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| 1 | ALDH2 contributes to melatonin-induced protection against APP/PS1 mutation-prompted cardiac anomalies through cGAS-STING-TBK1-mediated regulation of mitophagy显示文摘Ample clinical evidence suggests a high incidence of cardiovascular events in Alzheimer’s disease(AD),although neither precise etiology nor effective treatment is available.This study was designed to evaluate cardiac function in AD patients and APP/PS1 mutant mice,along with circulating levels of melatonin,mitochondrial aldehyde dehydrogenase(ALDH2)and autophagy.AD patients and APP/PS1 mice displayed cognitive and myocardial deficits,low levels of circulating melatonin,ALDH2 activity,and autophagy,ultrastructural,geometric(cardiac atrophy and interstitial fibrosis)and functional(reduced fractional shortening and cardiomyocyte contraction)anomalies,mitochondrial injury,cytosolic mtDNA buildup,apoptosis,and suppressed autophagy and mitophagy.APP/PS1 mutation downregulated cyclic GMP-AMP synthase(cGAS)and stimulator of interferon genes(STING)levels and TBK1 phosphorylation,while promoting Aβaccumulation.Treatment with melatonin overtly ameliorated unfavorable APP/PS1-induced changes in cardiac geometry and function,apoptosis,mitochondrial integrity,cytosolic mtDNA accumulation(using both immunocytochemistry and qPCR),mitophagy,and cGAS-STING-TBK1 signaling,although these benefits were absent in APP/PS1/ALDH2−/−mice.In vitro evidence indicated that melatonin attenuated APP/PS1-induced suppression of mitophagy and cardiomyocyte function,and the effect was negated by the nonselective melatonin receptor blocker luzindole,inhibitors or RNA interference of cGAS,STING,TBK1,and autophagy.Our data collectively established a correlation among cardiac dysfunction,low levels of melatonin,ALDH2 activity,and autophagy in AD patients,with compelling support in APP/PS1 mice,in which melatonin rescued myopathic changes by promoting cGAS-STING-TBK1 signaling and mitophagy via an ALDH2-dependent mechanism. | Shuyi Wang Lin Wang Xing Qin Subat Turdi Dongdong Sun Bruce Culver Russel JReiter Xiaoming Wang Hao Zhou Jun Ren | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 2 | Expression and signal regulation of the alternative oxidase genes under abiotic stresses显示文摘在他们的自然环境的植物经常面对各种各样的不能生活的压力,例如干旱,高咸度,并且寒心。植物线粒体包含其他的 oxidase (AOX ) ,它被原子基因的一个小家庭编码。AOX 基因被显示了对不能生活的压力高度应答。用有改变 AOX 表示的层次的转基因的植物, AOX 基因为不能生活的应力公差是重要的,这被证实了。尽管在不能生活的压力下面的 AOX 的角色广泛地被学习了,这个话题上有几优秀评论, AOX 基因家庭成员和在不能生活的压力下面的 AOX 基因的信号规定的微分表情模式广泛地没被总结。这里,我们考察并且讨论这二个重要问题的当前的进步。 | Hanqing Feng Dongdong Guan Kun Sun Yifeng Wang Tengguo Zhang Rongfang Wang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，12： | 7 |
| 3 | Oncostatin M-induced cardiomyocyte dedifferentiation regulates the progression of diabetic cardiomyopathy through B-Raf/Mek/Erk signaling pathway显示文摘oncostatin M (OSM ) 能在 vivo 并且在 vitro 开始 cardiomyocyte dedifferentiation,这被报导了。导致 OSM 的 cardiomyocyte dedifferentiation 可能是为糖尿病的心肌症(DCM ) 的处理的一个新目标。这研究被设计在 cardiomyocyte dedifferentiation 和 DCM 的前进决定 OSM 的角色。一个老鼠 DCM 模型被建立在 vivo 评估 OSM 的效果。Echocardiography 被使用决定心脏的功能。染色的天狼星红被用来检测纤维变性区域。传播电子显微镜学被用来评估线粒体缺陷。实时聚合酶链反应和西方的污点分析被执行检测相对 mRNA 表情和 cardiomyocyte dedifferentiation 相关的蛋白质表情分别地。OSM 处理导致了类似的损害心脏的功能和心脏的超微结构缺陷到在 DCM 鼠标检测的那些。cardiomyocyte 的 dedifferentiation 标记的表达式(Runx1,和 -SM-actin) 与在控制组的那些相比在对待 OSM 的鼠标是起来调整的。为了推进,表明 OSM 的重要角色, OSM 受体大美人(O ko ) 老鼠被使用。在 O ko 老鼠, c 工具包的 cardiomyocytes dedifferentiation 标记, Runx1,和 atrial natriuretic 肽是下面调整的,与稀释 DCM 损害和废除 OSM/B-Raf/Mek/Erk 发信号小径。在结论,导致 OSM 的 cardiomyocyte dedifferentiation 在 DCM 的前进起一个关键作用。导致 OSM 的 cardiomyocyte dedifferentiation 的机制与通过 OSM 受体 O 表明小径的 B-Raf/Mek/Erk 被联系。 | Xiaotian Zhang Sai Ma Ran Zhang Shuang Li Di Zhu Dong Han Xiuiuan Li Congye Li Wei Yan Dongdong Sun Bin Xu Yabin Wang Feng Cao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，3： | 7 |
