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| 1 | Biomarkers for the early diagnosis of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the fifth most common cancer and the second leading cause of cancer-related deaths worldwide. Although the prognosis of patients with HCC is generally poor, the5-year survival rate is > 70% if patients are diagnosed at an early stage. However, early diagnosis of HCC is complicated by the coexistence of inflammation and cirrhosis. Thus, novel biomarkers for the early diagnosis of HCC are required. Currently, the diagnosis of HCC without pathological correlation is achieved by analyzing serum α.fetoprotein levels combined with imaging techniques. Advances in genomics and proteomics platforms and biomarker assay techniques over the last decade have resulted in the identification of numerous novel biomarkers and have improved the diagnosis of HCC. The most promising biomarkers,such as glypican-3, osteopontin, Golgi protein-73 and nucleic acids including microRNAs, are most likely to become clinically validated in the near future. These biomarkers are not only useful for early diagnosis of HCC, but also provide insight into the mechanisms driving oncogenesis. In addition, such molecular insight creates the basis for the development of potentially more effective treatment strategies. In this article,we provide an overview of the biomarkers that are currently used for the early diagnosis of HCC. | Nobuhiro Tsuchiya Yu Sawada Itaru Endo Keigo Saito Yasushi Uemura Tetsuya Nakatsura | 2015 | World Journal of Gastroenterology2015，21，37： | 72 |
| 2 | Endoscopic management for congenital esophageal stenosis: A systematic review显示文摘Congenital esophageal stenosis(CES) is an extremely rare malformation, and standard treatment have not been completely established. By years of clinical research, evidence has been accumulated. We conducted systematic review to assess outcomes of the treatment for CES, especially the role of endoscopic modalities. A total of 144 literatures were screened and reviewed. CES was categorized in fibromuscularthickening, tracheobronchial remnants(TBR) and membranous web, and the frequency was 54%, 30% and 16%, respectively. Therapeutic option includes surgery and dilatation, and surgery tends to be reserved for ineffective dilatation. An essential point is that dilatation for TBR type of CES has low success rate and high rate of perforation. TBR can be distinguished by using endoscopic ultrasonography(EUS). Overall success rate of dilatation for CES with or without case selection by using EUS was 90% and 29%, respectively. Overall rate of perforation with or without case selection was 7% and 24%, respectively. By case selection using EUS, high success rate with low rate of perforation could be achieved. In conclusion, endoscopic dilatation has been established as a primary therapy for CES except TBR type. Repetitive dilatation with gradual step-up might be one of safe ways to minimize the risk of perforation. | Keita Terui Takeshi Saito Tetsuya Mitsunaga Mitsuyuki Nakata Hideo Yoshida | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，3： | 8 |
| 3 | Hepatitis C virus enhances incidence of idiopathic pulmonary fibrosis显示文摘AIM: To investigate the cumulative development incidence and predictive factors for idiopathic pulmonary fibrosis in hepatitis C virus (HCV) positive patients. METHODS: We studied 6150 HCV infected patients who were between 40-70 years old (HCV-group). Another 2050 patients with hepatitis B virus (HBV) were selected as control (HBV-group). The mean observation period was 8.0 ± 5.9 years in HCV-group and 6.3 ± 5.5 years in HBV-group. The primary goal is the development of idiopathic pulmonary fibrosis (IPF) in both groups. The cumulative appearance rate of IPF and independent factors associated with the incidence rate of IPF were