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| 1 | MicroRNA528 Affects Lodging Resistance of Maize by Regulating Lignin Biosynthesis under Nitrogen-Luxury Conditions显示文摘在氮(N) 奢侈条件下面的住宿实质地减少庄稼产量和种子质量。然而,植物住宿抵抗的分子的机制仍然保持大部分不清楚,特别在玉米。我们这里报导 ZmmiR528 的表示, monocot 特定的 microRNA,被 N 导致 ? 奢侈但是由 N 缺乏减少了。我们由 thioacidolysis 和 N 奢侈显著地减少的乙酰溴化物分析证明在玉米的木质素以及它的全部的内容的 H, G,和 S 单体的产生射击。我们进一步示威 ? 那 ZmLACCASE3 (ZmLAC3 ) 编码包含铜的 laccases,和 ZmLACCASE5 (ZmLAC5 ) 是 ZmmiR528 的目标。在杂交显示出的 situ, ZmmiR528 是,这主要在玉米表示了脉管的纸巾。显著地增加的 ZmLAC3 的 ZmmiR528 或 overexpression 击倒木质素内容和玉米的树皮透度计抵抗起源。相反,转基因的玉米植物 overexpressing ZmmiR528 减少了木质素内容和树皮透度计抵抗并且对在揭示的 N 奢侈定序 conditions.?RNA 分析下面的住宿敏感那 ZmPAL7 和 ZmPAL8 是在转基因的玉米线 downregulating ZmmiR528 的 upregulated。在 N 奢侈条件下面, ZmPALs 的表示层次比在野类型在 ZmmiR528 击倒的线是高得多的并且 ? 转基因的玉米线 overexpressing ZmmiR528。一起拿,这些结果显示由调整 ZmLAC3 和 ZmLAC5 的表示, ZmmiR528 在 N 奢侈条件下面影响玉米住宿抵抗。 | Qing Sun Xiaogang Liu Juan Yang Wenwen Liu Qingguo Du Hongqiu Wang Chunxiang Fu Wen-Xue Li | 2018 | Molecular Plant2018，11，6： | 21 |
| 2 | Response to paleoatmospheric CO_2 concentration of Solenites vimineus(Phillips)Harris(Ginkgophyta)from the Middle Jurassic of the Yaojie Basin,Gansu Province,China显示文摘Solenites vimineus (Phillips) Harris (Ginkgophyta) specimens with well-preserved cuticles were collected from five different beds in the oil shale member of the Middle Jurassic Yaojie Formation in the Yaojie Basin, Gansu Province, northwestern China. Gross morphology and fine structures of the fossil leaves were studied, and stomatal parameters were analyzed, according to which, the paleoatmospheric CO2 concentration can be deduced as 1512-1896 ppm that would have caused an increase in mean temperature of about 6.5-7.4℃. Carbon isotopes from the fossils indicate that the carbon isotopic discrimination and water use efficiency (WUE) of S. vimineus were raised nearly obtaining the ideal physiologic state in increased CO2 concentrations and temperature conditions, suggesting that S. vimineus records the paleoenvironmental information of the Middle Jurassic Yaojie Basin and can be used for environmental reconstruction. | YAN DeFei SUN BaiNian XIE SanPing LI XiangChuan WEN WenWen | 2009 | Science China Earth Sciences2009，52，12： | 13 |
| 3 | Analysis of EET on Ca increasing the melting point of Mg_(17)Al_(12) phase显示文摘The present investigation showed that the additions of Ca to the alloy AZ91 were mainly dissolved into the Mg17Al12 phase and increased its melting point and thermal stability, which would have great effects on the high-temperature properties of AZ91 alloy. The empirical electron theory (EET) of solid and molecules was used to calculate the valence electron structures (VES) of Mg17Al12 intermetallic compound with and without Ca addition. The results showed that Ca dissolving in Mg17Al12 phase increased the strength of bonds that control the thermal stability of Mg17Al12 phase. Additions of Ca also made the distribution of the valence electrons on the dominant bond network more uniform in the whole unit cell of Mg17Al12. The theoretical conclusions well account for the experimental results. | MIN Xuegang, DU Wenwen, XUE Feng & SUN YangshanDepartment of Material Science and Engineering, Southeast University, Nanjing 210096, China | 2002 | Chinese Science Bulletin2002，47，13： | 13 |
