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| 1 | Evolution of the Yellow River delta, China: Impacts of channel avulsion and progradation显示文摘The evolution of the Yellow River delta is characterized by heavy sediment load,rapid seaward migration,frequent avulsions,and intense anthropogenic disturbances.Evolution of the delta channel following avulsions is very complex and has not yet been thoroughly understood.In the research presented by this paper,we conducted comprehensive analyses of the changes in the water stages,slopes,longitudinal profiles,and the erosion and deposition in the Yellow River delta channels during a time period of over five decades.Results showed that,following each avulsion,channels migrated seaward at decaying rates and the slopes at the downstream of the avulsion point decreased exponentially with time and completed its major adjustment within about four to five years.A generalized geometric model was proposed to describe the changes in the longitudinal profiles of the delta channels.A calculation method to determine the characteristic water stages at the delta was proposed based on the geometric model and the delayed response model for the morphological responses of fluvial rivers to perturbations.Water stages corresponding to a discharge of 3000 m^3/s at Lijin and Xihekou during 1954 through 2012 were calculated by using the proposed method.The proposed method may be used to predict the evolution of the delta channels in response to artificial avulsions at the Yellow River delta in the future. | Shan Zheng Baosheng Wu Kairong Wang Guangming Tan Shasha Han Colin R. Thorne | 2017 | International Journal of Sediment Research2017，32，1： | 9 |
| 2 | Topographical relief characteristics and its impact on population and economy:A case study of the mountainous area in western Henan,China显示文摘Topographical relief is a key factor that limits population distribution and economic development in mountainous areas.The limitation is especially apparent in the mountain?plain t「ansition zone.Taking the transition zone between the Qinling Mountains and the North China Plain(i.e.the mountainous area in western Henan Province)as an example and based on the 200-m resolution DEM data,we used the mean change-point analysis to determine the optimal statistical unit for topographical relief,and thereafter extracted the relief degree.Taking the 1:100,000 land use data,township population and county-level industrial data,population and economic spatial models were constructed,and 200?m resolution grid population and economic density maps were gen erated.Afterwards,statistical analysis was carried out to quantitatively reveal the impact of topographical relief on population and economy.In addition,the impacts of other topographical factors were discussed.The results showed the following.(1)The relief degree in western Henan is generally low,where 58.6%of the regional topography does not exceed half the height of a reference mountain(relative elevation W250 m).Spatially,the relief degree is high in the west while low in the east,and high in the middle while low in the north and south.There is a positive correlation between relief degree and elevation,and a much stronger correlation between relief degree and slope.(2)The linear fitting degree between the population and economic validation data and the corresponding simulation data are 0.943 and 0.909,respectively,indicating that the spatialized results can reflect the actual population and economic distribution.(3)The impact of topographical relief on population and economy was stronger than that of other topographical factors.The relief degree showed a good logarithmic fit relati on ship with population density(0.911)and economic density(0.874).Specifically,88.65%of the population lives in areas where the topographical relief is W0.5 and 88.03%of the gross regional product was from areas where the relief is W0.3.Compared with the population distribution,the economic development showed an obvious agglomeration trend towards low relief areas. | ZHANG Jingjing ZHU Wenbo ZHU Lianqi CUI Yaoping HE Shasha REN Han | 2019 | Journal of Geographical Sciences2019，29，4： | 8 |
