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| 1 | Trans-regional transmission of large-scale hydropower: problems and solutions in receiving power grid显示文摘Large-capacity hydropower transmission from southwestern China to load centers via ultra-high voltage direct current(UHVDC) or ultra-high voltage alternating current(UHVAC) transmission lines is an important measure of the accommodation of large-scale hydropower in China. The East China Grid(ECG) is the main hydropower receiver of the west–east power transmission channel in China. Moreover, it has been subject to a rapidly increasing rate of hydropower integration over the past decade. Currently, large-scale outer hydropower is one of the primary ECG power sources. However, the integration of rapidly increasing outer hydropower into the power grid is subject to a series of severe drawbacks. Therefore, this study considered the load demands and hydropower transmission characteristics for the analysis of several major problems and the determination of appropriate solutions. The power supply-demand balance problem, hydropower transmission schedule problem, and peakshaving problem were considered in this study. Correspondingly, three solutions are suggested in this paper, which include coordination between the outer hydropower and local power sources, an inter-provincial power complementary operation, and the introduction of a market mechanism. The findings of this study can serve as a basis to ensure that the ECG effectively receives an increased amount of outer hydropower in the future. | Jianyu Lu Jianjian Shen Chengguo Su Qianqian Shen | 2019 | Global Energy Interconnection2019，2，4： | 4 |
| 2 | Effect of constant compressive stress induced by imitating tuina stimulation with various durations on the cell cycle,cellular secretion,apoptosis,and expression of myogenic differentiation and myogenic factor 5 of rat skeletal muscle cells in vitro显示文摘OBJECTIVE:To investigate the effect of constant compressive stress induced by imitating Tuina stimulation with various durations on the cell cycle,cellular secretion,apoptosis,and expression of myogenic regulatory factors(MRFs),myogenic factor 5(Myf5)and myogenic differentiation(MyoD)of rat skeletal muscle cells(RSkMCs)in vitro.METHODS:Third passage RSkMCs were subjected to constant compressive stresses with various durations at 2000μstrain for 15,30,60,90,and 120 min via a four-point bending system.The control group(CG)was cultured in the absence of mechanical loading.Alterations of the cell cycle and apoptosis rate were detected by flow cytometry(FCM).The concentrations of interleukin 6(IL-6)/prostaglandin E2(PGE2)and nitric oxide(NO)in supernatants were determined by enzyme-linked immunosorbent assays and the nitrate reductase method,respectively.Expression of Myf5 and MyoD was detected by immunohistochemistry.RESULTS:Compared with the CG,a significant alteration was observed in the synthesis phase fraction(SPF)(P<0.01).The SPF and proliferation index(PI)were reduced from 15 to 90 min,but reached levels similar to those at 120 min.Apoptosis was increased significantly at 30 min(P<0.05)and especially at 90 and 120 min(P<0.01).Expression of MyoD and Myf5 was increased significantly at 15,30,and 90 min(P<0.01).Compared with 15 and 30 min,MyoD and Myf5 expression at 60 and 120 min was decreased significantly(P<0.01).Compared with 60 min,M yoD expression at 90 min was increased significantly(P<0.05),whereas MyoD and Myf5 expression at 120 min was significantly lower(P<0.05).The IL-6 concentration was increased at 60 min compared with the CG and 15 min(P<0.05),whereas the concentrations of PGE2 and NO were the highest at 15 and 30 min,respectively,compared with the CG and other time points(P<0.05).CONCLUSION:The cell cycle,secretion,apoptosis,and Myf5 and MyoD expression of RSkMCs were regulated by compressive stress in a time-dependent manner.SPF and PI were inhibited at short durations(<90 min),but NO and PGE2 secretion was the highest at shorter durations(<30 min).With the prolongation of stimulation time,SPF,PI,and apoptosis were increased,but Myf5 and MyoD expression was decreased gradually at 15-30 min. | Lu Qunwen Su Chengguo Liu Huahui Luo Caigui Yan Bohua | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 1 |