| 4 | Isolation,structural determination and cytotoxic activity of two new ceramides from the root of Isatis indigotica显示文摘Two new ceramides were isolated from the 95% EtOH extract of traditional Chinese medicinal plant Isatis indigotica. Their structures were elucidated as 1-O-β-D-glucopyranosyl-(2S, 3R)-N-(2'-hydroxypentacosanoyl)-octadeca-11E-sphingenine (1) and 1-O-β-D-glucopyranosyl-(2S,3R)-N-(2'-hydroxyhe xacosanoyl)-octadeca-11E-sphingenine (2) on the basis of spectroscopic data. Their cytotoxic effects were evaluated by using MTT method. | SUN DongDong DONG WeiWei LI Xiang ZHANG HanQing | 2009 | Science China Chemistry2009，52，5： | 7 |
| 5 | Stability influence factors analysis and construction of a deep beam anchorage structure in roadway roof显示文摘Deep beam anchorage structures based on spatial distribution analysis of the cable prestressed field have been proposed for roadway roof support. Stability and other factors that influence deep beam structures are studied in this paper using mechanical calculations, numerical analysis and field measurements. A mechanical model of deep beam structure subjected to multiple loading is established, including analysis of roof support in the return airway of S1203 working face in the Yuwu coal mine, China. The expression of maximum shear stress in the deep beam structure is deduced according to the stress superposition criterion. It is found that the primary factors affecting deep beam structure stability are deep beam thickness, cable pre-tension and cable spacing. The variation of maximum shear stress distribution and prestressed field diffusion effects according to various factors are analyzed using Matlabòand FLAC3D^(TM) software, and practical support parameters of the S1203 return airway roof are determined.According to the observations of rock pressure, there is no evidence of roof separation, and the maximum values of roof subsidence and convergence of wall rock are 72 and 48 mm, respectively. The results show that the proposed roof support design with a deep beam structure is feasible and achieves effective control of the roadway roof. | Xie Shengrong Gao Mingming Chen Dongdong Sun Yanding Pan Hao Su Hai Lan Shizhong | 2018 | International Journal of Mining Science and Technology2018，28，3： | 7 |
| 6 | Atomic mobilities and diffusivities in Al alloys显示文摘Knowledge of diffusivity is a prerequisite for understanding many scientific and technological disciplines.In this paper,firstly major experimental methods,which are employed to provide various diffusivity data,are briefly described.Secondly,the fundamentals of various computational methods,including first-principles method,embedded atomic method/molecular dynamic simulation,semi-empirical approaches,and phenomenological DICTRA technique,are demonstrated.Diffusion models recently developed for order/disorder transitions and stoichiometric compounds are also briefly depicted.Thirdly,a newly established diffusivity database for liquid,fcc_A1,L12,bcc_A2,bcc_B2,and intermetallic phases in the multicomponent Al alloys is presented via a few case studies in binary,ternary and quaternary systems.And the integration of various computational techniques and experimental methods is highlighted.The reliability of this diffusivity database is validated by comparing the calculated and measured concentration profiles,diffusion paths,and Kirkendall shifts in various binary,ternary and quaternary diffusion couples.Next,the established diffusivity databases along with thermodynamic and other thermo-physical properties are utilized to simulate the microstructural evolution for Al alloys during solidification,interdiffusion and precipitation.A special discussion is presented on the phase-field simulation of interdiffusion microstructures in a series of Ni-Al diffusion couples composed of γ,γ',and β phases under the effects of both coherent strain and external compressive force.Future orientations in the establishment of next generation of diffusivity database are finally addressed. | DU Yong ZHANG LiJun CUI SenLin ZHAO DongDong LIU DanDan ZHANG WeiBin SUN WeiHua JIE WanQi | 2012 | Science China(Technological Sciences)2012，55，2： | 6 |
