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| 1 | A Strigolactone Biosynthesis Gene Contributed to the Green Revolution in Rice显示文摘Plant architecture is a complex agronomic trait and a major factor of crop yield,which is affected by several important hormones.Strigolactones(SLs)are identified as a new class hormoneinhibiting branching in many plant species and have been shown to be involved in various developmental processes.Genetical and chemical modulation of the SL pathway is recognized as a promising approach to modify plant architecture.However,whether and how the genes involved in the SL pathway could be utilized in breeding still remain elusive.Here,we demonstrate that a partial loss-of-function allele of the SL biosynthesis gene,HIGH TILLERING AND DWARF 1/DWARF17(HTD1/D17),which encodes CAROTENOID CLEAVAGE DIOXYGENASE 7(CCD7),increases tiller number and improves grain yield in rice.We found that the HTD1 gene had been widely utilized and co-selected with Semidwarf 1(SD1),both contributing to the improvement of plant architecture in modern rice varieties since the Green Revolution in the 1960s.Understanding how phytohormone pathway genes regulate plant architecture and how they have been utilized and selected in breeding will lay the foundation for developing the rational approaches toward improving crop yield. | Yuexing Wang Lianguang Shang Hong Yu Longjun Zeng Jiang Hu Shen Ni Yuchun Rao Sanfeng Li Jinfang Chu Xiangbing Meng Lei Wang Ping Hu Jijun Yan Shujing Kang Minghao Qu Hai Lin Tao Wang Quan Wang Xingming Hu Hongqi Chen Bing Wang Zhenyu Gao Longbiao Guo Dali Zeng Xudong Zhu Guosheng Xiong Jiayang Li Qian Qian | 2020 | Molecular Plant2020，13，6： | 23 |
| 2 | Genetic Variation of the VP1 Gene of the Virulent Duck Hepatitis A Virus Type 1(DHAV-1) Isolates in Shandong Province of China显示文摘To investigate the relationship of the variation of virulence and the external capsid proteins of the pandemic duck hepatitis A virus type 1(DHAV-1) isolates,the virulence,cross neutralization assays and the complete sequence of the virion protein 1(VP1) gene of nine virulent DHAV-1 strains,which were isolated from infected ducklings with clinical symptoms in Shandong province of China in 2007-2008,were tested.The fifth generation duck embryo allantoic liquids of the 9 isolates were tested on 12-day-old duck embryos and on 7-day-old ducklings for the median embryonal lethal doses(ELD 50 s) and the median lethal doses(LD 50 s),respectively.The results showed that the ELD 50 s of embryonic duck eggs of the 9 DHAV-1 isolates were between 1.9 × 10 6 /mL to 1.44 × 10 7 /mL,while the LD 50 s were 2.39 × 10 5 /mL to 6.15 × 10 6 /mL.Cross-neutralization tests revealed that the 9 DHAV-1 isolates were completely neutralized by the standard serum and the hyperimmune sera against the 9 DHAV-1 isolates,respectively.Compared with other virulent,moderate virulent,attenuated vaccine and mild strains,the VP1 genes of the 9 strains shared 89.8%-99.7% similarity at the nucleotide level and 92.4%-99.6% at amino acid level with other DHAV-1 strains.There were three hypervariable regions at the C-terminus(aa 158-160,180-193 and 205-219) and other variable points in VP1 protein,but which didn't cause virulence of DHAV-1 change. | Jiming Gao Junhao Chen Xingkui Si Zhijing Xie Yanli Zhu Xingxiao Zhang Shujing Wang Shijin Jiang | 2012 | Virologica Sinica2012，27，4： | 10 |
| 3 | Multi-channel micro neural probe fabricated with SOI显示文摘Silicon-on-insulator(SOI) substrate is widely used in micro-electro-mechanical systems(MEMS).With the buried oxide layer of SOI acting as an etching stop,silicon based micro neural probe can be fabri-cated with improved uniformity and manufacturability.A seven-record-site neural probe was formed by inductive-coupled plasma(ICP) dry etching of an SOI substrate.The thickness of the probe is 15 μm.The shaft of the probe has dimensions of 3 mm×100 μm×15 μm with typical area of the record site of 78.5 μm2.The impedance of the record site was measured in-vitro.The typical impedance characteris-tics of the record sites are around 2 MΩ at 1 kHz.The performance of the neural probe in-vivo was tested on anesthetic rat.The recorded neural spike was typically around 140 μV.Spike from individual site could exceed 700 μV.The average signal noise ratio was 7 or more. | PEI WeiHua ZHU Lin WANG ShuJing GUO Kai TANG Jun ZHANG Xu LU Lin GAO ShangKai CHEN HongDa | 2009 | Science China(Technological Sciences)2009，52，5： | 6 |
