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| 1 | miR-221/222 activate the Wnt/β-catenin signaling to promote triple-negative breast cancer显示文摘 | Sanhong Liu Zifeng Wang Zukai Liu Shuo Shi Zhaoran Zhang Jiawei Zhang Haifan Lin | 2018 | Journal of Molecular Cell Biology2018，10，4： | 16 |
| 2 | Exosomal piRNA profiling revealed unique circulating piRNA signatures of cholangiocarcinoma and gallbladder carcinoma显示文摘Cholangiocarcinoma(CCA)and gallbladder carcinoma(GBC)are biliary tract cancers with poor five-year survival and high recurrence rates.Both CCA and GBC patients suffer from lack of circulating diagnostic biomarkers at the early stage.Extracellular vesicles,especially exosomes,have been emerged as promising diagnostic sources for cancers due to easy and quick accessibility.Hence,identification of exosomal biomarkers provides a novel strategy for CCA and GBC diagnosis.Here,five CCA patients and four GBC patients were enrolled for exosomal small RNA sequencing.Our data showed that exosomal piwi-interacting RNA(piRNA)populations were altered in the plasma of CCA and GBC patients.In comparison to healthy individuals,694 and 323 piRNAs were upregulated in CCA and GBC,respectively,while 36 and 191 piRNAs were down regulated.Interestingly,sequencing results predicted that piR-2660989,piR-10506469,piR-20548188,piR-10822895,piR-hsa-23209,and piR-18044111 were upregulated in both CCA and GBC plasma.Importantly,we further included blood samples from 50 health individuals,40 CCA patients,and 25 GBC patients and found that piR-10506469 were significantly increased in the exosomes of plasma from both CCA and GBC patients.Moreover,we analyzed the expression levels of differentially expressed exosomal piRNAs in the plasma of CCA and GBC patient before and after surgeries and found that piR-10506469 and piR-20548188 were significantly decreased in patients underwent surgeries.Taken together,our data revealed that exosomal piRNAs those are differentially expressed in CCA and GBC plasma may serve as potential biomarkers for the diagnosis of CCA and GBC. | Xinjin Gu Chen Wang Hui Deng Chong Qing Rong Liu Sanhong Liu Xinying Xue | 2020 | Acta Biochimica et Biophysica Sinica2020，52，5： | 7 |
| 3 | The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation显示文摘Interleukin(IL)17-producing T helper(Th17)cells play critical roles in the clearance of extracellular bacteria and fungi as well as the pathogenesis of various autoimmune diseases,such as multiple sclerosis,psoriasis,and ulcerative colitis.Although a global transcriptional regulatory network of Th17 cell differentiation has been mapped recently,the participation of epigenetic modifications in the differentiation process has yet to be elucidated.We demonstrated here that histone H3 lysine-27(H3K27)demethylation,predominantly mediated by the H3K27 demethylase Jmjd3,crucially regulated Th17 cell differentiation.Activation of naı¨ve CD41 T cells immediately induced high expression of Jmjd3.Genetic depletion of Jmjd3 in CD41 T cells specifically impaired Th17 cell differentiation both in vitro and in vivo.Ectopic expression of Jmjd3 largely rescued the impaired differentiation of Th17 cells in vitro in Jmjd3-deficientCD41 T cells.Importantly,Jmjd3-deficient mice were resistant to the induction of experimental autoimmune encephalomyelitis(EAE).Furthermore,inhibition of the H3K27 demethylase activity with the specific inhibitor GSK-J4 dramatically suppressed Th17 cell differentiation in vitro.At the molecular level,Jmjd3 directly bound to and reduced the level of H3K27 trimethylation(me3)at the genomic sites ofRorc,which encodes the masterTh17 transcription factorRorgt,and Th17 cytokine genes such as Il17,Il17f,and Il22.Therefore,our studies established acritical role of Jmjd3-mediatedH3K27demethylation inTh17 cell differentiation andsuggest that Jmjd3 can be a novel therapeutic target for suppressing autoimmune responses. | Zhi Liu Wei Cao Longxia Xu Xi Chen Yu Zhan Qian Yang Sanhong Liu Pengfei Chen Yuhang Jiang Xiaohua Sun Yu Tao Yiming Hu Cuifeng Li Qi Wang Ying Wang Charlie Degui Chen Yufang Shi Xiaoren Zhang | 2015 | Journal of Molecular Cell Biology2015，7，6： | 6 |