| 7 | Effects of laser scanning strategies on selective laser melting of pure tungsten显示文摘Three types of scanning strategies,including the chessboard scanning strategy,the zigzag scanning strategy and the remelting scanning strategy,were conducted to study the effects of scanning strategies on surface morphology,microstructure,mechanical properties and the grain orientation of selective laser melted pure tungsten.The results showed that the pores and cracks were main defects in SLM-processed tungsten parts.The pores could be eliminated using the remelting scanning strategy.However,the cracks seemed to be inevitable regardless of the applied scanning strategies.The microstructures of SLM-processed tungsten were columnar grains and showed strong epitaxial growth along the building direction.A compressive strength of 923 MPa with an elongation of 7.7%was obtained when the zigzag scanning strategy was applied,which was the highest among the three scanning strategies.By changing the scanning strategies,the texture of SLM-processed tungsten in the direction of processing could be changed. | Dongdong Gu Meng Guo Hongmei Zhang Yixuan Sun Rui Wang Lei Zhang | 2020 | International Journal of Extreme Manufacturing2020，2，2： | 6 |
| 8 | The enhanced permeability and retention effect based nanomedicine at the site of injury显示文摘The enhanced permeability retention(EPR)effect based nanomedicine has been widely used for tumor targeting during the past decades.Here we unexpectedly observed the similar'EPR effect'at the site of iniury.We found that the temporary dilated and leaky blood vessels caused by the potent vasodilator histamine in response to injury allowed the injected nanoparticles to pass through the vasculature and reached the injured tissue.Our finding shows the potential underline mechanism of'EPR effect'at the injured site.By loading with antibiotics,we further demonstrated a new strategy for prevention of infection at the site of injury. | Yingjun Liu Dongdong Sun Qin Fan Qingle Ma Ziliang Dong Weiwei Tao Huiquan Tao Zhuang Liu Chao Wang | 2020 | Nano Research2020，13，2： | 6 |
| 9 | Modeling complex crack problems using the three-node triangular element fitted to numerical manifold method with continuous nodal stress显示文摘A three-node triangular element fitted to numerical manifold method with continuous nodal stress, called Trig_3-CNS(NMM)element, was recently proposed for linear elastic continuous problems and linear elastic simple crack problems. The Trig_3-CNS(NMM) element can be considered as a development of both the Trig_3-CNS element and the numerical manifold method(NMM).Inheriting all the advantages of Trig_3-CNS element, calculations using Trig_3-CNS(NMM) element can obtain higher accuracy than Trig_3 element without extra degrees of freedom(DOFs) and yield continuous nodal stress without stress smoothing. Inheriting all the advantages of NMM, Trig_3-CNS(NMM) element can conveniently treat crack problems without deploying conforming mathematical mesh. In this paper,complex problems such as a crucifix crack and a star-shaped crack with many branches are studied to exhibit the advantageous features of the Trig_3-CNS(NMM) element. Numerical results show that the Trig_3-CNS(NMM) element is prominent in modeling complex crack problems. | YANG YongTao XU DongDong SUN GuanHua ZHENG Hong | 2017 | Science China(Technological Sciences)2017，60，10： | 6 |
| 10 | Strongly Coupled 2D Transition Metal Chalcogenide-MXene-Carbonaceous Nanoribbon Heterostructures with Ultrafast Ion Transport for Boosting Sodium/Potassium Ions Storage显示文摘Combining with the advantages of two-dimensional(2D)nanomaterials,MXenes have shown great potential in next generation rechargeable batteries.Similar with other 2D materials,MXenes generally suffer severe self-agglomeration,low capacity,and unsatisfied durability,particularly for larger sodium/potassium ions,compromising their practical values.In this work,a novel ternary heterostructure self-assembled from transition metal selenides(MSe,M=Cu,Ni,and Co),MXene nanosheets and