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| 1 | Long-term effect of lamivudine treatment on the incidence of hepatocellular carcinoma in patients with hepatitis B virus infection显示文摘 | Mika Kurokawa Naoki Hiramatsu Tsugiko Oze Takayuki Yakushijin Masanori Miyazaki Atsushi Hosui Takuya Miyagi Yuichi Yoshida Hisashi Ishida Tomohide Tatsumi Shinichi Kiso Tatsuya Kanto Akinori Kasahara Sadaharu Iio Yoshinori Doi Akira Yamada Masahide Oshita | 2012 | Journal of Gastroenterology2012，，5： | 4 |
| 2 | Factors affecting the quality of life of patients after gastrectomy as assessed using the newly developed PGSAS-45 scale: A nationwide multi-institutional study显示文摘AIM To identify certain clinical factors other than the type of gastrectomy which affect the postoperative quality of life(QOL) of patients after gastrectomy.METHODS The postgastrectomy syndrome assessment scale(PGSAS)-45 was designed to assess the severity of symptoms, the living status and the QOL of gastrectomized patients. It consists of 45 items, of which 22 are original items while 23 were retrieved from the SF-8 and Gastrointestinal Symptoms Rating Scale questionnaires with permission. A nationwide surveillance study to validate PGSAS was conducted and 2368 gastric cancer patients who underwent various types of gastrectomy at 52 medical institutions were enrolled. Of these, 1777 patients who underwent total gastrectomy(TG) reconstructed with Roux-Y(n = 393), distal gastrectomy(DG) reconstructed with Billroth-I(n = 909), or DG reconstructed with Roux-Y(n = 475) were evaluated in the current study. The influence of the type of gastrectomy and other clinical factors such as age, sex, duration after surgery, the symptom severity, the degree of weight loss, dietary intake, and the ability for working on the postoperative QOL(i.e., dissatisfaction for daily life subscale, physical component summary and mental component summary of the SF-8) were examined by multiple regression analysis(MRA). In addition, importance of various symptoms such as esophageal reflux, abdominal pain, meal-related distress, indigestion, diarrhea, constipation and dumping on the postoperative living status and QOL were also appraised by MRA.RESULTS The postoperative QOL were significantly deteriorated in patients who underwent TG compared to those after DG. However, the extent of gastrectomy was not an influential factor on patients' QOL when adjusted by the MRA. Among various clinical factors, the symptom severity, ability for working, and necessity for additional meals were the most influential factorsto the postoperative QOL. As for the individual symptoms, meal-related distress, dumping, abdominal pain, and esophageal reflux significantly affected the postoperative QOL in that order, while the influence of indigestion, diarrhea and constipation was insignificant. CONCLUSION Several clinical factors such as the symptom severity(especially in meal-related distress and dumping), ability for working and necessity for additional meals were the main factors which affected the patients' wellbeing after gastrectomy. | Koji Nakada Masazumi Takahashi Masami Ikeda Shinichi Kinami Masashi Yoshida Yoshikazu Uenosono Yoshiyuki Kawashima Sayumi Nakao Atsushi Oshio Yoshimi Suzukamo Masanori Terashima Yasuhiro Kodera | 2016 | World Journal of Gastroenterology2016，22，40： | 4 |
| 3 | Quality of life after total vs distal gastrectomy with Rouxen-Y reconstruction: Use of the Postgastrectomy Syndrome Assessment Scale-45显示文摘AIM To investigate the detrimental impact of loss of reservoir capacity by comparing total gastrectomy(TGRY) and distal gastrectomy with the same Rouxen-Y(DGRY) reconstruction. The study was conducted using an integrated questionnaire, the Postgastrectomy Syndrome Assessment Scale(PGSAS)-45, recently developed by the Japan Postgastrectomy Syndrome Working Party.METHODS The PGSAS-45 comprises 8 items from the Short Form-8, 15 from the Gastrointestinal Symptom Rating Scale, and 22 newly selected items. Uni-and multivariate analysis was performed on 868 questionnaires completed by patients who underwent either TGRY(n = 393) or DGRY(n = 475) for stage I gastric cancer(52 institutions). Multivariate analysis weighed of six explanatory variables, including the type of gastrectomy(TGRY/DGRY), interval after surgery, age, gender, surgical approach(laparoscopic/open), and whether the celiac branch of the vagus nerve was preserved/divided on the quality of life(QOL).RESULTS The patients who underwent TGRY experienced the poorer QOL compared to DGRY in the 15 of 19 main outcome measures of PGSAS-45. Moreover, multiple regression analysis indicated that the type of gastrectomy, TGRY, most strongly and broadly impaired the postoperative QOL among six explanatory variables. CONCLUSION The results of the present study suggested that TGRY had a certain detrimental impact on the postoperative QOL, and the loss of reservoir capacity could be a major cause. | Masazumi Takahashi Masanori Terashima Hiroshi Kawahira Eishi Nagai Yoshikazu Uenosono Shinichi Kinami Yasuhiro Nagata Masashi Yoshida Keishiro Aoyagi Yasuhiro Kodera Koji Nakada | 2017 | World Journal of Gastroenterology2017，23，11： | 3 |
