|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Interventional treatment for unresectable hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the sixth most common cancer and third leading cause of cancer-related death in the world. The Barcelona clinic liver cancer classification is the current standard classification system for the clinical management of patients with HCC and suggests that patients with intermediate-stage HCC benefit from transcatheter arterial chemoembolization(TACE). Interventional treatments such as TACE, balloon-occluded TACE, drug-eluting bead embolization, radioembolization, and combined therapies including TACE and radiofrequency ablation, continue to evolve, resulting in improved patient prognosis. However, patients with advanced-stage HCC typically receive only chemotherapy with sorafenib, a multi-kinase inhibitor, or palliative and conservative therapy. Most patients receive palliative or conservative therapy only, and approximately 50% of patients with HCC are candidatesfor systemic therapy. However, these patients require therapy that is more effective than sorafenib or conservative treatment. Several researchers try to perform more effective therapies, such as combined therapies(TACE with radiotherapy and sorafenib with TACE), modified TACE for HCC with arterioportal or arteriohepatic vein shunts, TACE based on hepatic hemodynamics, and isolated hepatic perfusion. This review summarizes the published data and data on important ongoing studies concerning interventional treatments for unresectable HCC and discusses the technical improvements in these interventions, particularly for advanced-stage HCC. | Satoru Murata Takahiko Mine Fumie Sugihara Daisuke Yasui Hidenori Yamaguchi Tatsuo Ueda Shiro Onozawa Shin-ichiro Kumita | 2014 | World Journal of Gastroenterology2014，20，37： | 38 |
| 2 | Evaluation of the relationship between hepatocellular carcinoma location and transarterial chemoembolization efficacy显示文摘AIM To evaluate the relationship between the location of hepatocellular carcinoma(HCC) and the efficacy of transarterial chemoembolization(TACE).METHODS We evaluated 115 patients(127 nodules), excluding recurrent nodules, treated with TACE between January 2011 and June 2014. TACE efficacy was evaluated according to m RECIST. The HCC location coefficient was calculated as the distance from the central portal portion to the HCC center(mm)/liver diameter(mm) on multiplanar reconstruction images rendered(MPR) to visualize bifurcation of the right and left branches of the portal vein and HCC center. The HCC location coefficient was compared between complete response(CR) and non-CR groups in Child-Pugh grade A and B patients.RESULTS The median location coefficient of HCC among all nodules, the right lobe, and the medial segment was significantly higher in the CR group than in the non-CR group in the Child-Pugh grade A patients(0.82 vs 0.62, P < 0.001; 0.71 vs 0.59, P < 0.01; 0.81 vs 0.49, P < 0.05, respectively). However, there was no significant difference in the median location coefficient of the HCC in the lateral segment between in the CR and in the non-CR groups(0.67 vs 0.65, P > 0.05). On the other hand, in the Child-Pugh grade B patients, the HCC median location coefficient in each lobe and segment was not significantly different between in the CR and in the non-CR groups.CONCLUSION Improved TACE efficacy may be obtained for HCC in the peripheral zone of the right lobe and the medial segment in Child-Pugh grade A patients. | Izumi Miki Satoru Murata Fumio Uchiyama Daisuke Yasui Tatsuo Ueda Fumie Sugihara Hidemasa Saito Hidenori Yamaguchi Ryusuke Murakami Chiaki Kawamoto Eiji Uchida Shin-ichiro Kumita | 2017 | World Journal of Gastroenterology2017，23，35： | 8 |