calculated using the Kaplan- Meier method and the Cox proportional hazard model. All of the studies were performed retrospectively by collecting and analyzing data from the patient records in our hospital. RESULTS: Fifteen patients in HCV-group developedIPF. On the other hand, none of the patients developed IPF in HBV-group. In HCV-group, the cumulative rates of IPF development were 0.3% at 10th year and 0.9% at 20th year. The IPF development rate in HCV-group was higher than that in HBV-group (P = 0.021). The IPF development rate in patients with HCV or HBV was high with statistical significance in the following cases: (1) patients ≥ 55 years (P < 0.001); (2) patients who had smoking index (package per day × year) of ≥ 20 (P = 0.002); (3) patients with liver cirrhosis (P = 0.042). CONCLUSION: Our results indicate that age, smoking and liver cirrhosis enhance the development of IPF in HCV positive patients. | Yasuji Arase Fumitaka Suzuki Yoshiyuki Suzuki Norio Akuta Masahiro Kobayashi Yusuke Kawamura Hiromi Yatsuji Hitomi Sezaki Tetsuya Hosaka Miharu Hirakawa Satoshi Saito Kenji Ikeda Hiromitsu Kumada | 2008 | World Journal of Gastroenterology2008，14，38： | 8 |
| 4 | A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells显示文摘 | Toshiaki Teratani Kengo Tomita Takahiro Suzuki Tetsuya Oshikawa Hirokazu Yokoyama Katsuyoshi Shimamura Susumu Tominaga Sadayuki Hiroi Rie Irie Yoshikiyo Okada Chie Kurihara Hirotoshi Ebinuma Hidetsugu Saito Ryota Hokari Kazuo Sugiyama Takanori Kanai Soich | 2012 | Gastroenterology2012，，1： | 2 |
| 5 | Effect of type 2 diabetes on risk for malignancies includes hepatocellular carcinoma in chronic hepatitis C显示文摘 | Yasuji Arase Mariko Kobayashi Fumitaka Suzuki Yoshiyuki Suzuki Yusuke Kawamura Norio Akuta Masahiro Kobayashi Hitomi Sezaki Satoshi Saito Tetsuya Hosaka Kenji Ikeda Hiromitsu Kumada Tetsuro Kobayashi | 2013 | Hepatology2013，，3： | 2 |
| 6 | Prevalence of hepatitis C virus variants resistant to NS3 protease inhibitors or the NS5A inhibitor (BMS-790052) in hepatitis patients with genotype 1b显示文摘 | Fumitaka Suzuki Hitomi Sezaki Norio Akuta Yoshiyuki Suzuki Yuya Seko Yusuke Kawamura Tetsuya Hosaka Masahiro Kobayashi Satoshi Saito Yasuji Arase Kenji Ikeda Mariko Kobayashi Rie Mineta Sachiyo Watahiki Yuzo Miyakawa Hiromitsu Kumada | 2012 | Journal of Clinical Virology2012，，4： | 2 |
| 7 | Impact of CYP3A4 haplotypes on irinotecan pharmacokinetics in Japanese cancer patients显示文摘 | Kimie Sai Yoshiro Saito Hiromi Fukushima-Uesaka Koichi Kurose Nahoko Kaniwa Naoyuki Kamatani Kuniaki Shirao Noboru Yamamoto Tetsuya Hamaguchi Hideo Kunitoh Yuichiro Ohe Tomohide Tamura Yasuhide Yamada Hironobu Minami Atsushi Ohtsu Teruhiko Yoshida Nagahir | 2008 | Cancer Chemotherapy and Pharmacology2008，，3： | 1 |
| 8 | Bacteria closely resemblingHelicobacter pylori detected immunohistologically and genetically in resected gallbladder mucosa显示文摘 | Minoru Kawaguchi Toshihiko Saito Hiroyuki Ohno Shoko Midorikawa Tetsuya Sanji Yutaka Handa Shigefumi Morita Hajime Yoshida Mitsuji Tsurui Ryoichi Misaka Teruyuki Hirota Mitsuo Saito Kohei Minami | 1996 | Journal of Gastroenterology1996，，2： | 1 |
| 9 | Production of Nitric Oxide,but Not Prostacyclin,Is Reduced in Klotho Mice显示文摘 | Tetsuya Nakamura Yuichiro Saito Yoshio Ohyama | 2002 | The Japanese Journal of Pharmacology2002，89，2： | 1 |
| 10 | Expression of EphA2 and E-cadherin in colorectal cancer: Correlationwith cancer metastasis显示文摘 | Tetsuya Saito Norihiro Masuda Tatsuya Miyazaki Kenichi Kanoh Hideki Suzuki Tatsuo Shimura Takayuki Asao Hiroyuki Kuwano | 2004 | Oncology Reports2004，，3： | 1 |
| 11 | VopV, an F-Actin-Binding Type III Secretion Effector, Is Required for Vibrio parahaemolyticus -Induced Enterotoxicity显示文摘 | Hirotaka Hiyoshi Toshio Kodama Kazunobu Saito Kazuyoshi Gotoh Shigeaki Matsuda Yukihiro Akeda Takeshi Honda Tetsuya Iida | 2011 | Cell Host & Microbe2011，，4： | 1 |
