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| 1 | MdGSTF6,activated by MdMYB1,plays an essential role in anthocyanin accumulation in apple显示文摘Anthocyanins are biosynthesized on the cytosolic surface of the endoplasmic reticulum and then transported into the vacuole for storage.Glutathione S-transferases(GSTs)are considered to be responsible for the transport of anthocyanins into the vacuole.However,the regulatory mechanisms of GSTs in plants are still unclear.Here,we performed a genome-wide analysis and identified 69 GST genes in apple.The expression of MdGSTF6 was positively correlated with the anthocyanin content(r=0.949)during‘Yanfu 8’fruit development.The overexpression of MdGSTF6 in the Arabidopsis thaliana tt19 mutant resulted in seedlings of 35S::MdGSTF6-GFP/tt19 that could accumulate anthocyanin and rescue its phenotype,suggesting that MdGSTF6 was an anthocyanin transporter.The silencing of MdGSTF6 affected anthocyanin accumulation in apple fruit.Moreover,the knockdown of MdGSTF6 by RNA interference in cultured‘Gala’seedlings inhibited anthocyanin accumulation.The interaction experiments showed that MdMYB1 could bind directly to the MdGSTF6 promoter to transcriptionally activate its expression.Collectively,our results demonstrate that MdGSTF6 encodes an important GST transporter of anthocyanins in apple fruit and provide evidence for the associated regulatory mechanisms.Therefore,MdMYB1 can not only regulate anthocyanin synthesis,but also control the transport of anthocyanin in apples.This information may be useful for further clarifying the regulation of anthocyanin transport in apple. | Shenghui Jiang Min Chen Naibo He Xiaoliu Chen Nan Wang Qingguo Sun Tianliang Zhang Haifeng Xu Hongcheng Fang Yicheng Wang Zongying Zhang Shujing Wu Xuesen Chen | 2019 | Horticulture Research2019，6，1： | 16 |
| 2 | Spatial-temporal Variation of Extreme Precipitation Events in Northwest China During 1961-2010显示文摘Using the daily precipitation data of 118 meteorological stations in Northwest China from January 1,1961 to December 31,2010,we analyzed extreme precipitation events from prime precipitation data by applying R-language Climate Index( RClimDex).The spatial-temporal change characteristics in the past 50 years have been examined using the method of trend analysis,Mann-Kendall and the spatial analysis module of Arcgis9.2.The results show that the spatial distribution of the indices for extreme precipitation in Northwest China is greatly influenced by geographic location,atmospheric circulation and topography,and the spatial difference of extreme precipitation events is very evident,while the indices reduce from the southeast to the northwest except Consecutive Dry Days( CDD).In Xinjiang region,high values appear in Tianshan Mountains and decrease towards the south and north respectively.In the past 50 years,the temporal variation tendency of the indices for extreme precipitation in Northwest China has a great spatial distinction.It shows that the variation tendency is opposite between the east( decrease) and the west( increase),and CDD has a decreasing tendency while other indices increase.For each region,it is found that the indices for extreme precipitation in Xinjiang and Qinghai Province shows an increasing trend,and it is remarkable in Tianshan Mountains,the north of Xinjiang and the northeast of Qinghai Province.The temporal variation tendency of the indices for extreme precipitation in Ningxia,Shaanxi and Gansu has a large spatial distinction.The stations which have an increasing tend are mainly found in the north of Ningxia,south of Shaanxi and Hexi Corridor of Gansu.However,the south of Ningxia,north of Shaanxi and Longnan of Gansu Province mainly present a decreasing trend.The temporal variation tendency of the indices for extreme precipitation in Inner Mongolia is not obvious.Overall,the east part of Northwest China has a dry tendency,while the west part has an opposite trend. | Lian Lishu Xu Shujing Li Zhifu Sun Xiaoyin | 2014 | Meteorological and Environmental Research2014，5，1： | 5 |
| 3 | Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors显示文摘Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 infection.Herein,we briefly provide a concise report on the medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors with representative examples in different strategies from the medicinal chemistry perspective. | Shenghua Gao Tianguang Huang Letian Song Shujing Xu Yusen Cheng Srinivasulu Cherukupalli Dongwei Kang Tong Zhao Lin Sun Jian Zhang Peng Zhan Xinyong Liu | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 5 |
