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| 1 | Interleukin-33 drives hepatic fibrosis through activation of hepatic stellate cells显示文摘Liver fibrosis is a consequence of chronic liver disease,causing morbidity and mortality.Interleukin-33(IL-33)is a critical mediator of inflammation,which may be involved in the development of liver fibrosis.Here,we investigated the role of IL-33 in human patients and experimental bile-duct ligation(BDL)-induced fibrosis in mice.We report increased hepatic IL-33 expression in the murine BDL model of fibrosis and in surgical samples obtained from patients with liver fibrosis.Liver injury,inflammatory cell infiltration and fibrosis were reduced in the absence of the IL-33/ST2 receptor,and the activation of hepatic stellate cells(HSCs)was decreased in ST2-deficient mice.Recombinant IL-33 activated HSCs isolated from C57BL/6 mice,leading to the expression of IL-6,TGF-β,α-SMA and collagen,which was abrogated in the absence of ST2 or by pharmacological inhibition of MAPK signaling.Finally,administration of recombinant IL-33 significantly increased hepatic inflammation in sham-operated BL6 mice but did not enhance BDL-induced hepatic inflammation and fibrosis.In conclusion,BDL-induced liver inflammation and fibrosis are dependent on ST2 signaling in HSCs,and therefore,the IL-33/ST2 pathway may be a potential therapeutic target in human patients with chronic hepatitis and liver fibrosis. | Zhongming Tan Qianghui Liu Runqiu Jiang Long Lv Siamak S Shoto Isabelle Maillet Valerie Quesniaux Junwei Tang Wenjie Zhang Beicheng Sun Bernhard Ryffel | 2018 | Cellular & Molecular Immunology2018，15，4： | 24 |
| 2 | Strigolactones and Brassinosteroids Antagonistically Regulate the Stability of the D53-OsBZR1 Complex to Determine FC1 Expression in Rice Tillering显示文摘Rice tillering,a key architecture trait determ ining grain yield,is highly regulated by a class of newly identified phytohorm ones,strigolactones(SLs).How ever,the whole SL signaling pathw ay from the receptor to dow nstream transcription factors to finally inhibit tillering remains unrevealed.In this study,we first found that brassinosteroids(BRs)strongly enhance tillering by prom oting bud outgrow th in rice,which is largely different from the function of BRs in Arabidopsis.Genetic and biochem ical analyses indicated that both the SL and BR signaling pathw ays control rice tillering by regulating the stability of D53 and/or the OsBZR1 RLA1-DLT module,a transcriptional complex in the rice BR signaling pathway.We further found that D53 interacts with OsBZR1 to inhibit the expression of FC1,a local inhibitor of tillering,and that this inhibition depends on direct DNA binding by OsBZR1,which recruits D53 to the FC1 promoter in rice buds.Taken together,these findings uncover a mechanism illustrating how SLs and BRs coordinately regulate rice tillering via the early responsive gene FC1. | Zhongming Fang Yuanyuan Ji Jie Hu Renkang Guo Shiyong Sun Xuelu Wang | 2020 | Molecular Plant2020，13，4： | 20 |
| 3 | Targets and molecular mechanisms of triptolide in cancer therapy显示文摘Triptolide(TPL/TL) is a natural drug with novel anticancer effects. Preclinical studies indicated that TPL inhibits cell proliferation, induces cell apoptosis, inhibits tumor metastasis and enhances the effect of other therapeutic methods in various cancer cell lines. Multiple molecules and signaling pathways, such as caspases, heat-shock proteins, NF-κB, and deoxyribonucleic acid(DNA) repair-associated factors, are associated with the anti-cancer effect. TPL also improves chemoradiosensitivity in cancer therapy. Phase I trials indicate the potential clinical value of TPL use. However, further trials with larger sample sizes are needed to confirm these results. | Cuicui Meng Hongcheng Zhu Hongmei Song Zhongming Wang Guanhong Huang Defan Li Zhaoming Ma Jianhua Ma Qin Qin Xinchen Sun Jianxin Ma | 2014 | Chinese Journal of Cancer Research2014，26，5： | 16 |