| 4 | miR-223 and miR-142 attenuate hematopoietic cell proliferation, and miR-223 positively regulates miR-142 through LMO2 isoforms and CEBP-β显示文摘miR-142 和 miR-223 作为造血的特定的 microRNAs 被识别了。miR-223 在 myeloid 系开发有关键功能。然而, miR-142 的功能仍然保持不清楚。在这研究,我们发现那 miR-142, miR-223 稀释了造血的房间,和那 miR-223 的增长通过 LMO2-L/-S isoforms 和 CEBP- 尾的起来调整的 miR-142 表示。miR-223 否定地 post-transcriptionally 调整了 LMO2-L/-S isoforms 和 CEBP- 尾,当 CEBP- 尾断然调整了 LMO2-L/-S isoforms 并且否定地两个都 LMO2-L/-S isoforms 调整了 miR-142 时。这些结果揭示一条新奇 miR-223 鈥擟E BP-尾鈥擫M O2 鈥攎i R-142 规章的小径,它在造血作用有枢轴的功能。 | Wei Sun Wenwen Shen Shuang Yang Fen Hu Huihui Li Tian-Hui Zhu | 2010 | Cell Research2010，20，10： | 12 |
| 5 | Mild hypothermia combined with a scaffold of Ng Rsilenced neural stem cells/Schwann cells to treat spinal cord injury显示文摘Because the inhibition of Nogo proteins can promote neurite growth and nerve cell differentiation, a cell-scaffold complex seeded with Nogo receptor(Ng R)-silenced neural stem cells and Schwann cells may be able to improve the microenvironment for spinal cord injury repair. Previous studies have found that mild hypothermia helps to attenuate secondary damage in the spinal cord and exerts a neuroprotective effect. Here, we constructed a cell-scaffold complex consisting of a poly(D,L-lactide-co-glycolic acid)(PLGA) scaffold seeded with Ng R-silenced neural stem cells and Schwann cells, and determined the effects of mild hypothermia combined with the cell-scaffold complexes on the spinal cord hemi-transection injury in the T9 segment in rats. Compared with the PLGA group and the Ng R-silencing cells + PLGA group, hindlimb motor function and nerve electrophysiological function were clearly improved, pathological changes in the injured spinal cord were attenuated, and the number of surviving cells and nerve fibers were increased in the group treated with the Ng R-silenced cell scaffold + mild hypothermia at 34°C for 6 hours. Furthermore, fewer pathological changes to the injured spinal cord and more surviving cells and nerve fibers were found after mild hypothermia therapy than in injuries not treated with mild hypothermia. These experimental results indicate that mild hypothermia combined with Ng R gene-silenced cells in a PLGA scaffold may be an effective therapy for treating spinal cord injury. | Dong Wang Jinhua Liang Jianjun Zhang Shuhong Liu Wenwen Sun | 2014 | Neural Regeneration Research2014，9，24： | 12 |
| 6 | Recent Progress on Engineering Highly Efficient Porous Semiconductor Photocatalysts Derived from Metal–Organic Frameworks显示文摘Porous structures o er highly accessible surfaces and rich pores, which facilitate the exposure of numerous active sites for photocatalytic reactions, leading to excellent performances. Recently, metal–organic frameworks(MOFs) have been considered ideal precursors for well-designed semiconductors with porous structures and/or heterostructures, which have shown enhanced photocatalytic activities. In this review, we summarize the recent development of porous structures, such as metal oxides and metal sulfides, and their heterostructures, derived from MOF-based materials as catalysts for various light-driven energy-/environment-related reactions, including water splitting, CO_2 reduction, organic redox reaction, and pollution degradation. A summary and outlook section is also included. | Wenwen Zhan Liming Sun Xiguang Han | 2019 | Nano-Micro Letters2019，11，1： | 9 |
