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| 1 | The effectiveness assessment of gas accumulation processes in Kuqa depression,Tarim Basin,Northwest China显示文摘The effectiveness of gas accumulation processes is controlled by several main geological factors in-cluding charging force,features of gas conduit,sealing properties of caprock,etc. Based on the analysis and statistics of the large-medium size gas accumulations in China,the main parameters,in-cluding the excess pressure difference between the source rock and reservoir bed,the area coefficient of the gas conduit,and the thickness or displacement pressure of caprock,and the criteria for the as-sessment of gas accumulation processes have been established. Using the parameters and the criteria above,the effectiveness of gas accumulation processes in the Kuqa depression was quantitatively evaluated. By integrating the parameters of the excess pressure difference between the source rock and reservoir bed,the area coefficient of fault conduit system,and the caprock thickness in gas charging period,a comprehensive assessment of the effectiveness of gas accumulation in the Kuqa depression has been made. The result reveals that the Tubei-Dawan area,the Central Kelasu area and the Dongqiu-Dina area are three highly-effective areas for gas accumulation in the Kuqa depression. | LIU GuangDi1,SUN MingLiang1,L YanFang2 & SUN YongHe2 1 State Key Laboratory of Petroleum Resource and Prospecting,China University of Petroleum,Beijing 102249,China 2 Daqing Institute of Petroleum,Daqing 163318,China | 2008 | Science China Earth Sciences2008，51，S2： | 4 |
| 2 | Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration显示文摘Heart regeneration occurs by dedifferentiation and proliferation of pre-existing cardiomyocytes(CMs).However,the signaling mechanisms by which injury induces CM renewal remain incompletely understood.Here,we find that cardiac injury in zebrafish induces expression of the secreted Wnt inhibitors,including Dickkopf 1(Dkkl),Dkk3,secreted Frizzled-related protein 1(sFrpl),and sFrp2,in cardiac tissue adjacent to injury sites.Experimental blocking of Wnt activity via Dkkl overexpression enhances CM proliferation and heart regeneration,whereas ectopic activation of Wnt8 signaling blunts injury-induced CM dedifferentiation and proliferation.Although Wnt signaling is dampened upon injury,the cytoplasmic β-catenin is unexpectedly increased at disarrayed CM sarcomeres in myocardial wound edges.Our analyses indicated that p21-activated kinase 2(Pak2)is induced at regenerating CMs,where it phosphorylates cytoplasmic β-catenin at Ser 675 and increases its stability at disassembled sarcomeres.Myocardial-specific induction of the phospho-mimeticβ-catenin(S675E)enhances CM dedifferentiation and sarcomere disassembly in response to injury.Conversely,inactivation of Pak2 kinase activity reduces the Ser 675-phosphorylatedβ-catenin(pS675-β-catenin)and attenuates CM sarcomere disorganization and dedifferentiation・Taken together,these findings demonstrate that coordination of Wnt signaling inhibition and Pak2/pS675-βYatenin signaling enhances zebrafish heart regeneration by supporting CM dedifferentiation and proliferation. | Xiangwen Peng Kaa Seng Lai Peilu She Junsu Kang Tingting Wang Guobao Li Yating Zhou jianjian Sun Daqing Jin Xiaolei Xu Lujian Liao Jiandong Liu Ethan Lee Kenneth D.Poss Tao P.Zhong | 2021 | Journal of Molecular Cell Biology2021，13，1： | 3 |
| 3 | Epithelial-mesenchymal transition in organ fibrosis development:current understanding and treatment strategies显示文摘Organ fibrosis is a process in which cellular homeostasis is disrupted and extracellular matrix is excessively deposited.Fibrosis can lead to vital organ failure and there are no effective treatments yet.Although epithelial-mesenchymal transition(EMT)may be one of the key cellular mechanisms,the underlying mechanisms of fibrosis remain largely unknown.EMT is a cell phenotypic process in which epithelial cells lose their cell-to-cell adhesion and polarization,after which they acquire mesenchymal features such as infiltration and migration ability.Upon injurious stimulation in different organs,EMT can be triggered by multiple signaling pathways and is also regulated by epigenetic mechanisms.This narrative review summarizes the current understanding of the underlying mechanisms of EMT in fibrogenesis and discusses potential strategies for attenuating EMT to prevent and/or inhibit fibrosis.Despite better understanding the role of EMT in fibrosis development,targeting EMT and beyond in developing therapeutics to tackle fibrosis is challenging but likely feasible. | Lexin Liu Qizhe Sun Frank Davis Jianhua Mao Hailin Zhao Daqing Ma | 2022 | Burns & Trauma2022，10，1： | 3 |