| 4 | Therapeutic potential of intravenous Xuebijing on transforming growth factor β_1 and procollagen type III peptide in patients with acute paraquat poisoning显示文摘OBJECTIVE:Paraquat(PQ) poisoning-induced pulmonary fibrosis causes asphyxiation and death.The therapeutic potential of intravenous Xuebijing therapy in PQ poisoning patients and its underlying immunomodulatory effects on transforming growth factor(TGF)-β1 and procollagen type III peptide(PIIIP) were investigated.METHODS:Thirty-six acute PQ poisoning patients were randomly assigned to conventional therapy(Group A) and intravenous Xuebijing administration plus conventional therapy(Group B).Twenty volunteers served as controls(Group C).Blood samples were collected upon admission(day 0) and at post-treatment days 5,10,and 14.TGF-β1 and PIIIP concentrations were determined by ELISA and analyzed for intra-and inter-group differences over time.One-month follow-up was conducted for determining the mortality rate.RESULTS:TGF-β1 and PIIIP levels were significantly higher in PQ poisoning patients and increased over time(Groups A and B vs C,P<0.01).However,the TGF-β1 and PIIIP levels were consistently significantly lower in Group B compared with those of Group A(P<0.01).The 1-month mortality rate was also lower in Group B compared with that of Group A(P<0.05).PQ poisoning patients showed remarkably high levels of TGF-β1 and PIIIP,which increased as PQ-induced pulmonary fibrosis progressed.CONCLUSION:Treatment with intravenous Xuebijing plus conventional therapy significantly lowered TGF-β1 and PIIIP levels,which indicates therapeutic efficacy in the treatment of PQ poisoning patients. | Xuebing Zheng Xiaoli Sun Piyong Ma Zhongming Liu Nan Jiang | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 11 |
| 5 | Machine learning in materials science显示文摘Traditional methods of discovering new materials,such as the empirical trial and error method and the density functional theory(DFT)-based method,are unable to keep pace with the development of materials science today due to their long development cycles,low efficiency,and high costs.Accordingly,due to its low computational cost and short development cycle,machine learning is coupled with powerful data processing and high prediction performance and is being widely used in material detection,material analysis,and material design.In this article,we discuss the basic operational procedures in analyzing material properties via machine learning,summarize recent applications of machine learning algorithms to several mature fields in materials science,and discuss the improvements that are required for wide-ranging application. | Jing Wei Xuan Chu Xiang-Yu Sun Kun Xu Hui-Xiong Deng Jigen Chen Zhongming Wei Ming Lei | 2019 | InfoMat2019，1，3： | 9 |
| 6 | Chemical characteristics of precipitation at Nanping Mangdang Mountain in eastern China during spring显示文摘To study the characteristics of precipitation in eastern China,an automatic sampler was used to collect rainwater samples from 19 precipitation events at Mangdang Mountain,Nanping City,Fujiang Province,in the spring of 2009.We used ion chromatography to analyze the ionic components and concentrations,and inductively coupled plasma mass spectrometry (ICP-MS) to analyze element compositions and contents.The results demonstrated remarkable acidic characteristics:in more than 80% of precipitation events the pH was less than 5.6,with an average of 4.81.Mass concentration results showed SO 4 2 was the main anionic component (36.2% of the total anion mass),while NH 4+ was the main cationic component (47.7% of the total cation mass) and main ion for acidity