| 3 | A survey of social network and information dissemination analysis显示文摘In recent years,with the rapid growth of social network services(SNS),social networks pervade nearly every aspect of our daily lives.Social networks are influencing today’s societal and cultural issues,and changing the way of people seeing themselves.To fully understand the running mechanisms of social networks,in this paper,we aim at series of high knitted and important elements of online social networks.We mainly focus on 3 important but also open research problems,they are(1)structural properties and evolving laws,(2)social crowds and their interaction behaviors and(3)information and its diffusion.In this paper,we review the related work on the 3 problems.Then,we briefly introduce some interesting research directions and our progress on these research problems. | Binxing Fang Yan Jia Yi Han Shasha Li Bin Zhou | 2014 | Chinese Science Bulletin2014，59，32： | 7 |
| 4 | Donor-Derived CD19-Targeted T Cell Infusion Eliminates B Cell Acute Lymphoblastic Leukemia Minimal Residual Disease with No Response to Donor Lymphocytes after Allogeneic Hematopoietic Stem Cell Transplantation显示文摘Leukemia relapse is still the leading cause of treatment failure after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for B cell acute lymphoblastic leukemia (B-ALL). Relapsed patients with BALL after allo-HSCT have a very short median survival. Minimal residual disease (MRD) is predictive of forthcoming hematological relapse after hematopoietic stem cell transplantation (HSCT);furthermore, eliminating MRD effectively prevents relapse. Donor lymphoblastic infusion (DLI) is the main established approach to treat B-ALL with MRD after allo-HSCT. However, about one-third of patients with MRD are non-responsive to DLI and their prognosis worsens. Although donor-derived cluster of differentiation (CD)19-directed chimeric antigen receptor-modified (CAR) T cells (CART19s) can potentially cure leukemia, the efficiency and safety of infusions with these cells have not yet been investigated in patients with MRD after HSCT. Between September 2014 and February 2018, six patients each received one or more infusions of CART19s from HSCT donors. Five (83.33%) achieved MRD-negative remission, and one case was not responsive to the administration of CAR T cells. Three of the six patients are currently alive without leukemia. No patient developed acute graft-versus-host disease (aGVHD), and no patient died of cytokine release syndrome. Donor-derived CAR T cell infusions seem to be an effective and safe intervention for patients with MRD in B-ALL after allo-HSCT and for those who were not responsive to DLI. | Yifei Cheng Yuhong Chen Chenhua Yan Yu Wang Xiangyu Zhao Yao Chen Wei Han Lanping Xu Xiaohui Zhang Kaiyan Liu Shasha Wang Lungji Chang Lei Xiao Xiaojun Huang | 2019 | Engineering2019，5，1： | 7 |
| 5 | Developmental Gerontology and Active Population Aging in China显示文摘Population aging is an irreversible process in the development of modern society,which brings challenges to comprehensive modernized social governance.Population aging is a“dualistic”development issue that not only leads to aging of the labor force structure but also creates new demographic dividends.This study describes the core thoughts of developmental gerontology(DG),which provides new insight into the relationship between active aging and comprehensive governance for modernized society.The development of DG will provide a feasible and sustainable path to integrate and coordinate the relationship between population aging,society,and economy. | Xiaoying Zheng Yanan Luo Binbin Su Ping He Chao Guo Yaohua Tian Shasha Han Chen Chen Yiran Wang Jufen Liu Jun Li | 2023 | China CDC weekly2023，5，8： | 4 |
| 6 | A bifunctional MnO_x@PTFE catalytic membrane for efficient low temperature NO_x-SCR and dust removal显示文摘Low-temperature selective catalytic reduction of NOx combined with dust removal technique due to its energy conservation characteristic has been attracted much attention for fume purification.In this work,the MnOx wrapped PTFE membrane with efficient dust removal and low-temperature NH3-SCR has been prepared with a facile route.MnOxwith different crystal structures was uniformly grown around the PTFE fibrils through water bath.The flower-sphere-like MnOx@PTFE(O-MnOx@PTFE)and lamellar-interlaced ripple-like MnOx@PTFE(W-MnOx@PTFE)have large specific surface area which