| 4 | Elevating H3K27me3 level sensitizes colorectal cancer to oxaliplatin显示文摘Histone methylation is a context-dependent modification that regulates gene expression,and the trimethylation of histone H3 lysine 27(H3K27me3)usually induces gene silencing.Overcoming colorectal cancer(CRC)chemoresistance is currently a huge challenge,but the relationship between H3K27me3 modification and chemoresistance remains largely unclear.Here,we found that H3K27me3 levels positively correlated with the metastasis-free survival of CRC patients and a low H3K27me3 level predicted a poor outcome upon chemotherapeutic drug treatment.Oxaliplatin stimulation significantly induced the expression of H3K27 lysine demethylase 6A/6B(KDM6A/6B),thus decreasing the level of H3K27me3 in CRC cells.Elevation of H3K27me3 level through KDM6A/6B depletion or GSK-J4(a KDM6A/6B inhibitor)treatment significantly enhanced oxaliplatin-induced apoptosis.Conversely,when inhibiting the expression of H3K27me3 by EPZ-6438,an inhibitor of the histone methyltransferase EZH2,the proportion of apoptotic cells remarkably decreased.In addition,the combination of GSK-J4 and oxaliplatin significantly inhibited tumor growth in an oxaliplatin-resistant patient-derived xenograft model.Importantly,we revealed that oxaliplatin treatment dramatically induced NOTCH2 expression,which was caused by downregulation of H3K27me3 level on the NOTCH2 transcription initiation site.Thus,the activated NOTCH signaling promoted the expression of stemness-related genes,which resulted in oxaliplatin resistance.Furthermore,oxaliplatin-induced NOTCH signaling could be interrupted by GSK-J4 treatment.Collectively,our findings suggest that elevating H3K27me3 level can improve drug sensitivity in CRC patients. | Qi Wang Xi Chen Yuhang Jiang Sanhong Liu Hanshao Liu Xiaohua Sun Haohao Zhang Zhi Liu Yu Tao Cuifeng Li Yiming Hu Dandan Liu Deji Ye Yongzhong Liu Mingliang Wang Xiaoren Zhang | 2020 | Journal of Molecular Cell Biology2020，12，2： | 6 |
| 5 | Exosomal miRNA profiling before and after surgery revealed potential diagnostic and prognostic markers for lung adenocarcinoma显示文摘Exosome is a crucial manner for cancer cell to cell communication and circulating exosomes sever as promising diagnostic and prognostic markers for various types of diseases.A predominant type of cargo of exosome is small RNAs,especially miRNAs.Here,we profiled plasma exosomal miRNAs of six lung adenocarcinoma patients before and after surgery,as well as six healthy individuals as normal control.Our profiling revealed 38 upregulated and 37 downregulated exosomal miRNAs in the plasma of lung adenocarcinoma patients.Additionally,we found that most upregulated miRNAs were increased in the lung adenocarcinoma samples of TCGA database.We further evaluated the correlation between the upregulated exosomal miRNAs and overall survival with Kaplan-Meier survival analysis using online databases.Our resu ltS suggested that exosomal miR-151a-5p,miR-10b-5p,miR-192-5p,miR-106b-3p,and miR-484 are potential prognostic markers for lung adenocarcinoma.Importantly,we validated candidate miRNAs in lung adenocarcinoma patients before and after surgery as well as in healthy controls and found that miR-484 was significantly increased in the plasma of lung adenocarcinoma patients and strikingly decreased post-surgery.Hence,we provided novel information on lung adenocarcinoma-derived exosomal miRNA and potential non-invasive diagnostic and prognostic markers for lung adenocarcinoma. | Xinying Xue Chen Wang Zhiqiang Xue Jiaxin Wen Jun Han Xidong Ma Xuelei Zang Hui Deng Rui Guo Idorenyin Polycarp Asuquo Chong Qin Haijiao Wang Quansheng Gao Sanhong Liu Jianxin Wang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，3： | 6 |
| 6 | miR-27 inhibits adipocyte differentiation via suppressing CREB expression显示文摘miR-27 在 adipogenesis 的规定起一个否定作用。然而,分子的机制尚待是 clarified.In 现在的学习,我们发现 miR-27 由镇压部分禁止 adipogenesis 由直接指向它的 3 untranslated 区域的早 adipogenic transcriptionfactor 营地反应元素绑定蛋白质。另外,我们 demonstratedthat 肿瘤坏死因素 --(TNF-) 通过 NF-B 小径的处理起来调整 miR-27。而且, anti-miR-27 reducesthe TNF -- adipogenesis 的导致的抑制。同时, miR-27 表示的层次在成熟 adipocytesof 被减少肥胖的老鼠什么时候与瘦老鼠相比。我们的数据在 adipogenesis 的规定揭示了 miR-27 的新奇机制。 | Yingjie Zhu Xiaodong Zhang Xingpo Ding Huichao Wang Xiantao Chen Hanzheng Zhao Yudong Jia Sanhong Liu Youwen Liu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，7： | 5 |
