|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 2 | Land-surface processes and summer-cloud-precipitation characteristics in the Tibetan Plateau and their effects on downstream weather:a review and perspective显示文摘Correct understanding of the land-surface processes and cloud-precipitation processes in the Tibetan Plateau(TP)is an important prerequisite for the study and forecast of the downstream activities of weather systems and one of the key points for understanding the global atmospheric movement.In order to show the achievements that have been made,this paper reviews the progress on the observations for the atmospheric boundary layer,land-surface heat fluxes,cloud-precipitation distributions and vertical structures by using ground-and space-based multiplatform,multisensor instruments and the effect of the cloud system in the TP on the downstream weather.The results show that the form drag related to the topography,land-atmosphere momentum and scalar fluxes is an important part of the parameterization process.The sensible heat flux decreased especially in the central and northern TP caused by the decrease in wind speeds and the differences in the ground-air temperatures.Observations show that the cloud and precipitation over the TP have a strong diurnal variation.Studies also show the compressed-air column in the troposphere by the higher-altitude terrain of the TP makes particles inside clouds vary at a shorter distance in the vertical direction than those in the non-plateau area so that precipitation intensity over the TP is usually small with short duration,and the vertical structure of the convective precipitation over the TP is obviously different from that in other regions.In addition,the influence of the TP on severe weather downstream is preliminarily understood from the mechanism.It is necessary to use model simulations and observation techniques to reveal the difference between cloud precipitation in the TP and non-plateau areas in order to understand the cloud microphysical parameters over the TP and the processes of the land boundary layer affecting cloud,precipitation and weather in the downstream regions. | Yunfei Fu Yaoming Ma Lei Zhong Yuanjian Yang Xueliang Guo Chenghai Wang Xiaofeng Xu Kun Yang Xiangde Xu Liping Liu Guangzhou Fan Yueqing Li Donghai Wang | 2020 | National Science Review2020，7，3： | 10 |
| 3 | Actual evapotranspiration of subalpine meadows in the Qilian Mountains, Northwest China显示文摘As a main component in water balance,evapotranspiration(ET)is of great importance for water saving,especially in arid and semi-arid areas.In this study,the FAO(Food and Agriculture Organization)Penman-Monteith model was used to estimate the magnitude and temporal dynamics of reference evapotranspiration(ET0)in 2014 in subalpine meadows of the Qilian Mountains,Northwest China.Meanwhile,actual ET(ETc)was also investigated by the eddy covariance(EC)system.Results indicated that ETc estimated by the EC System was 583 mm,lower than ET0(923 mm)estimated by the FAO Penman-Monteith model in 2014.Moreover,ET0 began to increase in March and reached the peak value in August and then declined in September,however,ETc began to increase from April and reached the peak value in July,and then declined in August.Total ETc and ET0 values during the growing season(from May to September)were 441 and 666 mm,respectively,which accounted for 75.73%of annual cumulative ETc and 72.34%of annual cumulative ET0,respectively.A crop coefficient(kc)was also estimated for calculating the ETc,and average value of kc during the growing season was 0.81(ranging from 0.45 to 1.16).Air temperature(Ta),wind speed(u),net radiation(Rn)and soil temperature(Ts)at the depth of 5 cm and aboveground biomass were critical factors for affecting kc,furthermore,a daily empirical kc equation including these main driving factors was developed.Our result demonstrated that the ETc value estimated by the data of kc and ET0 was validated and consistent with the growing season data in 2015 and 2016. | GAO Yunfei ZHAO Chuanyan Muhammad W ASHIQ WANG Qingtao RONG Zhanlei LIU Junjie MAO Yahua GUO Zhaoxia WANG Wenbin | 2019 | Journal of Arid Land2019，11，3： | 8 |