| 7 | IL-37b suppresses T cell priming by modulating dendritic cell maturation and cytokine production via dampening ERK/NF-κB/S6K signalings显示文摘Interleukin 37b (IL-37b ) 在压制有免疫力的回答起一个关键作用,部分由 modulating 树枝状的房间(DC ) 的功能。然而,精确机制大部分仍然是未知的。这里,我们在回答由 DC 导致了的 DC 成熟和 T 房间上调查了 IL-37b 的效果,并且探索了深奥发信号的小径。它被发现那 IL-37b 下面调整在 vitro 的 DC 上的 co-stimulatory 分子 CD80 和 CD86 的表情。同时,支持 inflammatory cytokines 的表情例如 TNF-6, 和 IL-6,被压制,当时 T 房间的表示禁止的 cytokine TGF- 在 IL-37b-treated DC 被增加。另外, T 房间上的 DC 的激活效果被 IL-37b 损害。我们进一步表明细胞外的调整单人赛的 kinase (英皇家空军之阶级最低之兵) ,原子 factor-B (NF-B ) ,和表明小径的 mTOR-S6K 涉及 IL-37b 导致的 DC 的抑制。这被化学禁止者的同样镇压的效果在 DC 在 IL-6 和 TNF- 的表情上对 NF-B,英皇家空军之阶级最低之兵,和 S6K 证实。在结论,这些结果证明 IL-37b 由在英皇家空军之阶级最低之兵, NF-B,和基于 S6K 的禁止的发信号小径包含在 T 房间 priming 压制了 DC 成熟和 immunostimulatory 能力。 | Wantong Wu Weiqiang Wang Yun Wang Wenwen Li Gang Yu Zhonglong Li Chunmin Fang Yue Shen Zhina Sun Ling Han Juan Yu Lijun Fang Song Chen Kui Dong Zhongchao Han Hanzhi Liu Yuechen Luo Xiaoming Feng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
| 8 | Recent Progress on Carbonaceous Material Engineering for Electrochemical Hydrogen Peroxide Generation显示文摘Electrochemical synthesis of hydrogen peroxide(H2 O2)provides a clean and safe technology for large-scale H2 O2 production.The core of this project is the development of highly active and highly selective catalysts.Recent studies demonstrate that carbonaceous materials are favorable catalysts because of their low-cost and tunable surface structures.This brief review first summarizes the strategies of carbonaceous material engineering for selective two-electron O2 reduction reaction and discusses potential mechanisms.In addition,several device designs using carbonaceous materials as catalysts for H2 O2 production are introduced.Finally,research directions are proposed for practical application and performance improvement. | Baoshan Zhang Wenwen Xu Zhiyi Lu Jie Sun | 2020 | Transactions of Tianjin University2020，26，3： | 6 |
| 9 | Selectivity regulation of CO2 electroreduction through contact interface engineering on superwetting Cu nanoarray electrodes显示文摘Electrocatalytic CO2 reduction is a promising way to mitigate the urgent energy and environmental issues, but how to increase the selectivity for desired product among multiple competi ng reaction pathways remains a bottle neck. Here, we demonstrate that engineering the gas-liquid-solid contact interface on the electrode surface could tailor the selectivity of CO2 reducti on and meanwhile suppress H2 production through regulated reacti on kin etics. Specifically, polytetrafl uoroethyle ne (PTFE) was utilized to modify a Cu nano array electrode as an example, which is able to cha nge the electrode surface from aerophobic to aerophilic state. The en riched nano-tunnels of the Cu nano array electrode can facilitate CO2 transportation and pin gaseous products on the electrode surface. The latter is believed to be the reason that boosts the Faradaic efficie ncy of liquid products by 67% and limits the H2 producti on to less than half of before. This in terface engin eeri ng strategy also lowered H2O (proton) affinity, therefore promoting CO and HCOOH production. Engineering the electrode contact interface controls the reaction kinetics and the selectivity of products, which should be inspiring for other electrochemical reactions. | Zhao Cai Yusheng Zhang Yuxin Zhao Yueshen Wu Wenwen Xu Xuemei Wen Yang Zhong Ying Zhang Wen Liu Hailiang Wang Yun Kuang Xiaoming Sun | 2019 | Nano Research2019，12，2： | 5 |