N-rich carbonaceous nanoribbons(CNRibs)with ultrafast ion transport properties is designed for sluggish sodium-ion(SIB)and potassium-ion(PIB)batteries.Benefiting from the diverse chemical characteristics,the positively charged MSe anchored onto the electronegative hydroxy(-OH)functionalized MXene surfaces through electrostatic adsorption,while the fungal-derived CNRibs bonded with the other side of MXene through amino bridging and hydrogen bonds.This unique MXene-based heterostructure prevents the restacking of 2D materials,increases the intrinsic conductivity,and most importantly,provides ultrafast interfacial ion transport pathways and extra surficial and interfacial storage sites,and thus,boosts the high-rate storage performances in SIB and PIB applications.Both the quantitatively kinetic analysis and the density functional theory(DFT)calculations revealed that the interfacial ion transport is several orders higher than that of the pristine MXenes,which delivered much enhanced Na+(536.3 mAh g^(−1)@0.1 A g^(−1))and K^(+)(305.6 mAh g^(−1)@1.0 A g^(−1))storage capabilities and excel-lent long-term cycling stability.Therefore,this work provides new insights into 2D materials engineering and low-cost,but kinetically sluggish post-Li batteries. | Junming Cao Junzhi Li Dongdong Li Zeyu Yuan Yuming Zhang Valerii Shulga Ziqi Sun Wei Han | 2021 | Nano-Micro Letters2021，13，7： | 5 |
| 11 | Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics显示文摘Colorectal cancer(CRC), a malignant tumor worldwide consists of microsatellite instability(MSI) and stable(MSS) phenotypes. Although SHP2 is a hopeful target for cancer therapy, its relationship with innate immunosuppression remains elusive. To address that, single-cell RNA sequencing wasperformed to explore the role of SHP2 in all cell types of tumor microenvironment(TME) from murine MC38 xenografts. Intratumoral cells were found to be functionally heterogeneous and responded significantly to SHP099, a SHP2 allosteric inhibitor. The malignant evolution of tumor cells was remarkably arrested by SHP099. Mechanistically, STING-TBK1-IRF3-mediated type I interferon signaling was highly activated by SHP099 in infiltrated myeloid cells. Notably, CRC patients with MSS phenotype exhibited greater macrophage infiltration and more potent SHP2 phosphorylation in CD68;macrophages than MSI-high phenotypes, suggesting the potential role of macrophagic SHP2 in TME. Collectively,our data reveals a mechanism of innate immunosuppression mediated by SHP2, suggesting that SHP2 is a promising target for colon cancer immunotherapy. | Jian Gao Zhigui Wu Mingxia Zhao Rui Zhang Manru Li Dongdong Sun Haibo Cheng Xianjia Qi Yuxian Shen Qiang Xu Hongqi Chen Dijun Chen Yang Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 5 |
| 12 | Cloning of plastid division gene GlFtsZ from Gentiana lutea and its expression during petal development显示文摘A full-length cDNA of GlFtsZ was isolated by screening the cDNA library of Gentiana lutea. Analysis of the deduced amino acid sequence encoded by GlFtsZ indicated that GlFtsZ protein possesses the typical conservative motifs existed in all FtsZ proteins. The existence of putative plastid transit peptide in its N-terminus suggested that GlFtsZ might function inside of plastids. With the deve- lopmental process of petals of Gentiana lutea, the expression of plastid division gene GlFtsZ declined gradually, whereas the expression of carotenoids biosynthesis gene Zds increased obviously; meanwhile, in contrast to the increment of carotenoids, the content of chlorophyll in petals decreased sharply. The chloroplasts turned into chromoplasts, and the color of petals also turned from green to golden. All of these results suggested that the expression of GlFtsZ is accompanied with the development and differentiation of plastids. | HE Yikun , ZHU Changfu , WANG Dong, KONG Dongdong and SUN Jingsan(1. Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China 2. Department of Biology, Capital Normal University, Beijing 100037, China 3. College of Life Science, Northeast Normal University, Changchun 130024, China) | 2002 | Progress in Natural Science:Materials International2002，12，8： | 5 |