| 4 | Influence of Sanao Tang on urine volume and expression of aquaporin 2 in rats with respiratory function impairment induced by passive smoking and lipopolysaccharide显示文摘OBJECTIVE: To investigate the effect of Sanao Tang(SAT) on urine volume and the expression of aquaporin-2(AQP2) in rats with lung dysfunction induced by passive smoking and lipopolysaccharide.METHODS: Totally 45 healthy Specific pathogen Free Wistar Rats were randomized into 3 groups:normal control group, model group and SAT group.A rat model of respiratory dysfunction induced by exposure to cigarette smoking and lipopolysaccharide(LPS). Lavage of decoction of the Chinese medicine was performed for rats in the SAT group. Anires 2005 System was used to analyze the pulmonary function. Urine of rats was collected through metabolism cage method. Enzyme-linked immunosorbent assay(ELISA) was used to determine content of antidiuretic hormone(ADH), angiotensin Ⅱ(AngⅡ), atrial natriuretic factor(ANP), endothelin 1(ET-1), nitric oxide(NO) and prostaglandin E2(PGE2) in serum, lung and kidney. The expression of AQP2 in rat renal tissue was determined with real-time fluorescence quantitative PCR(RT-PCR).RESULTS:(a) In comparison with the normal control, It was found that enforced vital capacity(FVC),1-second forced expiratory volume/forced vital capacity%(FEV1/FVC%), 24 h urine volume content of NO and PGE2 were decreased, while AQP2 m RNA level and content of ADH, Agn Ⅱ, ANP and ET-1were increased in the model group with statistical significance(P < 0.05).(b) In comparison with the model group, It was found that FVC, FEV1, FEV1/FVC%, 24 h urine volume, content of PGE2 and NO decreased, while AQP2 m RNA level, content of ANP,ADH and AngⅡ decreased in the SAT group with statistical significance(P < 0.05).CONCLUSION: SAT might effectively regulate the urine volume in the modeled rats; ADH, Ang Ⅱ,ANP, ET-1, NO and PGE2 might play an important role in the regulation on urine volume by lungs.This might be the mechanisms underpinning the function of lung governing water passage in terms of the theory of Traditional Chinese Medicine. | Zhang Jinchao Sun Yan Zhang Shujing Gao Yushan Wang Zhenyi Liu Xiaolei Yang Jiamin Li Yuhang | 2016 | Journal of Traditional Chinese Medicine2016，36，6： | 2 |
| 5 | Mechanism of improving skin barrier function in a mouse model of atopic dermatitis using Mahuang Lianqiao Chixiaodou decoction and its disassembled formula显示文摘Objective: To reveal the mechanism of Mahuang Lianqiao Chixiaodou decoction and its disassembled formula for improving the skin barrier function in a mouse model of atopic dermatitis(AD).Methods: Sixty specific-pathogen free male BALB/c mice were randomly divided into the control group,model group, whole formula group(WF), exterior-releasing formula group(ERF), interior-clearing formula group(ICF), and positive control group(PC). A mouse model of AD was established using the semiantigen 2,4-dinitrofluorobenzene induction method. The lesion scores, transepidermal water loss and p H, and skin histopathology of mice in each group were observed. The expressions of filaggrin, loricrin,and involucrin were detected by the streptavidin peroxidase immunohistochemical method and western blotting, and their mRNA expressions were detected by quantitative polymerase chain reaction.Results: Mice in the WF, ERF, ICF, and PC groups showed reduced skin lesion performance, improved histopathology, decreased skin lesion score, transepidermal water loss and pH, and upregulated expressions of proteins including filaggrin, loricrin, and involucrin, and their mRNAs. The most obvious regulatory effect was observed in the WF group, followed by the ICF, ERF, and PC groups, accordingly.Conclusions: Mahuang Lianqiao Chixiaodou decoction and its disassembled formula can improve the skin barrier function in a mouse model of AD by upregulating filaggrin, loricrin, and involucrin, and their mRNA expressions, and the most optimal effect was noted in the WF group, followed by the ICF and ERF groups, which suggests that the effect of clearing heat and resolving dampness in improving the skin barrier function of AD is more obvious and is one of the key treatments for AD. | Jingang Liu Yan Sun Huimin Yuan Yuda Li Jing Feng Yushan Gao Yang Tang Shujing Zhang Hang Wang Fengjie Zheng | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，4： | 2 |