is favorable for enhancing catalytic performance.Also,the uniformly wrapped W-MnOxaround the PTFE fibrils optimized the pore structure for ultrafine dust capture.The membrane can almost 100%reject particles that are smaller than 1.0μm with a low filtration resistance.Meanwhile,W-MnOx@PTFE with more surface chemisorbed oxygen has the best NO conversion efficiency of 100%at a comparatively low and wide activity temperature window of 160–210°C,which is far to the thermal limitation of the PTFE.Therefore,this efficient and energy conserving membrane has a bright application prospects for tail gas treatment compared to the original treatment process. | Shasha Feng Mengdi Zhou Feng Han Zhaoxiang Zhong Weihong Xing | 2020 | Chinese Journal of Chemical Engineering2020，28，5： | 4 |
| 7 | The Incoming Influenza Season—China,the United Kingdom,and the United States,2021–2022显示文摘Introduction:Seasonal influenza activity has declined globally since the widespread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)transmission.There has been scarce information to understand the future dynamics of influenza—and under different hypothesis on relaxation of nonpharmaceutical interventions(NPIs)in particular—after the disruptions to seasonal patterns.Methods:We collected data from public sources in China,the United Kingdom,and the United States,and forecasted the influenza dynamics in the incoming 2021–2022 season under different NPIs.We considered Northern China and Southern China separately,due to the sharp difference in the patterns of seasonal influenza.For the United Kingdom,data were collected for England only.Results:Compared to the epidemics in 2017–2019,longer and blunter influenza outbreaks could occur should NPIs be fully lifted,with percent positivity varying from 10.5 to 18.6 in the studying regions.The rebounds would be smaller if the maskwearing intervention continued or the international mobility stayed low,but sharper if the mask-wearing intervention was lifted in the middle of influenza season.Further,influenza activity could stay low under a much less stringent mask-wearing intervention coordinated with influenza vaccination.Conclusions:The results added to our understandings of future influenza dynamics after the global decline during the coronavirus disease 2019(COVID-19)pandemic.In light of the uncertainty on the incoming circulation strains and the relatively low negative impacts of mask wearing on society,our findings suggested that wearing mask could be considered as an accompanying mitigation measure in influenza prevention and control,especially for seasons after long periods of low-exposure to influenza viruses.Seasonal influenza activity declines globally during the coronavirus disease 2019(COVID-19)pandemic(1–4).For instance,in China,influenza activity,as measured by percentage of submitted specimens testing positive,dropped from 11.8%to 2.0%in 2020–2021 influenza season,compared to the past 5 years(5).The long-period of low-exposure to influenza viruses adds great uncertainty on preparedness for the incoming 2021–2022 influenza season.Influenza vaccination is one of the most effective measures in seasonal influenza prevention and control,but with only a few influenza viruses circulating,it could be difficult to determine the targeted strains for vaccination.In this context,it is of primary importance to identify alternative mitigation measures for the incoming 2021–2022 influenza season,the first season after long periods of virtually no influenza outbreaks worldwide.Using data from China,the United Kingdom,and the United States,we forecasted the influenza activity in the incoming 2021–2022 influenza season under hypothetical scenarios without non-pharmaceutical interventions(NPIs)and with different assumptions on mask-wearing and mobility levels. | Shasha Han Ting Zhang Yan Lyu Shengjie Lai Peixi Dai Jiandong Zheng Weizhong Yang Xiaohua Zhou Luzhao Feng | 2021 | China CDC weekly2021，3，49： | 3 |