| 10 | Near-infrared light-activated cancer cell targeting and drug delivery with aptamer-modified nanostructures显示文摘为肿瘤的高度精确的治疗的激活刺激的指向的交货系统在最近的年里收到了可观的注意。此处,我们揭示使用一个互补 DNA 序列到 hybridize 和结合到象金 nanorods 或围单人赛的碳 nanotubes (SWNT ) 那样的 photothermal 代理人上的面具 sgc8 aptamers 的光能被活化的指向癌症的策略。在暴露到之上在红外线附近(NIR ) 激光,局部性的 photothermal 在双 stranded DNA 的 dehybridization 加热那些 nano 代理人结果的表面并且 aptamer 顺序放允许指向的特定的癌症房间。作为一个模型系统利用装载 doxorubicin 的 SWNT,到 NIR 光激活的癌症房间的指向的药交货被完成。这个工作与有约束力的可控制的癌症房间表明 NIR 能被活化的指向肿瘤的交货系统的概念潜在地启用高度特定、有效的癌症治疗。 | Yu Yang Jingjing Liu Xiaoqi Sun Liangzhu Feng Wenwen Zhu Zhuang Liu Meiwan Chen | 2016 | Nano Research2016，0，1： | 4 |
| 11 | Organogelators based on p-alkoxylbenzamide and their self-assembling properties显示文摘展示长烷基链的一系列 p-alkoxylbenzamides 被综合了并且是乐意地在许多器官的溶剂形成稳定的胶化。他们的自己组装性质和结构性质关系被扫描电子显微镜学调查, X 光检查衍射, 1 H 原子磁性的回声,和 Fourier 变换红外线的光谱学。形成的胶化对象温度和氟化物阴离子那样的环境刺激多应答。结果显示出那结合的氢的联合, - 叠并且在 p-alkoxylbenzamides 到的聚集的货车 der Waals 相互作用结果形成三尺寸的网络,取决于长烷基链的长度。 | Yan Zhai Wei Chai Wenwen Cao Zipei Sun Yaodong Huang | 2015 | Frontiers of Chemical Science and Engineering2015，9，4： | 3 |
| 12 | Common-Ion Effect Triggered Highly Sustained Seawater Electrolysis with Additional NaCl Production显示文摘Developing efficient seawater-electrolysis system for mass production of hydrogen is highly desirable due to the abundance of seawater.However,continuous electrolysis with seawater feeding boosts the concentration of sodium chloride in the electrolyzer,leading to severe electrode corrosion and chlorine evolution.Herein,the common-ion effect was utilized into the electrolyzer to depress the solubility of NaCl.Specifically,utilization of 6M NaOH halved the solubility of NaCl in the electrolyte,affording efficient,durable,and sustained seawater electrolysis in NaCl-saturated electrolytes with triple production of H_(2),O_(2),and crystalline NaCl.Ternary NiCoFe phosphide was employed as a bifunctional anode and cathode in simulative and Ca/Mg-free seawater-electrolysis systems,which could stably work under 500 mA/cm^(2) for over 100 h.We attribute the high stability to the increased Na^(+)concentration,which reduces the concentration of dissolved Cl-in the electrolyte according to the common-ion effect,resulting in crystallization of NaCl,eliminated anode corrosion,and chlorine oxidation during continuous supplementation of Ca/Mg-free seawater to the electrolysis system. | Pengsong Li Shiyuan Wang Imran Ahmed Samo Xingheng Zhang Zhaolei Wang Cheng Wang Yang Li Yiyun Du Yang Zhong Congtian Cheng Wenwen Xu Xijun Liu Yun Kuang Zhiyi Lu Xiaoming Sun | 2020 | Research2020，，1： | 3 |
| 13 | Spatial difference features and organization optimization of cities and towns in Tarim River Basin显示文摘This paper analyzes the urban spatial structure of Tarim River Basin from the perspectives of urbanization, urban density, grading scales and spatial evolution patterns, using geographical theories and methods, such as fractal theory, principle component analysis, urbanization imbalance index, urban scale imbalance indicator, and urban spatial interaction. The results show that the urban spatial structure displays balanced distribution in the overall pattern, while an imbalanced distribution in each region. The development of town pattern tends to be gathering to the central towns in the oasis of Tarim River Basin and a development axis has begun to form along the southern Xinjiang railway. Based on the division of urban hinterland, and the development characteristics of oasis economy, this paper puts forward an urban spatial organization model. This model uses 'breakpoint model' and divides Tarim River Basin into five urban clusters: Korla urban cluster, Kuqa urban cluster, Aksu urban cluster, Kashgar urban cluster and Hotan urban cluster. As a conclusion, this article puts forward an overall framework of urban spatial organization in Tarim River Basin: 'one axis, double core, and five groups'. | ChangLong SUN XiaoLei ZHANG Nuo JIN HongRu DU WenWen MA | 2010 | Journal of Arid Land2010，2，1： | 3 |