| 4 | Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial显示文摘Tocilizumab has been reported to attenuate the“cytokine storm”in COVID-19 patients.We attempted to verify the effectiveness and safety of tocilizumab therapy in COVID-19 and identify patients most likely to benefit from this treatment.We conducted a randomized,controlled,open-label multicenter trial among COVID-19 patients.The patients were randomly assigned in a 1:1 ratio to receive either tocilizumab in addition to standard care or standard care alone.The cure rate,changes of oxygen saturation and interference,and inflammation biomarkers were observed.Thirty-three patients were randomized to the tocilizumab group,and 32 patients to the control group.The cure rate in the tocilizumab group was higher than that in the control group,but the difference was not statistically significant(94.12%vs.87.10%,rate difference 95%CI−7.19%–21.23%,P=0.4133).The improvement in hypoxia for the tocilizumab group was higher from day 4 onward and statistically significant from day 12(P=0.0359).In moderate disease patients with bilateral pulmonary lesions,the hypoxia ameliorated earlier after tocilizumab treatment,and less patients(1/12,8.33%)needed an increase of inhaled oxygen concentration compared with the controls(4/6,66.67%;rate difference 95%CI−99.17%to−17.50%,P=0.0217).No severe adverse events occurred.More mild temporary adverse events were recorded in tocilizumab recipients(20/34,58.82%)than the controls(4/31,12.90%).Tocilizumab can improve hypoxia without unacceptable side effect profile and significant influences on the time virus load becomes negative.For patients with bilateral pulmonary lesions and elevated IL-6 levels,tocilizumab could be recommended to improve outcome. | Dongsheng Wang Binqing Fu Zhen Peng Dongliang Yang Mingfeng Han Min Li Yun Yang Tianjun Yang Liangye Sun Wei Li Wei Shi Xin Yao Yan Ma Fei Xu Xiaojing Wang Jun Chen Daqing Xia Yubei Sun Lin Dong Jumei Wang Xiaoyu Zhu Min Zhang Yonggang Zhou Aijun Pan Xiaowen Hu Xiaodong Mei Haiming Wei Xiaoling Xu | 2021 | Frontiers of Medicine2021，15，3： | 2 |
| 5 | Understanding taxi serv- ice strategies from taxi GPS traces显示文摘 | Zhang Daqing Sun Lin Li Bin | 2015 | IEEE Trans on Intelli- gent Transportation Systems2015，16，1： | 1 |
| 6 | Mechanical properties and deformation mechanisms of a novel fine-grained Mg-Gd-Y-Ag-Zr-Ce alloy with high strength-ductility synergy显示文摘Grain boundary precipitation and segregation play an important role in determining mechanical properties of Mg alloys. In the present work, we studied work focuses on the strengthening and deformation mechanism of coarse-grained(CG) and fine-grained(FG) Mg-Gd-Y-Ag-Zr-Ce alloy. The CG alloy is strengthened by means of age-strengthening with the formation of both basal plate γ' and prismatic plate β’ precipitates in the grain interior. While the strengthening of FC alloy is completed by intergranular alloying segregation and intragranular precipitates γ' and β’. The segregation of alloying elements at the grain boundary and formation of sub-micron particles can stabilize the grain boundary and suppress the intergranular deformation. Consequently, dislocations could be trapped near γ' and β’ precipitates in the grain interior. Unlike CG alloys, the FG alloys exhibit a heterogeneous transition from elastic to plastic deformation via the Lüders plateau. The rapid gliding dislocation multiplications and fine-grained size are necessary and sufficient conditions for the Lüders strains. Our work provides the insights on the evolution of fine-grained microstructure and helps for the design of Mg alloys with good mechanical properties. | Xiaofei Cui Wei Fu Daqing Fang Guangli Bi Zijun Ren Shengwu Guo Suzhi Li Xiangdong Ding Jun Sun | 2021 | Journal of Materials Science & Technology2021，，7： | 1 |
| 7 | Laparoscopic Treatment for Choledochal Cysts with Stenosis of the Com- mon Hepatic Duct 显示文摘 | Jian Wang Wentong Zhang Daqing Sun | 2012 | The Jourl of American College of Surgeons2012，214，6： | 1 |
| 8 | Production of or-amylase by aspergillus oryzae as 3951in solid state fermentation using spent brewing grains as substrate 显示文摘 | Xu Hui Sun Lanping Zhao Daqing | 2008 | Journal of the Science of Food and Agriculture2008，88，3： | 1 |