| 3 | Aberrant expression of microRNAs in gastric cancer and biological significance of miR-574-3p显示文摘 | Yingying Su Zhaohui Ni Guoqing Wang Juan Cui Chengguo Wei Jihan Wang Qing Yang Ying Xu Fan Li | 2012 | International Immunopharmacology2012，，4： | 1 |
| 4 | 6 - 35 Measurement Results of Soil Radiation Level around HIRFL in 2012显示文摘 | Xu Chong Xu Junkui Su Youwu Pang Chengguo Mao Wang | 2012 | IMP & HIRFL Annual Report2012，，1： | 0 |
| 5 | 6-44 Studying of Residual Activity Induced by 300 MeV/u Carbon Ion in Copper Target显示文摘Activation of accelerator components due to beam losses is an important issue for a high-energy heavy ion accelerator.The induced components may become a main source of exposure to maintenance workers and a serious access-restriction for“hand-on”maintenance,and also have a certain radiation influence over the environment.In this work,experimental of residual activation induced by 300 MeV/u carbon ions was studied at the deep-therapy terminal of HIRFL. | Xu Junkui Su Youwu Li Wuyuan Pang Chengguo Yan Weiwei Xu Chong Mao Wang | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 6 | 6-42 Radiation Safety Report of HIRFL in 2015显示文摘The total operation time of HIRFL is 7 536 h in 2015; the user beam time is about 5 451.5 (from 21 Dec.2014 to 21 Dec. 2015); 4 836 h were used for experiments; 615.5 h were used for accelerator research. There are 26 heavy ions beams were provided by HIRFL in 2015. The highest ions energy provided is 464 MeV/u, the maximum accumulated ion intensity is 1 400 A for carbon ion. | Su Youwu Xu Junkui Li Zongqiang Mao Wang Li Wuyuan Xu Chong Yan Weiwei Pang Chengguo | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 7 | Efficacy of electroacupuncture stimulating Zusanli(ST36)and Xuanzhong(GB39)on synovial angiogenesis in rats with adjuvant arthritis显示文摘OBJECTIVE:To investigate the efficacy of electroacupuncture(EA)stimulating Zusanli(ST36)and Xuanzhong(GB39)on synovial angiogenesis in rats with adjuvant arthritis(AA).METHODS:AA models were established by bilateral injection of Freund's complete adjuvant(FCA)in male Sprague-Dawley rats.Three days after injection,rats were given EA at Zusanli(ST36)and Xuanzhong(GB39)acupoints,once every other day,for 16 d.The arthritis index score,paw volume,and hematoxylin-eosin(HE)staining was performed for each animal.Angiogenesis marker cluster of differentiation 34(CD34)expression and synovial cell apoptosis in synovial tissue were observed.The levels of Notch1,hairy and enhancer of split homolog-1(Hes1),transforming growth factor-beta(TGF-β)and basic fibroblast growth factor(bFGF)were subsequently detected.RESULTS:We found that EA significantly decreased arthritis index scores,paw volume,and HE staining scores.EA could significantly inhibit the expression of CD34,promoting apoptosis of synovial cells in the joint synovial tissue of AA rats.The expression of Notch1 signaling pathway proteins and mR NAs(Notch1,Hes1,TGF-β,and bFGF)were markedly downregulated by EA treatment.CONCLUSIONS:These results prove that EA attenuates synovial angiogenesis by inhibiting the Notch1 signaling pathway in AA rat models.Based on our findings,we propose that EA is a promising complementary and alternative therapy in rheumatoid arthritis. | JIANG Jianzhen ZHANG Xin LUO Zhenguo SU Chengguo ZHOU Haiyan JIANG Yuqing XIAO Xianjun CHEN Yunfei ZHU Jun | 2023 | Journal of Traditional Chinese Medicine2023，43，5： | 0 |
| 8 | Effect of Tuina along“bladder meridian”alleviating intervertebral disc degeneration by regulating the transforming growth factor-β1/Smad signaling pathway in a rabbit model显示文摘OBJECTIVE:The aim of this study was to investigate the protective effects of Tuina(a traditional Chinese massage therapy)on intervertebral disc(IVD)degeneration and the regulatory mechanisms of the transforming growth factor-β1(TGF-β1)/small mothers against decapentaplegic(Smad)signaling pathway.METHODS:Thirty New Zealand white rabbits were randomized into five groups:the control group,model group,model+Tuina group(Tuina group),model+TGF-β1 group(TGF-β1 group),and model+TGF-β1 inhibitor SB431542 