| 13 | Enterprise stent for symptomatic complex intracranial atherosclerotic stenosis: safety and efficiency显示文摘Purpose: To evaluate the safety and efficacy of Enterprise stent in the treatment of symptomatic complex intracranial atherosclerotic stenosis. Methods and materials: 20 complex cases among 53 patients with symptomatic ischemic stroke who were treated with balloon angioplasty and enterprise stents in Department of Neuro-interventional Radiology, The First Affiliated Hospital of Zhengzhou University from Jan. 2014 to Dec. 2017 were retrospectively enrolled in this study. Diagnostic criteria for complex intracranial atherosclerotic stenosis were as follows: 1) intracranial atherosclerotic stenosis was ≥70% confirmed by digital subtraction angiography(DSA) using the formulas described by the Warfarin Aspirin Symptomatic Intracranial Disease(WASID) method; 2) length of lesion was >10 mm. Basic characteristics of target lesions, technical success rate, perioperative safety, follow-up outcomes were investigated. Results: 20 patients were enrolled in this study, including 15 males and 5 females from 44 to 70 years old with an average age of 57.20 ± 9.25. 20 lesions were treated with 20 enterprise stents. The average preoperative and postoperative residual stenosis was reduced from(77.45 ± 8.44)% to(24.89 ± 16.61)%. The successful rate of operation was 100%. Among the perioperative complications, only 1 case(5%) experienced perforating branch event. The average clinical follow-up period was 13.15 ± 11.33 months(time range: 5–38). There were no ischemic events, no bleeding events and no various causes of death during the follow-up period. 8 lesions(40.0%) underwent DSA follow-up examinations and 12 lesions(60.0%) were checked by CT angiography during the follow-up period. 3 lesions(15.0%) developed ISR without any cerebral ischemia symptoms. Conclusion: This retrospective, single-center study suggests that enterprise stent is effective in the treatment of symptomatic complex intracranial atherosclerotic stenosis with less perioperative complications. Prospective, multicenter, randomized controlled trials are expected. | Yanhua Dong Chao Liu Dongdong Li Zhen Chen Xiaozhen Sun Sheng Guan | 2018 | Journal of Interventional Medicine2018，1，4： | 5 |
| 14 | Preparation of 5-fluorouracil-loaded chitosan nanoparticles and study of the sustained release in vitro and in vivo显示文摘The sustained-release properties of the biodegradable nano-drug delivery systems were used to improve the residence time of the chemotherapeutic agent in the body. These drug delivery systems were widely used to deliver chemotherapeutic drugs. The 5-fluorouracil loaded chitosan nanoparticles prepared in this paper have the above advantage. Here, we found that when the mass ratio of 5-fluorouracil and chitosan was 1:1, the maximum drug loading of nanoparticles was 20.13 ± 0.007%, the encapsulation efficiency was 44.28 ± 1.69%, the particle size was 283.9 ± 5.25 nm and the zeta potential was 45.3 ± 3.23 mV. The prepared nanoparticles had both burst-release and sustained-release phases in vitro release studies.In addition, the inhibitory effect of the prepared nanoparticles on gastric cancer SGC-7901 cells was similar to that of 5-fluorouracil injection, and the blank vector had no obvious inhibitory effect on SGC-7901 cells. In the pharmacokinetic study of rats in vivo, we found that AUC(0-t), MRT(0-t) and t1/2 z of nanoparticles were significantly increased in vivo compared with 5-fluorouracil solution, indicating that the prepared nanoparticles can play a role in sustained-release. | Li Sun Yunna Chen Yali Zhou Dongdong Guo Yufan Fan Fangyan Guo Yufeng Zheng Weidong Chen | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，5： | 4 |