| 9 | Heterogeneous fiberous structured Mg-Zn-Zr alloy with superior strength-ductility synergy显示文摘Here we reported a heterogeneous fiberous structured Mg-5.6Zn-0.6Zr(wt%)alloy obtained by conventional extrusion method,which exhibited high yield strength of∼345 MPa,ultimate tensile strength of∼370 MPa,and high tensile strain of∼20.5%,superior to most of the Mg-Zn based alloys reported so far.The extraordinarily high mechanical properties were mainly attributed to the heterogeneous fiberous structure consisting of alternating coarse-and fine-grain layers.Grains in the different layers grew into the neighboring layers,ensuring a good layer bonding.A high Schmid factor and geometric compatibility factor for pyramidal slip led to full slip transfer between the neighboring coarse grains and fine grains,which could help to release the stress concentration and avoid early fracture.The profuse acti-vatedglide dislocations could render the unprecedented high tensile strain.The constraint by the hard fine-grain domains made the soft coarse-grain domains strong like the hard fine-grain domains,as well as the nanoscale precipitates pinning dislocations,contributed to the high strength.The hetero-geneous microstructure design was shown to have synergistic improvement in strength-ductility balance,which could be an inspiring strategy to improve mechanical properties of hexagonal close-packed(hcp)metals. | Wei Fu Pengfei Dang Shengwu Guo Zijun Ren Daqing Fang Xiangdong Ding Jun Sun | 2023 | Journal of Materials Science & Technology2023，，3： | 1 |
| 10 | High strength-ductility and rapid degradation rate of as-cast Mg-Cu-Al alloys for application in fracturing balls显示文摘Specially designed Mg-Cu-Al alloys were prepared for the application in fracturing balls.In comparison to Mg-2.5 Cu alloy,Mg-2.5 Cu-6.0 Al alloy exhibits an improved compressive strength of 378 MPa and compressive strain of 27%,combined with a high degradation rate of 383 mm/y.Two kinds of second-phases are found in Mg-Cu-Al alloys,i.e.MgAlCu andβ-Mg_(17)Al_(12)+Al_(2)Cu phases.They form a discontinuous network and act as cathodes for micro-galvanic corrosion,leading to a high degradation rate.Moreover,the addition of Al could improve the strength and ductility simultaneously in Mg-Cu alloys.The enhancement of strength primarily arises from the solid-solution strengthening and second-phase hardening.A high density of basal,non-basal dislocations and stacking faults were activated upon mechanical deformation.This accounts for the good ductility in Mg-Cu-Al alloys. | Wei Tan Tianshu Li Suzhi Li Daqing Fang Xiangdong Ding Jun Sun | 2021 | Journal of Materials Science & Technology2021，，35： | 1 |
| 11 | Dexmedetomidine Attenuates Isoflurane-induced Neurocognitive Impairment in Neonatal Rats显示文摘 | Robert D. Sanders Jing Xu Yi Shu Adam Januszewski Sunil Halder Antonio Fidalgo Pamela Sun Mahmuda Hossain Daqing Ma Mervyn Maze | 2009 | Anesthesiology2009，，5： | 1 |
| 12 | The 3932 and 3933 extruded Pt/Re reforming catalysts and commercial application of the two-step loading process显示文摘 | Wang Chengdong Zhang Daqing Sun Zuolin | 2000 | Petroleum Processing and Petrochemicals2000，31，7： | 1 |
| 13 | Changes of lipid peroxidation in carbon disulfide-treated rat nerve tissues and serum显示文摘 | SUN Daqing LI Aiwu LI Ju | 2009 | Chemico-Biological Interactions2009，179，23： | 1 |
| 14 | Synthesis and Spectroscopic Characterization of Organophosphoryl Polyoxotungstates α-A-[RP(O)]_2PW_9O_(34)^(5-)显示文摘 | SUN Zhen-gang LIU Ju-tao and LIU Jing-fu (Department of Chemistry, Northeast Normal University, Changchun 1 30024, P. R. China) LI Jing (Daqing Staff and Workers University, Daqing 163255, P. R. China) | 2000 | Chemical Research in Chinese Universities2000，16，1： | 1 |
| 15 | Enhancing corrosion resistance of ZK60 magnesium alloys via Ca microalloying: The impact of nanoscale precipitates显示文摘Enhancing corrosion resistance of Mg-Zn alloys with high strength and low cost was critical for broadening their large-scale practical applications. Here we prepared solutionized, peak-and over-aged ZK60 alloys with and without microalloying Ca(0.26 wt.%) to explore the effects of nanoscale precipitates on their corrosion behavior in detail via experimental analyses and theoretical calculations. The results suggested the peak-aged ZK60 alloy with Ca addition showed improved corrosion resistance in comparison with the alloys without Ca,owing to the contribution of Ca on the refinement of precipitates and increase in their number density. Although the precipitates and Mg matrix formed micro-galvanic couples leading to dissolution, the fine and dense precipitates could generate “in-situ pinning” effect on the corrosion products, forming a spider-web-like structure and improving the corrosion inhibition ability accordingly. The pinning effect was closely related to the size and number density of precipitates. This study provided important insight into the design and development of advanced corrosion resistant Mg alloys. | Wei Fu Hejie Yang Tianshu Li Jiapeng Sun Shengwu Guo Daqing Fang Weichao Qin Xiangdong Ding Yimin Gao Jun Sun | 2023 | Journal of Magnesium and Alloys2023，11，9： | 0 |