| 4 | Surgical treatment for a combined anterior cruciate ligament and posterior cruciate ligament avulsion fracture: A case report显示文摘BACKGROUND Independent avulsion fractures with anterior cruciate ligament(ACL)or posterior cruciate ligament(PCL)attachment are relatively common among tibial intercondylar eminence fractures,and their postoperative outcomes are generally favorable.Conversely,huge avulsion fractures of the intercondylar eminence containing the attachment site of both the ACL and the PCL are extremely rare,and the reported clinical outcomes are poor.CASE SUMMARY We describe a 30-year-old Japanese male's huge avulsion fracture of the intercondylar eminence of a tibia containing the attachment site of both the ACL and PCL,together with a complete tear of the medial collateral ligament and a partial tear of both the medial and lateral menisci caused by a fall from a high place.All of these injuries were treated surgically,with anatomical reduction and stable fixation.The limb function at 1 year post-surgery was excellent(Lysholm score:100 points).CONCLUSION Although this patient's complete surgical repair was complex,it should be performed in similar cases for an excellent final clinical outcome. | Katsuhiro Yoshida Michiyuki Hakozaki Hideo Kobayashi Masashi Kimura Shinichi Konno | 2022 | World Journal of Clinical Cases2022，10，12： | 2 |
| 5 | A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous γδ T cells <sup>☆</sup> , <sup>☆☆</sup>显示文摘 | Jun Nakajima Tomohiro Murakawa Takeshi Fukami Shigenori Goto Toru Kaneko Yukihiro Yoshida Shinichi Takamoto Kazuhiro Kakimi | 2010 | European Journal of Cardio-Thoracic Surgery2010，，5： | 2 |
| 6 | Sporadic gastric carcinoid tumor successfully treated by two-stage laparoscopic surgery:A case report显示文摘We report a case of sporadic gastric carcinoid tumor successfully treated by two-stage laparoscopic surgery.A 38-year old asymptomatic woman was referred to our hospital for evaluation of a submucosal tumor of the stomach.Endoscopic examination showed a solitary submucosal tumor without ulceration or central depression on the posterior wall of the antrum and biopsy specimens were not sufficient to determine the diagnosis.Endoscopic ultrasound revealed a tumor nearly 2 cm in diameter arising from the muscle layer and a computed tomography scan showed the tumor enhanced in the arterial phase.Laparoscopic wedge resection was performed for definitive diagnosis.Pathologically,the tumor was shown to be gastric carcinoid infiltrating the muscle layer which indicated the probability of lymph node metastasis.Serum gastrin levels were normal.As a radical treatment,laparoscopy-assisted distal gastrectomy with regional lymphadenectomy was performed 3 wk after the initial surgery.Finally,pathological examination revealed no lymph node metastasis. | Takahiro Kinoshita Takashi Oshiro Tasuku Urita Yutaka Yoshida Mitsuru Ooshiro Shinichi Okazumi Ryoji Katoh Daisuke Sasai Nobuyuki Hiruta | 2010 | World Journal of Gastrointestinal Surgery2010，2，11： | 2 |
| 7 | A high performance planar pump using electro-conjugate fluid with improved electrode patterns显示文摘 | Woo-Suk Seo Kazuhiro Yoshida Shinichi Yokota Kazuya Edamura | 2006 | Sensors & Actuators: A Physical2006，，2： | 1 |
| 8 | Long-term effect of lamivudine treatment on the incidence of hepatocellular carcinoma in patients with hepatitis B virus infection显示文摘 | Mika Kurokawa Naoki Hiramatsu Tsugiko Oze Takayuki Yakushijin Masanori Miyazaki Atsushi Hosui Takuya Miyagi Yuichi Yoshida Hisashi Ishida Tomohide Tatsumi Shinichi Kiso Tatsuya Kanto Akinori Kasahara Sadaharu Iio Yoshinori Doi Akira Yamada Masahide Oshita | 2012 | Journal of Gastroenterology2012，，5： | 1 |
| 9 | Antitumor effects of scutenariac radix and its components baicalein, baicalin, and wogonia on bladder cancer cell lines 显示文摘 | Shinichi Ikemoto Kaiunobu Sugimuka Naomasa Yoshida | 2000 | Urology2000，55，6： | 1 |