| 3 | Endovascular treatment of post-laparoscopic pancreatectomy splenic arteriovenous fistula with splenic vein aneurysm显示文摘Splenic arteriovenous fistulas(SAVFs) with splenic vein aneurysms are extremely rare entities. There have been no prior reports of SAVFs developing after laparoscopic pancreatectomy. Here, we report the first case. A 40-year-old man underwent a laparoscopic, spleen-preserving, distal pancreatectomy for an endocrine neoplasm of the pancreatic tail. Three months after surgery, a computed tomography(CT) scan demonstrated an SAVF with a dilated splenic vein. The SAVF, together with the splenic vein aneurysm, was successfully treated using percutaneous transarterial coil embolization of the splenic artery, including the SAVF and drainage vein. After the endovascular treatment, the patient's recovery was uneventful. He was discharged on postoperative day 6 and continues to be well 3 mo after discharge. An abdominal CT scan performed at his 3-mo follow-up demonstrated complete thrombosis of the splenic vein aneurysm, which had decreased to a 40 mm diameter. This is the first reported case of SAVF following a laparoscopic pancreatectomy and demonstrates the usefulness of endovascular treatment for this type of complication. | Tatsuo Ueda Satoru Murata Akira Yamamoto Jin Tamai Yuko Kobayashi Chiaki Hiranuma Hiroshi Yoshida Shin-ichiro Kumita | 2015 | World Journal of Gastroenterology2015，21，25： | 5 |
| 4 | Levovist ultrasonography imaging in intracystic hemorrhage of simple liver cyst显示文摘The differential diagnosis between intracystic hemorrhage and cystadenocarcinoma of the liver is often difficult even with the use of various imaging modalities. A 73-year-old woman was admitted to our hospital with the complaint of right upper quadrant pain. Ultrasonography (US) demonstrated a heterogeneous echogenic cyst measuring 11 cm × 8 cm in size in S2 of the liver, indicated intracystic hemorrhage of simple liver cyst or cystadenocarcinoma, but the differential diagnosis was considerably difficult. Levovist (Schering, Berlin, Germany) US revealed no enhancement of the intracystic structures, suggesting a clot in the case of intracystic hemorrhage. An operation was performed and the resected lesion showed a solitary benign liver cyst, measuring 5.5 cm × 4.7 cm × 8.5 cm containing a large blood clot. The patient had an uneventful recovery after the surgery. Levovist US may play an important role in discrimination between intracystic hemorrhage of simple hepatic cysts and cystadenocarcinoma of the liver. | Tomoyuki Akiyama Masahiko Inamori Satoru Saito Hirokazu Takahashi Masato Yoneda Koji Fujita Toshio Fujisawa Yasunobu Abe Hiroyuki Kirikoshi Kensuke Kubota Michio Ueda Kuniya Tanaka Shinji Togo Norio Ueno Hiroshi Shimada Atsushi Nakajima | 2008 | World Journal of Gastroenterology2008，14，5： | 4 |
| 5 | Combination gene therapy of HGF and truncated type II TGF-β receptor for rat liver cirrhosis after partial hepatectomy显示文摘 | Satoru Ozawa Kazuhisa Uchiyama Mikihito Nakamori Kentaro Ueda Makoto Iwahashi Hikaru Ueno Yasuteru Muragaki Akira Ooshima Hiroki Yamaue | 2006 | Surgery2006，，4： | 2 |
| 6 | Therapeutic approaches targeting midkine suppress tumor growth and lung metastasis in osteosarcoma显示文摘 | Takanao Sueyoshi Hirofumi Jono Satoru Shinriki Kazutoshi Ota Tomoko Ota Masayoshi Tasaki Eri Atsuyama Toshitake Yakushiji Mitsuharu Ueda Konen Obayashi Hiroshi Mizuta Yukio Ando | 2011 | Cancer Letters2011，，1： | 1 |
| 7 | Differential Diagnosis of Hepatic Tumors: Value of Contrast-Enhanced Harmonic Sonography Using the Newly Developed Contrast Agent, Sonazoid显示文摘 | Hatanaka Kinuyo Kudo Masatoshi Minami Yasunori Ueda Taisuke Tatsumi Chie Kitai Satoshi Takahashi Shunsuke Inoue Tatsuo Hagiwara Satoru Chung Hobyung Ueshima Kazuomi Maekawa Kiyoshi | 2008 | Intervirology2008，，： | 1 |
| 8 | Transcath- eter Arterial Chemoembolization Based on Hepatic Hemodynam- ics for Hepatocellular Carcinoma 显示文摘 | Satoru Murata Takahiko Mine Tatsuo Ueda | 2013 | Scientific World Journal2013，13，： | 1 |