| 4 | Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors显示文摘Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 infection.Herein,we briefly provide a concise report on the medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors with representative examples in different strategies from the medicinal chemistry perspective. | Shenghua Gao Tianguang Huang Letian Song Shujing Xu Yusen Cheng Srinivasulu Cherukupalli Dongwei Kang Tong Zhao Lin Sun Jian Zhang Peng Zhan Xinyong Liu | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 5 |
| 5 | SLIDE, the Protein Interacting Domain of Imitation Switch Remodelers, Binds DDT-Domain Proteins of Different Subfamilies in Chromatin Remodeling Complexes显示文摘The Imitation Switch(ISWI)type adenosine triphosphate(ATP)-dependent chromatin remodeling factors are conserved proteins in eukaryotes,and some of them are known to form stable remodeling complexes with members from a family of proteins,termed DDT domain proteins.Although it is well documented that ISWIs play important roles in different biological processes in many eukaryotic species,the molecular basis for protein interactions in ISWI complexes has not been fully addressed.Here,we report the identi cation of interaction domains for both ISWI and DDT domain proteins.By analyzing CHROMATIN REMODELING11(CHR11)and RINGLET1(RLT1),an Arabidopsis thaliana ISWI(AtISWI)and AtDDT domain protein,respectively,we show that the SLIDE domain of CHR11 and the DDT domain together with an adjacent sequence of RLT1 are responsible for their binding.The Arabidopsis genome contains at least 12genes that encode DDT domain proteins,which could be grouped into ve subfamilies based on the sequence similarity.The SLIDE domain of AtISWI is able to bind members from different AtDDT subfamilies.Moreover,a human ISWI protein SNF2H is capable of binding AtDDT domain proteins through its SLIDE domain,suggesting that binding to DDT domain proteins is a conserved biochemical function for the SLIDE domain of ISWIs in eukaryotes. | Jiaqiang Dong Zheng Gao Shujing Liu Guang Li Zhongnan Yang Hai Huang Lin Xu | 2013 | Journal of Integrative Plant Biology2013，55，10： | 4 |
| 6 | Influence of Sanao Tang on urine volume and expression of aquaporin 2 in rats with respiratory function impairment induced by passive smoking and lipopolysaccharide显示文摘OBJECTIVE: To investigate the effect of Sanao Tang(SAT) on urine volume and the expression of aquaporin-2(AQP2) in rats with lung dysfunction induced by passive smoking and lipopolysaccharide.METHODS: Totally 45 healthy Specific pathogen Free Wistar Rats were randomized into 3 groups:normal control group, model group and SAT group.A rat model of respiratory dysfunction induced by exposure to cigarette smoking and lipopolysaccharide(LPS). Lavage of decoction of the Chinese medicine was performed for rats in the SAT group. Anires 2005 System was used to analyze the pulmonary function. Urine of rats was collected through metabolism cage method. Enzyme-linked immunosorbent assay(ELISA) was used to determine content of antidiuretic hormone(ADH), angiotensin Ⅱ(AngⅡ), atrial natriuretic factor(ANP), endothelin 1(ET-1), nitric oxide(NO) and prostaglandin E2(PGE2) in serum, lung and kidney. The expression of AQP2 in rat renal tissue was determined with real-time fluorescence quantitative PCR(RT-PCR).RESULTS:(a) In comparison with the normal control, It was found that enforced vital capacity(FVC),1-second forced expiratory volume/forced vital capacity%(FEV1/FVC%), 24 h urine volume content of NO and PGE2 were decreased, while AQP2 m RNA level and content of ADH, Agn Ⅱ, ANP and ET-1were increased in the model group with statistical significance(P < 0.05).(b) In comparison with the model group, It was found that FVC, FEV1, FEV1/FVC%, 24 h urine volume, content of PGE2 and NO decreased, while AQP2 m RNA level, content of ANP,ADH and AngⅡ decreased in the SAT group with statistical significance(P < 0.05).CONCLUSION: SAT might effectively regulate the urine volume in the modeled rats; ADH, Ang Ⅱ,ANP, ET-1, NO and PGE2 might play an important role in the regulation on urine volume by lungs.This might be the mechanisms underpinning the function of lung governing water passage in terms of the theory of Traditional Chinese Medicine. | Zhang Jinchao Sun Yan Zhang Shujing Gao Yushan Wang Zhenyi Liu Xiaolei Yang Jiamin Li Yuhang | 2016 | Journal of Traditional Chinese Medicine2016，36，6： | 2 |