| 10 | Antitumor effects of scutcllariac radix and its components baiealein, baicalin and wogonin on bladder cancer cell lines 显示文摘 | Shinichi lkemoto kaiuhobu Sugimuka Naomasa Yoshida | 2000 | Urology2000，55，6： | 1 |
| 11 | Fuzzy functional link network and its application to the representation of the extended kolmogorov theorem显示文摘 | SHINICHI YOSHIDA KAORU HIROTA | 2002 | International Journal of Fuzzy System2002，4，2： | 1 |
| 12 | Obstruction of Inferior Vena Caval Orifice by Giant Left Atrium in Patients With Mitral Stenosis: A Doppler Echocardiographic Study From the Right Parasternal Approach显示文摘 | Shinichi Minagoe Junichi Yoshikawa Kiyoshi Yoshida Takashi Akasaka Masahiro Shakudo Kenji Maeda Chuwa Tei | 1992 | Circulation1992，，： | 1 |
| 13 | RTRA differentially regulates interleukin-1β and interleukin-1 receptor antagonist production by human alveolar macrophages 显示文摘 | Shu Hashimoto Shinichi Hayashi Sachiko Yoshida | 1998 | Leukemia Research1998，22，： | 1 |
| 14 | Efficient syntheses of 1 -arylnapthalene lignan lactones and relat- ed compounds from cyanohydrins显示文摘 | Ogiku Tsuyoshi Yoshida Shinichi Ohmizu Hiroshi | 1995 | J Org Chem1995，60，45： | 1 |
| 15 | Resonantly driven piezoelectric micropump fabrication of a mieropump having high power density显示文摘 | Jung-Ho Park Kazuhiro Yoshida Shinichi Yokota | 1999 | Mechatronics1999，9，7： | 1 |
| 16 | ,Release of Metals from MSW Fly Ash and Availability in Alkali Condition显示文摘 | Satoshi Mizutani Tsuneyuki Yoshida Shinichi Sakai | 1996 | Waste Management1996，16，6： | 1 |
| 17 | A Solid-phase Mi- cro extraction Method for the Detection of Ignitable Liquids in Fire Debris 显示文摘 | Hiroaki Yoshida Tsuyoshi Kaneko Shinichi Suzuki | 2008 | Journal of Forensic Science2008，53，3： | 1 |
| 18 | Hemorrhagic gastric and duodenal ulcers after the Great East Japan Earthquake Disaster显示文摘AIM:To elucidate the characteristics of hemorrhagic gastric/duodenal ulcers in a post-earthquake period within one medical district.METHODS:Hemorrhagic gastric/duodenal ulcers in the Iwate Prefectural Kamaishi Hospital during the 6-mo period after the Great East Japan Earthquake Disaster were reviewed retrospectively.The subjects were 27patients who visited our hospital with a chief complaint of hematemesis or hemorrhagic stool and were diagnosed as having hemorrhagic gastric/duodenal ulcers by upper gastrointestinal endoscopy during a 6-mo period starting on March 11,2011.This period was divided into two phases:the acute stress phase,comprising the first month after the earthquake disaster,and the chronic stress phase,from the second through the sixth month.The following items were analyzed according to these phases:age,sex,sites and number of ulcers,peptic ulcer history,status of Helicobacter pylori(H.pylori)infection,intake of non-steroidal anti-inflammatory drugs,and degree of impact of the earthquake disaster.RESULTS:In the acute stress phase from 10 d to 1mo after the disaster,the number of patients increased rapidly,with a nearly equal male-to-female ratio,and the rate of multiple ulcers was significantly higher than in the previous year(88.9%vs 25%,P<0.005).In the chronic stress phase starting 1 mo after the earthquake disaster,the number of patients decreased to a level similar to that of the previous year.There were more male patients during this period,and many patients tended to have a solitary ulcer.All patients with duodenal ulcers found in the acute stress phase were negative for serum H.pylori antibodies,and this was significantly different from the previous year’s positive rate of 75%(P<0.05).CONCLUSION:Severe stress caused by an earthquake disaster may have affected the characteristics of hemorrhagic gastric/duodenal ulcers. | Kenichi Yamanaka Hiroyuki Miyatani Yukio Yoshida Shinichi Asabe Toru Yoshida Misaki Nakano Shin Obara Hidehiko Endo | 2013 | World Journal of Gastroenterology2013，19，42： | 1 |
| 19 | Retention of Multilineage Differentiation Potential of Mesenchymal Cells during Proliferation in Response to FGF显示文摘 | Shinichi Tsutsumi Atsushi Shimazu Kazuko Miyazaki Haiou Pan Chika Koike Eri Yoshida Kenji Takagishi Yukio Kato | 2001 | Biochemical and Biophysical Research Communications2001，，2： | 1 |
| 20 | LGR5‐Positive Colon Cancer Stem Cells Interconvert with Drug‐Resistant LGR5‐Negative cells and are Capable of Tumor Reconstitution显示文摘 | Shinta Kobayashi Hisafumi Yamada‐Okabe Masami Suzuki Osamu Natori Atsuhiko Kato Koichi Matsubara Yu Jau Chen Masaki Yamazaki Shinichi Funahashi Kenji Yoshida Eri Hashimoto Yoshinori Watanabe Hironori Mutoh Motooki Ashihara Chie Kato Takeshi Watanabe Takas | 2012 | STEM CELLS2012，，12： | 1 |
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