| 14 | Comparative metabolic profiling of Vitis amurensis and Vitis vinifera during cold acclimation显示文摘Vitis amurensis is a wild Vitis plant that can withstand extreme cold temperatures.However,the accumulation of metabolites during cold acclimation(CA)in V.amurensis remains largely unknown.In this study,plantlets of V.amurensis and V.vinifera cv.Muscat of Hamburg were treated at 4℃ for 24 and 72 h,and changes of metabolites in leaves were detected by gas chromatography coupled with time-of-flight mass spectrometry.Most of the identified metabolites,including carbohydrates,amino acids,and organic acids,accumulated in the two types of grape after CA.Galactinol,raffinose,fructose,mannose,glycine,and ascorbate were continuously induced by cold in V.amurensis,but not in Muscat of Hamburg.Twelve metabolites,including isoleucine,valine,proline,2-oxoglutarate,and putrescine,increased in V.amurensis during CA.More galactinol,ascorbate,2-oxoglutarate,and putrescine,accumulated in V.amurensis,but not in Muscat of Hamburg,during CA,which may be responsible for the excellent cold tolerance in V.amurensis.The expression levels of the genes encodingβ-amylase(BAMY),galactinol synthase(GolS),and raffinose synthase(RafS)were evaluated by quantitative reverse transcription-PCR.The expression BAMY(VIT_02s0012 g00170)and RafS(VIT_05s0077 g00840)were primarily responsible for the accumulation of maltose and raffinose,respectively.The accumulation of galactinol was attributed to different members of GolS in the two grapes.In conclusion,these results show the inherent differences in metabolites between V.amurensis and V.vinifera under CA. | Fengmei Chai Wenwen Liu Yue Xiang Xianbin Meng Xiaoming Sun Cheng Cheng Guotian Liu Lixin Duan Haiping Xin Shaohua Li | 2019 | Horticulture Research2019，6，1： | 3 |
| 15 | Spatial differences in soybean bioactive components across China and their influence by weather factors显示文摘Bioactive components are partially responsible for the nutritional and health benefits of soybeans. Four major bioactive components: isoflavones, oligosaccharides, phospholipids,and saponins, were quantified in 763 soybean samples collected from widely distributed regions across China from 2010 to 2013. A majority of the tested bioactive components showed generally declining trends from the north(high latitude) to the south(low latitude).A positive relationship between total oligosaccharides(TO) and altitude was observed. Total isoflavones(TI), phospholipids(TP) and TO were negatively correlated with cumulative temperature above or equal to 15 °C(AT15) and mean daily temperature(MDT), but positively correlated with diurnal temperature range(DTR) and hours of sunshine(HS).Total saponins(TS) were negatively correlated with MDT but positively correlated with rainfall(RF), whereas TO were negatively correlated with RF. Path-coefficient analysis showed that, besides genotype differences, temperature and HS during the reproductive period influenced TI and TP contents, while temperature and RF influenced TS and TO. The effects of weather factors on soybean bioactive components in diverse regions of China were characterized. These findings will be helpful in promoting soybean production for functional food purposes. | Wenwen Song Ruping Yang Xiushi Yang Shi Sun Srinivasa Rao Mentreddy Bingjun Jiang Tingting Wu Shiyan Tian Enoch Sapey Cunxiang Wu Wensheng Hou Guixing Ren Tianfu Han | 2018 | The Crop Journal2018，6，6： | 3 |