| 16 | Comparing mineral weathering and elemental transport between earth's critical zone with different parent rocks in Yanshan Mountain,Hebei province,China显示文摘Bedrock weathering performs a significant influence on the evolution of Earth’s critical zone.Carbonate rock(dolostone),metamorphic rock(gneiss),and sedimentary rock(sandstone)geological formations in Yanshan Mountain,Hebei Province,are taken as objects to probe the controlling of geological formations on weathering characteristics,migration,and enrichment of elements as well as structure of Earth’s critical zone under the identical climate conditions through geological field survey,analysis on minerals component,element distribution in the weathering profile.The dolostone geological formation(DGF)is lithologically dominated by dolostone,characterized by the strongest and predominant chemical weathering.During bedrock weathering and pedogenesis,DGF is marked by significant depletion of CaO,Mg O,S,Mn,Mo and enrichment of N,K,Fe_(2)O_(3),and Zn with concentrations of P,Cu,and B keeping stable.Shortage of soil-forming materials and significant loss are driven by soil erosion,which results in thin regolith and soil.The soil thickness is less than 10 cm,and the regolith thickness is less than 30 cm.The vegetation community is predominantly rock arbor or brush,which is calcivorous and tolerant of barrenness.Plagiogneiss is a dominant rock type of gneiss geological formation(GGF),characterized by the weakest weathering and fast chemical and physical weathering rate.GGF is masked by significant depletion of P,K,CaO,MgO,Fe_(2)O_(3),Mn,Cu and enrichment of N,S,Mo,and B,with contents of Zn keeping stable.Both soil and regolith developed in GGF are relatively thick for one of the reasons that biotite expands during weathering.The soil thickness is more than 50 cm,and the regolith thickness ranges from 100 to 200 cm.The vegetation community is predominantly high-quality economic forests and various arbors because of the enrichment of nutrients in GGF.Sandstone is primarily a rock type of sandstone geological formation(SGF),characterized by moderate weathering degree and slow chemical weathering rate.SGF is marked by significant depletion of P,K,CaO,MgO,Fe_(2)O_(3),and enrichment of N,S,Mn,Cu,Zn,and Mo,with fluctuant changes of Zn and B.The thickness of soil developed in SGF varies between that of DGF and GGF.The soil thickness ranges from 30 to 50 cm,and the regolith thickness ranges from 50 to 100 cm.Chinese pines are widely spread on the shady slopes of SGF.Research provides theoretical support for screening dominant ecological resource areas,ecological industry development and ecological protection and restoration for Yanshan Mountain,Hebei Province. | Zijian Sun Zhen Liao Wei Shen Daqing Fu Xiaofeng Wei Huiqiong Zhang Ziran Chen Lianghui Xiong Tianhao An Hao Wei | 2022 | Acta Geochimica2022，41，6： | 0 |
| 17 | Percolation-based health management of complex traffic systems显示文摘System health management,which aims to ensure the safe and efficient operation of systems by reducing uncertain risks and cascading failures during their lifetime,is proposed for complex transportation systems and other critical infrastructures,especially under the background of the New Infrastructure Projects launched in China.Previous studies proposed numerous approaches to evaluate or improve traffic reliability or efficiency.Nevertheless,most existing studies neglected the core failure mechanism(i.e.,spatio-temporal propagation of traffic congestion).In this article,we review existing studies on traffic reliability management and propose a health management framework covering the entire traffic congestion lifetime,from emergence,evolution to dissipation,based on the study of core failure modes with percolation theory.Aiming to be'reliable,invulnerable,resilient,potential,and active',our proposed traffic health management framework includes modeling,evaluation,diagnosis,and improvement.Our proposed framework may shed light on traffic management for megacities and urban agglomerations around the world.This new approach may offer innovative insights for systems science and engineering in fiiture intelligent infrastructure management. | Guanwen ZENG Zhiyuan SUN Shiyan LIU Xiaoqi CHEN Daqing LI Jianjun WU Ziyou GAO | 2021 | Frontiers of Engineering Management2021，8，4： | 0 |