| 9 | Identification of CXCL5/ENA‐78 as a factor involved in the interaction between cholangiocarcinoma cells and cancer‐associated fibroblasts显示文摘 | Hirohisa Okabe Toru Beppu Mitsuharu Ueda Hiromitsu Hayashi Takatoshi Ishiko Toshiro Masuda Ryu Otao Hasita Horlad Kosuke Mima Keisuke Miyake Masaaki Iwatsuki Yoshifumi Baba Hiroshi Takamori Hirofumi Jono Satoru Shinriki Yukio Ando Hideo Baba | 2012 | Int J Cancer2012，，10： | 1 |
| 10 | Anti-High-Mobility Group Box Chromosomal Protein 1 Antibodies Improve Survival of Rats with Sepsis显示文摘 | Koichi Suda Yuko Kitagawa Soji Ozawa Yoshiro Saikawa Masakazu Ueda Masahito Ebina Shingo Yamada Satoru Hashimoto Shinji Fukata Edward Abraham Ikuro Maruyama Masaki Kitajima Akitoshi Ishizaka | 2006 | World Journal of Surgery2006，，9： | 1 |
| 11 | Portal hypertension with intra- and extrasplenic arterial aneurysms and large venous varices显示文摘 | Jun Ueda M.D. Ph.D. Satoru Takahashi Tomoaki Furukawa Yutaka Araki | 1995 | CardioVascular and Interventional Radiology1995，，4： | 1 |
| 12 | Accurate and simple method for quantification of hepatic fat content using magnetic resonance imaging: a prospective study in biopsy-proven nonalcoholic fatty liver disease显示文摘 | Tomoko Hatta Yasunari Fujinaga Masumi Kadoya Hitoshi Ueda Hiroaki Murayama Masahiro Kurozumi Kazuhiko Ueda Michiharu Komatsu Tadanobu Nagaya Satoru Joshita Ryo Kodama Eiji Tanaka Tsuyoshi Uehara Kenji Sano Naoki Tanaka | 2010 | Journal of Gastroenterology2010，，12： | 1 |
| 13 | The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR显示文摘 | Junko Sugatani Hiroyuki Kojima Akiko Ueda Satoru Kakizaki Kouichi Yoshinari Qi-Hui Gong Ida S. Owens Masahiko Negishi Tatsuya Sueyoshi | 2001 | Hepatology2001，，5： | 1 |
| 14 | Successful embolization of an intrahepatic portosystemic shunt using balloon-occluded retrograde transvenous obliteration:A case report显示文摘BACKGROUND A congenital intrahepatic portosystemic shunt(IPSVS)is a rare vascular abnormality that is characterized by an anomalous intrahepatic venous tract that connects the intrahepatic portal vein with the hepatic venous system.Hepatic encephalopathy is an indication for IPSVS embolization,which is technically challenging because rapid blood flow through shunts can induce the migration of embolization material to systemic veins.This case report discusses the efficacy of percutaneous balloon-occluded retrograde transvenous obliteration for treating patients with IPSVSs.CASE SUMMARY A 75-year-old woman presented with a six-month history of repeated hepatic encephalopathy due to an IPSVS without liver cirrhosis.We successfully embolized the IPSVS using percutaneous balloon-occluded retrograde transvenous obliteration with interlocking detachable coils.After the procedure,the patient exhibited no symptoms of hepatic encephalopathy for 14 mo.CONCLUSION Balloon-occluded retrograde transvenous obliteration with detachable coils can be effective for the endovascular treatment of an IPSVS. | Hidemasa Saito Satoru Murata Fumie Sugihara Tatsuo Ueda Daisuke Yasui Izumi Miki Hiromitsu Hayashi Shin-Ichiro Kumita | 2022 | World Journal of Clinical Cases2022，10，6： | 1 |
| 15 | Assessment of Gd-EOB-DTPA-enhanced MRI for HCC and dysplastic nodules and comparison of detection sensitivity versus MDCT显示文摘 | Tatsuo Inoue Masatoshi Kudo Mina Komuta Sosuke Hayaishi Taisuke Ueda Masahiro Takita Satoshi Kitai Kinuyo Hatanaka Norihisa Yada Satoru Hagiwara Hobyung Chung Toshiharu Sakurai Kazuomi Ueshima Michiie Sakamoto Osamu Maenishi Tomoko Hyodo Masahiro Okada Se | 2012 | Journal of Gastroenterology2012，，9： | 1 |
| 16 | Electro- chemical characteristics of direct dimethyl ether fuel ceils 显示文摘 | Satoru Ueda Mika Eguchi Katsuhiro Uno | 2006 | Solid State Ionics2006，，177： | 1 |