group(SB431542 group).The model was established by posterolateral annulus fibrosus puncturing(AFP).Recombinant TGF-β1 and inhibitor SB431542 was injected into the TGF-β1 group and SB431542 group with a microsyringe,respectively.The rabbits in the Tuina group received Tuina treatment along the bladder meridian for 4 weeks.Magnetic resonance imaging(MRI)was performed on rabbits before AFP and after 4 weeks of intervention.Lumbar IVDs(L2-L3 to L4-L5)were harvested after intervention.Histopathological changes in the IVDs were measured by hematoxylin and eosin(HE)staining.Type I collagen was analyzed by immunohistochemistry detection.The expression level of matrix metalloproteinase-3(MMP3)was determined by enzyme-linked immunosorbent assay.Cell apoptosis was evaluated by terminal deoxynucleotidyl transferasemediated nick end labeling and Western blotting.Realtime polymerase chain reaction and Western blotting were used to analyze the expression of TGF-β1 and Smad2/3/4 and a disintegrin and metalloproteinase with thrombospondin motifs 5.RESULTS:Posterolateral AFP induced IVD degeneration in rabbits with histopathological damage and noticeable changes in MRI images.Tuina alleviated histopathological changes and reversed the expression of extracellular matrix degeneration-related molecules and apoptosis-related proteins.Furthermore,AFP induced the activation of TGF-β1 and Smad2/3/4,whereas Tuina therapy markedly reduced the protein expression of Smad2/3 and the gene expression of TGF-β1 and Smad2/3/4.Additionally,the TGF-β1/Smad signaling pathway was activated in the TGF-β1 group,while the TGF-β1/Smad signaling pathway was inhibited in the SB431542 group.CONCLUSION:Posterolateral AFP induced disc degeneration as determined by MRI assessment and histological analysis.Tuina alleviated disc degeneration,possibly by inhibiting the fibrotic response mediated by the TGF-β1/Smad pathway,thus alleviating extracellular matrix degeneration and reducing cell apoptosis. | SU Chengguo ZHAO Xiaoyan YE Jiangnan ZHANG Xin JIANG Yuqing GUO Junjie ZHANG Xiyuan QI Wenchuan ZHU Jun | 2023 | Journal of Traditional Chinese Medicine2023，43，5： | 0 |
| 9 | 3-82 Study of Particle Fragments and Its Contribution in Carbon Ion Therapy显示文摘Carbon ions offer significant advantages for deep-seated local tumors therapy due to their physical and biologicalproperties, for heavy ions has a fixed range in the target matter, and characterized by a small entrance dose anda distinct maximum (Bragg peak) near the end of range. In 2006, IMP carried out some heavy ion cancer therapyexperiments. During the process of carbon ions cancer therapy, various kinds of secondary particle fragments arecreated from heavy ion reaction which will influence the treatment dose and healthy tissue of patient. Neutron isthe most abundant secondary particles in heavy ion reaction, which may influence largely patient body due to itsstrong penetrating power. Thus it is important to know the neutron contribution in heavy ion therapy to evaluatethe neutron impact and assess the patient safety. Particle fragments and its contribution from 430 MeV/u carbonions stopping in thick water target were calculated by Fluka Monte Carlo code[1]. | Xu Junkui Su Youwu Li Wuyuan Pang Chengguo | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 10 | 6-22 Radiation Safety Report of HIRFL in 2014显示文摘The total operation time of HIRFL is 7 272 h in 2014, and the user beam time is about 4 964.5 h(from 21stDec.2013 to 21st Dec. 2014). 3 749 h for physics experiment, 332 h for life science research, 883.5 h for materialscience and single particle effect research, and 235 h for machine research. There are 24 heavy ions beams wereprovided by HIRFL in 2014. The highest ions energy provided is 487 MeV/u, and the maximum accumulated ionintensity is 1 000 A. | Su Youwu Xu Junkui Li Zongqiang Mao Wang Li Wuyuan Xu Chong Yan Weiwei Pang Chengguo | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 11 | 6 - 32 Radiation Safety Reportof HIRFL in 2012显示文摘 | Su Youwu Li Zongqiang LiWuyuan Xu Junkui Mao Wang Xu Chong Yan Weiwei Pang Chengguo | 2012 | IMP & HIRFL Annual Report2012，，1： | 0 |
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