| 4 | In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids显示文摘Unlike most organs that mature during the fetal period,the male reproductive system reaches maturity only at puberty with the commencement of spermatogenesis.Robust modelling of human testicular organogenesis in vitro would facilitate research into mechanisms of and factors affecting human spermatogenic failure and male fertility preservation in prepubertal tumor patients.Here,we report successful recapitulation of human testicular organogenesis in vitro from fetal gonadal ridge.Our model displayed the formation of mature seminiferous epithelium and self-renewing spermatogonia.Remarkably,in vitro-derived haploid spermatids have undergone meiotic recombination,and showed increased genetic diversity as indicated by genetic analysis.Moreover,these spermatids were able to fertilize oocytes and support subsequent blastocyst formation.The in vitro testicular organogenesis system described here will play an important role in elucidating the regulation of human testis development and maintaining male fertility in prepubertal cancer patients. | Yan Yuan Laihua Li Qing Cheng Feiyang Diao Qiao Zeng Xiaoyu Yang Yibo Wu Hao Zhang Mingqian Huang Junqing Chen Quan Zhou Yunfei Zhu Rong Hua Jianyu Tian Xin Wang Zuomin Zhou Jie Hao Jinjin Yu Dong Hua Jiayin Liu Xuejiang Guo Qi Zhou Jiahao Sha | 2020 | Cell Research2020，30，3： | 6 |
| 5 | A novel mosquito-borne reassortant orbivirus isolated from Xishuangbanna,China显示文摘Dear Editor,The genus Orbivirus,within the family Reoviridae,includes 22 virus species(King et al.,2011).They are distributed globally,but are particularly prevalent in Europe,Asia,and Africa.In addition,they can be transmitted by ticks or other hematophagous insect vectors,including Culicoides,mosquitoes,and sandflies(Belaga- | Shaozhen Xing Xiaofang Guo Xianglilan Zhang Qiumin Zhao Lingli Li Shuqing Zuo Xiaoping An Guangqian Pei Qiang Sun Shi Cheng Yunfei Wang Hang Fan Zhiqiang Mi Yong Huang Zhiyi Zhang Hongning Zhou Jiusong Zhang Yigang Tong | 2017 | Virologica Sinica2017，32，2： | 4 |
| 6 | Effects of antiviral therapy on hepatitis B virus reactivation and liver function after resection or chemoembolization for hepatocellular carcinoma显示文摘 | Xiang‐Ming Lao Guangyu Luo Liang‐Tao Ye Cheng Luo Ming Shi Dian Wang Rongping Guo Minshan Chen Shengping Li Xiaojun Lin Yunfei Yuan | 2013 | Liver Int2013，，4： | 3 |
| 7 | An Effective and Scalable VM Migration Strategy to Mitigate Cross-VM Side-Channel Attacks in Cloud显示文摘Co-residency of virtual machines(VMs) of different tenants on the same physical platform would possibly lead to cross-VM side-channel attacks in the cloud. While most of current countermeasures fail for real or immediate deployment due to their requirement for modification of virtualization structure, we adopt dynamic migration, an inherent mechanism of the cloud platform, as a general defense against this kind of threats. To this end, we first set up a unified practical information leakage model which shows the factors affecting side channels and describes the way they influence the damage due to side-channel attacks. Since migration is adopted to limit the time duration of co-residency, we envision this defense as an optimization problem by setting up an Integer Linear Programming(ILP) to calculate optimal migration strategy, which is intractable due to high computational complexity. Therefore, we approximate the ILP with a baseline genetic algorithm, which is further improved for its optimality and scalability. Experimental results show that our migration-based defense can not only provide excellent security guarantees and affordable performance cost in both theoretical simulation and practical cloud environment, but also achieve better optimality and scalability than previous countermeasures. | Chao Yang Yunfei Guo Hongchao Hu Wenyan Liu Yawen Wang | 2019 | China Communications2019，16，4： | 3 |