neutralization in the rainwater.Organic acid content accounted for 30.9% of total anion mass.The main trace metals were Ca,K,and Na.The SO 4 2/NO 3 ratio was 1.4,indicating that precipitation in this region was influenced by complex air pollution-the product of individual coal-burning combined with vehicle exhaust pollution.Correlation analysis of the chemical composition of the precipitation indicated that acidity in this region was determined by a combination of all acidic and neutralization ions rather than any single ion component.The results also showed that Na+ and Cl contributions were mainly by seawater;Mg 2+ by seawater and crustal materials;the NH 4+,K+,Ca 2+,NO 3 and SO 4 2 by anthropogenic sources;the trace metals were from the Earth's crust;and organic acids were potentially from combustion of biomass. | Yanli Cheng Ying Liu Mingqun Huo Qian Sun Huixiang Wang Zhongming Chen Yuhua Bai | 2011 | Journal of Environmental Sciences2011，23，8： | 8 |
| 7 | Construction of a chloroplast protein interaction network and functional mining of photosynthetic proteins in Arabidopsis thaliana显示文摘叶绿体是光合作用发生的一个典型植物细胞细胞器。在这研究,在 Arabidopsis thaliana 的 1 808 叶绿体核心蛋白质的一个总数被联合以前出版的研究和我们的自己的预言的结果可靠地识别。我们然后首先基于这些核心蛋白质相互作用构造了一个叶绿体蛋白质相互作用网络。网络有 22 包含了 2 的 925 蛋白质相互作用对 214 蛋白质。160 的一个总数以前, uncharacterized 蛋白质在这个网络被注解。光合的建筑群的子单元被模块化,并且在 photosystem 之中的功能的关系我(希腊语的第二十三个字母), photosystem II ( PSII ), photosystem 的轻收获建筑群我( LHC 我)并且 photosystem 的轻收获建筑群( LHC II )我能在这个网络从预言的蛋白质相互作用被推出。我们进一步由酵母证实了在未知蛋白质 AT1G52220 和光合的子单元 PSI-D2 之间的一个相互作用二混血儿的分析。我们的叶绿体蛋白质相互作用网络应该为光合的蛋白质的功能的采矿和在在 Arabidopsis 的系统生物学水平的叶绿体相关的函数的调查是有用的。 | Qing-Bo Yu Guang Li Guan Wang Jing-Chun Sun Peng-Cheng Wang Chen Wang Hua-Ling Mi Wei-Min Ma Jian Cui Yong-Lan Cui Kang Chong Yi-Xue Li Yu-Hua Li Zhongming Zhao Tie-LiuShi Zhong-Nan Yang | 2008 | Cell Research2008，18，10： | 4 |
| 8 | RP11-40C6.2 Inactivates Hippo Signaling by Attenuating YAP1 Ubiquitylation in Hepatitis B Virus-associated Hepatocellular Carcinoma显示文摘Background and Aims:Chronic hepatitis caused by hepatitis B virus(HBV)infection is a leading cause of hepatocellular carcinoma(HCC).We investigated the roles of oncogenic HBV infection-associated long noncoding RNAs in HCC.Methods:Bioinformatics analysis of data from the Cancer Genome Atlas(TCGA)was performed to screen potential oncogenic HBV-related lncRNAs.Next,we assessed their expression in clinical samples and investigated their correlation with clinical characteristics.The detailed oncogenic effects were analyzed by performing in vitro and in vivo studies.Results:RP11-40C6.2,an HBV infection-related lncRNA,was identified by analysis of the TCGA–Liver Hepatocellular Carcinoma database.Gene Set Enrichment Analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis of differentially expressed genes revealed a strong association of RP11-40C6.2 with the Hippo signaling pathway.RP11-40C6.2 was overexpressed in HCC patients with HBV infection compared to those without HBV infection.RP11-40C6.2 transcription showed a positive association with HBV-X protein(HBx),but not HBV core protein(HBc)expression,both of which are carcinogenic proteins.Luciferase gene reporter and ChIP assays revealed that YAP1/TAZ/TEADs complex enhanced RP11-40C6.2 transcription by binding to its promoter area.RP11-40C6.2 showed oncogenic characteristics in HCC cell lines and in animal models that were mediated via activation of YAP1.In vitro ubiquitylation assay revealed that RP11-40C6.2 can promote the stabilization of YAP1 by stopping phosphorylation at its s127 residue and further stopping its degradation through binding to 14-3-3.Conclusions:RP11-40C6.2 is an HBV infection-related lncRNA that exerts its oncogenic effects by targeting the Hippo signaling pathway. | Han Zhuo Chen Wu Junwei Tang Feihong Zhang Zhenggang Xu Dongwei Sun Yue Teng Zhongming Tan | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 3 |