| 16 | Anti-aging effects of chlorpropamide depend on mitochondrial complex-Ⅱ and the production of mitochondrial reactive oxygen species显示文摘Sulfonylureas are widely used oral anti-diabetic drugs.However,its long-term usage effects on patients’lifespan remain controversial,with no reports of influence on animal longevity.Hence,the anti-aging effects of chlorpropamide along with glimepiride,glibenclamide,and tolbutamide were studied with special emphasis on the interaction of chlorpropamide with mitochondrial ATP-sensitive K+(mito K-ATP)channels and mitochondrial complex II.Chlorpropamide delayed aging in Caenorhabditis elegans,human lung fibroblast MRC-5 cells and reduced doxorubicin-induced senescence in both MRC-5 cells and mice.In addition,the mitochondrial membrane potential and ATP levels were significantly increased in chlorpropamide-treated worms,which is consistent with the function of its reported targets,mito K-ATP channels.Increased levels of mitochondrial reactive oxygen species(mt ROS)were observed in chlorpropamide-treated worms.Moreover,the lifespan extension by chlorpropamide required complex II and increased mt ROS levels,indicating that chlorpropamide acts on complex II directly or indirectly via mito K-ATP to increase the production of mt ROS as a pro-longevity signal.This study provides mechanistic insight into the anti-aging effects of sulfonylureas in C.elegans. | Zhifan Mao Wenwen Liu Yunyuan Huang Tianyue Sun Keting Bao Jiali Feng Alexey Moskalev Zelan Hu Jian Li | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 17 | Characterization of viromes within mosquito species in China显示文摘Mosquitoes are vectors of multiple disease-causing agents that cause worldwide outbreaks of serious infectious diseases in both humans and animals. These arboviral agents include Dengue virus (DENV), Zika virus (ZIKV), chikungunya virus, yellow fever virus, Japanese encephalitis virus (JEV),and Rift Valley fever virus. Thus, mosquitoes are key to the study of viral origin, spread, and the epidemic tendency of these infectious diseases (Hall and Macdonald, 2016). | Jiang Du Fan Li Yelin Han Shihong Fu Bo Liu Nan Shao Haoxiang Su Weijia Zhang Dandan Zheng Wenwen Lei Jie Dong Lilian Sun Ying He Jianmin Wang Fan Yang Huanyu Wang Guodong Liang Zhiqiang Wu Qi Jin | 2020 | Science China(Life Sciences)2020，63，7： | 2 |
| 18 | Newly self-administered two-step tool for screening cognitive function in an ageing Chinese population:an exploratory cross-sectional study显示文摘Background Early screening of cognitive function is critical to dementia treatment and care.However,traditional tests require face-to-face administration and are often limited by implementation costs and biases.Aims This study aimed to assess whether the Thoven Cognitive Self-Assessment(TCSA),a novel,innovative two-step touchscreen-based cognition assessment tool,could identify early cognitive impairment due to dementia in older adults.Methods The TCSA was administered to 61 healthy controls(HCs),46 participants with mild cognitive impairment(MCI)and 44 participants diagnosed with dementia recruited from Shanghai.Two outcome measures were generated from the TCSA test:the TCSA_(primary task)score and the TCSA_(secondary