| 15 | Effects of samarium content on microstructure and mechanical properties of Mg–0.5Zn–0.5Zr alloy显示文摘Effects of samarium (Sm) content (0, 2.0, 3.5, 5.0, 6.5 wt%) on microstructure and mechanical proper-ties of Mg-0.5Zn-0.5 Zr alloy under as-cast and as-extruded states were thoroughly investigated. Results indicate that grains of the as-cast alloys are gradually refined as Sm content increases. The dominant intermetallic ph^se changes from Mg3Sm to Mg4iSm5 till Sm content exceeds 5.0 wt%. The dynami-cally precipitated intermetallic phase during hot-extrusion in dll Sm-containing alloys is Mg3Sm. The intermetallic particles induced by Sm addition could act as heterogeneous nucleation sites for dynamic recrystallization during hot extrusion. They promoted dynamic recrystallization via the particle stim-ulated nucleation mechanism, and resulted in weakening the basal texture in the as-extruded alloys. Sm addition can significantly enhance the strength of the as-extruded Mg-0.5Zn-0.5Zr alloy at room temperature, with the optimal dosage of 3.5 wt%. The optimal yield strength (YS) and ultimate tensile strength (UTS) are 368 MPa and 383 MPa, which were enhanced by approximately 23.1% and 20.8% com-pared with the Sm-free alloy, respectively. Based on microstructural analysis, the dominant strengthening mechanisms are revealed to be grain boundary strengthening and dispersion strengthening. | Kai Guan Fanzhi Meng Pengfei Qin Qiang Yang Dongdong Zhang Baishun Li Wei Sun Shuhui Lv Yuanding Huang Norbert Hort Jian Meng | 2019 | Journal of Materials Science & Technology2019，35，7： | 4 |
| 16 | Time-varying reliability indexes for multi-AUV cooperative system显示文摘With the development of multi-autonomous underwater vehicle(AUV) cooperative systems, the evaluation of their reliability is becoming more and more important. Since AUVs are always in motion, the reliability of the system is not stationary, but it varies with time. This paper studies the time-varying reliability evaluation indexes for multi-AUV cooperative systems. Aimed at elucidating the characteristics of the system, by considering the motion of the AUVs, two time dependent reliability evaluation indexes, natural connectivity and all-terminal reliability of the basic reliability indexes, are determined with the graph theory. Then the timevarying reliability of multi-AUV cooperative systems is evaluated combining with an actual example. This paper provides a method to evaluate the time-varying reliability of multi-AUV cooperative systems. | Qingwei Liang Tianyuan Sun Dongdong Wang | 2017 | Journal of Systems Engineering and Electronics2017，28，2： | 4 |
| 17 | Cloning of two plastid division ftsZ genes from Nicotiana tabacum and their expression in E. coli显示文摘Two cDNAs of plastid division gene NtFtsZ1-1 and NtFtsZ1-2 are isolated from Nicotiana tabacum by RT-PCR and rapid amplification cDNA ends (RACE) method. Analysis of the deduced amino acid sequences encoded by NtFtsZ1-1 and NtFtsZ1-2 indicate that these two proteins possess the typical conservative motifs and GTP binding sites existing in all FtsZ proteins. The existence of putative plastid transit peptide in their N-terminal suggests that there are at least two transit-peptide containing FtsZ proteins in higher plants. Phylogenetic analysis based on amino acid sequences of FtsZ proteins also supports this interference. These two NtFtsZ genes demonstrate a similar expression pattern during the plant development, detected by Northern blot. Expression of NtFtsZ1-1 and NtFtsZ1-2 in E.coli interrupts the normal division process of host cells. These results suggest the diverse functions of FtsZ proteins in higher plants. | WANG Dong KONG Dongdong HU Yong JU Chuanli HE Yikun and SUN Jingsan(1. Department of Biology, Capital Normal University, Beijing 100037, China 2. Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China 3. College of Life Sciences, Beijing Normal University, Beijing 100875, China) | 2002 | Progress in Natural Science:Materials International2002，12，12： | 4 |