| 9 | Comparative study of nuclear masses in the relativistic mean-field model显示文摘With experimental masses updated from AME11,the predictive power of relativistic mean-field(RMF) mass model is carefully examined and compared with HFB-17,FRDM,WS*,and DZ28 mass models.In the relativistic mean-field model,the calculation with the PC-PK1 has improved significantly in describing masses compared to the TMA,especially for the neutron-deficient nuclei.The corresponding rms deviation with respect to the known masses falls to 1.4 MeV.Furthermore,it is found that the RMF mass model better describes the nuclei with large deformations.The rms deviation for nuclei with the absolute value of quadrupole deformation parameter greater than 0.25 falls to 0.93,crossing the 1 MeV accuracy threshold for the PC-PK1,which may indicate the new model is more suitable for those largely-deformed nuclei.In addition,the necessity of new high-precision experimental data to evaluate and develop the nuclear mass models is emphasized as well. | HUA XueMin HENG TaiHua NIU ZhongMing SUN BaoHua GUO JianYou | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，12： | 3 |
| 10 | IL-17A Plays a Critical Role in the Pathogenesis of Liver Fibrosis through Hepatic Stellate Cell Activation显示文摘 | Zhongming Tan Xiaofeng Qian Runqiu Jiang Qianghui Liu Youjing Wang Chen Chen Xuehao Wang Bernhard Ryffel Beicheng Sun | 2013 | The Journal of Immunology2013，，4： | 2 |
| 11 | Construction of miRNA-mRNA network reveals crucial miRNAs and genes in acute myocardial infarction显示文摘Acute myocardial infarction(AMI)is a severe cardiovascular disease.This study aimed to identify crucial microRNAs(miRNAs)and mRNAs in AMI by establishing a miRNA-mRNA network.The microarray datasets GSE31568,GSE148153,and GSE66360 were downloaded from the Gene Expression Omnibus(GEO)database.We identified differentially expressed miRNAs(DE-miRNAs)and mRNAs(DE-mRNAs)in AMI samples compared with normal control samples.The consistently changing miRNAs in both GSE31568 and GSE148153 datasets were selected as candidate DE-miRNAs.The interactions between the candidate DE-miRNAs and DE-mRNAs were analyzed,and a miRNA-mRNA network and a protein-protein interaction network were constructed,along with functional enrichment and pathway analyses.A total of 209 DE-miRNAs in the GSE31568 dataset,857 DE-miRNAs in the GSE148153 dataset,and 351 DE-mRNAs in the GSE66360 dataset were identified.Eighteen candidate DE-miRNAs were selected from both the GSE31568 and GSE148153 datasets.Furthermore,miR-646,miR-127-5p,miR-509-5p,miR-509-3-5p,and miR-767-5p were shown to have a higher degree in the miRNA-mRNA network.THBS-1 as well as FOS was a hub gene in the miRNA-mRNA network and the protein-protein interaction(PPI)network,respectively.CDKN1A was important in both miRNA-mRNA network and PPI network.We established a miRNA-mRNA network in AMI and identified five miRNAs and three genes,which might be used as biomarkers and potential therapeutic targets for patients with AMI. | Kai Wang Zhongming Li Wenjie Ma Yan Sun Xianling Liu Lijun Qian Jian Hong Dasheng Lu Jing Zhang Di Xu | 2021 | The Journal of Biomedical Research2021，35，6： | 2 |
| 12 | Synthesis of Cu-In-S ternary nanocrystals with tunable structure and composition显示文摘 | Pan Daocheng An Lijia Sun Zhongming | | 0，，17： | 1 |
