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| 1 | Trends and Challenges for Population and Health During Population Aging——China,2015-2050显示文摘Summary What is already known about this topic?As the largest country in the world,China experienced a demographic transition at a historic scale during the past 50 years with extraordinarily associated changes in the age structure of the population,declining fertility rates,accelerating process of population aging,and growing population scale. | Yanan Luo Binbin Su Xiaoying Zheng | 2021 | China CDC weekly2021，3，28： | 61 |
| 2 | Quantitative assessment of acute kidney injury by noninvasive arterial spin labeling perfusion MRI:a pilot study显示文摘The kidneys are essential for maintaining homeostasis,are responsible for the reabsorption of water,glucose and amino acids,and filter the blood by removing waste.Acute kidney injury(AKI) is a syndrome characterized by the rapid loss of renal excretory function and the accumulation of end metabolic products of urea and creatinine.AKI is associated with the later development of chronic kidney disease and end-stage kidney disease,and may eventually be fatal.Early diagnosis of AKI and assessments of the effects of treatment,however,are challenging.The pathophysiological mechanism of AKI is thought to be the imbalance between oxygen supply and demand in the kidneys.We have assessed the ability of arterial spin labeling(ASL) perfusion magnetic resonance imaging(MRI),without the administration of contrast media,to quantify renal blood flow(RBF) non-invasively.We found that RBF was significantly lower in AKI patients than in healthy volunteers.These results suggest that ASL perfusion MRI,a noninvasive measurement of RBF,may be useful in the early diagnosis of AKI. | DONG Jian YANG Li SU Tao YANG XueDong CHEN Bin ZHANG Jue WANG XiaoYing JIANG XueXiang | 2013 | Science China(Life Sciences)2013，56，8： | 8 |
| 3 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 4 | Surveying brain tumor heterogeneity by single-cell RNA-sequencing of multi-sector biopsies显示文摘Brain tumors are among the most challenging human tumors for which the mechanisms driving progression and heterogeneity remain poorly understood.We combined single-cell RNA-seq with multi-sector biopsies to sample and analyze single-cell expression profiles of gliomas from 13 Chinese patients.After classifying individual cells;we generated a spatial and temporal landscape of glioma that revealed the patterns of invasion between the different sub-regions of gliomas.We also used single-cell inferred copy number variations and pseudotime trajectories to inform on the crucial branches that dominate tumor progression.The dynamic cell components of the multi-region biopsy analysis allowed us to spatially deconvolute with unprecedented accuracy the transcriptomic features of the core and those of the periphery of glioma at single-cell level.Through this rich and geographically detailed dataset,we were also able to characterize and construct the chemokine and chemokine receptor interactions that exist among different tumor and non-tumor cells.This study provides the first spatial-level analysis of the cellular states that characterize human gliomas.It also presents an initial molecular map of the cross-talks between glioma cells and the surrounding microenvironment with single-cell resolution. | Kai Yu Yuqiong Hu Fan Wu Qiufang Guo Zenghui Qian Waner Hu Jing Chen Kuanyu Wang Xiaoying Fan Xinglong Wu John EJ Rasko Xiaolong Fan Antonio lavarone Tao Jiang Fuchou Tang Xiao-Dong Su | 2020 | National Science Review2020，7，8： | 4 |