| 8 | Defensive deception framework against reconnaissance attacks in the cloud with deep reinforcement learning显示文摘Implementing defensive deception in the cloud is promising to proactively counter reconnaissance attack. This technique presents decoys to camouflage cloud assets and distracts attack resource. However,the major challenge is to develop an effective deception strategy to orchestrate digital decoys. To address this issue, we propose a deep reinforcement learning(DRL)-based defensive deception framework. First,we formulate a utility function, which mathematically models underlying threats associated with common vulnerabilities among virtual machines in the cloud. Then, we customize training interfaces and the neural networks for a DRL agent. The reward function reflects the effectiveness of asset concealment and the waste of attack resources, referring to a comprehensive defense goal. Finally, the well-trained DRL agent generates the optimal defense strategy. It specifies a more granular deception strategy than existing proposals. Simulation results show that the proposed framework leads to a 7.87% average advantage in realizing the comprehensive defense goal. Moreover, it can stably improve the concealment degree of cloud assets up to 20.58%, and increase the attack cost up to 40.40%. This study shows that it is promising to improve cloud security with deception defense and artificial intelligence techniques. | Huanruo LI Yunfei GUO Shumin HUO Hongchao HU Penghao SUN | 2022 | Science China(Information Sciences)2022，65，7： | 3 |
| 9 | Feedback structure based entropy approach for multiple-model estimation显示文摘The variable-structure multiple-model(VSMM)approach,one of the multiple-model(MM)methods,is a popular and effective approach in handling problems with mode uncertainties.The model sequence set adaptation(MSA)is the key to design a better VSMM.However,MSA methods in the literature have big room to improve both theoretically and practically.To this end,we propose a feedback structure based entropy approach that could fnd the model sequence sets with the smallest size under certain conditions.The fltered data are fed back in real time and can be used by the minimum entropy(ME)based VSMM algorithms,i.e.,MEVSMM.Firstly,the full Markov chains are used to achieve optimal solutions.Secondly,the myopic method together with particle flter(PF)and the challenge match algorithm are also used to achieve sub-optimal solutions,a trade-off between practicability and optimality.The numerical results show that the proposed algorithm provides not only refned model sets but also a good robustness margin and very high accuracy. | Shen-tu Han Xue Anke Guo Yunfei | 2013 | Chinese Journal of Aeronautics2013，26，6： | 3 |
| 10 | Leaf gas exchange and photosynthesis curves of Elymus nutans and Potentilla anserina under fencing and grazing conditions in the Qilian Mountains, Northwest China显示文摘Potentilla anserina L.and Elymus nutans Griseb.are dominant species in the subalpine meadows of China.Grazing is one of the most important factors that influence community structure and productivity of subalpine meadows.Understanding how grazing changes photosynthetic capability is essential for preservation and restoration of grasslands.However,information about the effects of grazing on photosynthetic capability remains inadequate.Experiments were conducted in fencing and grazing areas in the Qilian Mountains,Northwest China.The leaf gas exchange and photosynthetic curves of P.anserina and E.nutans were measured at different growth stages.Results showed that grazing decreased the values of leaf gas exchange parameters,such as net photosynthetic rate,stomatal conductance,transpiration rate,and intercellular CO2 concentration of P.anserina and E.nutans.In addition,grazing decreased the values of net photosynthetic rate-photosynthetically active radiation(PN-PAR)curve parameters,such as light-saturated net photosynthetic rate,apparent quantum efficiency,light compensation point,light saturation point,and dark respiration rate.Our results demonstrated that grazing was the primary limiting factor for photosynthesis of dominant grassland species in the study area. | LIU Junjie WANG Xiaoping GAO Yunfei RONG Zhanlei ZHANG Guangde WANG Wenbin GE Lijuan MAO Yahua GUO Zhaoxia ZHAO Chuanyan | 2019 | Journal of Arid Land2019，11，3： | 3 |
| 11 | Real-time elastography with a novel quantitative technology for assessment of liver fibrosis in chronic hepatitis B显示文摘 | Juan Wang Long Guo Xiuying Shi Wenqian Pan Yunfei Bai Hong Ai | 2011 | European Journal of Radiology2011，，1： | 3 |