| 18 | Reliability indexes for multi-AUV cooperative systems显示文摘With the development of multi-autonomous underwater vehicle(AUV) cooperative systems, the evaluation of their reliability is becoming more and more important. Aimed at the characteristics of the system, three reliability indexes – standard entropy of rank distribution, all-terminal reliability and standard natural connectivity are determined in this paper. Topology structure and underwater acoustic communication are considered. The calculation methods of the three reliability indexes are proposed, and the characteristics of these indexes are analyzed. The reliability indexes of two multi-AUV cooperative systems are obtained as examples. Results show that these three indexes reflect different aspects of reliability for multi-AUV cooperative systems. This paper provides some methods to evaluate the reliability of multi-AUV cooperative systems, which is of practical value. | Qingwei Liang Tianyuan Sun Dongdong Wang | 2017 | Journal of Systems Engineering and Electronics2017，28，1： | 4 |
| 19 | Hd1,Ghd7,and DTH8 synergistically determine the rice heading date and yield-related agronomic traits显示文摘Heading date determines the seasonal and regional adaptation of rice(Oryza sativa L.)varieties and is mainly controlled by photoperiod sensitivity(PS).The core heading date genes Hd1,Ghd7,DTH8,and PRR37 act synergistically in regulating the PS.In this study,we systematically analyze the heading date,PS,and agronomic traits of eight homozygous lines with various combinations of Hd1,Ghd7,and DTH8 alleles in the prr37 background under long-day(LD)and short-day(SD)conditions,respectively.We find that Hd1 alone promotes heading,regardless of the day length.However,under LDs,Hd1 suppresses flowering,in coordination with functional Ghd7 or with Ghd7 and DTH8.These loci cooperate to negatively regulate the Ehd1-Hd3 a/RFT1 pathway and delay heading.Under SDs,Hd1 competes with various heading suppressors to promote heading.Therefore,the dual function of Hd1 is vital for PS.The lines carrying Hd1 alone show reduced plant height with fewer primary and secondary branches in panicles.Lines carrying Ghd7 and DTH8(with hd1)show delayed heading and improve agronomic traits.Overall,our results reveal the regulation of rice PS flowering by the core heading date genes and their effects on agronomic traits,providing valuable information for the selection of rice varieties for adaptation to different light and temperature conditions. | Kangli Sun Minghui Huang Wubei Zong Dongdong Xiao Chen Lei Yanqiu Luo Yingang Song Shengting Li Yu Hao Wanni Luo Bingqun Xu Xiaotong Guo Guangliang Wei Letian Chen Yao-Guang Liu Jingxin Guo | 2022 | Journal of Genetics and Genomics2022，49，5： | 4 |
| 20 | Fast mapping of a chlorophyll b synthesis-deficiency gene in barley(Hordeum vulgare L.) via bulked-segregant analysis with reduced-representation sequencing显示文摘Bulked-segregant analysis coupled with next-generation sequencing(BSA-seq) has emerged as an efficient tool for genetic mapping of single genes or major quantitative trait loci controlling(agronomic) traits of interest. However, such a mapping-by-sequencing approach usually relies on deep sequencing and advanced statistical methods. Application of BSA-Seq based on construction of reduced-representation libraries and allele frequency analysis permitted anchoring the barley pale-green(pg) gene on chromosome 3 HL. With further marker-assisted validation, pg was mapped to a 3.9 Mb physical-map interval. In the pg mutant a complete deletion of chlorophyllide a oxygenase(HvCAO) gene was identified.Because the product of this gene converts Chl a to Chl b, the pg mutant is deficient in Chl b.An independent Chl b-less mutant line M4437_2 carried a nonsynonymous substitution(F263 L) in the C domain of HvCAO. The study demonstrates an optimized pooling strategy for fast mapping of agronomically important genes using a segregating population. | Dongdong Xu Dan Sun Yanling Diao Minxuan Liu Jia Gao Bin Wu Xingmiao Yuan Ping Lu Zongwen Zhang Jing Zhang Ganggang Guo | 2019 | The Crop Journal2019，7，1： | 3 |
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