task)score.Results The total average scores in the control group for the TCSA_(primary task)and TCSA_(secondary task)were significantly higher than those in the MCI and dementia groups(TCSA_(primary task):HCs vs MCI group vs dementia group,8.58±1.76 vs 5.40±2.67 vs 2.74±2.11,F=75.40,p<0.001;TCSA_(secondary task):HCs vs MCI group vs dementia group,23.02±3.31 vs 17.95±4.93 vs 11.93±5.50,F=76.46,p<0.001).Moreover,receiver operating characteristic analysis showed that a score below 7.5 for the TCSA_(primary task)and a score below 22.5 for the TCSA_(secondary task)were indicators of MCI.Conclusions The TCSA appears to be efficacious for the detection of cognitive impairment in older adults.It demonstrates the potential for large-scale cognition screening in community service settings. | Jing Nie Yang Yang Yining Gao Wenwen Jiang Aisikeer Aidina Fei Sun Lucas R Prieto Jie Yu Kang Ju Lisheng Song Xia Li | 2023 | General Psychiatry2023，36，1： | 2 |
| 19 | Functional Connectivity-Based Modelling Simulates SubjectSpecific Network Spreading Effects of Focal Brain Stimulation显示文摘Neurostimulation remarkably alleviates the symptoms in a variety of brain disorders by modulating the brain-wide network. However, how brain-wide effects on the direct and indirect pathways evoked by focal neurostimulation elicit therapeutic effects in an individual patient is unknown. Understanding this remains crucial for advancing neural circuit-based guidance to optimize candidate patient screening, pre-surgical target selection, and post-surgical parameter tuning. To address this issue, we propose a functional brain connectome-based modeling approach that simulates the spreading effects of stimulating different brain regions and quantifies the rectification of abnormal network topology in silico. We validated these analyses by pinpointing nuclei in the basal ganglia circuits as top-ranked targets for 43 local patients with Parkinson's disease and 90 patients from a public database. Individual connectome-based analysis demonstrated that the globus pallidus was the best choice for 21.1% and the subthalamic nucleus for 19.5% of patients. Down-regulation of functional connectivity(up to 12%) at these prioritized targets optimally maximized the therapeutic effects. Notably, the priority rank of the subthalamic nucleus significantly correlated with motor symptom severity(Unified Parkinson's Disease Rating Scale III) in the local cohort. These findings underscore the potential of neural network modeling for advancing personalized brain stimulation therapy,and warrant future experimental investigation to validate its clinical utility. | Xiaoyu Chen Chencheng Zhang Yuxin Li Pei Huang Qian Lv Wenwen Yu Shengdi Chen Bomin Sun Zheng Wang | 2018 | Neuroscience Bulletin2018，34，6： | 2 |
| 20 | Dehydrated layered double hydroxides: Alcohothermal synthesis and oxygen evolution activity显示文摘分层的双氢氧化物(LDH ) 是一个班二维(2D ) 有在水的媒介的广泛的应用程序和开发得好的综合方法的分层的材料。在这个工作,我们为与使脱水的画廊制作 NiFe-LDHs 介绍一个 alcohothermal 合成方法。建议过程为金属离子的同时的降水包含脲的不完全的水解作用,与结果导致使脱水的结构的形成的水缺乏的乙醇环境。使画廊脱水的层结构的形成被 X 光检查衍射(XRD ) ,以及由一个随后的水和过程证实。这里介绍的方法论为制作基于 Fe 的 LDH (NiFe-LDH 和 NiCoFe-LDH ) 也是适用的 nanoarrays,它因为包含的不同降水过程,不能在水的媒介在一样的条件下面被生产。LDH nanoarrays 展览在氧进化反应的优秀 electrocatalytic 性能,由于他们的高内在的活动和唯一的结构的特征。在摘要,这研究不仅为综合介绍一个新方法 LDH 材料,而且为 electrocatalysis 向高度活跃、柔韧的电极提供一条新线路。 | Zhiyi Lu Li Qian Wenwen Xu Yang Tian Ming Jiang Yaping Li Xiaoming Sun Xue Duan | 2016 | Nano Research2016，9，10： | 2 |
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