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| 1 | Over-expression of CD163, CD169, and CD151 is not sufficient to improve the susceptibility to porcine reproductive and respiratory syndrome virus infection in transgenic mice显示文摘Porcine reproductive and respiratory syndrome virus(PRRSV)is a major pathogen that causes reproductive failure and respiratory disease in pigs,resulting in devastating economic losses worldwide[1].Porcine alveolar macrophages(PAMs)are the primary target cells of PRRSV[2],and the putative receptors,including CD163,CD169,and CD151,play key roles during infection[3–6].However,the understanding of PRRSV infection and pathogenesis is | Zhengzhi Cui Shuaishuai Niu Jingjing Liu Lei Xu Yunping Dai Ning Li Youmin Kang Linlin Zhang Lei Zhou Shuyang Yu | 2017 | Science Bulletin2017，62，24： | 1 |
| 2 | Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1显示文摘Macrophages in tumors(tumor-associated macrophages,TAMs),a major population within most tumors,play key homeostatic functions by stimulating angiogenesis,enhancing tumor cell growth,and suppressing antitumor immunity.Resetting TAMs by simple,efficacious and safe approach(s)is highly desirable to enhance antitumor immunity and attenuate tumor cell malignancy.Previously,we used tumor cell-derived microparticles to package chemotherapeutic drugs(drug-MPs),which resulted in a significant treatment outcome in human malignant pleural effusions via neutrophil recruitments,implicating that drug-MPs might reset TAMs,considering the inhibitory effects of M2 macrophages on neutrophil recruitment and activation.Here,we show that drug-MPs can function as an antitumor immunomodulator by resetting TAMs with M1 phenotype and IFN-βrelease.Mechanistically,drug molecules in tumor MPs activate macrophage lysosomal P450 monooxygenases,resulting in superoxide anion formation,which further amplifies lysosomal ROS production and pH value by activating lysosomal NOX2.Consequently,lysosomal Ca^(2+)signaling is activated,thus polarizing macrophages towards M1.Meanwhile,the drug molecules are delivered from lysosomes into the nucleus where they activate DNA sensor hnRNPA2B1 for IFN-βproduction.This lysosomal-nuclear machinery fully arouses the antitumor activity of macrophages by targeting both lysosomal pH and the nuclear innate immunity.These findings highlight that drug-MPs can act as a new immunotherapeutic approach by revitalizing antitumor activity of macrophages.This mechanistic elucidation can be translated to treat malignant ascites by drug-MPs combined with PD-1 blockade. | Keke Wei Huafeng Zhang Shuaishuai Yang Yuxiao Cui Bingxia Zhang Jincheng Liu Liang Tang Yaoyao Tan Simin Liu Shiqi Chen Wu Yuan Xiao Luo Chen Chen Fei Li Junwei Liu Jie Chen Pingwei Xu Jiadi Lv Ke Tang Yi Zhang Jingwei Ma Bo Huang | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 3 | Two-flavor quark matter in the perturbation theory with full thermodynamic consistency显示文摘Direct extrapolation of the strong interaction between quarks in pure perturbative calculation has a problem of thermodynamic inconsistency.A new term determined by thermodynamic consistency requirement could resolve it.This new term plays an important role at lower density in describing the equation of state of quark matter,while it is negligible at high density.Accordingly,the density behavior of the sound velocity becomes more reasonable,and the maximum mass of quark stars can be as large as two times the solar mass. | XU JianFeng PENG GuangXiong LU ZhenYan CUI ShuaiShuai | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，4： | 0 |
| 4 | Co-regulator NCOA5 and cancer显示文摘NCOA5 encodes a co-regulator for estrogen receptors(ERαand ERβ),orphan nuclear receptors(REV-ERBαand REV-ERBβ)and liver X receptor.It can influence many cellular processes by either promoting or inhibiting gene expression through its two important functional motifs:LxxLL(co-activator)andΦxxΦΦ(co-repressor).Many reports have revealed the important roles of NCOA5 in diseases,such as diabetes,reproductive defects and autoimmune disease.In this review,we focus on its function in cancers and summary the current research progresses regarding its different roles in various cancers. | YUANYUAN CHEN SHUAISHUAI CUI YUNFEI GUO DAHU CHEN | 2022 | BIOCELL2022，46，7： | 0 |
| 5 | Video Conference System in Mixed Reality Using a Hololens显示文摘The mixed reality conference system proposed in this paper is a robust,real-time video conference application software that makes up for the simple interaction and lack of immersion and realism of traditional video conference,which realizes the entire process of holographic video conference from client to cloud to the client.This paper mainly focuses on designing and implementing a video conference system based on AI segmentation technology and mixed reality.Several mixed reality conference system components are discussed,including data collection,data transmission,processing,and mixed reality presentation.The data layer is mainly used for data collection,integration,and video and audio codecs.The network layer uses Web-RTC to realize peer-to-peer data communication.The data processing layer is the core part of the system,mainly for human video matting and human-computer interaction,which is the key to realizing mixed reality conferences and improving the interactive experience.The presentation layer explicitly includes the login interface of the mixed reality conference system,the presentation of real-time matting of human subjects,and the presentation objects.With the mixed reality conference system,conference participants in different places can see each other in real-time in their mixed reality scene and share presentation content and 3D models based on mixed reality technology to have a more interactive and immersive experience. | Baolin Sun Xuesong Gao Weiqiang Chen Qihao Sun Xiaoxiao Cui HaoGuo Cishahayo Remesha Kevin Shuaishuai Liu Zhi Liu | 2023 | Computer Modeling in Engineering & Sciences2023，，1： | 0 |
| 6 | TM_(3)(TM=V,Fe,Mo,W)single-cluster catalyst confined on porous BN for electrocatalytic nitrogen reduction显示文摘Confined metal clusters as sub-nanometer reactors for electrocatalytic N_(2) reduction reaction(eNRR)have received increasing attention due to the unique metal-metal interaction and higher activity than singleatom catalysts.Herein,the inspiration of the superior capacitance and unique microenvironment with regular surface cavities of the porous boron nitride(p-BN)nanosheets,we systematically studied the catalytic activity for NRR of transition-metal single-clusters in the triplet form(V_(3),Fe_(3),Mo_(3) and W_(3))confined in the surface cavities of the p-BN sheets by spin-polarized density functional theory(DFT)calculations.After a two-step screening strategy,Mo_(3)@p-BN was found to have high catalytic activity and selectivity with a rather low limiting potential(-0.34 V)for the NRR.The anchored Mo_(3) singlecluster can be stably embedded on the surface cavities of the substrate preventing the diffusion of the active Mo atoms.More importantly,the Mo atoms in the Mo_(3) single-cluster would act as“cache”to accelerate electron transfer between active metal centers and nitrogen-containing intermediates via the intimate Mo-Mo interactions.The cooperation of Mo atoms can also provide a large number of occupied and unoccupied d orbitals to make the'donation-backdonation'mechanism more effective.This work not only provides a quite promising electrocatalyst for NRR,but also brings new insights into the rational design of triple-atom NRR catalysts. | Shuaishuai Gao Zuju Ma Chengwei Xiao Zhitao Cui Wei Du Xueqin Sun Qiaohong Li Rongjian Sa Chenghua Sun | 2022 | Journal of Materials Science & Technology2022，，13： | 0 |
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