| 7 | Bruceine D inhibits HIF-1α-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT/β-catenin interaction显示文摘Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-related deaths,characterized by highly hypoxic tumor microenvironment.Hypoxia-inducible factor-1α(HIF-1α)is a major regulator involved in cellular response to changes of oxygen levels,supporting the adaptation of tumor cells to hypoxia.Bruceine D(BD)is an isolated natural quassinoid with multiple anti-cancer effects.Here,we identified BD could significantly inhibit the HIF-1α expression and its subsequently mediated HCC cell metabolism.Using biophysical proteomics approaches,we identified inhibitor of β-catenin and T-cell factor(ICAT)as the functional target of BD.By targeting ICAT,BD disrupted the interaction of bcatenin and ICAT,and promoted β-catenin degradation,which in turn induced the decrease of HIF-1α expression.Furthermore,BD could inhibit HCC cells proliferation and tumor growth in vivo,and knockdown of ICAT substantially increased resistance to BD treatment in vitro.Our data highlight the potential of BD as a modulator of β-catenin/HIF-1α axis mediated HCC metabolism. | Rui Huang Lijun Zhang Jinmei Jin Yudong Zhou Hongwei Zhang Chao Lv Dong Lu Ye Wu Hong Zhang Sanhong Liu Hongzhuan Chen Xin Luan Weidong Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 4 |
| 8 | Non-equilibrium segregation of solute to grain boundary显示文摘 | Sanhong Zhang Xinlai He T. Ko | 1994 | Journal of Materials Science1994，，10： | 1 |
| 9 | Molecular characteristics of S-RNase alleles as the determ inant of self-i ncompatibility in the style of Fragaria viridi显示文摘Strawberry(Fragaria spp.)is a member of the Rosoideae subfamily in the family Rosaceae.The self-incompatibility(SI)of some diploid species is a key agronomic trait that acts as a basic pollination barrier;however,the genetic mechanism underlying SI control in strawberry remains unclear.Two candidate S-RNases(S a-and S^-RNase)identi fi ed in the transcriptome of the styles of the self-incompatible Fragaria viridis 42 were con fi rmed to be SI determinants at the S locus following genotype identi fi cation and intraspeci fi c hybridization using sel fi ng progenies.Whole-genome collinearity and RNase T2 family analysis revealed that only an S locus exists in Fragaria;however,none of the compatible species contained S-RNase.Although the results of interspeci fi c hybridization experiments showed that F.viridis(SI)styles could accept pollen from F.mandshurica(self-compatible),the reciprocal cross was incompatible.S a and S b-RNase contain large introns,and their noncoding sequences(promotors and introns)can be transcribed into long noncoding RNAs(lncRNAs).Overall,the genus Fragaria exhibits S-RNase-based gametophytic SI,and S-RNase loss occurs at the S locus of compatible germplasms.In addition,a type of SI-independent unilateral incompatibility exists between compatible and incompatible Fragaria species.Furthermore,the large introns and neighboring lncRNAs in S-RNase in Fragaria could offer clues about S-RNase expression strategies. | Jianke Du Chunfeng Ge Tingting Li Sanhong Wang Zhihong Gao Hidenori Sassa Yushan Qiao | 2021 | Horticulture Research2021，8，1： | 1 |
| 10 | The effects of whole mushrooms during inflammatinn显示文摘 | YU Sanhong WEAVER V MARTIN K | 2009 | BMC Immtmol2009，，10： | 1 |
| 11 | Ferrite Nucleation at Ceramic/Austenite Interfaces显示文摘 | Sanhong Zhang Nobuyuki Hattori Masato Enomoto | 1996 | ISIJ International1996，，10： | 1 |
| 12 | BEHAVIOUR OF VACANCY INFLUENCE DURING DIFFUSION IN METALS显示文摘The effects of vacancies on diffusion of interstitial and substitutional atoms as well asinteraction between them in metals were discussed.In the interstitial alloy,a coupling betweeninterstitial atoms and vacancy is interrelated through the reaction of formation anddissociation of complex.For substitutional alloy with |E_b|<kT,if the atom diffusion is of thevacancies exchange mechanism,the vacancies may considerably affect atom diffusion.Basedon the micromechanism of diffusion in these two alloys,their diffusion equations under generalcondition may be obtained,and the second Fick’ s law is only an approximate form when neg-lecting vacancy influence. | ZHANG Sanhong HE Xinlai CHU Youyi KE Jun (T.Ko) University of Science and Technology Beijing,China Doctor,Department of Materials Physics,University of Science and Technology Beijing,Beijing 100083 | 1992 | Acta Metallurgica Sinica(English Letters)1992，5，6： | 1 |