| 8 | Efficacy and safety of high-dose esomeprazole–amoxicillin dual therapy for Helicobacter pylori rescue treatment:a multicenter,prospective,randomized,controlled trial显示文摘Background:High-dose dual therapy(HDDT)with proton pump inhibitors(PPIs)and amoxicillin has attracted widespread attention due to its favorable efficacy in eradicating Helicobacter pylori(H.pylori).This study aimed to compare the efficacy and safety of high-dose PPI-amoxicillin dual therapy and bismuth-containing quadruple therapy for H.pylori rescue treatment.Methods:This was a prospective,randomized,multicenter,non-inferiority trial.Patients recruited from eight centers who had failed previous treatment were randomly(1:1)allocated to two eradication groups:HDDT(esomeprazole 40 mg and amoxicillin 1000 mg three times daily;theHDDTgroup)and bismuth-containing quadruple therapy(esomeprazole 40 mg,bismuth potassium citrate 220 mg,and furazolidone 100 mg twice daily,combined with tetracycline 500 mg three times daily;the tetracycline,furazolidone,esomeprazole,and bismuth[TFEB]group)for 14 days.The primary endpoint was the H.pylori eradication rate.The secondary endpoints were adverse effects,symptom improvement rates,and patient compliance.Results:A total of 658 patients who met the criteria were enrolled in this study.The HDDT group achieved eradication rates of 75.4%(248/329),81.0%(248/306),and 81.3%(248/305)asdetermined by the intention-to-treat(ITT),modified intention-totreat(MITT),and per-protocol(PP)analyses,respectively.The eradication rates were similar to those in the TFEB group:78.1%(257/329),84.2%(257/305),and 85.1%(257/302).The lower 95%confidence interval boundary(9.19%in the ITT analysis,9.21%in the MITT analysis,and9.73%in the PP analysis)was greater than the predefined non-inferiority margin of10%,establishing a non-inferiority of the HDDT group vs.the TFEB group.The incidence of adverse events in the HDDT group was significantly lower than that in the TFEB group(11.1%vs.26.8%,P<0.001).Symptom improvement rates and patients’compliance were similar between the two groups.Conclusions:Fourteen-day HDDT is non-inferior to bismuth-containing quadruple therapy,with fewer adverse effects and good treatment compliance,suggesting HDDT as an alternative for H.pylori rescue treatment in the local region.Trial registration:Clinicaltrials.gov,NCT04678492. | Hanxin Bi Xingxing Chen Yuxin Chen Xin Zhao Shasha Wang Jiehong Wang Ting Lyu Shuang Han Tao Lin Mingquan Li Donghong Yuan Junye Liu Yongquan Shi | 2022 | Chinese Medical Journal2022，，14： | 3 |
| 9 | Intensification of the East Asian Monsoon in Southern China at about300-400 kaBP Inferred from Eolian Deposits in the Middle-lower Reaches of the Yangtze River显示文摘In the East Asian monsoon region,eolian deposits widely distributed in the middle-lower reaches of the Yantgze River are among the best materials available for studies on Quaternary climate change in the subtropical zone of Southern China.Typical eolian deposits in this region include upper Xiashu Loess(XL) and underlying Vermiculated Red Soil(VRS) layers.In this paper,chronological and paleoclimatic studies are conducted on an eolian deposit sequence near Jiujiang(JJ) city in northern Jiangxi province.A magnetostratigraphic study,combined with optically stimulated luminescence(OSL) dating,is conducted on the JJ section and provides further evidence that eolian deposits in the middle-lower reaches of the Yangtze River have been formed since the late Early Pleistocene,and that the boundary age between the XL and VRS layers is about 300-400 kaBP.In grain-size records of the JJ section,the median grain-size and content of the >30 μm size fraction increase sharply after 300-400 kaBP,representing an East Asian winter monsoon intensification event.Further pollen analysis reveals differing pollen assemblages before and after 300-400 kaBP:there is an evident increase in plants adapted to grow in a warm humid environment after 300-400 kaBP,implying an increase in precipitation caused by intensification of the East Asian summer monsoon.Global ice volume and uplift of the Tibet Plateau(TP) are regarded as crucial factors influencing variations of the East Asian monsoon on a long-term scale.The deep-sea δ^(18)O record,which reflects variations in global ice volume,shows no obvious change after 300-400 kaBP.Moreover,the influence of global ice volume changes on the East Asian summer and winter monsoons is inverse;the global ice volume increase(decrease) implies a strengthened(weakened) winter monsoon and weakened(strengthened) summer monsoon.We therefore interpret the coupled intensifications of the East Asian summer and winter monsoons at about 300-400 kaBP to the uplift of the TP in the Middle Pleistocene.This climate event is also documented in eolian deposits from the southern margin of the Chinese Loess Plateau(CLP) and from the desert-loess transitional belt.However,it is not recorded in the loess-paleosol sequences from the central part of the CLP,thereby indicating differing climate responses to TP uplift in different regions,which requires further study. | QI Lin QIAO Yansong LI Yuehui WANG Yan PENG Shasha HE Zexin YANG Shuaibin HAN Chao ZHANG Xujiao | 2017 | Acta Geologica Sinica(English Edition)2017，91，3： | 3 |