| 12 | Predicting the grades of Astragali radix using mass spectrometrybased metabolomics and machine learning显示文摘Astragali radix(AR,the dried root of Astragalus)is a popular herbal remedy in both China and the United States.The commercially available AR is commonly classified into premium graded(PG)and ungraded(UG)ones only according to the appearance.To uncover novel sensitive and specific markers for AR grading,we took the integrated mass spectrometry-based untargeted and targeted metabolomics approaches to characterize chemical features of PG and UG samples in a discovery set(n=16 batches).A series of five differential compounds were screened out by univariate statistical analysis,including arginine,calycosin,ononin,formononetin,and astragalosideⅣ,most of which were observed to be accumulated in PG samples except for astragalosideⅣ.Then,we performed machine learning on the quantification data of five compounds and constructed a logistic regression prediction model.Finally,the external validation in an independent validation set of AR(n=20 batches)verified that the five compounds,as well as the model,had strong capability to distinguish the two grades of AR,with the prediction accuracy>90%.Our findings present a panel of meaningful candidate markers that would significantly catalyze the innovation in AR grading. | Xinyue Yu Jingxue Nai Huimin Guo Xuping Yang Xiaoying Deng Xia Yuan Yunfei Hua Yuan Tian Fengguo Xu Zunjian Zhang Yin Huang | 2021 | Journal of Pharmaceutical Analysis2021，11，5： | 2 |
| 13 | A novel minimally invasive percutaneous nephrolithotomy technique: safety and efficacy report显示文摘 | Guanghui Hu Zhuifeng Guo Huan Liu Ming Luo Min Liu Peng Lai Haimin Zhang Jing Yuan Xudong Yao Junhua Zheng Yunfei Xu | 2014 | Scandinavian Journal of Urology2014，，2： | 2 |
| 14 | Study on dispersion, adsorption and flow retaining behaviors of cement mortars with TPEG-type polyether kind polycarboxylate superplasticizers显示文摘 | Yinwen Li Chaolong Yang Yunfei Zhang Jian Zheng Huilong Guo Mangeng Lu | 2014 | Construction and Building Materials2014，，： | 2 |
| 15 | Modified non-rectangular hyperbola equation with plant height for photosynthetic light-response curves of Potentilla anserina and Elymus nutans at various growth phases in the Heihe River Basin, Northwest China显示文摘The non-rectangular hyperbola(NRH)equation is the most popular method that plots the photosynthetic light-response(PLR)curve and helps to identify plant photosynthetic capability.However,the PLR curve can't be plotted well by the NRH equation at different plant growth phases due to the variations of plant development.Recently,plant physiological parameters have been considered into the NRH equation to establish the modified NRH equation,but plant height(H),an important parameter in plant growth phases,is not taken into account.In this study,H was incorporated into the NRH equation to establish the modified NRH equation,which could be used to estimate photosynthetic capability of herbage at different growth phases.To explore photosynthetic capability of herbage,we selected the dominant herbage species Potentilla anserina L.and Elymus nutans Griseb.in the Heihe River Basin,Northwest China as the research materials.Totally,twenty-four PLR curves and H at different growth phases were measured during the growing season in 2016.Results showed that the maximum net photosynthetic rate and the initial slope of PLR curve linearly increased with H.The modified NRH equation,which is established by introducing H and an H-based adjustment factor into the NRH equation,described better the PLR curves of P.anserina and E.nutans than the original ones.The results may provide an effective method to estimate the net primary productivity of grasslands in the study area. | LIU Junjie WANG Xiaoping RONG Zhanlei GAO Yunfei ZHANG Guangde WANGWenbin GE Lijuan MAO Yahua GUO Zhaoxia WANG Qingtao ZHAO Chuanyan | 2019 | Journal of Arid Land2019，11，5： | 1 |