| 13 | CitationAS: A Tool of Automatic Survey Generation Based on Citation Content显示文摘Purpose: This study aims to build an automatic survey generation tool, named CitationAS, based on citation content as represented by the set of citing sentences in the original articles.Design/methodology/approach: Firstly, we apply LDA to analyse topic distribution of citation content. Secondly, in CitationAS, we use bisecting K-means, Lingo and STC to cluster retrieved citation content. Then Word2Vec, Word Net and combination of them are applied to generate cluster labels. Next, we employ TF-IDF, MMR, as well as considering sentence location information, to extract important sentences, which are used to generate surveys. Finally, we adopt manual evaluation for the generated surveys.Findings: In experiments, we choose 20 high-frequency phrases as search terms. Results show that Lingo-Word2Vec, STC-Word Net and bisecting K-means-Word2Vec have better clustering effects. In 5 points evaluation system, survey quality scores obtained by designing methods are close to 3, indicating surveys are within acceptable limits. When considering sentence location information, survey quality will be improved. Combination of Lingo, Word2Vec, TF-IDF or MMR can acquire higher survey quality.Research limitations: The manual evaluation method may have a certain subjectivity. We use a simple linear function to combine Word2Vec and Word Net that may not bring out their strengths. The generated surveys may not contain some newly created knowledge of some articles which may concentrate on sentences with no citing.Practical implications: CitationAS tool can automatically generate a comprehensive, detailed and accurate survey according to user's search terms. It can also help researchers learn about research status in a certain field.Originality/value: Citaiton AS tool is of practicability. It merges cluster labels from semantic level to improve clustering results. The tool also considers sentence location information when calculating sentence score by TF-IDF and MMR. | jie wang chengzhi zhang mengying zhang sanhong deng | 2018 | Journal of Data and Information Science2018，3，2： | 1 |
| 14 | Preparation and properties of multilayer pyroelectric thin film infrared detectors显示文摘 | Wang Sanhong Wu Xiaoqing Li Bo | 2001 | Ferroelectrics2001，263，： | 1 |
| 15 | Ferrite Nucleation at Ceramic/Austenite Interfaces显示文摘 | Sanhong ZHANG | 1996 | ISIJ Int1996，，： | 1 |
| 16 | Circulating miR-221/222 reduces CD4^(+) T cells by inhibiting CD4 expression in colorectal cancer显示文摘Many patients with cancers have low levels of CD4+in their peripheral blood.However,the molecular mechanism is still unclear.Here,we found that the blood levels of miR-221 and miR-222 were dramatically increased in patients with colorectal cancer(CRC),and both circulating miR-211 and miR-222 served as sensitive diagnostic markers with an area under the curve of 0.8790 and 0.9148,respectively.Transfection of either miR-221 or miR-222 resulted in the reduction of the surface CD4 antigen level but not the surface CD8 antigen level.The luciferase reporter assay showed that miR-221/222 directly regulated CD4 expression in human primary T cells.These data showed that miR-221/222 levels were upregulated in the blood of patients with CRC and that the expression of CD4 in human primary T cells was inhibited by miR-221/222.These findings provide a novel strategy for modulating the number of CD4+T cells in the blood and further adjusting the microenvironment suitable for immunotherapy. | Jiajia Hu Jiawei Zhang Meng Yu Zukai Liu Yan Zou Liwen Hong Tianyu Zhang Jing Sun Minhua Zheng Xuekai Zhu Zhengting Wang Sanhong Liu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，10： | 1 |
| 17 | Non-equilibrium segregation of solutes to grain boundary显示文摘 | Sanhong Zhang Xinlai He T. Ko | 1994 | Journal of Materials Science1994，，10： | 1 |
| 18 | Progress in genome and methonogenesis of methanogens 显示文摘 | SHAN Liwei FENG Guiying FAN Sanhong | 1976 | Journal of Mierobiol1976，22，： | 1 |
| 19 | Co-ordinate expression of glycine betaine synthesis genes linked by the FMDV 2A region in a single open reading frame in Pichia pastoris显示文摘 | Sanhong Wang Quanhong Yao Jianmin Tao Yushan Qiao Zhen Zhang | 2007 | Applied Microbiology and Biotechnology2007，，4： | 1 |
| 20 | Innate immunity in the lung regulates the development of asthma显示文摘 | Rosemarie H. DeKruyff Sanhong Yu Hye Young Kim Dale T. Umetsu | 2014 | Immunol Rev2014，，1： | 1 |
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