| 10 | Approaching ohmic contact to two-dimensional semiconductors显示文摘Two-dimensional semiconductors have attracted immense research interests owing to their intriguing properties and promising applications in electronic and optoelectronic devices.However,the performance of these devices is drastically hindered by the large Schottky barrier at the electric contact interface,which is hardly tunable due to the Fermi level pinning effect.In this review,we will analyze the root causes of the contact problems for the two-dimensional semiconductor devices and summarize the strategies on the basis of different contact geometries,aiming to lift out the Fermi level pinning effect and achieve the ohmic contact.Moreover,the remarkable improvement of the device performance thanks to these optimized contacts will be emphasized.At the end,the merits and limitations of these strategies will be discussed as well,which potentially gives a guideline for handling the electric contact issues in two-dimensional semiconductors devices. | Kailang Liu Peng Luo Wei Han Sanjun Yang Shasha Zhou Huiqiao Li Tianyou Zhai | 2019 | Science Bulletin2019，64，19： | 2 |
| 11 | Phylogenetic analysis and comparison of eight strains of pigeon paramyxovirus type 1 (PPMV-1) isolated in China between 2010 and 2012显示文摘 | Hongbo Guo Xiaoli Liu Zongxi Han Yuhao Shao Jinding Chen Shasha Zhao Xiangang Kong Shengwang Liu | 2013 | Archives of Virology2013，，6： | 1 |
| 12 | Strain-sensitive ferromagnetic two-dimensional Cr_(2)Te_(3)显示文摘Searching for room temperature magnetic two-dimensional(2D)materials is a charming goal,but the number of satisfied materials is tiny.Strain can introduce considerable deformation into the lattice structure of 2D materials,and thus significantly modulate their intrinsic properties.In this work,we demonstrated a remarkable strain-modulated magnetic properties in the chemical vapor deposited Cr_(2)Te_(3) nanoflakes grown on mica substrate.We found the Curie temperature of Cr_(2)Te_(3) nanoflakes can be positively and negatively modulated under tensile and compressive strain respectively,with a maximum varied value of -40 and-90 K,dependent on the thickness of samples.Besides,the coercive field of Cr_(2)Te_(3) nanoflakes also showed a significant decrease under the applied strain,suggesting the decrease of exchange interaction or the change of the magnetization direction.This work suggests a promise to employ interfacial strain to accelerate the practical application of room temperature 2D magnetics. | Junchuan Zhong Mingshan Wang Teng Liu Yinghe Zhao Xiang Xu Shasha Zhou Junbo Han Lin Gan Tianyou Zhai | 2022 | Nano Research2022，15，2： | 1 |
| 13 | Effects of the spacer length of gemini surfactants on the ordered pore of silica 显示文摘 | WANG SHASHA HAN SHUHUA CUI XIAOYAN | 2012 | Journal of Porous Materials2012，19，： | 1 |
| 14 | Short and simple peptide-based pH-sensitive hydrogel for antitumor drug delivery显示文摘Since self-assembled peptide hydrogels can solve the problems such as low solubility, poor selectivity and serious adverse effects of traditional chemotherapy drugs, they have been widely used as carrier materials for drug delivery. In this study, we developed a novel and injectable drug delivery platform for the antitumor drug doxorubicin(DOX) using a p H-responsive ionic-complementary octapeptide FOE.This octapeptide could self-assemble into stable hydrogel under neutral conditions, while disassemble under the tumor microenvironment. Especially, at p H 5.8, its micromorphology displayed a transition from nanofibers to nanospheres with the change of secondary structure, which enhanced cellular uptake of DOX. In addition, FOE hydrogel serves as a smart drug reservoir by localized injection to achieve sustained drug release and improve antitumor efficacy. This octapeptide opens up new avenues for promoting the clinical translation of anticancer drugs on account of excellent injectable properties and economic benefits of simple and short sequence. | Jie Li Zhongshi Wang Han Han Zhonghua Xu Shasha Li Ying Zhu Yuejian Chen Liang Ge Yuan Zhang | 2022 | Chinese Chemical Letters2022，33，4： | 1 |