| 16 | Fuzzy Reliability Analysis of One Paralleling System显示文摘In this paper,we analyze the fuzzy reliability of paralleling system,focusing on the situation of the early failure mode.The early failure mode of fuzzy reliability mainly obeys the Weibull distribution.Based on this,we obtain the distribution function,density function,failure function,reliability function and the formula of the mean time to failure.For the paralleling system composed of multiple components,C1,C2,???,Cn,especially whenη=1,we also obtain the corresponding formulas.Finally,we cite an example to verify the formula and deepen the understanding. | Chenhui Liu Jinhui Li Yunfei Guo | 2015 | 数学计算(中英文版)2015，4，3： | 1 |
| 17 | Quantification constraints on time gap for comagmatic gold deposits:Evidence from chronological statistics显示文摘The time gap between diagenesis and mineralization (TGDM) for comagmatic gold deposits (CGD) plays an important role in confirming the genetic relationship between gold deposits and their related intrusions. With the help of preciously published isotopic ages of some typical gold deposits and their related rocks in China,the authors have discussed and quantified the distribution characteristics and scope of the TGDM. Statistical analyses and Kolmogorov tests showed that mineralizing events are either contemporaneous with or slightly postdate their cognate magma. The TGDM conforms with normal distributions at a 0.05 confidence level and clusters between 0 and 16.0 Ma with a mean of 7.0 Ma. Thus,if the TGDM of CGD is less than 16.0 Ma,it is reasonable to consider,with the aid of other evidence,the possibility of its comagmatic genetic affiliation. The authors also emphasized that to get a precise time gap it is necessary to strengthen the diagenesis-mineralization geological background of the deposits studied,and to pay attention to the study of time gap in combination with trace elements and isotope tracing. | TAN Jun WEI Junhao LI Shuiru ZHANG Chunhua LI Yanjun GUO Lingli YAN Yunfei | 2008 | Chinese Journal Of Geochemistry2008，27，4： | 1 |
| 18 | Trans-cinnamaldehyde inhibits Penicillium italicum by damaging mitochondria and inducing apoptosis mechanisms显示文摘Plant-derived essential oils have excellent antifungal effects and can be used for the preservation of fresh foods such as fruits and vegetables, but the detailed mechanism has not been fully elucidated. In this study, we investigated the inhibitory effects of trans-cinnamaldehyde on Penicillium italicum, a common pollution fungus in citrus, and explored the antifungal mechanism of trans-cinnamaldehyde by detecting fungal oxidative damage, mitochondrial metabolism, and cell apoptosis. These results showed that transcinnamaldehyde made the carboxylic acid cycle deregulated by altering the related enzyme activities(succinate dehydrogenase, malate dehydrogenase) and mid product. Moreover, the level of reactive oxygen species rose sharply while the redox level was out of regulation. The mitochondrial membrane potential collapsed, leading to the leakage of cytochrome c, and then triggering the activation of apoptotic protease, which was further confirmed by the significant increase in caspase-3 activity from(3.6 ± 0.6) U to(8.8 ± 1.1) U(P < 0.05). The cytochrome c in mitochondria was detected by confocal Raman microspectroscopy, the characteristic intensity index(I750/I2944) was decreased, indicating that the cytochrome c in mitochondria was reduced and leakage. Besides, the strong negative correlation between Raman intensity and the amount of cytochrome c leakage was established with the correlation coefficient of-0.981 7. This study revealed that destroying the integrity of the mitochondrial membrane, activating the mitochondrial-mediated apoptosis pathway was the in-depth antifungal mechanism of trans-cinnamaldehyde;and Raman spectroscopy technology provided new ideas to study this process with high sensitivity determination of cytochrome c. | Fangwei Yang Jiaqi Mi Fei Huang Prompong Pienpinijtham Yahui Guo Yuliang Cheng Weirong Yao Yunfei Xie | 2022 | Food Science and Human Wellness2022，11，4： | 1 |
| 19 | Real-time elastography with a novel quantitative technology for assessment of liver fibrosis in chronic hepatitis B显示文摘 | Juan Wang Long Guo Xiuying Shi Wenqian Pan Yunfei Bai Hong Ai | 2011 | European Journal of Radiology2011，，1： | 1 |
| 20 | Strong performance guarantees for asynchronous crossbar schedulers显示文摘 | Hu Hongchao Guo YunFei Yi Peng | 2011 | IET COMMU- NICATIONS2011，13，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员