| 5 | Developmental Gerontology and Active Population Aging in China显示文摘Population aging is an irreversible process in the development of modern society,which brings challenges to comprehensive modernized social governance.Population aging is a“dualistic”development issue that not only leads to aging of the labor force structure but also creates new demographic dividends.This study describes the core thoughts of developmental gerontology(DG),which provides new insight into the relationship between active aging and comprehensive governance for modernized society.The development of DG will provide a feasible and sustainable path to integrate and coordinate the relationship between population aging,society,and economy. | Xiaoying Zheng Yanan Luo Binbin Su Ping He Chao Guo Yaohua Tian Shasha Han Chen Chen Yiran Wang Jufen Liu Jun Li | 2023 | China CDC weekly2023，5，8： | 4 |
| 6 | Extension of the low diffusion particle method for near-continuum two-phase flow simulations显示文摘The low diffusion (LD) particle method, proposed by Burt and Boyd, is modified for the near-continuum two-phase flow simulations. The LD method has the advantages of easily coupling with the direct simulation Monte Carlo (DSMC) method for multi-scale flow simulations and dramatically reducing the numerical diffusion error and statistical scatter of the equilibrium particle methods. Liquidor solid-phase particles are introduced in the LD method. Their velocity and temperature updating are respectively, calculated from the motion equation and the temperature equation according to the local gas properties. Coupling effects from condensed phase to gas phase are modeled as momentum and energy sources, which are respectively, equal to the negative values of the total momentum and energy increase in liquid or solid phase. The modified method is compared with theoretical results for unsteady flows, and good agreements are obtained to indicate the reliability of the one-way gas-to-particle coupling models. Hybrid LD-DSMC algorithm is implemented and performed for nozzle discharging gas-liquid flow to show the prospect of the LD-DSMC scheme for multi-scale two-phase flow simulations. | Su Wei He Xiaoying Cai Guobiao | 2013 | Chinese Journal of Aeronautics2013，26，1： | 3 |
| 7 | Impact of damping on high speed 850 nm VCSEL performance显示文摘High speed VCSELs are important optical devices in short-reach optical communication links and interconnects because of their low cost and high modulation speeds. In this paper, the impact of damping on the their static and dynamic characteristics is analyzed and demonstrated. Through the shallow corrosion of the top layer DBR, the VCSELs with different damping is designed and fabricated. With the increase of the surface etch depth from 0 to ~55 nm for 9 μm oxide-aperture VCSEL, the K factor related with the damping is reduced from0.31 to 0.23 ns^(-1). When the etch depth of the VCSEL with 9 μm oxide-aperture is decreased to ~25 nm,output power is increased from 4.03 to 4.70 mW and small signal modulation bandwidth is also increased from15.46 to 16.37 GHz. It shows that there is a tradeoff between damping and differential gain for improving modulation speed. | Shuai Hu Xiaoying He Yan He Jiale Su Chong Li Anqi Hu Xia Guo | 2018 | Journal of Semiconductors2018，39，11： | 2 |
| 8 | Progress in octahedral spherical hohlraum study显示文摘In this paper,we give a review of our theoretical and experimental progress in octahedral spherical hohlraum study.From our theoretical study,the octahedral spherical hohlraums with 6 Laser Entrance Holes(LEHs)of octahedral symmetry have robust high symmetry during the capsule implosion at hohlraum-to-capsule radius ratio larger than 3.7.In addition,the octahedral spherical hohlraums also have potential superiority on low backscattering without supplementary technology.We studied the laser arrangement and constraints of the octahedral spherical hohlraums,and gave a design on the laser arrangement for ignition octahedral hohlraums.As a result,the injection angle of laser beams of 50°-60°was proposed as the optimum candidate range for the octahedral spherical hohlraums.We proposed a novel octahedral spherical