| 15 | City-Specific Effects of Lifting Mobility Restrictions—China, February–March 2020显示文摘Summary What is already known about this topic?Government used mobility restrictions to help contain the first wave of coronavirus disease 2019(COVID-19)across cities in China.The restrictions were lifted during times of non-zero incidence in response to a return to work order that went into effect on February 10,2020.What is added by this report?The effect of lifting mobility restrictions on COVID-19 death rate and incidence varied by city,with smaller increases or even reductions in cities with low community connectivity and small floating volume,and larger increases in cities with high community connectivity and large floating volume.Effects on recovery rates were similar across cities.What are the implications for public health practice?City-specific mobility restriction lifting is likely to be beneficial.Two indexes,community connectivity and floating volume,can inform the design of city-specific mobility restriction lifting policies. | Shasha Han Libing Ma Ting Zhang Luzhao Feng Weizhong Yang Xiaoying Zheng | 2022 | China CDC weekly2022，4，31： | 0 |
| 16 | In Situ Super-Hindrance-Triggered Multilayer Cracks for Random Lasing inπ-Functional Nanopolymer Films显示文摘In situ self-assembly of semiconducting emitters into multilayer cracks is a significant solution-processing method to fabricate organic high-Q lasers.However,it is still difficult to realize from conventional conjugated polymers.Herein,we create the molecular super-hindrance-etching technology,based on theπ-functional nanopolymer PG-Cz,to modulate multilayer cracks applied in organic single-component random lasers.Massive interface cracks are formed by promoting interchain disentanglement with the super-steric hindrance effect ofπ-interrupted main chains,and multilayer morphologies with photonic-crystal-like ordering are also generated simultaneously during the drop-casting method.Meanwhile,the enhancement of quantum yields on micrometer-thick films(Φ=40%to 50%)ensures high-efficient and ultrastable deep-blue emission.Furthermore,a deep-blue random lasing is achieved with narrow linewidths~0.08 nm and high-quality factors Q≈5,500 to 6,200.These findings will offer promising pathways of organicπ-nanopolymers for the simplification of solution processes applied in lasing devices and wearable photonics. | Dongqing Lin Yang Li He Zhang Shuai Zhang Yuezheng Gao Tianrui Zhai Shu Hu Chuanxiang Sheng Heng Guo Chunxiang Xu Ying Wei Shifeng Li Yelong Han Quanyou Feng Shasha Wang Linghai Xie Wei Huang | 2023 | Research2023，，3： | 0 |
| 17 | Boosting ferroptosis and microtubule inhibition for antitumor therapy via a carrier-free supermolecule nanoreactor显示文摘Traditional microtubule inhibitors fail to significantly enhance+e effect of colorectal cancer;hence,new and efficient strategies are necessary.In+is study,a supramolecular nanoreactor(DOC@TA-Fe^(3+))based on tannic acid(TA),iron ion(Fe^(3+)),and docetaxel(DOC)wi+microtubule inhibition,reactive oxygen species(ROS)generation,and gluta+ione peroxidase 4(GPX4)inhibition,is prepared for ferroptosis/apoptosis treatment.After internalization by CT26 cells,+e DOC@TA-Fe^(3+)nanoreactor escapes from+e lysosomes to release payloads.+e subsequent Fe^(3+)/Fe^(2+)conversion mediated by TA reducibility can trigger+e Fenton reaction to enhance+e ROS concentration.Additionally,Fe^(3+)can consume gluta+ione to repress+e activity of GPX4 to induce ferroptosis.Meanwhile,+e released DOC controls microtubule dynamics to activate+e apoptosis pa+way.+e superior in vivo antitumor efficacy of DOC@TA-Fe^(3+)nanoreactor in terms of tumor grow+inhibition and improved survival is verified in CT26 tumor-bearing mouse model.+erefore,+e nanoreactor can act as an effective apoptosis and ferroptosis inducer for application in colorectal cancer+erapy. | Min Mu Xiaoyan Liang Na Zhao Di Chuan Bo Chen Shasha Zhao Guoqing Wang Rangrang Fan Bingwen Zou Bo Han Gang Guo | 2023 | Journal of Pharmaceutical Analysis2023，13，1： | 0 |