| 6 | Construction of WO_(3)/Ti-doped WO_(3)bi-layer nanopore arrays with superior electrochromic and capacitive performances显示文摘Crystalline WO_(3)/Ti-doped WO_(3)bi-layer nanopore arrays were constructed by the template synthesis of a WO_(3)nanopore layer modified by a magnetron sputtering of an amorphous Ti-doped/WO_(3)layer.The obtained bi-layer nanopore array shows a remarkable electrochromic performance with large dual-band optical modulation in both visible(VIS)and near infrared(NIR)regions(optical modulation of over 70%in the wavelength range from 600 to 1600 nm)and the fast response speed(coloring for 3.4 s and bleaching for 6.6 s).In addition,the bi-layer WO_(3)/Ti-doped WO_(3)nanopore array also present superior energy-storage properties(areal capacitance of 44.0 mF cm−2 and good rate capability),better than that of titanium-free thin films.The special bifunctional characteristics of electrochromism and pseudocapacitance can be ascribed to the large specific surface area provided by the architectural design,rich ion channels in the amorphous layer as well as proper titanium doping,which bestows the bi-layer nanopore array a great potential in clean energy applications. | Yingdi Shi Shujing Liu Yong Zhang Mingjun Sun Kai Tang Jiewu Cui Xia Shu Yan Wang Jiaqin Liu Yucheng Wu | 2019 | Tungsten2019，1，3： | 2 |
| 7 | Surface modification of PET films by atmospheric pressure plasma-induced acrylic acid inverse emulsion graft polymerization显示文摘 | Jie Sun Lan Yao Zhiqiang Gao Shujing Peng Chunxia Wang Yiping Qiu | 2010 | Surface & Coatings Technology2010，，24： | 1 |
| 8 | Analysis of genetic diversity in Ganoderma population with a novel molecular marker SRAP显示文摘 | Sun Shujing Gao Wei Lin Shuqian | 2006 | Appl Microbiol Biotechnol2006，72，： | 1 |
| 9 | Functional analysis of a novel Cys2/His2-type zinc finger protein involved in salt tolerance in rice显示文摘 | Sun Shujing Guo Shuqiao Yang Xia | 2010 | Journal of Experimental Botany2010，61，10： | 1 |
| 10 | Influence of argon/oxygen atmospheric dielectric barrier discharge treatment on desizing and scouring of poly (vinyl alcohol ) on cotton fabrics 显示文摘 | PENG Shujing GAO Zhiqiang SUN Jie | 2009 | Applied Surface Science2009，，255： | 1 |
| 11 | Back Analysis of the Draining Process of the Tangjiashan Barrier Lake显示文摘 | Zuyu Chen Liqiu Ma Shu Yu Shujing Chen Xingbo Zhou Ping Sun Xu Li | 2014 | Journal of Hydraulic Engineering2014，，： | 1 |
| 12 | Influence of processing parameters on atmospheric pressure plasma etching of polyamide 6 films 显示文摘 | GAO Zhiqiang PENG Shujing SUN Jie | 2009 | Applied Surface Science2009，，255： | 1 |
| 13 | Influence of processing parameters on atmospheric pressure plasma etching of polyamide 6 film 显示文摘 | GAO Zhiqiang PENG Shujing SUN Jie | 2009 | Applied Surface Science2009，，255： | 1 |
| 14 | Dynamic complexities in a seasonal prevention epidemic model with birth pulses显示文摘 | Shujing Gao Lansun Chen Lihua Sun | 2005 | Chaos Solitons and Fractals2005，，26： | 1 |
| 15 | Influence of argon/oxygen atmospheric dielectric barrier discharge treatment on desizing and scouring of poly (vinyl alcohol) on cotton fabrics 显示文摘 | PENG Shujing GAO Zhiqiang SUN Jie | 2009 | Applied Surface Science2009，，255： | 1 |
| 16 | Effect of constant glucose feeding on the production of exopolysaccharides by Tremella fuciformis spores显示文摘 | ZHU Hu SUN Shujing | 2009 | Appl Biochem Biotechnol2009，152，3： | 1 |
| 17 | Electrochemical degradation characteristics of refractory organic pollutants in coking wastewater on multiwall carbon nanotube-modified electrode显示文摘 | WANG Yan SUN Shujing DING Guifu | 2012 | Journal of Nanomaterials2012，2012，： | 1 |
| 18 | Chromoso- mal integration of the Vitreoscilla hemoglobin gene and its physiological actions in Tremellafuciformis显示文摘 | ZHU Hu WANG Tianwen SUN Shujing | 2006 | Appl Micmb- iol Biotechnol2006，72，4： | 1 |
| 19 | Growth modulation of simultaneous epitaxy of ZnO obliquely aligned nanowire arrays and film on r-plane sapphire substrate显示文摘底层上的电影和 nanowire 数组的同时的取向附生的生长为 nanoscale 光电子具有科学意义和实际重要性。不过,在造的 situ 进行在在绝缘的底层上种的个别地孤立的 nanowires 之间的连接仍然是挑战性的。此处,我们在 Au 涂的 r 飞机蓝宝石底层上为 nonpolar 一飞机 ZnO 电影和倾斜地排列的 nanowire 数组的同时的取向附生的生长表明新奇、灵巧的策略。同样综合的 ZnO nanostructures 的形态学,结构,部件,和光性质用扫描电子显微镜学, X 光检查衍射,地排放传播电子显微镜学,精力散的光谱学, X 光检查光电子光谱学,和光致发光的地排放被调查光谱学。合作生长机制被建议: 催化Au 的蒸汽运输开始 nonpolar 一飞机和极的c飞机 ZnO 原子核的同现,并且随后,极的c飞机 ZnO 原子核同时开发进倾斜地排列的 nanowire 数组的 nonpolar 一飞机 ZnO 原子核在自我催化的 vapor-liquid-solid 生长帮助的底部和锌开发进一部 ZnO 传导性的电影的非向上的指导 Au 催化剂帮助。与传导性的连接和它在 nanowires 的 situ 合成认识到的建议策略能在光电子有益于 ZnO nanowires 的应用程序。 | Yongchun Xiao Yaoyao Tian Shujing sun Chenlong Chen Buguo Wang | 2018 | Nano Research2018，11，7： | 1 |
| 20 | Influence of argon/oxygen atmospheric dielectric barrier discharge treatment on desizing and scouring of poly (vinyl alcohol) on cotton fabrics显示文摘 | PENG Shujing GAO Zhiqiang SUN Jie | | 0，，： | 1 |
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