| 12 | 转型中的亚洲林业显示文摘在过去的20年里,亚洲林业经历了引人注目的转型,包括从计划经济到市场经济的转变,从天然林供给木材到人工林供给木材的转变,木材替代品与非木质林产品的增加,地方分权与当地群众的参与,生态时代的发展与生态系统管理。在促进亚洲可持续森林资源管理中,市场工具、社区参与和环境服务都得到了应用。亚洲林业的转型表现出多样化,其森林、社会与环境之间的联系是丰富多彩的。 | 刘璨(校) Maxim Lobovikov Daniel Murdiyarso Hiroyasu Oka Yeo-Chang Youn Keith Barney Makoto Inoue Hariadi Kartodihardjo Pia Katila Tetsuya Saito Bintang Simangunsong Yasuhiro Yokota 吕金芝(译) 林海燕(译) | 2005 | 绿色中国(理论版)2005，，09M： | 1 |
| 13 | Successful treatment of severe refractory anastomotic stricture in an infant after esophageal atresia repair by endoscopic balloon dilation combined with systemic administration of dexamethasone显示文摘 | Tomoro Hishiki Katsunori Kouchi Takeshi Saito Keita Terui Yoshiharu Sato Tetsuya Mitsunaga Mitsuyuki Nakata Hideo Yoshida | 2009 | Pediatric Surgery International2009，，6： | 1 |
| 14 | Multiplex real-time PCR assays for the detection of group C rotavirus, astrovirus, and Subgenus F adenovirus in stool specimens显示文摘 | Kohji Mori Yukinao Hayashi Tetsuya Akiba Miyuki Nagano Tatsuya Tanaka Mitsugu Hosaka Akiko Nakama Akemi Kai Kengo Saito Hiroshi Shirasawa | 2013 | Journal of Virological Methods2013，，2： | 1 |
| 15 | Rosuvastatin Improves Plaque Morphology in Cerebral Embolism Patients with Normal Low-Density Lipoprotein and Severe Aortic Arch Plaque显示文摘 | Kazuyoshi Kaneko Hiroki Saito Tetsuya Takahashi Nobuyuki Kiribayashi Koki Ohmi Toshiki Sasaki Takeshi Niizeki Shigeo Sugawara Masahiro Akasaka Isao Kubota | 2014 | Journal of Stroke and Cerebrovascular Diseases2014，，： | 1 |
| 16 | High Yield Synthesis and Characterization of the Structural and Magnetic Properties of Crystalline ErCl_(3) Nanowires in Single-Walled Carbon Nanotube Templates显示文摘Crystalline ErCl_(3) nanowires have been fabricated in single-walled carbon nanotubes(SWCNTs)with high yield(~90%),and the structural and magnetic properties of the resulting ErCl_(3) nanowires encapsulated in SWCNTs(ErCl_(3)@SWCNTs)characterized.Encapsulation under high temperature and vacuum using high quality SWCNTs results in a high fi lling-ratio of ErCl_(3) nanowires in the SWCNTs.The high fi lling-ratio of ErCl_(3) nanowires and the use of highly pure SWCNTs with only a small amount of residual Fe catalyst nanoparticles enabled us to observe the magnetic properties of ErCl_(3)@SWCNTs.Structure determination based on simulated annealing calculations and high-resolution transmission electron microscope(HRTEM)image simulations revealed that the structure of the ErCl_(3) nanowires is unusual with respect to the coordination environment of the Eu3+ions.This work opens up new possibilities to fabricate various metal complex nanowires with high yield and may also be of more general importance in understanding and exploring magnetic properties in low-dimensional magnetic systems. | Ryo Kitaura Daisuke Ogawa keita Kobayashi Takeshi Saito Satoshi Ohshima Tetsuya Nakamura Hirofumi Yoshikawa Kunio Awaga Hisanori Shinohara | 2008 | Nano Research2008，1，2： | 1 |
| 17 | A 402-output TFT-LCD driver IC with power control based on the number of colors selected显示文摘 | Itakura Tetsuro Minamizaki Hionori Saito Tetsuya | 2003 | IEEE J Solid-state Circuits2003，38，3： | 1 |
| 18 | Vascular endothelial growth factor-D is a key molecule that enhances lymphatic metastasis of soft tissue sarcomas显示文摘 | Takashi Yanagawa Tetsuya Shinozaki Hideomi Watanabe Kenichi Saito Avraham Raz Kenji Takagishi | 2012 | Experimental Cell Research2012，，7： | 1 |
| 19 | A case of blue rubber bleb nevus syndrome treated by etidronate显示文摘 | Hirofumi Kishikawa Yosuke Okada Tetsuya Kawahara Kazuyoshi Saito Yoshiya Tanaka | | 0，，： | 1 |
| 20 | Eradication of insulin resistance显示文摘 | Junta Imai Tetsuya Yamada Tokuo Saito Yasushi Ishigaki Yoshinori Hinokio Hidetoshi Kotake Yoshitomo Oka Hideki Katagiri | 2009 | The Lancet2009，，9685： | 1 |
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