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| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | 牛体内重组牛生长激素(rbST)的快速高灵敏度检测显示文摘重组牛生长激素(rbST)在一些国家和地区常被作为猪或牛的生长促进剂(用于乳牛可以增加牛奶产量),但在欧盟国家,有法规明确禁止生长激素的使用。重组牛生长激素本身是蛋白质,在生物基质中的浓度较低,且样品基质十分复杂,对其进行有效分析还存在一定难度,因而,长久以来其分析方法一直局限为酶联免疫检测法。 | Gaud Pinel Sandrine Roulet-Rochereau ylvain Chéreau Fabrice Monteau Bruno Le Bizec Paul Silcock Marie-Hélène Le Breton | 2010 | 食品安全导刊2010，，8： | 2 |
| 3 | Soluble CD40 ligand in prediction of acute severe pancreatitis显示文摘瞄准:在胰腺炎严厉估计可溶的 CD40L (sCD40L ) 的早可预测性。方法:在 2000 年 2 月和 2003 年 2 月之间,有尖锐胰腺炎的 279 个连续病人有希望地在我们的学习被注册。在这份报告, 40 个病人与温和并且有严重胰腺炎的 40 个病人随机被学习。sCD40L 集中被测量在承认以后的 48 个小时。结果:sCD40L 层次显著地更高在在严重胰腺炎的承认以后的 48 个小时比在温和胰腺炎。用 1000 的截止,检测疾病的一堂严重功课的 sCD40L 的 pg/L,敏感和特性为 CRP 与 72% 和 81% 相比分别地是 78% 和 62% 。发现那 CRP 的逻辑回归分析统计上是唯一的能检测疾病的一堂严重功课的重要标记。结论:这些调查结果显示 CRP 仍然是一个珍贵标记而 sCD40L 层次应该在进一步的研究被估计,决定尖锐胰腺炎的严厉和预后。 | Jean Louis Frossard Philippe Morel Brenda Kwak Catherine Pastor Thierry Berney Léo Buhler Alain Von Laufen Sandrine Demulder Francois Mach | 2006 | World Journal of Gastroenterology2006，12，10： | 2 |
| 4 | The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system显示文摘 | Sandrine Funes Joseph A Hedrick Galya Vassileva Lisa Markowitz Susan Abbondanzo Andrei Golovko Shijun Yang Frederick J Monsma Eric L Gustafson | 2003 | Biochemical and Biophysical Research Communications2003，，： | 2 |
| 5 | The copper/plasmapolymerized octofluorocyclobutane interface 显示文摘 | Silberstein M S Sandrin L Sacher E | 2001 | Polymer2001，42，： | 1 |
| 6 | Transient elastography : a new noninvasive method for assessment of hepatic fibrosis 显示文摘 | Sandrin L Fourquet B Hasquenoph JM | 2003 | Ultrasound in medicine & biology2003，29，12： | 1 |
| 7 | Transient elastography: A new noninvasive method for assessment of hepatic fibrosis 显示文摘 | Sandrin L Fourquet B Hasquenoph JM | 2003 | Ultrasound in Medicine and Biology2003，29，12： | 1 |
| 8 | Transient elastography: a new noninvasive method for assessment of hepatic fibrosis 显示文摘 | Sandrin L Fourquet B Hasquenoph JM | 2003 | Ultrasound Med Biol2003，29，3： | 1 |
| 9 | Circadian Timing in Cancer Treatments显示文摘 | Francis L' evi Alper Okyar Sandrine Dulong | 2010 | Annu Rev Pharmacol Toxi- col2010，50，： | 1 |
| 10 | Transient elaslography: a new noninvasive method for assessment of hepatic fibrosis显示文摘 | Sandrin L Fourquet B Hasquenoph JM | 2003 | Uhrasound MedBiol2003，29，12： | 1 |
| 11 | Transient elastography: a new noninvasive method for assessment of hepatic fibrosis 显示文摘 | Sandrin L Fourquet B Hasquenoph JM | 2003 | Ultrasound Med Bid2003，29，12： | 1 |
| 12 | Transientelastography:a new noninvasive method for assessment ofhepaticfibrosis显示文摘 | Sandrin L Fourquet B Hasquenoph JM | 2003 | UltrasoundMed Biol2003，29，12： | 1 |
| 13 | Liver Stiffness Measurement in Children Using FibroScan: Feasibility Study and Comparison With Fibrotest, Aspartate Transaminase to Platelets Ratio Index, and Liver Biopsy显示文摘 | Victor de Lédinghen Brigitte Le Bail Laurent Rebouissoux Céline Fournier Juliette Foucher Véronique Miette Laurent Castéra Laurent Sandrin Wassil Merrouche Frédéric Lavrand Thierry Lamireau | 2007 | Journal of Pediatric Gastroenterology and Nutrition2007，，4： | 1 |
| 14 | Immobilization of silver in polypyrrole/polyanionmposite coatings:Preparation,characterization,antibacterial activity显示文摘 | MILENA I DAVID L SANDRINE L | 2003 | Langmuir2003，19，3： | 1 |
| 15 | The chaperoning and assistance roles of the HIV-1 nucleocapsid protein in proviral DNA synthesis and maintenance显示文摘 | CAROLE B SANDRINE J DANIELA L | 2004 | Int J Biochem Cell Biol2004，36，： | 1 |
| 16 | Near-perfect elastoplasticity in pure nanocrystalline copper 显示文摘 | Yannick C Cyril L Sandrine G M | 2003 | Science2003，300，56： | 1 |
| 17 | A long-term Copper exposure on freshwater ecosystem using lotic mesocosms:Primary producer community responses显示文摘 | HéLèNE R LO(I)C T H Sandrine J | 2007 | Aquatic Toxicology2007，81，2： | 1 |
| 18 | Detection of recombinant bovine somatotropin in milk and effect of industrial processes on its stability显示文摘 | Marie-Hélène Le Breton Andrea Beck-Henzelin Janique Richoz-Payot Sandrine Rochereau-Roulet Gaud Pinel Thierry Delatour Bruno Le Bizec | 2010 | Analytica Chimica Acta2010，，1： | 1 |
| 19 | Transient elastography: a new noninvasive method for assessment of hepatic fibrosis 显示文摘 | Sandrin L Fourquet B Hasquenoph JM | 2003 | Ultrasound Med Biol2003，29，12： | 1 |
| 20 | Transient elastography:a new noninvasive method for assessment of hepatic fibrosis显示文摘 | Sandrin L Fourquet B Hasquenoph JM | | 0，，： | 1 |
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