| 13 | Electrochemical detection of methyl-paraoxon based on bifunctional cerium oxide nanozyme with catalytic activity and signal amplification effect显示文摘A new electrochemical sensor for organophosphate pesticide(methyl-paraoxon)detection based on bifunctional cerium oxide(CeO_(2))nanozyme is here reported for the first time.Methyl-paraoxon was degraded into p-nitrophenol by using CeO_(2) with phosphatase mimicking activity.The CeO_(2) nanozymemodified electrode was then synthesized to detect p-nitrophenol.Cyclic voltammetry was applied to investigate the electrochemical behavior of the modified electrode,which indicates that the signal enhancement effect may attribute to the coating of CeO_(2) nanozyme.The current research also studied and discussed the main parameters affecting the analytical signal,including accumulation potential,accumulation time,and pH.Under the optimum conditions,the present method provided a wider linear range from 0.1 to 100 mmol/L for methyl-paraoxon with a detection limit of 0.06 mmol/L.To validate the proof of concept,the electrochemical sensor was then successfully applied for the determination of methyl-paraoxon in three herb samples,i.e.,Coix lacryma-jobi,Adenophora stricta and Semen nelumbinis.Our findings may provide new insights into the application of bifunctional nanozyme in electrochemical detection of organophosphorus pesticide. | Yuzhou Sun Jinchao Wei Jian Zou Zehua Cheng Zhongming Huang Liqiang Gu Zhangfeng Zhong Shengliang Li Yitao Wang Peng Li | 2021 | Journal of Pharmaceutical Analysis2021，11，5： | 1 |
| 14 | Se2 (B2O7 ): a new type of second-order nlomaterial 显示文摘 | KONG Fang HUANG Shuping SUN Zhongming | 2006 | J Am Chem Soc2006，128，24： | 1 |
| 15 | A scheme for pixel-scale aerodynamic surface temperature over hilly land显示文摘 | Min Wenbin Chen Zhongming Sun Linsheng | 2004 | Advances in Atmospheric Science2004，21，： | 1 |
| 16 | Influence of High Magnetic Field on Peritectic Transformation during Solidification of Bi-Mn Alloy显示文摘 | Ren Zhongming Li Xi Sun Yanhui | 2006 | Calphad2006，30，： | 1 |
| 17 | A scheme for pixel-scale aerodynamic surface temperature over hilly land 显示文摘 | Min Wenbin Chen Zhongming Sun Linsheng | 2004 | Advances in Atmospheric Science2004，21，： | 1 |
| 18 | High precision nuclear mass predictions towards a hundred kilo-electron-volt accuracy显示文摘Mass is a fundamental property and an important fingerprint of atomic nucleus.It provides an extremely useful test ground for nuclear models and is crucial to understand energy generation in stars as well as the heavy elements synthesized in stellar explosions.Nuclear physicists have been attempting at developing a precise,reliable,and predictive nuclear model that is suitable for the whole nuclear chart,while this still remains a great challenge even in recent days.Here we employ the Fourier spectral analysis to examine the deviations of nuclear mass predictions to the experimental data and to present a novel way for accurate nuclear mass predictions.In this analysis,we map the mass deviations from the space of nucleon number to its conjugate space of frequency,and are able to pin down the main contributions to the model deficiencies.By using the radial basis function approach we can further isolate and quantify the sources.Taking a pedagogical mass model as an example,we examine explicitly the correlation between nuclear effective interactions and the distributions of mass deviations in the frequency domain.The method presented in this work,therefore,opens up a new way for improving the nuclear mass predictions towards a hundred kilo-electron-volt accuracy,which is argued to be the chaos-related limit for the nuclear mass predictions. | Zhongming Niu Haozhao Liang Baohua Sun Yifei Niu Jianyou Guo Jie Meng | 2018 | Science Bulletin2018，63，12： | 1 |
| 19 | Construction of phylogenetic profiles based on the genetic distance of hundreds of genomes显示文摘 | Jingchun Sun and Zhongming Zhao | 2007 | ScienceDirect2007，355，3： | 1 |
| 20 | Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway显示文摘 | Qian Zhongming Li Hongyan Sun Hongzhe | 2002 | Pharmacol Rev2002，54，： | 1 |
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