| 7 | Mechanism of improving skin barrier function in a mouse model of atopic dermatitis using Mahuang Lianqiao Chixiaodou decoction and its disassembled formula显示文摘Objective: To reveal the mechanism of Mahuang Lianqiao Chixiaodou decoction and its disassembled formula for improving the skin barrier function in a mouse model of atopic dermatitis(AD).Methods: Sixty specific-pathogen free male BALB/c mice were randomly divided into the control group,model group, whole formula group(WF), exterior-releasing formula group(ERF), interior-clearing formula group(ICF), and positive control group(PC). A mouse model of AD was established using the semiantigen 2,4-dinitrofluorobenzene induction method. The lesion scores, transepidermal water loss and p H, and skin histopathology of mice in each group were observed. The expressions of filaggrin, loricrin,and involucrin were detected by the streptavidin peroxidase immunohistochemical method and western blotting, and their mRNA expressions were detected by quantitative polymerase chain reaction.Results: Mice in the WF, ERF, ICF, and PC groups showed reduced skin lesion performance, improved histopathology, decreased skin lesion score, transepidermal water loss and pH, and upregulated expressions of proteins including filaggrin, loricrin, and involucrin, and their mRNAs. The most obvious regulatory effect was observed in the WF group, followed by the ICF, ERF, and PC groups, accordingly.Conclusions: Mahuang Lianqiao Chixiaodou decoction and its disassembled formula can improve the skin barrier function in a mouse model of AD by upregulating filaggrin, loricrin, and involucrin, and their mRNA expressions, and the most optimal effect was noted in the WF group, followed by the ICF and ERF groups, which suggests that the effect of clearing heat and resolving dampness in improving the skin barrier function of AD is more obvious and is one of the key treatments for AD. | Jingang Liu Yan Sun Huimin Yuan Yuda Li Jing Feng Yushan Gao Yang Tang Shujing Zhang Hang Wang Fengjie Zheng | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，4： | 2 |
| 8 | Extinction in nonautonomous Lotka-volterra competitive system with pure-delays and feedback controls显示文摘 | Hua Hongxiao Teng Zhidong Gao Shujing | 2009 | Nonlinear Analysis2009，10，： | 1 |
| 9 | Permanence and global stability for nonautonomous N -species Lotka–Valterra competitive system with impulses显示文摘 | Juan Hou Zhidong Teng Shujing Gao | 2009 | Nonlinear Analysis: Real World Applications2009，，3： | 1 |
| 10 | Extinction in nonautonomous Lotka–Volterra competitive system with pure-delays and feedback controls显示文摘 | Hongxiao Hu Zhidong Teng Shujing Gao | 2008 | Nonlinear Analysis: Real World Applications2008，，4： | 1 |
| 11 | Pulse vaccination strategy in a delayed SIR epidemic model with vertical transmission显示文摘 | Chen Lansun | 2007 | Discrete and Continuous Dynamical Systems Series B2007，7，： | 1 |
| 12 | Pulse vaccination of an SEIR epidemic model with time delay 显示文摘 | Gao Shujing Chen Lansun Teng Zhidong | 2008 | Nonlinear Analysis: Real World Applications2008，9，2： | 1 |
| 13 | Analysis of a nonautonomous model for migratory birds with saturation incidence rate 显示文摘 | Zhang Yan Gao Shujing Liu Yujiang | 2012 | Commun Nonlinear Sci Numer Simulat2012，17，： | 1 |
| 14 | The Effects of Pulse Vaccination on SEIR Model with Two Time Delays显示文摘 | GAO Shujing TENG Zhidong XIE Dehui | 2007 | Applied Mathematics and Computation2007，201，4： | 1 |
| 15 | Treadmill exercise promotes angiogenesis in the ischemic penumbra of rat brains through caveolin-1/VEGF signaling pathways显示文摘 | Yong Gao Yun Zhao Jingzi Pan Liu Yang Tingting Huang Xiaomin Feng Chao Li Shujing Liang Dingfu Zhou Chan Liu Fengxia Tu Cai Tao Xiang Chen | 2014 | Brain Research2014，，： | 1 |
| 16 | Analysis of a delayed epidemic model with pulse vaccination and satu- ration incidence 显示文摘 | Gao Shujing Chen Lansun Nieto J | 2006 | Lancet2006，24，3536： | 1 |
| 17 | Seasonality and mixed vaccination strategy in an epidemic model with vertical transmission显示文摘 | Gao Shujing Liu Yujiang Juan J | 2011 | Mathematies and Computers in Simulation2011，81，： | 1 |
| 18 | Surface modification of PET films by atmospheric pressure plasma-induced acrylic acid inverse emulsion graft polymerization显示文摘 | Jie Sun Lan Yao Zhiqiang Gao Shujing Peng Chunxia Wang Yiping Qiu | 2010 | Surface & Coatings Technology2010，，24： | 1 |
| 19 | Modeling the effects of cross-protection control in plant disease with seasonality显示文摘 | Shujing Gao Lijun Xia Jialin Wang Zujin Zhang | 2017 | International Journal of Biomathematics2017，10，6： | 1 |
| 20 | Analysis of a delayed epidemic model with pulse vaccination and saturation incidence显示文摘 | Gao Shujing Chen Lansun Juan J Nieto Angela Torres | 2006 | Vaccine2006，，24： | 1 |
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