| 17 | BCR–ABL-specific CD4^(+) T-helper cells promote the priming of antigen-specific cytotoxic T cells via dendritic cells显示文摘The advent of tyrosine kinase inhibitor(TKI)therapy markedly improved the outcome of patients with chronic-phase chronic myeloid leukemia(CML).However,the poor prognosis of patients with advanced-phase CML and the lifelong dependency on TKIs are remaining challenges;therefore,an effective therapeutic has been sought.The BCR–ABL p210 fusion protein’s junction region represents a leukemia-specific neoantigen and is thus an attractive target for antigen-specific T-cell immunotherapy.BCR–ABL p210 fusion-region-specific CD4+T-helper(Th)cells possess antileukemic potential,but their function remains unclear.In this study,we established a BCR–ABL p210 b3a2 fusion-region-specific CD4+Th-cell clone(b3a2-specific Th clone)and examined its dendritic cell(DC)-mediated antileukemic potential.The b3a2-specific Th clone recognized the b3a2 peptide in the context of HLA-DRB1*09:01 and exhibited a Th1 profile.Activation of this clone through T-cell antigen receptor stimulation triggered DC maturation,as indicated by upregulated production of CD86 and IL-12p70 by DCs,which depended on CD40 ligation by CD40L expressed on b3a2-specific Th cells.Moreover,in the presence of HLA-A*24:02-restricted Wilms tumor 1(WT1)235–243 peptide,DCs conditioned by b3a2-specific Th cells efficiently stimulated the primary expansion of WTI-specific cytotoxic T lymphocytes(CTLs).The expanded CTLs were cytotoxic toward WT1235–243-peptide-loaded HLA-A*24:02-positive cell lines and exerted a potent antileukemic effect in vivo.However,the b3a2-specific Th-clone-mediated antileukemic CTL responses were strongly inhibited by both TKIs and interferon-α.Our findings indicate a crucial role of b3a2-specific Th cells in leukemia antigen-specific CTL-mediated immunity and provide an experimental basis for establishing novel CML immunotherapies. | Norihiro Ueda Rong Zhang Minako Tatsumi Tian-YiLiu Shuichi Kitayama YutakaYasui Shiori Sugai Tatsuaki Iwama Satoru Senju Seiji Okada Tetsuya Nakatsura Kiyotaka Kuzushima Hitoshi Kiyoi Tomoki Naoe Shin Kaneko Yasushi Uemura | 2018 | Cellular & Molecular Immunology2018，15，1： | 1 |
| 18 | Solid state syntheses of 12SrO · 7Al2O3 and formation of high density oxygen radical anions, O- andO^2- 显示文摘 | Katsuro Hayashi Naoto Ueda Satoru Matsuishi | 2008 | Chemistry of Materials2008，20，： | 1 |
| 19 | Factors influencing the length of emergency room stay and hospital stay in non-fatal bicycle accidents:A retrospective analysis显示文摘Purpose:Lengthy hospitalization places a burden on patients and healthcare resources.However,the factors affecting the length of hospital stay(LHoS)and length of emergency room stay(LERS)in non-fatal bicycle accidents are currently unclear.We investigated these factors to inform efforts to minimize hospitalization.Methods:We performed a retrospective analysis of data from non-fatal injured bicyclists admitted to the Emergency and Critical Care Center at Kyoto Medical Center between January 2012 and December 2016.We measured LHoS,LERS,mechanism of injury,head injury prevalence,polytrauma,operations performed,injury severity score(ISS),abbreviated injury scale(AIS)score,maximum AIS score,and trauma and injury severity score probability of survival.We conducted multiple regression analysis to determine predictors of LHoS and LERS.Results:Within the study period,82 victims met the inclusion and exclusion criteria and were included.Mean age was(46.0±24.7)years.Overall mean LHoS was(16.8±25.2)days,mean LERS was(10.6±14.7)days,median ISS was 9(interquartile range(IQR):3-16),median maximum AIS was 3(IQR:1-4),and median trauma and injury severity score probability of survival was 98.0%(IQR:95.5%-99.6%).Age,maximum AIS,ISS,and prevalence of surgery were significantly greater in long LHoS and LERS group compared with short LHoS and LERS group(p<0.05).Performance of surgery independently explained LHoS(p=0.0003)and ISS independently explained LERS(p=0.0009).Conclusion:Surgery was associated with long hospital stays and ISS was associated with long emergency room stays.To improve the quality life of the bicyclists,preventive measures for reducing injury severity or avoiding injuries needing operation are required. | Satoru Beppu Masahito Hitosugi Tadahiro Ueda Mirae Koh Kei Nishiyama | 2021 | Chinese Journal of Traumatology2021，24，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员