations based on our preliminary simulation results.We find that a monolithic off-axis space telescope with primary mirror diameter larger than 6 m equipped with a high contrast coronagraph can identify water in the atmosphere of a habitable-zone Earth-like planet around a Sunlike star.More simulations for the detectability of other key biosignatures including O_(3),O_(2),CH_(4)and chlorophyll are coming. | Wei Wang Meng Zhai Gang Zhao Shen Wang Jifeng Liu Jin Chang Xuejun Zhang Jihong Dong Boqian Xu Frank Grupp | 2023 | Research in Astronomy and Astrophysics2023，23，9： | 0 |
| 12 | Ultrafast Optical Response of Phthalocyanine Langmuir-Blodegett Film显示文摘The mechanism of 2,9,16,23-tetra-heptadecylamido substituted vanadyl phthalocyanine Langmuir-Blodegett film was studied with femtosecond laser pulses.An ultrafast decay due to phonon-exciton coupling greatly affected by temperature,and exciton-exciton annihilation leading to the recovery of the ground state(T~lops)and an even slower relaxation were observed. | YUAN Ping XIA Zongju ZOU Yinghua QIU Ling SHEN Jifeng SHEN Yuquan XU Huijun | 1994 | Chinese Physics Letters1994，11，4： | 0 |
| 13 | Ultrafast Time-Resolved Optical Kerr Effect in Phthalocyanine Langmuir-Blodegett Film显示文摘The resonant optical Kerr effect in the Langmuir-Blodegett film of 2,9,16,23-tetra heptadecylamido substituted vanadyl phthalocyanine was measured with femtosecond laser pulses to determine the relaxation time,and meanwhile slow decay components were observed.The ultrafast nonlinearity of the molecule was also measured. | YUAN Ping XIA Zongju ZOU Yinghua QIU Ling SHEN Jifeng SHEN Yuquan XU Huijun | 1994 | Chinese Physics Letters1994，11，7： | 0 |
| 14 | Paclitaxel and cisplatin with or without cetuximab in metastatic esophageal squamous cell carcinoma:a randomized,multicenter phase II trial显示文摘Lack of effective targeted therapy in metastatic esophageal squamous cell carcinoma(ESCC)underscores the urgent need for identifying new treatment approaches for this challenging disease.We sought to assess the addition of cetuximab to paclitaxel-cisplatin chemotherapy for first-line treatment in patients with metastatic ESCC.In this randomized,multicenter,open-label,phase II clinical trial,patients were randomized to receive paclitaxel-cisplatin(TP)(paclitaxel[175 mg/m^(2) intravenously(i.v.)on day 1 of every 3-week cycle]and cisplatin[75 mg/m^(2) i.v.on day 1 of every 3-week cycle])and TP plus cetuximab(CTP)(cetuximab,400 mg/m^(2) i.v.on day 1 of week 1,followed by 250 mg/m^(2) weekly). | Zhihao Lu Yanqiao Zhang Qingxia Fan Yueyin Pan Da Jiang Ping Lu Jingdong Zhang Xianglin Yuan Jifeng Feng Shujun Yang Wenbin Yue Lin Zhao Yunhua Xu Jinhua Luo Lin Shen | 2022 | The Innovation2022，3，3： | 0 |
| 15 | Drought-Tolerant Rice at Molecular Breeding Eras:An Emerging Reality显示文摘Rice(Oryza sativa L.)stands as the most significantly influential food crop in the developing world,with its total production and yield stability affected by environmental stress.Drought stress impacts about 45%of the world’s rice area,affecting plants at molecular,biochemical,physiological,and phenotypic levels.The conventional breeding method,predominantly employing single pedigree selection,has been widely utilized in breeding numerous drought-tolerant rice varieties since the Green Revolution.With rapid progress in plant molecular biology,hundreds of drought-tolerant QTLs/genes have been identified and tested in rice crops under both indoor and field conditions.Several genes have been introgressed into elite germplasm to develop commercially accepted drought-tolerant varieties,resulting in the development of several drought-tolerant rice varieties through marker-assisted selection and genetically engineered approaches.This review provides up-to-date information on proof-of-concept genes and breeding methods in the molecular breeding era,offering guidance for rice breeders to develop drought-tolerant rice varieties. | ZHU Chengqi YE Yuxuan QIU Tian HUANG Yafan YING Jifeng SHEN Zhicheng | 2024 | Rice science2024，31，2： | 0 |
| 16 | Association of variants in the KIF1A gene with amyotrophic lateral sclerosis显示文摘Background:Amyotrophic lateral sclerosis(ALS)is a devastating progressive neurodegenerative disease that affects neurons in the central nervous system and the spinal cord.As in many other neurodegenerative disorders,the genetic risk factors and pathogenesis of ALS involve dysregulation of cytoskeleton and neuronal transport.Notably,sen-sory and motor neuron diseases such as hereditary sensory and autonomic neuropathy type 2(HSAN2)and spastic paraplegia 30(SPG30)share several causative genes with ALS,as well as having common clinical phenotypes.KIF1A encodes a kinesin 3 motor that transports presynaptic vesicle precursors(SVPs)and dense core vesicles and has been reported as a causative gene for HSAN2 and SPG30.Methods:Here,we analyzed whole-exome sequencing data from 941 patients with ALS to investigate the genetic association of KIF1A with ALS.Results:We identified rare damage variants(RDVs)in the KIF1A gene associated with ALS and delineated the clini-cal characteristics of ALS patients with KIF1A RDVs.Clinically,these patients tended to exhibit sensory disturbance.Interestingly,the majority of these variants are located at the C-terminal cargo-binding region of the KIF1A protein.Functional examination revealed that the ALS-associated KIF1A variants located in the C-terminal region preferentially enhanced the binding of SVPs containing RAB3A,VAMP2,and synaptophysin.Expression of several disease-related KIF1A mutants in cultured mouse cortical neurons led to enhanced colocalization of RAB3A or VAMP2 with the KIF1A motor.Conclusions:Our study highlighted the importance of KIF1A motor-mediated transport in the pathogenesis of ALS,indicating KIF1A as an important player in the oligogenic scenario of ALS. | Panlin Liao Yanchun Yuan Zhen Liu Xiaorong Hou Wanzhen Li Jin Wen Kexuan Zhang Bin Jiao Lu Shen Hong Jiang Jifeng Guo Beisha Tang Zhuohua Zhang Zhonghua Hu Junling Wang | 2022 | Translational Neurodegeneration2022，11，1： | 0 |
| 17 | Observation of Optical Bistabilities in a Doped Polymer Thin Film Quasi-waveguide显示文摘Optical bistability was observed and studied in the output of reflected beam as well as in that of m-lines in a doped polymer thin film quasi-waveguide.The physical origin was demonstrated to be the existence of a mode spectrum and the high third order nonlinearity of the polymer film.It was also observed for the first time that the intensity variation of the reflected beam and the m-line in the hysteresis loops are complementary to each other. | WANG Huitian DONG Fengzhong ZHANG Zhanxiang YE Peixian QIU Ling SHEN Jifeng FU Xingfa SHEN Yuquan | 1995 | Chinese Physics Letters1995，12，4： | 0 |
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