| 18 | Activation of the 5-hydroxytryptamine 4 receptor ameliorates tight junction barrier dysfunction in the colon of type 1 diabetic mice显示文摘Hyperglycemia drives dysfunction of the intestinal barrier.5-Hydroxytryptaine 4 receptor(5-HT4R)agonists have been considered therapeutics for constipation in clnic.However,the roles of 5-HT4R activation in mucosa should be fully realized.Here,we investigate the effects of 5-HT4R activation on diabetes-induced disruption of the tight junction(TJ)barrier in the colon.Not surprisingly,the TJ barrier in diabetic mice with or without 5-HT4R is tremendously destroyed,as indicated by increased serum fluorescein isothiocyanate(FITC)-dextran and decreased transepithelial electrical resistance(TER).Simultaneously,decreased expressions of TJ proteins are shown in both wild-type(WT)and 5-HT4R knockout(KO)mice with diabetes.Notably,chronic treatment with intraperitoneal injection of a 5-HT4R agonist in WT mice with diabetes repairs the TJ barrier and promotes TJ protein expressions,including occludin,claudin-1 and ZO-1,in the colon,whereas a 5-HT4R agonist does not improve TJ barrier function or TJ protein expressions in 5-HT4R KO mice with diabetes.Furthermore,stimulation of 5-HT4R inhibits diabetesinduced upregulation of myosin light chain kinase(MLCK),Rho-associated coiled coil protein kinase 1(ROCK1),and phosphorylated myosin light chain(p-MLC),which are key molecules that regulate TJ integrity,in the colonic mucosa of WT mice.However,such action induced by a 5-HT4R agonist is not observed in 5-HT4R KO mice with diabetes.These findings indicate that 5-HT4R activation may restore TJ integrity by inhibiting the expressions of MLCK,ROCK1 and p-MLC,improving epithelial barrier function in diabetes. | Shasha Hu Yueting Kou Xiaochen Liu Weifang Rong Hongxiu Han Guohua Zhang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，12： | 0 |
| 19 | Influence of Beta-Cyclodextrin Functionalized Tin Phenylphosphonate on the Thermal Stability and Flame Retardancy of Epoxy Composites显示文摘To enhance the thermal stability and flame retardancy of epoxy resin(EP),beta-cyclodextrin(β-CD)is successfully introduced into the layered tin phenylphosphonate(SnPP),which is incorporated into EP matrix for preparing EP/β-CD@SnPP composites.The results indicate that the addition ofβ-CD@SnPP obviously improve the thermal stability and residual yield of EP composites at higher temperature.When the amount ofβ-CD@SnPP is only 4 wt%,EP/4β-CD@SnPP composites pass V-1 rating,and LOI value is up to 30.8%.Meanwhile,β-CD@SnPP effectively suppress the heat release and reduce the smoke production of EP/β-CD@SnPP composites in combustion,and the peak heat release rate(PHRR),total heat release(THR),smoke production rate(SPR)of EP/6β-CD@SnPP composites reduce by 28.4%,33.0%and 44.8%by comparison with those of pure EP.The good flame retardancy and smoke suppression are ascribed to the synergistic effect of excellent carbon-forming capability and fire retardancy ofβ-CD@SnPP. | Yongming Chen Shuai Huang Han Zhao Ru Yang Yining He Tianyu Zhao Yunlong Zhang Qinghong Kong Shasha Sun Junhao Zhang | 2022 | Journal of Renewable Materials2022，10，12： | 0 |
| 20 | Genetic Diversity Analysis of Balsam Pear(Momordica charantia L.) by ISSR Marker显示文摘[Objective] The aim was to explore the relationship between the classification and regional distribution of balsam pear. [Method] In the research, 30 varieties of balsam pear were analyzed by ISSR marker. [Result] The research showed that172 bands were amplified by 18 primers, in which, 132 bands were polymorphism and the polymorphic proportion was 76.7%. All of the samples can be divided into four categories by UPGMA analysis. [Conclusion] The results indicated that the classification of balsam pear is similar as varieties' regional distribution, which will be useful for genetic relationships analysis and parents selection in hybridization breeding. | Junhua JI Shasha HAN Jia WANG Qiao HE Bo HE Zhengming ZENG Xiaolin LI Guolu LIANG Qigao GUO | 2014 | Agricultural Science & Technology2014，15，7： | 0 |
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