hohlraum with cylindrical LEHs and LEH shields,in order to increase the laser coupling efficiency and improve the capsule symmetry and to mitigate the influence of the wall blowoff on laser transport.We studied on the sensitivity of the octahedral spherical hohlraums to random errors and compared the sensitivity among the octahedral spherical hohlraums,the rugby hohlraums and the cylindrical hohlraums,and the results show that the octahedral spherical hohlraums are robust to these random errors while the cylindrical hohlraums are the most sensitive.Up till to now,we have carried out three experiments on the spherical hohlraum with 2 LEHs on Shenguang(SG)laser facilities,including demonstration of improving laser transport by using the cylindrical LEHs in the spherical hohlraums,spherical hohlraum energetics on the SGIII prototype laser facility,and comparisons of laser plasma instabilities between the spherical hohlraums and the cylindrical hohlraums on the SGIII laser facility. | Ke Lan Jie Liu Zhichao Li Xufei Xie Wenyi Huo Yaohua Chen Guoli Ren Chunyang Zheng Dong Yang Sanwei Li Zhiwen Yang Liang Guo Shu Li Mingyu Zhang Xiaoying Han Chuanlei Zhai Lifei Hou Yukun Li Keli Deng Zheng Yuan Xiayu Zhan Feng Wang Guanghui Yuan Haijun Zhang Bobin Jiang Lizhen Huang Wei Zhang Kai Du Runchang Zhao Ping Li Wei Wang Jingqin Su Xuewei Deng Dongxia Hu Wei Zhou Huaiting Jia Yongkun Ding Wanguo Zheng Xiantu He | 2016 | Matter and Radiation at Extremes2016，1，1： | 2 |
| 9 | The families Distoseptisporaceae fam.nov.,Kirschsteiniotheliaceae,Sporormiaceae and Torulaceae,with new species from freshwater in Yunnan Province,China显示文摘During a north–south latitudinal survey of aquatic fungi on submerged wood and herbaceous material in streams in the Asian region,we collected several hyphomycetous taxa.This paper is part of a series where we provide illustrated accounts of these taxa and place them in a natural classification in the fungi.DNA sequence based phylogenies in recent literature have shown that Dendryphion,Sporidesmium and Torula-like species are polyphyletic in the phylum Ascomycota and their taxonomyhas been problematic due to a lack of understanding of the importance of morphological characters used to delimit taxa,as well as the lack of ex-type or reference strains.Based on multi-locus phylogenies together with morphology,we propose the novel family Distoseptisporaceae(Sordariomycetes)and three novel genera Neotorula(Pleosporales,Dothideomycetes),Distoseptispora(Sordariomycetes)and Pseudosporidesmium(Sordariomycetes).In addition,Dendryphion aquaticum,D.submersum,Distoseptispora fluminicola,D.aquatica,Kirschsteiniothelia submersa,Neotorula aquatica,Sporidesmium aquaticum,S.submersum and S.fluminicola are introduced as new species.Pseudosporidesmium knawiae comb.nov.is proposed to accommodate Sporidesmium knawiae in Sordariomycetes.The polyphyletic nature of Dendryphion,Sporidesmium and Torula-like species are partially resolved,but further sampling with fresh collections and molecular data of species are needed to obtain a natural classification. | HongYan Su Kevin D.Hyde Sajeewa S.N.Maharachchikumbura Hiran A.Ariyawansa ZongLong Luo Itthayakorn Promputtha Qing Tian ChuanGen Lin QiuJu Shang YongChang Zhao HongMei Chai XiaoYing Liu Ali H.Bahkali Jayarama D.Bhat Eric H.C.McKenzie DeQun Zhou | 2016 | Fungal Diversity2016，，5： | 2 |