| 18 | Beneficial effects of deep cryogenic treatment on mechanical properties of additively manufactured high entropy alloy:cyclic vs single cryogenic cooling显示文摘Additively manufactured(AM)metallic materials commonly possess substantial tensile surface residual stress,which is detrimental to the load-bearing service behavior.Recently,we demonstrated that deep cryogenic treatment(DCT)is an effective method for improving the tensile properties of CoCrFeMnNi high-entropy alloy(HEA)samples fabricated by laser melting deposition(LMD),by introducing high compressive residual stress and deformation microstructures without destroying the AM shape.However,carrying out the DCT in a single-step mode does not improve the residual stress gradients inherent from the LMD process,which are undesirable as the mechanical properties will not be homogeneous within the sample.In this work,we show that carrying out the DCT in a cyclic mode with repeated cryogenic cooling and reheating can significantly homogenize the residual stress in LMD-fabricated Co Cr Fe Mn Ni HEA,and improve tensile strength and ductility,compared with single-step DCT of the same cryogenic soaking duration.Under cyclic DCT,the thermal stress is re-elevated to a high value at each cryogenic cooling step,leading to the formation of denser and more intersecting reinforcing crystalline defects and hcp phase transformation,compared to single-step DCT of the same total cryogenic soaking duration in which the thermal stress relaxes towards a low value over time.The enhancement of defect formation in the cyclic mode of DCT also leads to more uniform residual stress distribution in the sample after the DCT.The results here provide important insights on optimizing DCT processes for post-fabrication improvement of mechanical properties of AM metallic net shapes. | Hongge Li Wenjie Zhao Tian Chen Yongjiang Huang Jianfei Sun Ping Zhu Yunzhuo Lu Alfonso H.W.Ngan Daqing Wei Qing Du Yongchun Zou | 2022 | Journal of Materials Science & Technology2022，，20： | 0 |
| 19 | Studies on the Structure-Activity Relationship of p-Substituted Thiobenzanilides as Extractant for Pd( Ⅱ )显示文摘Introduction The metal extraction is a process of complex formation by organic ligands with metal ions or corresponding ionic groups, that is to say, it is a multicomponent coordination process in the heterogeneous phase system. The property of extraction is chiefly dependent on the stability of metal complexes, which is closely related to both the structure of ligands and the nature of metal ions. Therefore, the physicochemical behaviour of the substituent in the ligand will influence the extractive ability of the extractant for a | Lu Zhong’ e, Zeng Runsheng and Sun Daqing (Department of Chemistry, Suzhou University, Suzhou) | 1991 | Chemical Research in Chinese Universities1991，7，3： | 0 |
| 20 | High Expression of the RECK Gene in Breast Cancer Cells is Related to Low Invasive Capacity显示文摘OBJECTIVE To investigate the expression of the RECK gene in human breast (cancer) cell lines, and to determine the relationship between RECK gene expression and the invasive capacity of the breast cancer cell lines. METHODS The invasive capacity of breast (cancer) cell lines including HBL-100, MCF-7 and MDA-MB-435S were determined by the Tran-swell method. The protein expression levels of RECK, MMP-2 and MMP-9 genes in these three cell lines were measured by immunocytochemical methods. The expressions of the RECK gene and protein level were measured by RT-PCR and Western blots in the cell lines respectively. RESULTS The order of the invasive capacity of the breast (cancer) cell lines was MDA-MB-435S, being the highest, and HBL-100, being the lowest. The invasive capacity difference between any two groups among the three groups was significant (P<0.01). The protein expression level of the RECK gene in the HBL-100 cell line was highest, and no expression was detected in MDA-MB-435S cells. Moreover, the expression of the RECK gene was negatively correlated with the expression of the MMP-2 and MMP-9 genes. The mRNA level of the RECK gene in HBL-100 cells was the highest, but no expression was found in the MDA-MB-435S cells (P<0.001). CONCLUSION There was a significant negative correlation between the expression level of the RECK gene and invasive capacity in vitro, and the RECK gene expression showed an inverse proportion to that of the MMP-2, MMP-9 genes. | Tao Sun Daqing Jiang Jinming Li Dongyun Han Zhiguo Song | 2006 | Chinese Journal of Clinical Oncology2006，3，5： | 0 |
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