| 10 | The key stage and moment of coalbed gas reservior evolution in the Qinshui Basin,China显示文摘The evolution of coalbed gas reservoir is characterized by coalbed gas geochemistry and gas content. On the basis of burial history and thermal history, the forming process of coalbed gas reservoir and the gas accumulative history in the Qinshui Basin are discussed in this paper. The difference of the thermal history, geochemistry characteristic, and gas accumulative history between Yangcheng and Huozhou areas shows that the formation of coalbed gas reservoir in the Qinshui Basin is controlled by the geological process in the critical stage and the critical moment. The components and isotopes of coalbed methane are determined by the stage at which the coal maturation reaches its maximum rank. The coalbed methane accumulative history is related to the temperature and pressure of the coal burial history, because the coalbed gas is mainly in adsorptive state. It is stated that the gas content in the coal seam is controlled by the moment when the coal seam is uplifted to the shallowest position. | ZHAO Mengjun SONG Yan SU Xianbo LIU Shaobo QIN Shengfei HONG Feng LIN Xiaoying | 2005 | Chinese Science Bulletin2005，50，S1： | 2 |
| 11 | Research Advances of Epidemiological Characteristics and Diagnosis Technology of Rabies Virus显示文摘Rabies is a zoonosis caused by rabies virus,which has been characterized by infection of central nervous system. Rabies virus,which can cause fatal infections in humans and other mammals,has the characteristic of neurotropism,and the mortality caused by rabies is almost 100%. Routine diagnosis of rabies include clinical symptoms,while a final diagnosis depends on laboratory diagnostic methods,such as etiological diagnosis,serological diagnosis and molecular biological diagnosis. As a zoonotic infectious disease,rabies presents a global distribution situation,and the deaths caused by rabies virus infection in China ranks the second place in the world. Therefore,strengthening the recognition of disease etiology and epidemiology is very important to comprehensive prevention measures of rabies. The author mainly introduced the research progress on pathogen,epidemiology and diagnosis technology of rabies virus at home and abroad. In addition,the advantages and disadvantages of various methods were compared respectively,in order to provide a scientific basis for further study and rapid diagnosis of rabies. | Sun Yu Ma Shichun Wang Xiaoying Wei Wei Su Zenghua Ma Jihong Xie Qiao Xu Yi Dong Hao Shi Jianzhong | 2015 | Animal Husbandry and Feed Science2015，7，4： | 2 |
| 12 | The upper Paleozoic coalbed methane system in the Qinshui basin,China显示文摘 | Xianbo Su Xiaoying Lin Mengjun Zhao Yan Song and Shaobo Liu | | AAPG Bulletin0，89，1： | 1 |
| 13 | Geology of coalbed methane reservoirs in the Southeast Qinshui Basin of China显示文摘 | Xiaobo Su Xiaoying Lin Shaobo Liu Mengjun Zhao Yan Song | | International Journal of Coal Geology0，62，： | 1 |
| 14 | Geology of Coalbed Methane Reservoirsinthe Southeast Qinshui Basin of China 显示文摘 | Xianbo Su Xiaoying Lin Shaobo Liu | 2005 | International Journal of Coal Geology2005，4，62： | 1 |
| 15 | Geology of coalbed methane reservoirs in the Southeast Qinshui Basin of China显示文摘 | Xianbo Su Xiaoying Lin Shaobo Liu | | 0，，： | 1 |
| 16 | The upper Paleozoic coalbed methane system in the Qinshui Basin,China显示文摘 | Su Xianbo Lin Xiaoying Zhao Mengjun | 2005 | AAPG Bulle- tin2005，89，1： | 1 |
| 17 | Geology of coalbed reservoirs in the South- east Qinshui Basin of China显示文摘 | Xianbo Su Xiaoying Lin | 2005 | International Journal of Coal Geology2005，，62： | 1 |
| 18 | Different levels of thyroid hormones between impaired fasting glucose and impaired glucose tolerance: free T3 affects the prevalence of impaired fasting glucose and impaired glucose tolerance in opposite ways显示文摘 | Su Jing Ding Xiaoying Xu Ying Liu Rui Gu Mingyu Chen Yuting Yin Yanhua Wang Yufan Sun Haiyan Peng Yongde | 2014 | Clin Endocrinol2014，，6： | 1 |
| 19 | Geology of coalbed methane reservoirs in the southeast Qinshui Basin of China显示文摘 | Su Xianbo Lin Xiaoying Liu Shaobo | 2005 | International Journal of Coal Geology2005，62，： | 1 |
| 20 | The upper Paleozoic coalbed methane system in the Qinshui basin, Chi- na 显示文摘 | Xianbo Su Xiaoying Lin Mengjun Zhao Yan Song and Shaobo Liu | | AAPG Bulletin0，89，1： | 1 |
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